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Cefazolin Phthalidyl Ester의 흡수에 관한 연구
박용채,이진환,최준식,범진필 한국임상약학회 1993 한국임상약학회지 Vol.3 No.1
A new cephalosporin derivate, cefazolin phthalidyl ester(CFZ-PT) was synthesized to improve oral absorption and bioavailability of parent drug by esterification of sodium cefazolin(CFZ). Partition coefficient studies showed that CFZ-PR is more lipophilic than CFZ. The pharmacokinetic characteristics of CFZ-PT and CFZ preparations were compared following oral administrations of these compounds to rabbits. The analysis of CFZ in plasma was conducted by HPLC method. The ester compound was not detected in plasma following oral administration of CFZ-PT was increased by yielding 3.5-fold bioavailability rather than CFZ. From the results of this experiment, it was concluded that CFZ-PT could be a novel prodrug of CFZ which can improve the oral bioavailability of CFZ.
박용채,임명환,허필선,구본태,Park, Y.J.,Rim, M.H.,Heo, P.S.,Koo, B.T. 한국전자통신연구원 2010 전자통신동향분석 Vol.25 No.5
콘텐츠 산업은 디지털 기술의 발달로 콘텐츠 속성이 아날로그에서 디지털 융복화로 변화되고 있으며, IPTV, DMB, WiBro, 3DTV 등과 같은 뉴미디어를 통해 융복합 서비스로 제공되고 있다. 또한 디지털콘텐츠 산업의 영역은 과거 엔터테인먼트 위주에서 미래에는 제조, 서비스를 포함한 산업 전영역에 체화 및 융합되어 산업의 경계를 초월할 것으로 전망된다. 이러한 콘텐츠 산업에 있어서의 융합 현상은 산업간 경계약화, 기술의 발달 및 고객수요의 다양화 등에 의해 빠르게 확산중에 있으며, 특히 문화기술(CT)의 진보가 근본적으로 콘텐츠 산업에서의 융합을 가속화시키고 있다. 이에 본 연구는 콘텐츠 산업에서의 융합 유형을 4가지(강화, 확장, 결합, 창조)로 구분하여 주요 사례들을 살펴보고, 미래 콘텐츠 산업의 트렌드를 전망해 봄으로써 융합형 콘텐츠 산업의 육성 및 발전을 위한 정책을 수립하고 시행하는 데 기여하고자 한다.
세프테졸 에톡시카보닐옥시에칠 에스텔의 합성 및 생물약제학적 연구
박용채,이진환,박재영 ( Yong Chai Park,Jin Hwan Lee,Jae Young Park ) 한국약제학회 1997 Journal of Pharmaceutical Investigation Vol.27 No.2
N/A Ethoxycarbonyloxyethyl ester of ceftezole (CFZ-ET) was synthesized as a prodrug by esterification of ceftezole (CFZ) with ethoxycarbonyloxyethyl chloride and was confirmed by spectroscopic analyses. CFZ-ET was more lipophillic than CFZ as assessed by n-octanol and water partition coefficients at various pH. CFZ-ET itself did not show any microbiological activity in vitro, but showed substaintial microbiological activity after oral administration of CFZ-ET, indicating that CFZ-ET is converted to microbiologically active metabolite, probably CFZ, in the body. When CFZ-ET was incubated in blood, liver and intestine homogenates of rabbits, liver homogenate showed the fastest conversion of CFZ-ET. CFZ-ET appears rapidly metabolized in the liver when given orally due to the hydrolysis of the ester to CFZ, the parent drug of CFZ-ET. In vivo metabolism of CFZ-ET to CFZ was confirmed in rabbit by HPLC analysis. CFZ-ET were higher than those in the serum samples taken after oral administration of equivalent amount of CFZ. Oral bioavailability of CFZ-ET was 1.5-fold higher than that of CFZ in rabbits because of enhanced lipophilicity and absorption. Based on these findings. CFZ-ET appears useful as a prodrug of CFZ to improve the oral bioavailability of CFZ.
세프테졸 에톡시카보닐옥시에칠 에스텔의 합성 및 생물약제학적 연구
박용채,이진환,박재영 朝鮮大學校 1998 藥學硏究誌 Vol.19 No.2
Ethoxycarbonyloxyethyl ester of ceftezole (CFZ-ET) was synthesized as a prodrug by esterification of ceftezole (CFZ) with ethoxycarbonyloxyethyl chloride and was confirmed by spectroscopic analyses. CFZ-EX was more lipophillic than CFZ as assessed by n-octanol and water partition coefficients at various pH. CFZ-ET itself did not show any microbiological activity in vitro. but showed substaintial microbiological activity a h r oral administration of CFZ-ET. indicating that CFZ-ET is converted to microbiologically active metabolite. probably CFZ. in the body. When CFZ-ET was incubated in blood. liver and intestine homogenates of rabbits. liver homogenate showed the fastest conversion of CFZ-ET. CFZ-ET appears rapidly metabolized in the liver when given orally due to the hydrolysis of the ester to CFZ. the parent drug of CFZ-ET. In vivo metabolism of CFZ-ET to CFZ was confirmed in rabbit by HPLC analysis. CFZ-ET were higher than those in the serum samples taken after oral administration of equivalent amount of CFZ. Oral bioavailability of CFZ-ET was 1.5-fold higher than that of CFZ in rabbits because of enhanced lipophilicity and absorption. Based on these findings. CFZ-ET appears useful as a prodrug of CFZ to improve the oral bioavailability of CFZ.
최준식,유재신,박용채,인진환 한국약제학회 1996 Journal of Pharmaceutical Investigation Vol.26 No.2
This study was attempted to investigate the pharmacokinetic interaction between sodium valproate (4, 8, 16 ㎎/㎏, i.v.) and phenytoin (4 ㎎/㎏, i.v.) in rabbits. The plasma concentration and area under the curve (AUC) of phenytoin were increased significantly (p<0.05, p<0.01) when coadministered with sodium valproate (4, 8, 16 ㎎/㎏g) in rabbits. The volume of distribution and total body clearance of phenytoin were decreased significantly (p<0.05, p<0.01) when coadministered with sodium valproate (8, 16 ㎎/㎏) in rabbit. From the results of this experiment, it is desirable that dosage regimen of phenytoin should be adjusted and therapeutic drug monitoring should be performed for reduction of side or toxic effect when phenytoin will be coadministered with sodium valproate in clinical use.
세프테졸 피발로일옥시메칠 에스텔의 합성 및 생물약제학적 연구
이진환,김가나,박용채 한국약제학회 1995 Journal of Pharmaceutical Investigation Vol.25 No.4
Ceftezole pivaloyloxymethyl ester(CFZ-PV) was synthesized to improve oral absorption and bioavailability of parent drug by esterification of ceftezole(CFZ) with chloromethyl pivalate. The successful synthesis of CFZ-PV was conformed by spectroscopic analysis. Partition coefficient studies showed that CFZ-PV is more lipophillic than CFZ. The pharmacokinetic characteristics of CFZ-PV and CFZ were compared following oral administrations of these compounds to rabbits. The amount of CFZ in plasma was determined with an HPLC method. The ester compound (prodrug) was not detected in plasma following oral administration of CFZ-PV, and although CFZ-PV had not microbiological activity in vitro, the plasma taken after oral administration of CFZ-PV had microbiological activity. From above observations, it was noted that CFZ-PV is rapidly hydrolyzed to CFZ in the body. And the oral absorption of CFZ-PV was increased by yielding 2-fold bioavailability rather than CFZ. Therefore, CFZ-PV could be a novel prodrug of CFZ which can improve the oral bioavailability of CFZ.
최준식,유재신,박용채,이진환 朝鮮大學校 1997 藥學硏究誌 Vol.18 No.2
This study was attempted to investigate the pharmacokinetic interaction between sodium valproate (4. 8. 16 ㎎/㎏. i.v.) and phenytoin (4 ㎎/㎏. i.v) in rabbits. The plasma concentration and area under the curve (AUC) of phenytoin were increased significantly (p<0.05. p<0.01) when coadministered with sodium valproate (4. 8. 16 ㎎/㎏) in rabbits. The volume of distribution and total body clearance of phenytoin were decreased significantly (p<0.05. p<0.01) when coadministered with sodium valproate (8. 16 ㎎/㎏) in rabbit. From the results of this experiment. it is desirable that dosage regimen of phenytoin should be adjusted and therapeutic drug monitoring should be performed for reduction of side or toxic effect when phenytoin will be coadministered with sodium valproate in clinical use.