Maillard 反應에 關한 硏究 : Ⅲ. 아미노산과 5炭糖의 Maillard 反應 Ⅲ. Study on the Maillard Browing of Amino acids and Pentoses

李乙熙,崔相道,吳錫斗,高鏡畢 진주산업대학교 농업기술연구소 1991 農業技術硏究所報 Vol.4 No.-

아미노산과 5炭糖을 121℃에서 15분간 열처리하여 Maillard반응의 發色强度를 비교한 결과는 다음과 같다. 1. 아미노산은 發色强度가 높은것, 중간것, 낮은것으로 대별되었다. 2. 糖은 L(+)arabinose, D(-)-ribose, D(+)-xylose 순으로 發色强度가 높게 나타났다. 3. pH차이에 따른 영향은 反應液의 pH가 높아질수록 反應性은 增加되었다. 4. D(+)-xylose, D(-)-ribose 및 L(+)-arabinose의 농도가 높아질 수록 반응성은 높게 나타났다. Common amino acids and pentoses have been ranked acording to the intensity of Maillard browning formed when heated in an autoclave at 121℃ for 15 min. The results obtained as follows; 1. The amino compounds have been groupeed into high, intermediate and low browning producing groups. 2. The color intensity of pentoses tested was xylose>ribose>arabinose. 3. As the pH values of reaction solutions increased, the color intensity of melanoidins. 4. As the concentrations of xylose, ribose and arabinose increased, the color intensities of melanoidins.

감자를 첨가한 기능성 크림수프의 품질 특성

한경필,한재숙,소기신행,김동석,박미란,이갑랑 한국조리과학회 2005 한국식품조리과학회지 Vol.21 No.1

The purpose of this study was to investigate the quality characteristics of potato added functional cream soup. The highest crude protein (p<.01) and crude lipid (p<.001) were for the potato soup with added potato peel (S₃). The highest pH of 5.95 was for the potato soup with added potato peel (S₄). The highest lightness of 69.46(1, value) was for the potato soup with added potato peel (S₃) (p<.01). The redneess(a value) and yellowness(b value) were increased by the adding of potato peel to the potato soup(p<.01). Viscosity was increased by potato content, and was the highest for the potato soup (S₂) (p<.001). The glycoalkaloid content of the potato soup with added potato peel was 175 mg and 2.20 mg, for Si and S4 respectively. In sensory evaluation. the highest sensory scores for flavor and taste (p<.05) of mean 3.55 and 3.45, respectively, were obtained from the potato soup with added potato peel (S₄). The highest overall acceptability of mean 3.00 was for the potato soup with added potato peel (S₃) (p<.01).

마우스 대장암 모델 구축 및 항암제 활성 평가를 위한 예비 연구

김예솔,강봉석,이상은,이은주,이경록,정상헌,박정숙 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-

Abstract – Aberrant crypt foci (ACF) are early imorphological changes observed in rodents after administration of colon-specific carcinogen such as azoxymethane (AOM). ACF are considered to be putative preneoplastic lesions and are widely used as a surrogate biomarker to rapidly evaluate chemopreventive potential of compounds. The size of colorectal cancer was evaluated after administration of three anticancer drugs, 1 parent drug and 2 prodrugs. The body weights of mice were measured daily and considered as a surrogate for evaluation of general wellbeing. Colons were removed, cut along the longitudinal axis and flushed with phosphate-buffered saline. Each colon was cut into three equal lengths and fixed flat between filter papers. The fixed colon sections were stained with methylene blue. The number of ACF per colon, the number of aberrant crypts observed in each focus and the location of each focus were recorded. After single administration of AOM and multiple doses of anticancer drugs, no significant changes in the body weights of the mice was observed which was recorded for 52 days. However, an expected ACF was not observed in any treated groups. These findings suggest the induction of ACF in mice requires the promotion by dextran sulfate sodium as well as the initiation by AOM.

Ecological characteristics and trap plant attraction effect of Metcalfa pruinosa in red pepper cultivation area of Korea

Hwa-Young Seo,Gyeong-Ju Lee,In-Su Hwang,Mi-Sook Na,Yong-Seok Choi 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.10

Metcalfa pruinosa is the agricultural pest, first reported in Seoul, Gyeong-gi, Gyeongnam, Korea in 2009. This pests are difficult to control due to the wide range of hosts such as beans, apples, ginseng, pears, persimmon, and peaches. This study was carried out to investigate the ecological characteristics of M. pruinosa in pepper cultivation area. As a result of the density of M. pruinosa survey in Chungnam, Korea in 2018, the density of wintering-eggs, nymph, adult was the largest in Dang-jin area. And the results of the ecological characteristcs survey of M. pruinosa in red pepper cultivation area of Korea, M. pruinosa didn’t enter a red pepper field. In addition, the possibility of using three kinds of plants as attraction plants was examined in order to control environmentally friendly M. pruinosa. Among them, the greatest number of M. pruinosa nymph were attracted to Sunflower and Green perilla during nymph stage.

구강점막 부착용 케토프로펜 고분자 필름의 제조 및 평가

박진석,이상은,강봉석,이경록,이은주,박정숙 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-

Abstract – The objective of this study was to prepare ketoprofen-loaded buccal adhesive patch. The adhesive patch was formulated by casting method using aqueous soluble polymer povidone K17 (PVP 17PF) as film-forming agent and hydroxypropylmethylcellulose (HPMC) as adhesive agent. To compare the effect of HPMC type, different molecular weight of K4M and K15M HPMC was used. The physicochemical properties of patches such as appearance, thickness, in vitro release, and adhesiveness were investigated. The concentration of ketoprofen was determined spectrophotometrically at a wavelength of 233 nm. The appearance of prepared patches was semi-transparent, light-yellow or almost colorless, and odorless. Thickness of each patches (n=6) was 0.895 ± 0.033 mm for K4M patch and 0.727 ± 0.036 mm for K15M patch. In vitro release test, both K4M and K15M patches showed over 20% release within 30 min. At 120 min, K4M and K15M patches demonstrated 95% and 67.5% release of ketoprofen, respectively, and up to 240 min, both patches released drug completely. Maximum adhesive force of K4M and K15M patches was 6.571 ± 2.703 gf and 2.735 ± 1.151 gf, respectively. Moreover, it took 28.29 ± 0.38 sec and 28.30 ± 0.34 sec for K4M and K15M patch to peel off them after adhesion, showing no significant difference. In conclusion, thickness, in vitro release, and maximum adhesive force could be modulated by alteration of polymer types.

발달장애유아의 언어행동발달 연구

김춘희,변찬석,서경희,유은정,이효신,전헌선,최성규 大邱大學校 特殊敎育·再活科學硏究所 2000 特殊敎育硏究 Vol.23 No.1

본 논문은 발달장애유아 언어행동발달 컨텐츠 개발에 요구되는 기초연구로써 연구의 이론적 바탕을 확립하고자 하였다. 연구에 사용된 방법은 문헌조사 방법 및 현장 인터뷰기법을 병행하였다. 본 연구의 주된 목적은 크게 3가지로 구분된다. 첫째, 발달장애유아의 가정 내 교육 욕구를 분석하고자 하였다. 둘째, 발달장애유아의 언어발달 양상을 검토하고자 하였다. 세 번째 목적은 유아의 언어행동발달 컨텐츠 구성의 주요 지침을 설정하고자 하였다. 이상의 연구목적에 따른 연구결과를 요약하면 다음 몇 가지로 제시된다. 1.가정 내 부모-유아간 관계형성이 우선 고려 되어야하고, 이에 따른 상호작용은 발달적 애착형성이 가능한 방향으로 정립되어야한다. 2.발달장애유아의 언어행동발달양상을 검토한 결과에 따르면, Piaget는 언어행동발달에 있어 감각운동기적 환경탐색 기능을 강조하고 있고, 이는 현재까지 중요한 유아 발달의 기저로 정착되었다. 따라서, 발달장애유아의 언어행동발달을 위한 컨텐츠 개발 내용에 있어서도 이러한 기저에 충실함이 합리적이다. 3.발달장애유아들에게는 언어행동 양상의 갈래가 크게 운동장애 및 감각결함으로 나누어질 수 있으므로, 이 두 가지 갈래의 각기 다른 특성이 컨텐츠 구성에서 충분히 고려되어야한다. 4.자폐성과 같은 중증 전반적 발달장애 유아를 위한 언어행동발달 컨텐츠 구성에서 특히 고려해야 할 두 가지 요소는 모방행동기능과 반복단순훈련기능 향상으로 결론지을 수 있다. This article planed to establish the theoretical foundations of the research as a basic study needed for developing the contents of verbal(language) behavior development for the infants with developmental disabilities. The methods used in the study was previous literature researches and interviews with subjects. The purposes of the study were divided into three parts. First, it was to analyze the educational needs of the infants with developmental disabilities in home settings. Second, it was to review and discover the language patterns of the infants with developmental disabilities. The third purpose was to devise the major guidelines of their language development's contents. The results of the study were described as the followings. 1.The relationships between the infants with developmental disabilities and their parents and their interactions should move to build the developmental attachments between them. 2.According to the literature findings of their language development patterns, Piaget concentrated on the functions of sensory motor environmental exploring in the language behavior development. The functions have been settled down into the important foundation for the infants' development. Thus, it was resonable that the content's development of the language behaviors for the infants with developmental disabilities should based on the function addressed by Piaget. 3.The language behaviors' patterns of the infants with developmental disabilities generally were classified into motor disabilities and sensory defect(deficiency). Therefore, the two factors should be considered for the constructions of the contents. 4.Constructing the contents of the language behavior developments for the infants with severely pervasive developmental disabilities such as autism, the improvements of two functions, imitative behavior and repetitive simple training should be considered.

감자껍질을 첨가한 기능성 쿠키의 품질 특성

한재숙,김정애,한경필,김동석,소기신행,이갑랑 한국조리과학회 2004 한국식품조리과학회지 Vol.20 No.6

The purpose of this study was to investigate the quality characteristics of functional cookies made with potato peels (cortex layer) containing high amounts of glycoalkaloid. Cookies were processed by mixing ratios of 10, 15 and 20% potato peel relatively to flour. The spread ratio of the cookies was increased with increasing potato peel addition. Texture measurement for the cookies on substituting 10% of flour for potato peel showed a decreased hardness, but the cohesiveness and springiness were increased compared to the control and other ratios. The glycoalkaloid contents of the cookies on substituting 10, 15 and 20% of the flour forpotato peel were 6.27, 9.40 and 12.54mg, respectively, which according to the USAD guidelines are safe amounts for the human body, and also enough for making functional cookies. In the sensory evaluations, the cookies with 10% of the flour substituted for potato peel had the highest scores in flavor, taste, appearance and texture.

Development of flexible resistance type humidity sensor using screen printing

Gyeong-Seok Oh(오경석),Hyun-Ah Lee(이현아),Min-Seok Kim(김민석),Mi-Jin Won(원미진),Dong-Su Kim(김동수) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11

The printing process enables low-cost manufacturing and can bring flexible electronics to a wide range of markets. A printing process is most suitable for manufacturing a flexible electronic device, and recently, a sensor research using the printing process is being conducted. In the printing process, screen printing is a widely used technology because it can be manufactured with various inks and there is no limitation on the substrate. In this study, the sensor electrode part was printed using screen printing, and a flexible PET film was used as the substrate. In the case of the sensors IDE, as the distance between the thin line width and the line width gets closer, the sensors response speed changes. The performance of the humidity sensor was measured using a nanocellulose material for the sensor layer. Through this study, a flexible resistance type humidity sensor was fabricated and performance evaluation was conducted. Therefore, I think that a humidity sensor with a simple design that is flexible and relatively sensitive is a sensor that can be used for various purposes even in the field of humidity measurement.

A pathogenic role for ER stress-induced autophagy and ER chaperone GRP78/BiP in T lymphocyte systemic lupus erythematosus

Lee, Won-Seok,Sung, Myung-Soon,Lee, Eun-Gyeong,Yoo, Han-Gyul,Cheon, Yun-Hong,Chae, Han-Jung,Yoo, Wan-Hee Federation of American Societies for Experimental 2015 Journal of Leukocyte Biology Vol.97 No.2

<P>ER stress induced autophagy and decreased GRP78 expression of T lymphocytes are involved in the pathogenesis of SLE and potentially important therapeutic targets.</P><P>Abnormal regulation of ER stress and apoptosis has been implicated in autoimmune disorders. Particularly, ER stress-induced autophagy and the role of GRP78, or BiP in T lymphocyte survival and death in SLE are poorly understood. This study investigated the pathogenic roles of ER stress-induced autophagy and GRP78/BiP in apoptosis of T lymphocytes. We compared spontaneous and induced autophagy and apoptosis of T lymphocytes in healthy donors and patients with SLE. The molecular mechanism of altered autophagy and apoptosis was investigated in T lymphocytes transfected with siRNA for beclin 1 and CHOP and T lymphocytes overexpressing GRP78. Decreased autophagy and increased apoptosis in response to TG-induced ER stress were observed in lupus T lymphocytes. GRP78 and ER stress-signaling molecules, such as PERK, p-eIF2<I>α</I>, IRE1, and ATF6 decreased, whereas CHOP levels increased in lupus T cells in response to TG. The levels antiapoptotic molecules, Bcl-2 and Bcl-X<SUB>L</SUB> decreased, whereas the proapoptotic molecules, Bax and caspase 6, increased in lupus T cells. The TG-induced ER stress altered autophagy and apoptosis, which in turn, led to abnormal T cell homeostasis with increased apoptotic T cell death. We hypothesize that aberrant autophagy of T lymphocytes as a result of ER stress and decreased GRP78 expression is involved in the pathogenesis of SLE and might serve as important therapeutic targets.</P>

Combination Chemotherapy of Gemcitabine and Cisplatin in Patients with Advanced Non-Small Cell Lung Cancer As A Single Institutional Phase Il Study

Seok Hyun Kim,Gyeong Won Lee,Ki Shik Shim,Young Mi Lee,Yi Yeong Jeong,Ho Cheol Kim,Won Sup Lee,Young Sil Hwang,Jong Seok Lee,Joung Soon Jang 대한내과학회 2003 대한내과학회 추계학술대회 Vol.2003 No.1