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노주원,이동옥,서동훈,임명철,서상수,정진수,이선,박상윤 대한부인종양학회 2015 Journal of Gynecologic Oncology Vol.26 No.2
Objective: A prospective, randomized controlled trial was conducted to evaluate the efficacy of nerve-sparing radicalhysterectomy (NSRH) in preserving bladder function and its oncologic safety in the treatment of cervical cancer. Methods: From March 2003 to November 2005, 92 patients with cervical cancer stage IA2 to IIA were randomly assigned forsurgical treatment with conventional radical hysterectomy (CRH) or NSRH, and 86 patients finally included in the analysis. Adequacy of nerve sparing, radicality, bladder function, and oncologic safety were assessed by quantifying the nerve fibers inthe paracervix, measuring the extent of paracervix and harvested lymph nodes (LNs), urodynamic study (UDS) with InternationalProstate Symptom Score (IPSS), and 10-year disease-free survival (DFS), respectively. Results: There were no differences in clinicopathologic characteristics between two groups. The median number of nerve fiberwas 12 (range, 6 to 21) and 30 (range, 17 to 45) in the NSRH and CRH, respectively (p<0.001). The extent of resected paracervixand number of LNs were not different between the two groups. Volume of residual urine and bladder compliance weresignificantly deteriorated at 12 months after CRH. On the contrary, all parameters of UDS were recovered no later than 3 monthsafter NSRH. Evaluation of the IPSS showed that the frequency of long-term urinary symptom was higher in CRH than in theNSRH group. The median duration before the postvoid residual urine volume became less than 50 mL was 11 days (range, 7 to26 days) in NSRH group and was 18 days (range, 10 to 85 days) in CRH group (p<0.001). No significant difference was observedin the 10-year DFS between two groups. Conclusion: NSRH appears to be effective in preserving bladder function without sacrificing oncologic safety.
노주원(JuWon Roh),윤광호(KwangHo Yoon),김재광(Jaekwang Kim),이지형(Jee-Hyong Lee) 한국지능시스템학회 2008 한국지능시스템학회 학술발표 논문집 Vol.18 No.2
최근 사용자의 선호도를 고려한 음악추천 시스템의 연구가 활발히 진행되고 있다. 지금까지의 대부분의 음악추천 시스템은 사용자가 원하는 곡을 추천하기 위해서 콘텐츠의 정보와 사용자 정보간의 유사도를 측정하고 결과를 순위화하여 제공하는 콘텐츠 기반 필터링 기법을 사용했거나, 혹은 다른 단일 요소에 의한 필터링 기법을 사용하여 사용자의 성향에서 크게 벗어나지 못한 추천으로 다양한 사용자의 선호도를 만족시키는데 한계가 있었다. 본 논문에서는 비슷한 성향의 사용자들을 그룹 지은 후, 각 그룹 내 협업필터링을 통해 각 사용자의 선호도를 고려한 음악추천 시스템을 제안한다. 또, 사용자의 현재 상황요소를 고려하여 사용자의 만족도를 높이는 방법을 취한다. 실험 결과 단일 요소에 의한 필터링 기법을 사용한 기존의 음악추천 시스템에 비하여 더 나은 음악추천 결과를 보인다.
NUTRITIONAL REQUIREMENTS OF LYSOBACTER LACTAMGENUS FOR THE PRODUCTION OF CEPHABACINS
Roh, Ju Won,Bang, Jeong Hee,Nam, Doo H. 영남대학교 약품개발연구소 1992 영남대학교 약품개발연구소 연구업적집 Vol.2 No.-
To optimize the fermentation medium for the production of new cephem compounds, cephabacins, by an eubacteria Lysobacter lactamgenus IFO 14,288, the effects of medium components on cephabacin production were investigated. Supplementation of glucose as a sole carbon source in liquid media was the best for the antibiotic production as well as for the cell growth. Casamino acid was the best nitrogen source for antibiotic biosynthesis and cell growth among nitrogen sources tested, and this strain could utilize sulfate or thiosulfate as a sulfur source. No significant effects of growth factors (vitamins) on the antibiotic production and cell growth were observed, but ferrous, magnesium and nickel ions slightly enhanced the cephabacin production.
Biosynthesis of β- Lactam Antibiotics by Cell-free Extract from Lysobacter lactamgenus
Roh, Ju Won,Nam, DooHyun 영남대학교 약품개발연구소 1993 영남대학교 약품개발연구소 연구업적집 Vol.3 No.-
Using cell-free extract of Lysobacter lactamgenus, enzymatic conversion of δ-L-(α-aminoadipyl)-L-cysteinyl-D-valine (ACV), the first substrate of β-lactam biosynthesis, into antibiotic compounds was attempted. In high performance liquid chromatogaphic (HPLC) analysis, the biosynthetic intermediates for cephalosporin antibiotics including isopenicillin N, deacetoxycephalosporin C, deacetylcephalosporin C and unknown cephem compound were detected in reaction mixtures. It implies that cephabacin compounds from L. lactamgenus could be produced by biosynthetic routes through penicillin ring formation and its expansion to cephalosporin ring, likely as cephalosporin C from Cephalosporium or cephamycin C from Streptomyces. Among biosynthetic enzyme in cell-free extract, the ring formation activity (isopenicillin N synthetase activity) was separated in 50-60% of ammonium sulfate fraction, and ring expansion activity (deacetoxycephalosporin C synthetase activity) was found to be in 40-50% fraction. The partially purified isopenicillin N synthetase could convert as much as 90% ACV to isopenicillin N during 6-hour reaction.
김경옥,노주원,Eun Jung Shin,Junyong In,송태훈 한국간호과학회 2014 Asian Nursing Research Vol.8 No.4
Purpose: This study was undertaken to evaluate the factors affecting the unused remaining volume of intravenous patient-controlled analgesia (IV PCA) in patients who had undergone laparoscopic gynecologicsurgery. Methods: We retrospectively collected patient records from pre-existing PCA log sheets from 98 patients. Surgical factors and IV PCA-related data including remaining volume, administration duration, early discontinuation (yes or no), and adverse reactions were recorded. Chi-square test, one-way analysis of variance, and multiple linear regression were applied for data analysis. Results: The average age of the 98 patients was 40.0 ± 8.24 years. The incidence of postoperative nausea and vomiting (PONV) and early discontinuation were not statistically significant among the different surgical groups (p = .540 and p = .338, respectively). Twenty-eight patients wanted iscontinuation of IV PCA and the remaining volume was 33.6 ± 7.8 mL (range 20-55 mL). The significant determinants of remaining volume were whether IV PCA was discontinued due to PONV and duration of surgery (p < .001). The surgical duration was inversely correlated with the remaining volume. Conclusion: Early discontinuation of IV PCA due to PONV is a major contributing factor to wastage of medicine. Prevention and treatment of PONV is needed to encourage patients to maintain PCA use for pain control.
진창호,노주원,황금택 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.10
The aim of this study was to develop quantitativestructure–activity relationship (QSAR) models forpredicting antioxidant activities of phenolic compounds. The bond dissociation energy of O–H bond (BDE) wascalculated by semi-empirical quantum chemical methods. As a new parameter for QSAR models, sum of reciprocalsof BDE of enol and phenol groups (XBDE) was calculated. Significant correlations were observed between XBDE andantioxidant activities, and XBDE was introduced as aparameter for developing QSAR models. Linear regression-applied QSAR models and adaptive neuro-fuzzyinference system (ANFIS)-applied QSAR models weredeveloped. QSAR models by both of linear regression andANFIS achieved high prediction accuracies. Among thedeveloped models, ANFIS-applied models achieved betterprediction accuracies than linear regression-applied models. From these results, the proposed parameter of XBDEwas confirmed as an appropriate variable for predicting andanalysing antioxidant activities of phenolic compounds. Also, the ANFIS could be applied on QSAR models toimprove prediction accuracy.