국내 혈액질환 환자에서 침습성 아스페르길루스증의 구제치료로서 Voriconazole의 효과와 안전성

권재철,김시현,최수미,최재기,이동건,박선희,최정현,유진홍,신완식 대한감염학회 2010 감염과 화학요법 Vol.42 No.1

Background: Invasive aspergillosis (IA) is associated with significant morbidity and mortality in patients with hematologic malignancies. We investigated the efficacy and safety of voriconazole (VCZ) when used as salvage therapy for IA in Korean adults with hematologic malignancies who had not responded to prior antifungal therapy. Materials and Methods: We retrospectively reviewed data, collected from January 2007 to October 2008, from patients with proven or probable cases of IA. All were probable IA cases, except for one proven case. All cases were refractory or intolerant to antifungal therapy prior to administration of VCZ. Efficacy and safety were assessed in patients treated with VCZ for more than 3 days and for more than one dose, respectively. A favorable response [complete (CR) or partial (PR)] was defined by significant improvement of all clinical symptoms, signs, and radiologic abnormalities. Results: Fifty patients who met the inclusion criteria were enrolled. There were 27 male and 23 female patients with mean age of 44.4 years (range, 15-65 years). Underlying diseases were acute leukemia (35 cases), chronic myelogenous leukemia (4 cases), myelodysplastic syndrome (3 cases), lymphoma (3 cases) and other hematologic diseases (5 cases). Twenty-two patients had received chemotherapy and 13 patients had undergone hematopoietic stem cell transplantation. The lung was the main infection site (94%) followed by the sinus (6%). Amphotericin B deoxycholate alone was the most frequent previous antifungal therapy. The mean duration of antifungal therapy prior to VCZ therapy was 13.9±8.8 days (2-44 days). The median duration of VCZ therapy was 19 days (interquartile range, 49 days). Sixteen patients (32.0%) showed favorable responses (CR:PR=8:8) at the end of VCZ therapy. The numbers of patients with stable disease, progression and death were, 6 (12%), 6 (12%) and 22 (44%) respectively. Most of those with unfavorable responses had relapsed underlying malignancies or refractory graft versus host diseases. Twelve patients developed drug-related adverse events but only one patient stopped VCZ treatment prematurely. Conclusions: VCZ demonstrated an acceptable level of toxicity in patients with hematologic malignancies but further studies are required to prove its efficacy as salvage therapy.

CuO를 열확산시킨(Sr.Ca)TiO_(3) 입계층 커패시터의 전기적 특성

최운식,강재훈,오남석 대불대학교 2002 大佛大學校大學院 硏究論文集 Vol.- No.1

In this paper, the Sr_(1-x)Ca_(x)TiO_(3)(0≤x≤0.2)-based grain boundary layer ceramics were fabricated to measured dielectric properties with the sintering temperature and the thermal treatment time. The sintering temperature and time were 1420∼1520℃, 4hours, and the thermal treatment temperature and time of the specimen were 1150℃, 1, 2, 3,hours, respectively. The structural and the dielectric properties were investigated by SEM, X-ray, HP4194A and K6517. The average grain size was increased with increasing the sintering temperature, but decreased to 15㏖% with increasing content of Ca. X-ray diffraction analysis results showed that all specimens were the cubic structure, the main peaks were of Ca. The appropriate thermal treatment temperature and time of CuO to obtain dielectric properties of ε_(γ)>50000, tan δ<0.05 and ΔC<±10% were 1150℃ and 2hours, respectively.

발프로산나트륨과 페니토인과의 약물상호작용

최준식,유재신,박용채,이진환 朝鮮大學校 1997 藥學硏究誌 Vol.18 No.2

This study was attempted to investigate the pharmacokinetic interaction between sodium valproate (4. 8. 16 ㎎/㎏. i.v.) and phenytoin (4 ㎎/㎏. i.v) in rabbits. The plasma concentration and area under the curve (AUC) of phenytoin were increased significantly (p<0.05. p<0.01) when coadministered with sodium valproate (4. 8. 16 ㎎/㎏) in rabbits. The volume of distribution and total body clearance of phenytoin were decreased significantly (p<0.05. p<0.01) when coadministered with sodium valproate (8. 16 ㎎/㎏) in rabbit. From the results of this experiment. it is desirable that dosage regimen of phenytoin should be adjusted and therapeutic drug monitoring should be performed for reduction of side or toxic effect when phenytoin will be coadministered with sodium valproate in clinical use.

(Sr.Ca)TiO_(3)세라믹스의 C-V특성과 Ca의 역할

최운식,강재훈 대불대학교 2002 大佛大學校大學院 硏究論文集 Vol.- No.1

It this study, the capacitance-voltage properties of (Sr_(1-x)·Ca_(x))TiO_(3)(0.05≤x≤0.20)-based grain boundary layer ceramics were investigated. The ceramics were fabricated by the conventional oxide-mixed method. The sintering temperature and time were 1480∼1500℃ and 4hour, respectively. The 2nd phase formed by the thermal diffusion of CuO from the surface leads to very excellent dielectric properties, that is, ε_(γ)>50000, tanδ<0.05, ΔC<±10%. The capacitance is almost unchanged below about 20[V] but it decreases slowly over 20[V]. The results of the capacitance-voltage properties indicated that the grain boundary was composed of the continuous insulating layers. The voltage-current characteristics was due to space charge condensed to interface between grain and grain boundary. The specimens treated thermal diffusion in 1150℃ for 2hrs appeared nonlinearity characteristic of α>7.

Van der Woude 증후군 1예

최홍식,임재열,박준호,남지인 대한이비인후과학회 2001 대한이비인후과학회지 두경부외과학 Vol.44 No.11

IPS-LCD의 전기광학 특성

서대식,최재학 崇實大學校 生産技術硏究所 1998 論文集 Vol.28 No.-

We have investigated the electro-optical characteriatics of in-plane switching (IPS) liquid crystal display (LCD) were investigated. The response time of photo-aligned IPS-LCD is fast compared with rubbing-aligned IPS-LCD on polyimide (PI) surface. The decay time ?? is decreased with increasing the azimuthal anchoring energy Aψdue to the steric interaction between the LC molecules and side chain of polymer. The viewing angle of IPS-LCD is increased by using phto-depolymerizatin method ; about ??70。 at all direction.

감마線分光分析 및 熱螢光檢出法에 의한 自然放射線의 線量測定硏究

田載植,吳熙弼,崔哲圭,吳憲鎭,河正雨 충남대학교 기초과학연구소 1986 연구논문집 Vol.6 No.-

감마선분광분석 및 열형광선량측정법에 의한 자연환경방사선의 선량해석에 관한 연구를 1984년 10월부터 약 1년간에 걸쳐 충남대학교 대덕캠퍼스내의 1만㎡ 규모의 평면개활지에서 수행하였다. 이 연구에서 사용한 검출기는 3″ø×3″NaI(TI) 閃光計數器와 plastic에 밀봉하여 금속판에 압착 처리한 chip과 Teflon-disk 로된 2종의 LiF TLD였다. 실측실험으로는 3회에 걸친 24시간 cycle의 in-situ spectrometry와 2회의 3개월 cycle과 1회의 1개월 cycle에 걸친 TLD field dosimetry를 수행하였다. 측정한 모든 spectrum은 G(E)연산자법에 의하여 照射線量率로 환산하였고 그 결과로부터 환경방사선의 地殼成分을 산출하였다. 結果에 의하면 spectrometry로 구한 조사선량율이 평균(10.54±2.96)μR/hr, TLD chip으로 측정해석한 값은 (12.0±3.4)μR/hr, disk에서 얻은 값이 (11.0±3.6)μR/hr로 오차범위 안에서 매우 좋은 일치를 보이고 있다. 그러나 감마선분광분석에 의한 자연방사선의 日變化에는 가끔 심한동요가 관측되었다. 정확한 환경방사선량해석을 위하여 감마선분광분석과 TLD의 적절한 동시 배합사용이 바람직 하며, 보다 고감도의 TLD에 관한 연구와 국제비교등을 통한 선량평가의 精度向上을 위한 보다 깊이있는 연구가 필요하다는 結論에 도달하였다. A study for the assessment of natural environmental radiation exposure at a flat and open field of about 10,000㎡ in area in CNU Daeduk campus has been carried out by means of gamma-ray scintillation spectrometry and thermoluminescence dosimetry for one year period of time from October 1984. The detectors used were 3″ø×3″NaI(TI) and two different types of LiF TLD, namely, chip sealed in plastic sheet which tightly pressed on two open holes of a metal plate and Teflon disk. Three 24-hour cycles of in-situ spectrometry, and two 3-month and one 1-month cycles of field TL dosimetry were performed. All the spectra measured were converted into exposure rate by means of G(E) opertaion, and therefrom exposure rate due to terrestrial component of environmental radiation was figured out. Exposure rate determined by the spectrometry was, on average, (10.54±2.96)μR/hr, and the rates of (12.0±3.4)μR/hr and (11.0±3.6)μR/hr were obtained from chip and disk TLD, respectively. Fluctuations in diurnal variation of the exposure rate measured by the spectrometry were noticeable sometime even in a single cycle of 24 hours. It is concluded that appropriately combined use of TLD with iu-sitn gamma-ray spectrometry system can give more accurate and precise measure of environmental radiation exposure, and further study for more adequate and sensitive TLD for environmental dosimetry, including improvement and elevation of accuracy in data assessment through inter-laboratory or international intercomparison is necessary.

감마線分光分析 및 熱螢光檢出法에 의한 自然放射線의 線量測定硏究

田載植,吳熙弼,崔哲圭,吳憲鎭,河正雨 대한방사선 방어학회 1985 방사선방어학회지 Vol.10 No.2

감마선분광분석 및 열형광선량측정법에 의한 자연환경방사선의 선량해석에 관한 연구를 1984년 10월부터 약 1년간에 걸쳐 충남대학교 대덕캠퍼스내의 1만㎡규모의 평면개활지에서 수행하였다. 이 연구에서 사용한 검출기는 3"ø×3" NaI(Tl) ,閃光計數器와 plastic에 밀봉하여 금속판에 압착 처리한 chip과 Teflon-disk로된 2종의 LiF TLD였다. 실측실험으로는 3회에 걸친 24시간 cycle의 in-situ spectrometry와 2회의 3개월 cycle과 1회의 1개월 cycle에 걸친 TLD field dosimetry를 수행하였다. 측정한 모든 spectrum은 G(E)연산자법에 의하여 照射線量率로 환산하였고 그 결과로부터 환경 방사선의 地殼成分을 산출하였다. 結果에 의하면 spectrometry로 구한 조사선량율이 평균(10.54±2.96)μR/hr, TLD chip으로 측정해석한 값은 (12.0±3.4)μR/hr, disk에서 얻은 값이 (11.0±3.6)μR/hr로 오차범위 안에서 매우 좋은 일치를 보이고 있다. 그러나 감마선분광분석에 의한 자연방사선의 에는 가끔 심한동요가 관측되었다. 정확한 환경방사선량해석을 위하여 감마선분광분석과 TLD의 적절한 동시 배합사용이 바람직 하며, 보다 고감도의 TLD에 관한 연구와 국제비교등을 통한 선량평가의 精度向上을 위한 보다 깊이 있는 연구가 필요하다는 結論에 도달하였다. A study for the assessment of natural environmental radiation exposure at a flat and open field of about 10, 000m2 in area in CNU Daeduk campus has been carried out by means Oi gamma-ray scintillation spectrometry and thermoluminescence dosimetry for one year period of time from October 1984. The detectors used were 3"ø×3" NaI(Tl) and two different types of LiP TLD, namely, chip sealed in plastic sheet which tightly pressed on two open holes of a metal plate and Teflon disk. Three 24-hour cycles of in-situ spectrometry, and two 3-month and one 1-month cycles of field TL dosimetry were performed. All the spectra measured were converted into exposure rate by means of G (E) opertaion, and therefrom exposure rate due to terrestrial component of environmental radiation was figured out. Exposure rate determined by the spectrometry was, on average, (10.54±2.96)μR/hr, and the rates of (12.0±3.4)μR/hr and (11.±3.6)μR/hr were obtained from chip and disk TLD, respectively. Fluctuations in diurnal variation of the exposure rate measured by the spectrometry were noticeable sometime even in a single cycle of 24 hours. It is concluded that appropriately combined use of TLD with in-situ gamma-ray spectrometry system can give more accurate and precise measure of environmental radiation exposure, and further study for more adequate and sensitive TLD for environmental dosimetry, including improvement and elevation of accuracy in data assessment through inter-laboratory or international intercomparison is necessary.

에탄올 탈수 PSA 공정의 전산 모사 및 설계 최적화 연구

박융호,최재식 漢陽大學校 工學技術硏究所 1997 工學技術論文集 Vol.6 No.1

A model for scale-up of PSA process of ethanol dehydration was established using bench experimental data. LDF mass-transfer model, Langmuir adsorption isotherm and single-component adsorption were assumed in the model and the coefficients for heat and mass transfer in the beds were fitted against the experimental data. Model equations were solved using a DAE solver (Speed Up). The effects of cycle time, P/F ratio, adsorption pressure, bed length were examined, and the dimension and the operating condition which give optimum peformance for a commercial process were determined.

기하광학영역에서의 능동소나 표적신호합성

신기철,박재은,김재수,최상문,김우식 한국해양대학교 해양과학기술연구소 2001 硏究論文集 Vol.10 No.1

능동소나 시스템에서 표적신호의 근거리 정보가 중요해짐에 따라, 표적 음향산란 신호의 고유한특성을 분석하기 위해 실험적인 방법과 시뮬레이션 기법이 사용된다. 본 논문에서는 표적신호 합성을 위해 축소표적 반향실험을 수행하였고, 자료의 분석 결과 축소표적의 음향산란은 거울면 반사의 영향이 큰 것으로 분석되어, 표적신호 합성에서 기하광학이론을 응용하였다. 복잡한 형태의 표적을 여러 표본형상으로 분리하고, 각 표본형상의 기여도를 신호의 위상과 강도를 줌으로써 계산하였으며. 표적신호 합성모델의 검증을 위해 실제 축소표적 실험 결과와 비교하였다. 혁심용어: 기하광학이론. 음향산란, 거울면반사. 축소표적, 능동소나 투고분야: 수중음향 분야 (5.2) Since the near field iformation of target signal is important in the development and verification of active sonar system experimental method and simulation technique are widely used in order to analyze the detail characteristics of target scattered echoes. Therefore, in this paper, the scale target experiment is performed to develope and improve the target signal simulation model. Since the experimental results show that the specular reflection is the major component among scattering mechanisms, the target signal simulation model based on the Geometric Optics Theory (GOT) is developed. Complex target is separated into simple shapes, known as canonical shape. The contribution from individual canonical shapes are summed with proper phase and amplitude to produse the target strength of the whole complex body. Simulated target signal is compared with the experimental results fed discussed.