Modulation of Gene Expressions and Enzyme Activities of Methionine Sulfoxide Reductases by Cold, Aba or High Salt Treatments in Arabidopsis

Oh, Jee-Eun,Hong, Suk-Whan,Lee, Yunsook,Koh, Eun-Ji,Kim, Kideok,Seo, Youngwon,Chung, Namhyun,Jeong, Moonsoo,Chang,Chang, Cheolseong,Lee, Byoungcheon,Kim, Kyoung Heon,Lee, Kwangwon,Lee, Hojoung 생명자원연구 2005 생명자원연구 Vol.13 No.-

忠南大生의 理想的 人間像에 대한 意識調査硏究

張大熙,鄭弘錫,崔智銀 충남대학교 1989 學生生活硏究 Vol.16 No.-

대구지역 성인의 식생활과 건강에 관련된 생활습관에 관한 조사

이지숙,서창순,이옥주,조성희 대구효성가톨릭대학교 응용과학연구소 1994 응용과학연구논문집 Vol.3 No.-

In this study we investigated nutritional and anthropometric status, food, exercise, smoking and drinking habits in 50 men and 186 women living in Taegu. More than 80% of subjects were college students at their twenties. Average heights were 172.5cm for men and 162.9cm for women. Average weights were 67.0kg and 51.3kg for men and women, respectively. Av-rage BMIs were 22.6 and 19.9 for men and women. More than half of men did exercise either regularly or irregularly, but 64% of women did not exercise at all. Smoking habit was sharply contrasted between men and women as 56.5% vs 0.5%, while drinking habit was not very dif-ferent between them as 59.4% vs 50.8%. Twelve percent of drinkers was heavy habitual ones as five times per week. Food habits of subjects were generally not good. More than 40% of subjects had food habit score with no higher than 21. Analysis of 240hour recall reveals that fat, calcium intakes were higher but vitamins A and C and dietary fiber intakes were lower than Korean RDA and average Korean adult intakes shown in national nutrition survey for 1990. It is concluded that effective education programs for good food habit and exercise are needed as well as for correction of smoking and drinking habits.

녹내장에서 파장가변 빛간섭단층촬영을 이용한 황반부 신경절세포층의 진단력

이응석(Eung Suk Lee),장지호(Jee Ho Chang),박태관(Tae Kwan Park),온영훈(Young Hoon Ohn),박가희(Ka Hee Park) 대한안과학회 2016 대한안과학회지 Vol.57 No.6

목적: 녹내장 환자에서 파장가변 빛간섭단층촬영(DRI OCT-1, Topcon Co., Tokyo, Japan)을 이용하여 황반부 신경절세포복합체 (macular ganglion cell complex, mGCC)와 황반 신경절세포 및 내망상층(macular ganglion cell inner plexiform layer, mGCIPL)의 두께를 분석해 보고 두 방법의 진단력을 확인해 보고자 한다. 대상과 방법: 2014년 8월부터 2015년 7월까지 본원에 내원한 109명 109안을 대상으로 파장가변 빛간섭단층촬영을 이용하여 mGCC와 mGCIPL의 두께를 측정하여 정상군, 초기, 진행된 녹내장군 간의 차이를 확인해 보고, 각각의 진단력, 민감도, 특이도를 구하여 유두주위 망막신경섬유층(circumpapillary retinal nerve fiber layer, cpRNFL) 두께 분석 방법과 비교해 보았다. 결과: 초기와 진행된 녹내장에 대한 area under the curve를 비교해 보았을 때 mGCC는 0.78과 0.99 cpRNFL과 유의한 차이가 없었으나 mGCIPL은 0.70으로 cpRNFL과 초기 녹내장을 진단하는 경우 cpRNFL의 진단력과 유의한 차이를 나타내었고(p=0.018),녹내장 진단에 대한 민감도와 특이도는 mGCC가 0.95와 0.97, mGCIPL은 0.92와 0.97로 측정되었다. 결론: 두 가지 방법 모두 녹내장을 진단하는 데 있어 높은 민감도와 특이도를 지닌 진단 방법이나, mGCC의 두께 분석 방법이 녹내장의 초기 변화를 감지하는 데 보다 나은 진단력을 가지고 있는 것으로 생각된다. <대한안과학회지 2016;57(6):941-950> Purpose: To evaluate diagnostic ability of macular ganglion cell complex (mGCC), macular ganglion cell inner plexiform layer (mGCIPL) measurements in glaucoma using swept source deep range imaging optical coherence tomography (DRI OCT-1, Topcon Co., Tokyo, Japan). Methods: From August of 2014 to July of 2015, 109 eyes of 109 subjects were assessed for the average thickness and sectional thickness of both mGCC and mGCIPL to determine whether there exists any significant difference among advanced stage glaucoma group, early stage glaucoma group and normal group in Swept source OCT. Comparisons were also made between the above measurements and circumpapillary retinal nerve fiber layer (cpRNFL) thickness measurements in their diagnostic accuracy, sensitivity, and specificity. Results: The diagnostic ability of mGCC based-mean thickness value (area under the curve [AUC] = 0.78/ 0.99) in detecting early stage glaucoma group as well as advanced stage group was not significantly different from that of cpRNFL thickness measurement. However, there was a significant difference in thickness between mGCIPL (AUC = 0.70) and cpRNFL in early stage glaucoma groups (p = 0.018). The sensitivities and specificities of mGCC were 0.95/0.97, and those of mGCIPL were 0.92/0.97, respectively. Conclusions: The two swept source OCT based methods measuring retinal ganglion cell layer thickness appeared to have a good diagnostic accuracy, high sensitivity and specificity in detecting glaucomatous eyes. Nevertheless, of the two methods, mGCC thickness measurement was more efficient in detecting early glaucomatous changes. J Korean Ophthalmol Soc 2016;57(6):941-950

대장수술 후에 발생한 급성신부전의 위험인자

이혜미,황창재,김재황,김흥대,박대팔,서일숙,송선옥,김세연,이덕희,지대림 영남대학교 의과대학 2007 Yeungnam University Journal of Medicine Vol.24 No.2

연구 배경 : 급성 신부전은 술 후 발생할 수 있는 합병증 중에서 사망률은 큰 영향을 줄 수 있으므로 이 연구를 통해 위험인자를 알아보려고 한다. 재료 및 방법 : 2004년 1월부터 2006년 12월까지 3년간 영남대학교 의과대학 부속병원에서 대장 수술을 받은 570명의 환자들을 대상으로 하였다. 환자들의 성별과 연령, 미국 마취과학회 신체등급, 동반질환, 수술의 종류, 응급수술의 여부, 수술 시간, 재수술의 여부, 술 중의 투약 상황, 술 후에 자가 통증 조절기에 사용한 약제, 술 중에 저혈압의 유무, 수혈 여부, 술 후 기계적 환기를 시행한 경우를 비교하였다. 결과 : 비교 결과에서 성별과 수술의 종류, 응급 수술의 여부, 개복여부 등에는 유의한 차이를 보이지 않았다. 반면 환자의 나이와 수술 시간, 재수술의 여부, 술중에 이뇨제 등을 사용한 경우, 술 중에 저혈압의 유무, 술 후에 기계적 환기를 시행한 경우 등에는 유의한 차이를 보였다. 결론 : 이상의 결과로 급성신부전의 원인은 어느 한 가지라고 하기 보다는 위험인자에 얼마나 노출되어 있는가가 결정하는 것 같고, 그 원인들이 모여서 상승효과를 내는 것 같다. 그러므로 수술 전부터 많은 위험에 노출된 환자는 술 중 더 적극적인 감시를 시행하여 수술 후의 합병증 발생을 줄이는 노력을 기울여야 하겠다. Background : Acute renal failure is one of the leading causes of postoperative morbidity and mortality. The purpose of this study was to determine the risk factors that are associated with acute renal failure after colorectal surgery. Materials and Methods : Five hundred seventy patients who operated colorectal surgery at the Yeungnam University Medical Center over three years from 2004 to 2006 were enrolled in this study. The effects of gender, age, ASA classification, concomitant disease, surgery type and duration, reoperation, urogenital manipulation, medication, hypotension, hypovolemia, transfusion, and postoperative ventilatory care on the occurrence of acute renal failure after colorectal surgery were studied. Results : The major risk factors of acute renal failure after colorectal surgery were age of patients (P=0.003), ASA classification (P<0.001), concomitant disease (P<0.001), duration of the time surgery (P=0.034), reoperation (P=0.001), use of intraoperative diuretics (P=0.005), use of postoperative diuretics (P<0.001), intraoperative hypotension (P=0.018), intraoperative transfusion (P<0.001), postoperative transfusion (P<0.001), and postoperative ventilatory care (P=0.001). Conclusion : Multiple factors cause synergistic effects on the development of acute renal failure after colorectal surgery. Therefore, efforts to reduce the risk factors associated with acute renal failure are needed. In addition, intensive postoperative care should be provided to all patients.

한국 폐경여성에서 osteoprotegerin (OPG)-receptor activator of NF-kB Ligand (RANKL) 유전자 다형성과 호르몬치료 후 골밀도 변화 사이의 연관성

김정구 ( Jung Gu Kim ),구승엽 ( Seung Yup Ku ),지병철 ( Byung Chul Jee ),서창석 ( Chang Suk Suh ),김석현 ( Seok Hyun Kim ),최영민 ( Young Min Choi ),문신용 ( Shin Yong Moon ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.6

목적: 한국 폐경여성에서 OPG와 RANKL 유전자 다형성양상과 호르몬치료 후 골밀도 및 순환계내 OPG, sRANKL 농도 변화사이에 연관성이 있는가를 분석하고자 하였다. 연구 방법: 주기적 호르몬치료를 1년간 받은 자연폐경여성 236명에서 PCR-RFLP, 염시서열분석으로 OPG T245G, G1181C 다형성양상과 RANKL rs2277438 A/G 다형성양상을 분석하고 혈청 OPG, sRANKL, BAP, OST, CTX, calcitonin, PTH, 칼슘, 인 농도를 효소면역법, 면역측정법, 원자흡광법으로, 요추 및 대퇴 근위부에서의 골밀도를 DXA로 측정하였다. 결과: OPG와 RANKL 유전자형 및 이들의 복합 유전자형에 따른 호르몬 치료를 1년간 시행한 후의 골밀도 변화율에는 차이가 없었고 호르몬치료 반응군에서의 이러한 유전자형의 분포양상은 비반응군 (골밀도가 3% 이상 치료 전보다 감소된 경우)에서의 분포와 차이가 없었다. RANKL 유전자 다형성의 GG 유전자형에서 호르몬치료 후 혈청 sRANKL이 변화율아 AA, AG 유전자형의 변화율보다 유의하게 높았다 (p<0.05). 그러나 다른 OPG 유전자다형성의 단일 또는 복합 유전자형에 따른 OPG를 포함한 다른 골대사인자의 차이는 없었다. 결론: 한국 폐경여성에서 OPG T245G, G1181C 다형성과 RANKL rs2277438 A/G 다형성은 호르몬 치료 후 골밀도 변화양상과 연관성이 없으나 이 중 RANKL다형성은 순환계에서의 sRANKL 농도에 영향을 미친다. Objective: To investigate the relationship of polymorphisms in osteoprotegerin (OPG)-receptor activator of NF-kB ligand (RANKL) gene to changes in circulating OPG and soluble RANKL (sRANKL) levels and in bone mineral density (BMD) after hormone therapy (HT) in postmenopausal Korean women. Methods: The OPG T245G, and G1181C polymorphisms and RANKL rs2277438 A/G polymorphism were analyzed by polymerase chain reaction-restriction fragment length polymorphsim (PCR-RFLP) or direct DNA sequencing in 236 postmenopausal Korean women receiving sequential HT for 1 year. Serum OPG, sRANKL, bone alkaline phosphatase, CrossLaps (CTX), osteocalcin, clacitonin, parathyroid hormone, calicum, and phophorus were measured using enzyme-linked immunosorbent assay (ELISA), immunoassay and atomic absorptiometry respectively. BMD at the lumbar spine and proximal femur was determined by dual energy X-ray absorptiometry. Results: The annual percent changes of BMD were not associated with single or combined genotypes of OPG and RANKL gene polymorphisms, and the distributions of these genotypes were not different between HT-responders and HT-nonresponders (women who lose more than 3% of bone mass per year). After HT of 6 months, change in serum sRANKL levels was significantly higher in GG genotype than in other genotype of RANKL gene polymorphism. No differences in the 6 month changes of other bone turnover markers including circulating OPG levels after HT were noted across single OPG genotype and combined genotypes of OPG and RANKL polymorphisms. Conclusions: The OPG T245G, and G1181C polymorphisms, and RANKL polymorphism did not associate with change in BMD after HT in postmenopausal Korean women, and RANKL polymorphism affects change in circulating sRANKL levels after HT.

Bladder filling variations during concurrent chemotherapy and pelvic radiotherapy in rectal cancer patients

Jee Suk Chang,Hong In Yoon,Hye Jung Cha,Yoonsun Chung,Yeona Cho,Ki Chang Keum,Woong Sub Koom 대한방사선종양학회 2013 Radiation Oncology Journal Vol.31 No.1

Purpose: To describe the early experience of analyzing variations and time trends in bladder volume of the rectal cancer patients who received bladder ultrasound scan. Materials and Methods: We identified 20 consecutive rectal cancer patients who received whole pelvic radiotherapy (RT) and bladder ultrasound scan between February and April 2012. Before simulation and during the entire course of treatment, patients were scanned with portable automated ultrasonic bladder scanner, 5 times consecutively, and the median value was reported. Then a radiation oncologist contoured the bladder inner wall shown on simulation computed tomography (CT) and calculated its volume. Results: Before simulation, the median bladder volume measured using simulation CT and bladder ultrasound scan was 427 mL (range, 74 to 1,172 mL) and 417 mL (range, 147 to 1,245 mL), respectively. There was strong linear correlation (R = 0.93, p < 0.001) between the two results. During the course of treatment, there were wide variations in the bladder volume and every time, measurements were below the baseline with statistical significance (12/16). At 6 weeks after RT, the median volume was reduced by 59.3% to 175 mL. Compared to the baseline, bladder volume was reduced by 38% or 161 mL on average every week for 6 weeks. Conclusion: To our knowledge, this study is the first to prove that there are bladder volume variations and a reduction in bladder volume in rectal cancer patients. Moreover, our results will serve as the basis for implementation of bladder training to patients receiving RT with full bladder.

Bladder filling variations during concurrent chemotherapy and pelvic radiotherapy in rectal cancer patients: early experience of bladder volume assessment using ultrasound scanner

Chang, Jee Suk,Yoon, Hong In,Cha, Hye Jung,Chung, Yoonsun,Cho, Yeona,Keum, Ki Chang,Koom, Woong Sub The Korean Society for Radiation Oncology 2013 Radiation Oncology Journal Vol.31 No.1

Purpose: To describe the early experience of analyzing variations and time trends in bladder volume of the rectal cancer patients who received bladder ultrasound scan. Materials and Methods: We identified 20 consecutive rectal cancer patients who received whole pelvic radiotherapy (RT) and bladder ultrasound scan between February and April 2012. Before simulation and during the entire course of treatment, patients were scanned with portable automated ultrasonic bladder scanner, 5 times consecutively, and the median value was reported. Then a radiation oncologist contoured the bladder inner wall shown on simulation computed tomography (CT) and calculated its volume. Results: Before simulation, the median bladder volume measured using simulation CT and bladder ultrasound scan was 427 mL (range, 74 to 1,172 mL) and 417 mL (range, 147 to 1,245 mL), respectively. There was strong linear correlation (R = 0.93, p < 0.001) between the two results. During the course of treatment, there were wide variations in the bladder volume and every time, measurements were below the baseline with statistical significance (12/16). At 6 weeks after RT, the median volume was reduced by 59.3% to 175 mL. Compared to the baseline, bladder volume was reduced by 38% or 161 mL on average every week for 6 weeks. Conclusion: To our knowledge, this study is the first to prove that there are bladder volume variations and a reduction in bladder volume in rectal cancer patients. Moreover, our results will serve as the basis for implementation of bladder training to patients receiving RT with full bladder.

한국 폐경 여성에서 호르몬 대체요법시 치료 제제에 따른 유방 치밀도의 변화

이동윤 ( Dong Yun Lee ),김상돈 ( Sang Don Kim ),최영식 ( Young Sik Choi ),지병철 ( Byung Chul Jee ),구승엽 ( Seung Yup Ku ),서창석 ( Chang Suk Suh ),최영민 ( Young Min Choi ),김정구 ( Jung Gu Kim ),문신용 ( Shin Yong Moon ),김석현 대한폐경학회 2003 대한폐경학회지 Vol.9 No.3

목적 : 본 연구는 한국 폐경 여성에서 호르몬 대체요법과 연관된 유방 치밀도의 변화를 평가하기 위하여 시행되었다. 연구 대상 및 방법 : 본 연구에서는 호르몬 대체요법을 시행 받은 폐경 여성 294명을 대상으로 치료 제제에 따라 매일 tibolone 2.5 mg을 투여 받은 군(n=119), conjugated equine estrogen(CEE) 0.625 mg/medroxyprogesterone(MPA) 2.5 mg으로 지속적 병합요법을 시행 받은 군(n=93), CEE 0.625 mg으로 단독요법을 시행 받은 군(n=40) 및 raloxifene 30 mg을 투여 받은 군(n=42)으로 대변하였으며, 호르몬 대체요법을 시행 받지 않은 폐경 여성 36명을 대조군으로 설정하였다. 대상 여성에서 유방촬영술(mammography)을 호르몬 치료 시작 전과 치료 1년 후에 각각 시행한 후 유방 치밀도(breast density)의 변화를 후향적으로 각 군에서 비교 관찰하였다. 결과 : 대상 여성의 연령, 분만력, 폐경 연령, 폐경 후 기간, 체중, 신장 및 체질량지수(BMI)는 각 군간에 통계학적으로 유의한 차이가 없었다. 호르몬 대체요법 1년 후 유방촬영술에서 관찰된 유방 치밀도의 증가는 지속적 병합요법군에서 25.8%(24/93)로서 tibolonerns의 11.8%(14/119), raloxifene군의 2.4%(1/42)에 비하여 각각 유의하게 높았다(p<0.05). 결론 : 본 연구 결과 호르몬 대체요법을 시행 받은 폐경 여성에서 관찰된 유방 치밀도의 변화는 치료 제제에 따라 상이하다는 것을 확인하였으며, 특히 progestogen을 이용한 지속적 병합요법이 유방 치밀도 변화에 중요한 영향을 미치는 것으로 사료된다. Objective : This study was performed to evaluate the mammographic changes in breast density that were associated with hormone replacement therapy(HRT) in Korean postmenopausal women. Materials and Methods : In this retrospective study, 294 postmenopausal women were classified as the four groups according to the regimen of HRT; a daily treatment of tibolone 2.5 mg(n=119), conjugated equine estrogen(CEE) 0.625 mg/medroxyprogeserone(MPA) 2.5 mg(n=93), CEE 0.625 mg only(n=40) or raloxifene 60 mg(n=42), and they were compared with the control group of postmenopausal non-HRT users(n=36). Mammography was performed at baseline and after 1 year of treatment, and the incidence of changes in mammographic density was evaluated and compared among the groups. Results: There were no significant differences in age, parity, age at menopause, years after menopause, weight, height, and body mass index(BMI) among the groups. The risk of an increase in mammographic density after 1 year of treatment was significantly higher in CEE/MPA group(24/93, 25.8%), compared with tibolone(14/119, 11.8%) and raloxifene(1/42, 2.4%) group(p<0.05). Conclusion : This study showed that the changes in mammographic breast density related to postmenopausal HRT were dependent on the regimen of HRT. The continuous administration of progestogen as a component of the combined HRT seems to affect the breast density significantly.

아이스하키 공격수와 수비수간의 체성분, 체격, 체력별 수준 및 등속성 회전력에 대한 비교연구

지용석(Yong Suk Jee),김명화(Myung Hwa Kim),유재현(Jae Hyun Yoo),이창영(Chang Young Lee),변재종(Jae Jong Byun),현광석(Kwang Suk Hyun),이창규(Chang Kyu Lee),유광욱(Kwang Wook Yoo) 한국체육교육학회 2002 한국체육교육학회지 Vol.7 No.1

The purpose of this study was to investigate the difference in physique, physical fitness and isokinetic strength of Forward(FW=10) and Defense(DF=9) in Korean professional ice hockey players. The subjects selected for this study were composed of nineteen male professional ice hockey players. They didn`t have any previous medical or physical problems. They were measured physique, body composition, physical fitness and isokinetic knee strength test. All of data were analyzed utilizing independent t-test by SPSS 10.0. The level of statistical significance was set at p<.05. On the basis of the results analyzed in this study, the conclusion was as follow: 1. The variables of body composition were no significant differences between ice hockey FW players and DF players. 2. In physique variables, the height of ice hockey DF players was significant higher than FW players and remainders of physique variables were no significant differences between both groups. 3. The level of physical fitness variables were no significant differences between ice hockey FW players and DF players. 4. In knee isokinetic strength test, the peak torques of flexor and extensor in a left knee joint of ice hockey between DF and FW players were not significant different, but the peak torques of flexor and extensor in a right knee joint of ice hockey DF players were significantly higher than those of FW players. In conclusion, ice hockey players have the difference in physique and isokinetic knee strength between FW and DF players. Therefore, it is very important that the player should be trained up considering their characteristics according to the players` position.