一部地域 降水內 Ion 特性에 關한 調査

이재형,이문규,최문철,조흥기,기노석 의과학연구소 1990 全北醫大論文集 Vol.14 No.2

This study was conducted to know the chemical characteristics of rain and snow precipitation in Chonbuk province from December 1989 to February 1990, total 92 samples were collected at eight sites and analyzed for sulfate, nitrate, chloride, zinc, lead, cadmium and pH. The results were summarized as follows; 1. pH value was ranging fron 4.12 to 6.61 with an average 4.98 2. The order of anion content was CI> SO_4^-2 > NO_3 and the ratio of sulfat and nitrate content was 1.32. 3. The order of heavy metal concentration was Zn> Pb> Cd and the ionic correlations of heavy metal were higher than those of anion. 4. In rain and snow, there were no statistical difference among ion levels, but significant difference by area. (Key words: rain, snow, precipitation, heavy metal)

사군자탕이 항암제를 투여한 마우스의 면역세포에 미치는 영향

殷載淳,金大根,柳東和,權鎭,洪鍾星,蘇俊魯,全焄,吳贊鎬 우석대학교 의약품개발연구소 1997 藥學硏究誌 Vol.2 No.-

The purpose of this research was to investigate effects of Sa-Kunja-Tang(SKT) on immune cells of antitumor drugs administered mice. The apoptosis and T lymphocytes subpopulation were tested using a flow cytometry, and the proliferation was tested using a MTT assay. The administration of etoposide. vincristine or doxorubicin increased the apoptosis of T-lymphocytes, but the action of doxorubicin was decreased by the administration of SKT. The administration of etoposide or vincristine decreased helper T and cytotoxic T cells population of T lymphocytes, but the action of vincristine was recovered by the administration of SCT. The administration of etoposide, vincristine or doxorubicin decreased the proliferation of T-lymphocytes, but the action of doxorubicin was increased by the administration of SKT. These results suggest that SKT has a regulative function of T-lymphocytes in anti-tumor drugs administered mice.

소음 노출 남성 근로자에서의 청력저하와 혈청 마그네슘의 관련성

박완섭,이종영,정상재,유재영,최태성,홍성철,노성찬 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.1

목적 : 본 연구는 소음에 노출된 남자 근로자를 대상으로 장기간 소음 폭로가 혈청 마그네슘의 농도와 관련이 있는지를 검정하고 이러한 혈청 마그네슘의 농도가 또한 청력저하와 관련이 있는지를 파악하기 위하여 수행되었다. 방법 : 소음에 노출되는 178명의 연구대상자를 청력저하의 정도에 따라 세 그룹으로 분류하고, 구조화된 설문, 신체계측, 혈액검사 등으로 청력저하에 대한 감수성 요인과 혈청 마그네슘 등을 수집하고 측정하였으며, 대상자들의 청력 역치를 측정하기 위하여 청력검사를 실시하였다. 결과 : 본 연구의 결과를 요약하면 다음과 같다. 첫재, 청력저하에 관련된 개인의 감수성 인자라고 알려진 변수인 흡연유무, 나이, 혈압, 헤마토크리트, 콜레스테롤, 혈당 중에서 나이, 이완기 혈압이 단순분석에서 세 그룹간에 차이가 있었고(p〈0.05), 혈청 마그네슘의 농도 또한 세 그룹간에 통계적으로 유의한 차이가 있었으며(p〈0.05) 청력저하가 심할수록 혈청 마그네슘 농도는 낮아지는 경향을 보였다. 둘째, 그룹간의 소음 노출력은 차이가 있었지만 (p〈0.05) 청력보호구 착용상태에는 유의한 차이가 없었다. 셋째, 혈청 마그네슘 농도에 영향을 줄 수 있는 변수인 소음 노출 기간, 마그네슘 함량이 많은 음식의 섭취정도, 스트레스 수준 중에서 소음 노출기간이 혈청 마그네슘 농도와 유의한 상관관계를 보였고(p〈0.05) 노출기간이 길수록 마그네슘의 혈청농도는 낮아지는 경향을 나타내었다. 넷째, 주파수별로 청력저하와 관련된 감수성 요인들에 대한 다중회귀분석 결과 주파수 1,000 Hz에서는 연령이 좌,우측 귀 모두에서 유의한 변수로 채택되었으며 (p〈0.05), 연령이 증가할수록 청력저하가 심해지는 경향을 보였고, 주파수 4,000 Hz에서는 확장기 혈압, 소음 노출 기간, 혈청 마그네슘 등이 청력저하에 대한 감수성 요인으로 채택되었으며(p(0.05), 이완기 혈압이 높을수록, 소음노출 기간이 길수록, 혈청 마그네슘의 농도가 낮을수록 청력저하가 심해지는 것으로 나타났다. Objectivea : This study was conducted to investigate that the chronic noise exposure is associated with decreased serum magnesium concentrations and evaluate whether decreased serum magnesium is associated with noise induced hearing loss. Methods : One hundred seventy-eight male workers exposed to noise were selected and classified three groups by the degree of hearing loss. Hearing threshold levels were less than 30 dB at 1,000 Hz or less than 40 dB at 4,000 Hz In group I, more than 30 dB at 1,000 Hz or more than 40 dB at 4,000 Hz and 15 dB and less of pure tone average[PTA : (500 Hz+l,000 Hz+2,000 Hz)/3] in group II, more than 30 dB at 1,000 Hz or more than 40 dB at 4,000 Hz and over 15 dB of PTA in group III. Results : Serum magnesium concentrations were 2.42±0.26 mg/dl in group 1, 2.35±0.23 mg/dl in group n , 2.26±0.24 mg/dl in group II, respectively and significantly differ-ent between group I and group III (p〈0.01). It was negatively correlated with duration of the noise exposure as correlation coefficient (r) of -0.194 (p(0.05) . Analysis of the multipleregression on hearing threshold levels showed that serum magnesium, diastolic blood pres-sure, duration of the noise exposure were statistically significant at 4,000 Hz (p(0.05) . While only age was statistically significant at 7,000 Hz (p(0.05) . Conclusions : These results suggest that chronic noise exposure may induces decreasein serum magnesium concentrations and that its decreased concentration is related with noise induced hearing loss.

Efficacy of second line chemotherapeutic regimens in persistent/recurrent epithelial ovarian cancer or primary peritoneal cancer: A multicenter retrospective study

( Jae-hyun Cho ),( Hee-seung Kim ),( Maria Lee ),( Jae-weon Kim ),( Noh-hyun Park ),( Yong-sang Song ),( Dong Hoon Suh ),( Kidong Kim ),( Jae Hong No ),( Yong-beom Kim ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: This study evaluated the efficacy of the second line chemotherapeutic regimens in persistent or recurrent epithelial ovarian cancer (EOC) by analyzing the multicenter medical data retrospectively. Methods: We reviewed clinical data of 398 persistent or recurrent EOC/PPC patients treated with second-line chemotherapy between January 2006 and December 2016. And patients were divided into three groups, platinum resistant (less than 6 months), platinum-partially sensitive (6 to 12 month) and platinum sensitive group (over 12 months), based on the first recurrence time; also the second line chemotherapeutic regimen was identified in each group. Then the duration of recurrence after the completion of second-line chemotherapy was measured and the progression-free survival (PFS) according to the second line chemotherapeutic regimen was compared. Results: The study consisted of 222 eligible and assessable patients, median age 53 years, 69 (31.1%) were platinum-resistant, 66 (29.7%) were platinum-partial sensitive and 87 (39.2%) were platinum-sensitive group. There were no significant PFS differences between regimens in both platinum-resistant and platinum-sensitive group. In platinum-partially sensitive group, however, taxane containing regimen showed significantly longer PFS than other regimens (P < 0.05). In the 6-12 month group, Median PFS of taxane containing regimen was 25 weeks, S-phase inhibitor was 15 week, topoisomerase 1inhibitor was 16 weeks, and topoisomerase 2 inhibitor was 13 weeks, respectively. Conclusion: : PFS of taxane-containing regimen is better than other regimens in platinum-partially sensitive group. There were no significant PFS differences between regimens in both platinum-resistant and platinum-sensitive group.

Expression of MMP-2, MMP-9, and Urokinase-Type Plasminogen Activator in Cervical Intraepithelial Neoplasia

No, Jae Hong,Jo, Hoenil,Kim, Su-Hyeong,Park, In-Ae,Kang, Daehee,Lee, Chae Hyeong,Han, Seung-Su,Kim, Jae Weon,Park, Noh-Hyun,Kang, Soon-Beom,Song, Yong-Sang Wiley (Blackwell Publishing) 2009 Annals of the New York Academy of Sciences Vol.1171 No.1

<P>Matrix metalloproteinase-2 (MMP-2), MMP-9, and urokinase-type plasminogen activator (uPA) are important factors for cancer invasion and metastasis, degrading the extracellular matrix. They are also associated with angiogenesis. Angiogenic phenotype is another feature of high-grade cervical intraepithelial neoplasia (CIN). However, their associations with the progression of low-grade CIN to high-grade CIN are unexplored. We investigated whether these proteolytic enzyme expressions correlate with the progression of CIN. A total of 39 paraffin-embedded specimens from 10 patients with CIN grade 1, nine with CIN grade 2, and 20 with CIN grade 3 were assessed immunohistochemically by specific antibodies against MMP-2, MMP-9, and uPA. MMP-9 expression was higher in CIN 3 lesions (47.4%) than in CIN 1 (22.2%) and CIN 2 (20.2%) lesions, although the difference failed to reach statistical significance. The expression level of uPA and MMP-2 was not associated with the grade of CIN lesions. Interestingly, we found a significant association between expressions of uPA and MMP-2 (P= 0.028). Our results suggest that MMP-9 might play a role in the progression of CIN.</P>

고도정수공정에서의 BOM 제거특성 평가

노재순(No Jae Sun),손희종(Son Hui Jong),박홍기(Park Hong Gi),황영도(Hwang Yeong Do),류동춘(Ryu Dong Chun),강임석(Kang Im Seog),주기재(Joo Gi Jae) 大韓環境工學會 2003 대한환경공학회지 Vol.25 No.7

CCS를 이용한 보호 계전요소 S/W 모듈 시뮬레이터

노재근(Jae-Keun No),이돈시(Don-Si Lee),정순영(Soon-Young Jung),오재훈(Jae-Hoon Oh),오성민(Sung-Min Oh),권효철(Hyo-Chul Kwon),홍정기(Jung-Gi Hong) 대한전기학회 2008 대한전기학회 학술대회 논문집 Vol.2008 No.7(초록집)

The accuracy of frozen section in the diagnosis of ovarian masses

노재홍 ( Jae Hong No ),( Noh Hyun Park ),( Yong Sang Song ),( Soon Beom Kang ),( Hyo Pyo Lee ),( Jae Weon Kim ) 대한산부인과학회 2006 대한산부인과학회 학술대회 Vol.92 No.-

상피성 난소암 진단에 있어서 Tissue Polypeptide Specific Antigen (TPS)과 CA 125의 임상적 유효성에 관한 연구

노재홍 ( Jae Hong No ),서상수 ( Sang Soo Seo ),김용범 ( Yong Bum Kim ),김재원 ( Jae Won Kim ),박노현 ( Noh Hyun Park ),송용상 ( Yong Sang Song ),강순범 ( Soon Beom Kang ),이효표 ( Hyo Pyo Lee ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.12

목적 : 상피성 난소암을 진단하는데 있어 혈중 TPS 측정의 유용성을 CA 125와 비교 평가하고자 하였다. 연구 대상 및 방법 : 199년 1월부터 2000년 12월까지 난소 종양으로 개복 수술을 시행한 환자 93명으로 대상으로 하였다. 이들 중 51명은 경계성 종양 27명을 포함한 51명의 상피성 난소암 환자였으며 42명은 양성 난소 종양 환자였다. 모든 환자에서 수술 전에 채혈한 혈액을 이용하여 혈중 TPS 및 CA 125의 농도를 측정하였으며 후 Objective : The purpose of this study is to evaluate and compare the usefulness of the serum levels of tissue polypeptide specific antigen (TPS) and CA 125 for the diagnosis of epithelial ovarian cancer. Materials and Methods : A total of 93 patients were

경계성 난소종양에서 보존적 치료방침의 중요성

김재원,김문홍,박노현,송용상,이효표,강순범,정현훈,노주원 대한부인종양 콜포스코피학회 2000 Journal of Gynecologic Oncology Vol.11 No.3

Objectives: To clarify the clinicopathologic features of borderline malignancy of the ovary and analyze the treatment and survival characteristics through the study of our cases. Study Methods: 102 patients with borderline tumors of the ovary, aged from 14 to 79 years, treated between 1982 and 1999 at Seoul National University Hospital, were analyzed retrospectively for clinicopathologic features. Most informations about stage, treatment modality and prognosis were obtained by hospital record or contacting patient with telephone. Results: There were 77 patients (75.5%) with stage Ia, 5 stage Ib, 11 stage Ic, 4 with stage II and 5 with stage III by the classification of FIGO. 72 patients (70.6%) were mucinous type and 28 (27.5%) were serous type, 1 endometrioid type, 1 mixed. Total abdominal hysterectomy, bilateral adnexectomy, and omentectomy were performed in 43 (42.2%) patients and fertility saving surgery in 43 patients(cystectomy in 11 patients, USO in 32 patients). Twenty two patients (21.6%) were treated with postoperative adjuvant chemotherapy. The median duration of follow up was 54.0 months (1-204 months) and 6 patients developed recurrence after several years from the primary operation. The ten-year eumulative survival rate was 92.2% and the only independent prognostic factors evaluated by Cox analysis in regards to corrected survival were the FIGO stage (p=0.0197). There was no difference in the ten-year survival rate between surgery types - conservative surgery versus full surgical staging. And there was no difference in the 10-year survival rate between treatment groups - surgery only versus surgery followed by adjuvant chemotherapy. Conclusions: FIGO stage is the only independent prognostic factor in the borderline ovarian tumors. There was no difference in the 10-year survival rate of barderline ovarian tumors between surgery alone versus surgery followed by adjuvant chemothearpy. The slow clinical course, low recurrence rate and good prognosis in our patients explained again the reason for therapeutic approach relying on surgery alone.