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Balloon Sheaths for Gastrointestinal Guidance and Access: A Preliminary Phantom Study
Xu He,Ji Hoon Shin,Hyo-Cheol Kim,Cheol Woong Woo,Sung Ha Woo,Won-Chan Choi,Jong-Gyu Kim,Jin-Oh Lim,Tae-Hyung Kim,Chang Jin Yoon,강위창,Ho-Young Song 대한영상의학회 2005 Korean Journal of Radiology Vol.6 No.3
Objective: We wanted to evaluate the feasibility and usefulness of a newly designed balloon sheath for gastrointestinal guidance and access by conducting a phantom study. Materials and Methods: The newly designed balloon sheath consisted of an introducer sheath and a supporting balloon. A coil catheter was advanced over a guide wire into two gastroduodenal phantoms (one was with stricture and one was without stricture); group I was without a balloon sheath, group ll was with a deflated balloon sheath, and groups III and IV were with an inflated balloon and with the balloon in the fundus and body, respectively. Each test was performed for 2 minutes and it was repeated 10 times in each group by two researchers, and the positions reached by the catheter tip were recorded. Results: Both researchers had better performances with both phantoms in order of group IV, III, II and I. In group IV, both researchers advanced the catheter tip through the fourth duodenal segment in both the phantoms. In group I, however, the catheter tip never reached the third duodenal segment in both the phantoms by both the researchers. The numeric values for the four study groups were significantly different for both the phantoms (p < 0.001). A significant difference was also found between group III and IV for both phantoms (p < 0.001). Conclusion: The balloon sheath seems to be feasible for clinical use, and it has good clinical potential for gastrointestinal guidance and access, particularly when the inflated balloon is placed in the gastric body.
흰쥐에서 난소제거술로 유발시킨 골다공증에 유효한 기능성성분을 배합한 P 식이의 효능
서지혜(Ji He Seo),임병우(Beong Ou Lim),강순아(Sun A Kang),한인권(In Kwon Han),박동기(Dong Ki Park) 대한폐경학회 2002 대한폐경학회지 Vol.8 No.1
N/A The aim of this investigation was to examine the effects of serum alkaline phosphatase, phosphorous, calcium and bone mineral density in P diet on osteoporosis induced by ovariectomy in rats. Female Sprague-Dawely 20 rats of weighting 249±29g, were divided into four groups including the sham operation groups (5 heads) and ovariectomy groups (15 heads). They were fed low calcium diets for 4 weeks after experimental operation and 12 more weeks. The experimental group received a daily administration of P diet for 4 and 8 weeks after oophorectomy. Therefore, we measured levels of calcium, alkaline phophatase (ALP), phosphorous, trabecular density of tibia, ash weights in tibia and femur. The level of serum ALP of P diet was showed a significant decrease in comparison with sham group. Calcium and phosphorous were almost not changed between three groups. The weight of tibia and femur of P diet was increased in comparison with sham group in 8 week after oophorectomy. The trabecular bone density in ovariectomy group showed significant decrease in comparison with sham. Those in P diet-treated showed significant increase in comparison with sham after oophorectomy. Accordingly to the above results, effects of the P diet on the rat osteoporosis showed a efficiency in elevation of bone density by increasing bone weight by ovariectomy. So P diet can be used for preventing and curing of the postmenopausal osteoporosis, as for it's effects, continuous clinical study is needed.
Peripheral Effect of α-Melanocyte-stimulating Hormone on Fatty Acid Oxidation in Skeletal Muscle
An, Juan Ji,Rhee, Yumie,Kim, Se Hwa,Kim, Dol Mi,Han, Dong-He,Hwang, Jung Hee,Jin, Young-Jun,Cha, Bong Soo,Baik, Ja-Hyun,Lee, Won Tae,Lim, Sung-Kil American Society for Biochemistry and Molecular Bi 2007 The Journal of biological chemistry Vol.282 No.5
Yu, Sung-Lim,An, Yong Jin,Yang, Hey-ji,Kang, Mi-Sun,Kim, Ho-Yeol,Wen, He,Jin, Xing,Kwon, Hyuk Nam,Min, Kyung-Jin,Lee, Sung-Keun,Park, Sunghyouk American Chemical Society 2013 JOURNAL OF PROTEOME RESEARCH Vol.12 No.4
<P>Alterations in metabolic pathways are gaining attention as important environmental factors affecting life span, but the determination of specific metabolic pathways and enzymes involved in life span remains largely unexplored. By applying an NMR-based metabolomics approach to a calorie-restricted yeast (<I>Saccharomyces cerevisiae</I>) model, we found that alanine level is inversely correlated with yeast chronological life span. The involvement of the alanine-metabolizing pathway in the life span was tested using a deletion mutant of <I>ALT1</I>, the gene for a key alanine-metabolizing enzyme. The mutant exhibited increased endogenous alanine level and much shorter life span, demonstrating the importance of <I>ALT1</I> and alanine metabolic pathways in the life span. <I>ALT1</I>’s effect on life span was independent of the TOR pathway, as revealed by a <I>tor1</I> deletion mutant. Further mechanistic studies showed that <I>alt1</I> deletion suppresses cytochrome <I>c</I> oxidase subunit 2 expression, ultimately generating reactive oxygen species. Overall, <I>ALT1</I> seems critical in determining yeast life span, and our approach should be useful for the mechanistic studies of life span determinations.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jprobs/2013/jprobs.2013.12.issue-4/pr300979r/production/images/medium/pr-2012-00979r_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/pr300979r'>ACS Electronic Supporting Info</A></P>
Expression and Regulation of Osteoprotegerin in Adipose Tissue
An, Juan-Ji,Han, Dong-He,Kim, Dol-Mi,Kim, Se-Hwa,Rhee, Yumie,Lee, Eun-Jig,Lim, Sung-Kil Yonsei University College of Medicine 2007 Yonsei medical journal Vol.48 No.5
<P><B>Purpose</B></P><P>Osteoprotegerin (OPG), a potent inhibitor of osteoclastic bone resorption, has a variety of biological functions that include anti-inflammatory effects. Adipocytes and osteoblasts share a common origin, and the formation of new blood vessels often precedes adipogenesis in developing adipose tissue microvasculature. We examined whether OPG is secreted from adipocytes, therefore contributing to the prevention of neovascularization and protecting the vessels from intimal inflammation and medial calcification.</P><P><B>Materials and Methods</B></P><P>The mRNA expression of OPG and receptor activator of NF-κB ligand (RANKL) was measured in differentiated 3T3L1 adipocytes and adipose tissues.</P><P><B>Results</B></P><P>OPG mRNA expression increased with the differentiation of 3T3L1 adipocytes, while RANKL expression was not significantly altered. OPG mRNA was expressed at higher levels in white adipose tissue than in brown adipose tissue and was most abundant in the epididymal portion. In differentiated 3T3L1 adipocytes, Rosiglitazone and insulin reduced the OPG/RANKL expression ratio in a dose- and time-dependent manner. In contrast, tumor necrosis factor-α (TNF-α) increased the expression of both OPG and RANKL in a time-dependent manner. The OPG/RANKL ratio was at a maximum two hours after TNF-α treatment and then returned to control levels. Furthermore, OPG was abundantly secreted into the media after transfection of OPG cDNA with Phi C31 integrase into 3T3L1 cells.</P><P><B>Conclusion</B></P><P>Our results indicate that OPG mRNA is expressed and regulated in the adipose tissue. Considering the role of OPG in obesity-associated inflammatory changes in adipose tissue and vessels, we speculate that OPG may have both a protective function against inflammation and anti-angiogenic effects on adipose tissue.</P>
Production of porphyrin intermediates in<i>Escherichia coli</i>carrying soil metagenomic genes
Kim, Jin-Seog,Lim, He Kyoung,Lee, Myung Hwan,Park, Ji-Hye,Hwang, Eul Chul,Moon, Byung Ju,Lee, Seon-Woo Oxford University Press 2009 FEMS microbiology letters Vol.295 No.1
<P>Tetrapyrrole pigments are important components of many biological processes, and many of them are produced primarily by microorganisms. We constructed a soil metagenomic library using rice paddy soil consisting of 107 000 fosmid clones with an average DNA insert size of 35 kb. We isolated a clone carrying genes in the porphyrin biosynthetic pathway based on function-driven screening of the library. Through subcloning and mutagenesis analysis, we showed that two genes from soil metagenome, gtrA and hemC, were responsible for pigmentation in Escherichia coli. HPLC and LC-MS analysis of the purified pigments from E. coli carrying pSY143 identified coproporphyrin III without metal as a major compound as well as some other minor porphyrin intermediates. As gtrA and hemC encode glutamyl-tRNA reductase and porphobilinogen deaminase, respectively, which are enzymes involved in the C5 biosynthetic pathway for porphyrin intermediates, our results suggest that hemL, hemB, hemD, and hemE should be provided by the E. coli chromosome to generate a hybrid biosynthetic pathway for production of porphyrin intermediates using E. coli and metagenomic genes.</P>
만성 부비동염으로 오인된 안와를 침범한 부비동 미만성 거대 B 세포 림프종 1예
이영지,임지혜,유혜린,Young Ji Lee,Ji He Lim,Helen Lew 대한안과학회 2011 대한안과학회지 Vol.52 No.11
Purpose: To report a case of paranasal diffuse large B-cell lymphoma with orbital invasion extending to the intracranial lesion. Case summary: A 48-year-old male with chronic sinusitis visited our clinic for recent proptosis of his right eye, intermittent pain around the eyeball and headache. On a magnetic resonance image (MRI), a mass-like lesion was observed in the right frontal sinus, and its infiltration into the superior inner portion of the right orbital extraconal space and right intracranial dural space was suggestive of generalized inflammatory mucosal thickening in the paranasal sinuses. An incisional biopsy of the sinonasal tract was immediately performed. The pathology confirmed diffuse large B-cell lymphoma. Conclusions: A mass involving the paranasal sinus and orbit can masquerade as chronic sinusitis. Because diffuse large B-cell lymphoma is rare and is a high-grade aggressive malignant lymphoma, the possibility for diagnosis must be considered. J Korean Ophthalmol Soc 2011;52(11):1351-1356
Sun Young Lee,Yoo-Sun Kim,Ji Ye Lim,Namsoo Chang,Myung-Hee Kang,Se-Young Oh,He-Jin Lee,Hyesook Kim,Yuri Kim 대한지역사회영양학회 2014 Nutrition Research and Practice Vol.8 No.3
BACKGROUND/OBJECTIVES: The traditional Korean diet is plant-based and rich in antioxidants. Previous studies have investigated the potential health benefits of individual nutrients of Korean foods. However, the cumulative effects of a Korean diet on inflammation remain poorly understood. Therefore, the aim of this study was to investigate the anti-inflammatory effects of a plant-based Korean diet. MATERIALS/METHODS: Using data from the Fifth Korean National Health and Nutrition Examination Survey, 75 individual plant food items were selected which represent over 1% of the total diet intake of the Korean diet. These items were classified into ten different food groups, and the vegetable (Veg) and fruit (Fruit) groups were studied based on their high antioxidant capacity. For comparison, a mixture of all ten groups (Mix) was prepared. To produce a model of inflammation with which to test these Veg, Fruit, and Mix plant-based Korean food extracts (PKE), RAW264.7 macrophages were treated with lipopolysaccharide (LPS). RESULTS: Levels of nitric oxide (NO) and prostaglandin E2 (PGE2), as well as protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were found to be lower following PKE treatment. Furthermore, PKE treatment was found to suppress tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) via the nuclear transcription factor kappa-B (NF-κB) signaling pathway. Overall, the Mix group exhibited the greatest anti-inflammatory effects compared with Veg and Fruit PKE group. CONCLUSIONS: Inhibition of LPS-induced pro-inflammatory mediators by the PKE tested was found to involve an inhibition of NF-kB activation. Moreover, PKE tested have the potential to ameliorate various inflammation-related diseases by limiting the excessive production of pro-inflammatory mediators.