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한혜정(Hye-Jeong Han),이해준(Hae-June Lee),강성수(Seong-Soo Kang),이수한(Soo-Han Lee),조익현(Ick-Hyun Cho),이종환(Jong-Hwan Lee),나승열(Seung-Yeol Nah),박창현(Chang-Hyun Park),엄창섭(Chang-Sub Uhm),배춘식(Chun-Sik Bae) 고려인삼학회 2003 Journal of Ginseng Research Vol.27 No.3
We investigated the effect of ginseng total saponin (GTS) on the regeneration process of experimentally crush injured rat sciatic nerves. The bilateral sciatic nerves of fifty adult male Sprague-Dawley rats were compressed surgically with a straight hemostat for 30 seconds with 1 mm width. Twenty rats were divided into four groups to test the dosedependent effect of GTS (0, 50, 100, or 150 mg/kg, i.p.). Saline for vehicle control group or GTS dissolved in saline was administerd for three weeks. After that period of time, the numbers of total myelinated axon and degenerated myelin in<br/> the sciatic nerves of bilateral legs were examined and analyzed using image analysis system to confirm a morphological effect of GTS. We found that the most effective concentration of GTS for the regeneration of damaged sciatic nerve was 150 mg/kg. In another set of experiment, thirty rats were divided into two groups as saline-treated vehicle group and GTStreated group (150 mg/kg, i.p.) for three weeks. Every week we examined the numbers of total myelinated axon and degenerated myelin in the sciatic nerves of bilateral legs using image analysis system to evaluate the effect of GTS on<br/> injured nerves. We found that the regeneration of damaged sciatic nerves was facilitated in GTS-treated group compared to saline-treated group until two weeks. However, after that period of time we could not observe the significant difference between saline-treated group and GTS-treated group. These results suggest that GTS is a useful adjuvant therapy for the regeneration of the peripheral nerve injury in short period of treatment.
Preserved skin structure of a recently found fifteenth-century mummy in Daejeon, Korea
Chang, Byung Soo,Uhm, Chang Sub,Park, Chang Hyun,Kim, Han Kyeom,Lee, Gui Young,Cho, Han Hee,Kim, Myeung Ju,Chung, Yoon Hee,Song, Kang Won,Lim, Do Sun,Shin, Dong Hoon Blackwell Publishing Ltd 2006 Journal of anatomy Vol.209 No.5
<P>Abstract</P><P>Recently published reports on Korea's medieval mummies have been regarded as an invaluable source for studies into the physical characteristics of medieval Koreans. However, even though the mummified tissues have been investigated histologically on various previous occasions, there are many unanswered questions relating to their tissue preservation. The aim of this study was to obtain new data on the ultramicroscopic characteristics of the mummified skin of a fifteenth-century mummy found recently in Daejeon – one of the oldest ever found in Korea. Electron microscopy revealed that much of the epidermis had decayed; what remained of the dermis was filled with collagen fibres and melanin granules or invading bacterial spores present within the mummified epidermis. Considering the histological characteristics shared by naturally formed mummies in different parts of the world, we concluded that the ultramicroscopic patterns of the Daejeon mummy were more comparable with those naturally formed mummies than with artificially formed ones. This is the first full description of the morphological characteristics of the skin collected from this recently found medieval mummy from Daejeon, South Korea.</P>
Nak Song Sung,Sun Ho Uhm,Hyun Bae Kang,이남섭,Young-Gil Jeong,Do Kyung Kim,성낙윤,Dong-Sub Kim,Young Choon Yoo,Seung Yun Han 대한해부학회 2023 Anatomy & Cell Biology Vol.56 No.4
Vascular dementia (VaD) is characterized by progressive memory impairment, which is associated with microglia-mediated neuroinf lammation. Polyphenol-rich natural plants, which possess anti-inf lammatory activities, have attractedscientific interest worldwide. This study investigated whether Rubus fruticosus leaf extract (RFLE) can attenuate VaD. Sprague–Dawley rats were separated into five groups: SO, sham-operated and treated with vehicle; OP, operated and treatedwith vehicle; RFLE-L, operated and treated with low dose (30 mg/kg) of RFLE; RFLE-M, operated and treated with mediumdose (60 mg/kg) of RFLE; and RFLE-H, operated and treated with high dose (90 mg/kg) of RFLE. Bilateral commoncarotid artery and hypotension were used as a modeling procedure, and the RFLE were intraorally administered for 5 days(preoperative 2 and postoperative 3 days). The rats then underwent memory tests including the novel object recognition,Y-maze, Barnes maze, and passive avoidance tests, and neuronal viability and neuroinf lammation were quantified intheir hippocampi. The results showed that the OP group exhibited VaD-associated memory deficits, neuronal death, andmicroglial activation in hippocampi, while the RFLE-treated groups showed significant attenuation in all above parameters. Next, using BV-2 microglial cells challenged with lipopolysaccharide (LPS), we evaluated the effects of RFLE in dynamics ofproinf lammatory mediators and the upstream signaling pathway. RFLE pretreatment significantly inhibited the LPS-inducedrelease of nitric oxide, TNF-α, and IL-6 and upregulation of the MAPKs/NF-κB/iNOS pathway. Collectively, we suggest thatRFLE can attenuate the histologic alterations and memory deficits accompanied by VaD, and these roles are, partly due to theattenuation of microglial activation.
Hak-Rin Kim,Young June Hong,Joon Ho Choi,Byeong Seong Cho,Han Sub Uhm,최은하 한국정보디스플레이학회 2010 Journal of information display Vol.11 No.4
To improve the luminescence characteristics of high-efficiency alternating-current plasma display panels (AC-PDPs), we developed a new hoof-type electrode structure, and we studied the spatiotemporal behavior of the density of the excited Xenon atom in the 1s5 metastable state via laser absorption spectroscopy. Using this structure, the maximum density of the excited Xenon atom per cell was improved by 2.4 times that when the conventional electrode structure was used.
Kim, Yong-Hee,Hong, Young-June,Choi, Joon-Ho,Cho, Byeong-Seong,Uhm, Han-Sub,Choi, Eun-Ha The Korean Infomation Display Society 2010 Journal of information display Vol.11 No.4
To improve the luminescence characteristics of high-efficiency alternating-current plasma display panels (AC-PDPs), we developed a new hoof-type electrode structure, and we studied the spatiotemporal behavior of the density of the excited Xenon atom in the $1s_5$ metastable state via laser absorption spectroscopy. Using this structure, the maximum density of the excited Xenon atom per cell was improved by 2.4 times that when the conventional electrode structure was used.
Therapeutic Effects of Safflower (Carthamus tinctorius L.) Seed Powder on Osteoporosis
배춘식,박창현,조형진,한혜정,강성수,최석화,엄창섭,Bae, Chun-Sik,Park, Chang-Hyun,Cho, Hyung-Jin,Han, Hye-Jeong,Kang, Seong-Soo,Choi, Seok-Hwa,Uhm, Chang-Sub Korean Society of Electron Microscopy 2002 Applied microscopy Vol.32 No.3
The therapeutic effect of safflower seed powder on experimental osteoporosis in the rat induced by ovariectomy was evaluated. Thirty Sprague-Dawley rats were ovariectomized at the age of 12 weeks. Seven weeks postovariectomy, rats were divided into two groups: control and safflower seed powder treated group. Five animals from each group were sacrificed at the following time points: 1, 3, and 5 weeks. Scanning electron microscopic observation and morphometric analysis of the tibiae epiphysis showed that the administration of safflower seed powder significantly prevented reduction of cortical bone width and bone volume compared with the control group. In conclusion, safflower seed powder contains something that prevent bone loss due to estrogen deficiency, and was effective in preventing the osteoporotic decrease of bone mass. 홍화씨는 한방 및 민간에서 뼈에 우수한 작용이 있는 것으로 알려져 오랫동안 복용되어 왔다. 최근 고령화 사회를 맞이하면서 골다공증 문제는 사회적인 문제로 인식되고 있으며 저자들이 기존에 실시한 실험결과에 의하면 홍화씨 분말은 난소를 적출한 rat에서 골다공증의 예방효과를 나타내었다. 그러나 아직까지 골다공증이 유발된 rat에서 홍화씨 분말이 미치는 효과에 관한 실험적 자료가 제시된 것은 별로 없다. 이에 저자들은 홍화씨 분말이 골다공증의 치료에 미치는 효과를 알아보기 위하여 본 실험을 실시하였다. 실험동물은 체중 230 g의 12주령의 Sprague-Dawley Rats를 사용하였으며, 양쪽 난소제거 후 7주부터 홍화씨 분말을 매일 0.3 g씩 복용시키면서 1, 3 및 5주 후에 경골을 채취하여 관찰하였다. 채취된 조직은 통상적인 주사전자현미경 시료제작법으로 고겅과정을 거친 후 10% 질산으로 12시간 탈회하여 뼈의 단면을 노출시키고 탈수, 건조 및 금도금 과정을 거쳐 주사전자현미경(Hitachi, S-450)으로 관찰하여 촬영하였다. 관찰결과 대조군은 골수강에서 피질골까지의 두께의 감소와 골수강의 확장이 심하였으나, 홍화씨 분말을 투여한 실험군에서는 1주에서 5주까지 거의 같은 소견을 나타내었다. 이상의 결과를 종합해보면 홍화씨 분말은 여성호르몬 결핍으로 인한 골다공증의 치료에 효과가 있는 것으로 사료된다.
Proteomic analysis of pulmonary sclerosing hemangioma
Jin, Lian-Jin,Shin, Bong Kyung,Jung, Woon Yong,Lee, Hyun-Juu,Cho, Su Jin,Han, Joung-Ho,Ha, Seong-Yeon,Kim, Ae-Ree,Sik Kim, Young,Sun Kim, In,Uhm, Chang-Sub,Kim, Han Kyeom WILEY-VCH 2006 Proteomics Vol. No.
<P>Sclerosing hemangioma (SH) is a rare benign pulmonary tumor derived from the primitive respiratory epithelium. However, the pathogenesis of SH has not yet been clear. Surfactant protein, thyroid transcription factor-1, epithelial membrane antigen, cytokeratin, and vimentin have been identified in SH by immunohistochemistry and electron microscopy. To identify proteins specifically regulated in SH, 2-D PAGE was performed using SH and paired normal tissues. Ten selected differentially expressed protein spots were identified by PMF, MALDI-TOF-MS, and database searching. Apolipoprotein A-1, antizyme inhibitor, heat shock 27-kDa protein 1, and antioxidant proteins, such as peroxiredoxin II (Prx II) and GST, were identified among the down-regulated proteins in SH. Western blot and immunohistochemistry confirmed reduced expressions of Prx II and GST in SH versus normal lung tissue. This study is the first report on the reduced expressions of Prx II and GST in SH.</P>