유전성 철적모구성 빈혈 임신부의 산전관리 및 분만

이상학,김병욱,이영심,정인배,이영진,한혁동,이건영 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.9

Anemia is the one of the most common complications among pregnant women, but sideroblastic anemia is very rare condition. The sideroblastic anemias have diverse etiologies but have in common an impaired biosynthesis of heme in the erythroid cells of the marrow. The ringed sideroblasts in the bone marrow aspirate is diagnostic hallmark of sideroblastic anemia. We report here a prenatal care and delivery in a pregnant woman complicated by hereditary sideroblastic anemia. This patient was treated with 200mg of pyridoxine per day during entire pregnancy period and further more, 4mg of oral folate per day was supplemented because concomitant folate deficiency is frequent in case of erythroid hyperplasia. Intermittently, the transfusions of packed red blood cells were required to maintain the hemoglobin level in the 9 to 10gm/dl range. We have experienced healthy maternal and perinatal outcome.

광원의 종류, 주기와 세기의 변화에 따른 ‘신홍쌈’ 배추 내 글루코시놀레이트 함량

이건령(Geon-Ryoung Lee),김영진(Young Jin Kim),천진혁(Jin-Hyuk Chun),이민기(Min-Ki Lee),류동기(Dong-Ki Ryu),박수형(Suhyoung Park),정선옥(Sun-Ok Chung),박상언(Sang Un Park),임용표(Yong-Pyo Lim),김선주(Sun-Ju Kim) 충남대학교 농업과학연구소 2014 농업과학연구 Vol.41 No.2

The variation of glucosinolates (GSLs) in Chinese cabbage (‘Sinhongssam’) (Brassica rapa L. spp. pekinensis) cultivated under lights to control plant growth conditions was evaluated at different development stages. Under experimental conditions in plant factory system, plant growth conditions including light, temperature, and nutrients were designed to enhance GSLs. The variation of glucosinolates (GSLs) in Chinese cabbage (‘Sinhongssam’) (Brassica rapa L. spp. pekinensis) cultivated under lights to control plant growth conditions was evaluated at different development stages. Under experimental conditions in plant factory system, plant growth conditions including light, temperature, and nutrients were designed to enhance GSLs. The contents of GSLs were quantified in Chinese cabbage according to different light sources (Red+White, RW; Red+Blue+White, RBW, Fluorescence lamp, FL) at development stages (28, 42, and 56 days after sowing, DAS) using HPLC. Nine GSLs including five aliphatic (progoitrin, sinigrin, glucoalyssin, gluconapin, and glucobrassicanapin) three indolyl (glucobrassicin, 4-methoxyglucobrassicin, and neoglucobrassicin), and one aromatic (gluconasturtiin) GSLs were identified based on peak retention time in previous results of our laboratory. GSL contents were higher in RBW (36.55) and lower in FL (15.24 μ㏖/g DW). Results revealed that GSL contents were higher under controlled photoperiods (20/4 h) (58.35 μ㏖/g DW) and controlled light intensity (160 μ㏖/㎡/s) (34.02 μ㏖/g DW), respectively. Lower amount of progoitrin and comparatively higher amount of glucobrassicin and gluconasturtiin was noted in Chinese cabbage cultivated under FL light (2.38, 9.82, and 2.10) at 42 DAS, photoperiod 20/4 h (3.16, 2.52, and 1.30) at 28 DAS, and light intensity at 130 μ㏖/㎡/s (2.28, 2.24, and 1.51 μ㏖/g DW) at 42 DAS. Therefore FL light, photoperiod (20/4 h), and light intensity (130 μ㏖/㎡/s) were considered as most suitable for the enhancement of GSLs in Chinese cabbage.

깊은 신경망을 활용한 음성 기반의 자폐 스펙트럼 장애 판별에 관한 기초 연구

이정혁(Jung Hyuk Lee),이건우(Geon Woo Lee),김성주(Seong Ju Kim),봉귀영(Guiyoung Bong),유희정(Hee Jeong Yoo),김홍국(Hong Kook Kim) 한국통신학회 2020 한국통신학회 학술대회논문집 Vol.2020 No.8

PROTO-MODEL OF AN INFRARED WIDE-FIELD OFF-AXIS TELESCOPE

Kim, Sang-Hyuk,Pak, Soo-Jong,Chang, Seung-Hyuk,Kim, Geon-Hee,Yang, Sun-Choel,Kim, Myung-Sang,Lee, Sung-Ho,Lee, Han-Shin The Korean Astronomical Society 2010 Journal of The Korean Astronomical Society Vol.43 No.5

We develop a proto-model of an off-axis reflective telescope for infrared wide-field observations based on the design of Schwarzschild-Chang type telescope. With only two mirrors, this design achieves an entrance pupil diameter of 50 mm and an effective focal length of 100 mm. We can apply this design to a mid-infrared telescope with a field of view of $8^{\circ}{\times}8^{\circ}$. In spite of the substantial advantages of off-axis telescopes in the infrared compared to refractive or on-axis reflective telescopes, it is known to be difficult to align the mirrors in off-axis systems because of their asymmetric structures. Off-axis mirrors of our telescope are manufactured at the Korea Basic Science Institute (KBSI). We analyze the fabricated mirror surfaces by fitting polynomial functions to the measured data. We accomplish alignment of this two-mirror off-axis system using a ray tracing method. A simple imaging test is performed to compare a pinhole image with a simulated prediction.

소간세포암의 경피적 에탄올 주입 요법 효과

임대건,이원식,이옥주,장현정,이연재,이상혁,설상영,정정명,한상석 인제대학교 1996 仁濟醫學 Vol.17 No.3

영상 기술의 발달 및 간세포암 고위험군의 추적 관찰에 의한 소간암의 발견율이 높아져 간세포암의 절제율이 높아지고 있으나, 우리나라 간세포암의 경우에 대부분이 간경변을 동반하고 있어 간 절제 후 간 기능 예비력이 저하됨과 종양의 재발, 종양의 위치, 그리고 환자들의 수술 기피 등으로 인해 절제술이 제한을 받고 있다. 수술적 제한을 받는 소간세포암 10례에서 경피적 에탄올 주입요법(PEIT)을 시행하여 추적 관찰한 후 생존을 분석하고자 하였다. 치료 후 평균 생존 기간은 18.4±10.6개월이고, 1년 생존율은 70%, 2년 생존율은 30%, Child class A군의 평균 생존은 21.4개월, Child class B군의 평균 생존은 13.2개월 이었다. PEIT는 다양한 이유로 간절제술에 제한을 받는 원발성 소간암에서 비교적 안전하고 효과적인 치료법으로 사료되며 정기적인 추적 관찰로 재발 여부를 확인하여 2차 PEIT나 TAE 등의 병용이 필요할 것으로 사료된다. Object : The surgical resection for hepatocellular carcinoma(HCC) wish postnecrotic cirrhosis has been restricted due to poor postoperative functional reserve, the development of new lesion in remained liver and patient's refusal against operation. The aim of this study was to assess the effect of percutanous ethanol injection therapy (PEIT) for the patient with small HCC in whom surgical resection was restricted. Material and Method : The subjects of this study were ten patients who were confirmed as small HCC by ultrasound guided liver biopsy. The mean age of the patients was 53.9 ±7.5 years, the male to female ratio was 9 to 1. HBs Ag was noted in eight cases, Anti-HBs antibody was noted in one case, and only Anti-HBc IgG positive was noted in one case among 10 cases. Five cases were assessed as Child A, four cases were Child B, and one case was Child C. In AFP level, lesser than 350ng/ml was checked in four cases and more than 350ng/m1 was checked in six cases. The average size of tumor was 3.1±0.8cm. Under the guidance of ultrasonography, we punctured the mass with 21-22 guage needle and then injected optimal amounts of the mixture of 99.5% ethanol and 2% lidocaine (ratio of 9:1) until the echogeneisity of tumor was completely changed from hypoechoic to hyperechoic (if need, maximum, 3 puncture were done) as one tome. Above procedure was performed 3-6 tomes repeatedly every 2-3 days as one cycle. We followed up the tumor by abdominal ultrasonography and serum AFP after one month and then every three months. If the regrowth of the tumor was detected or if the development of new lesion was suspected, color Doppler ultrasound, abdominal computed tomography or hepatic angiography was performed. And then we performed the second cycle of PEIT or TAE for the regrowing or new lesion. Results: After the first cycle of PEIT the mean of survival duration was 18.4±10.6 months, one year survival rate was 70% and two years survival rate was 30%. The average duration of survival was 21.4 months in Child A, 13.2 months in Child B, and the maximal duration of survival was more than five years at now. Conclusion : The PEIT was considered relatively safe and effective method for inoperablesmall HCC, but one cycle therapy was not sufficient. We suggest that it is necessary to detech the relapse or regrowing of tumor early by careful observation after PEIT and to per form the combination of second PEIT or TAE.

임펄스전압에 의한 수중방전특성에 대한 연구

이복희(Bok-Hee Lee),최종혁(Jong-Hyuk Choi),박건훈(Geon-Hun Park),이봉(Feng Lee),김회구(Hoe-Gu Kim),이강수(Kang-Soo Lee),안창환(Chang-Hwan Ahn) 한국조명·전기설비학회 2007 한국조명·전기설비학회 학술대회논문집 Vol.2007 No.5월

This paper presents the experimental results of underwater discharges in 25 ㎜ point-plane gap caused by impulse voltage. Discharge phenomena were observed by digital cameras and recorded by oscilloscope. As a result, discharge patterns in positive and negative polarity have different shapes according to applied voltage amplitudes. The positive discharge is like root but the negative discharge is similar to bush. As the voltage is increased, the discharge routs are thick and have more branches. Also the time to breakdown is inversely proportional to voltage.

Insecticidal Effect of Environment Friendly Agricultural Materials (EFAMs) for Nilaparvata lugens and Cnaphalocrocis medinalis on Rice

Chae-Hoon Paik,Geon-Hwi Lee,Si-Hyuk Choi,Tae-Hwan Noh,Hyeong-Kwon Shim 한국응용곤충학회 2011 한국응용곤충학회 학술대회논문집 Vol.2011 No.05

The insecticidal effect for several commercially available environment friendly agricultural materials (EFAMs) is investigated to Cnaphalocrocis medinalis, Narana aenescens, Pseudaletia unipuncta and Parnara guttata on rice. In the insecticidal effects for 2-3rd instar larvae of lepidopteran after treatment with 19 EFAMs, more than 95% of mortality rate showed 5 EFAMs in C. medinalis, 12 EFAMs in N. aenescens, 9 EFAMs in P. unipuncta, and 14 EFAMs in P. guttata, respectively. Among 4 EFAMs selected for C. medinalis in indoor, more than 70% in control effect is seen EFAM-B(85.2%), EFAM-I(79.1%) and EFAM-M (78.3%), respectively, in rice field. The insecticidal effect for EFAMs is investigated to Nilaparvata lugens, Laodelphax striatellus and Nephotettix cincticeps on rice. In the insecticidal effects for 2-3rd nymph and adult after treatment with 19 EFAMs, more than 95% of mortality rate showed 5 EFAMs in N. lugens adult, 7 EFAMs in N. lugens nymph, 6 EFAMs in L. striatellus, and 5 EFAMs in N. cincticeps, respectively. Insecticidal effect for N. lugens was sustained until 10 day in rice treated with 7 EFAMs selected in indoor. Among them, EFAM-L, EFAM-P and EFAM-R was sustained in low density until 27 day. But EFAM-D, EFAM-L, EFAM-N and EFAM-S showed high density until 27 day and additional control was needed.

Discovery of an integrative network of microRNAs and transcriptomics changes for acute kidney injury

Lee, Chan Gyu,Kim, Jin Geol,Kim, Hyun Joo,Kwon, Hyuk-Kwon,Cho, Il Je,Choi, Dal Woong,Lee, Woo Hyung,Kim, Won Dong,Hwang, Se Jin,Choi, Sangdun,Kim, Sang Geon International Society of Nephrology 2014 Kidney international Vol.86 No.5

The contribution of miRNA to the pathogenesis of acute kidney injury (AKI) is not well understood. Here we evaluated an integrative network of miRNAs and mRNA data to discover a possible master regulator of AKI. Microarray analyses of the kidneys of mice treated with cisplatin were used to extract putative miRNAs that cause renal injury. Of them, miR-122 was mostly downregulated by cisplatin, whereas miR-34a was upregulated. A network integrating dysregulated miRNAs and altered mRNA expression along with target prediction enabled us to identify Foxo3 as a core protein to activate p53. The miR-122 inhibited Foxo3 translation as assessed using an miR mimic, an inhibitor, and a Foxo3 3′-UTR reporter. In a mouse model, Foxo3 levels paralleled the degree of tubular injury. The role of decreased miR-122 in inducing Foxo3 during AKI was strengthened by the ability of the miR-122 mimic or inhibitor to replicate results. Increase in miR-34a also promoted the acetylation of Foxo3 by repressing Sirt1. Consistently, cisplatin facilitated the binding of Foxo3 and p53 for activation, which depended not only on decreased miR-122 but also on increased miR-34a. Other nephrotoxicants had similar effects. Among targets of p53, Phlda3 was robustly induced by cisplatin, causing tubular injury. Consistently, treatment with miR mimics and/or inhibitors, or with Foxo3 and Phlda3 siRNAs, modulated apoptosis. Thus, our results uncovered an miR integrative network regulating toxicant-induced AKI and identified Foxo3 as a bridge molecule to the p53 pathway.

In Vivo and In Vitro Antimicrobial Effects of Natural Antibiotics Present In Crude Extracts of Various Medicinal Plants

Moon Geon LEE,Muhammad Imran KHAN,Jin Hyuk SHIN,Jun Su BAEK,Jong Deog KIM 한국생물공학회 2017 한국생물공학회 학술대회 Vol.2017 No.4

In vivo and In vitro Antimicrobial Effects of Natural Antibiotics Present in Crude Extracts of Various Medicinal Plants

Moon Geon Lee(이문건),Muhammad Imran Khan(무하마드 임란 칸),Hyo Jin Seo(서효진),Jin Hyuk Shin(신진혁),Min Yong Kim(김민용 ),Jong Deog Kim(김종덕) 한국생물공학회 2017 KSBB Journal Vol.32 No.1

Bacteria are among the most common causes of severe diseases in both plants and animals. Salmonella spp. has deleterious effects and is the cause of various transmittable diseases. Because of strains resistivity, side effects and high prices of synthetic antibiotics, it has become essential to explore safe and economical natural sources of antibiotics. In this study, growth inhibitory effects of natural antibiotics present in crude extracts of Galla rhois, Thujae semen, Paeonia japonica, and Armeniacae semen were investigated both in vivo and iv vitro. Ethanol extracts of the above-mentioned plants were prepared and tested against seven serovars of Salmonella and Escherichia coli by disc diffusion method. In addition, the antibacterial effects of the plant extracts were determined in vivo using ducks as model animals. Reverse transcription-polymerase chain reaction was performed using blood and fecal samples of control, infected, and treated groups of the ducks to determine the gene expression levels of the bacteria. Our results confirmed that the Galla rhois ethanol extract had the highest antibacterial activity among the plant extracts when they were used individually. However, the Galla rhois, Thujae semen, and P. japonica ethanol extracts showed stronger antibacterial effects against all the bacterial species used when the extracts were combined at a ratio of 3:3:2, respectively.