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Kim, Jae-Min,Bae, Kyung-Yeol,Stewart, Robert,Jung, Bo-Ok,Kang, Hee-Ju,Kim, Sung-Wan,Shin, Il-Seon,Hong, Young Joon,Kim, Ju Han,Shin, Hee-Young,Kang, Gaeun,Ahn, Youngkeun,Kim, Jong-Keun,Jeong, Myung Ho Physicians Postgraduate Press, Inc. 2015 The Journal of clinical psychiatry Vol.76 No.1
<P>Depression is common after acute coronary syndrome (ACS) and has adverse effects on prognosis. There are few evidence-based interventions for treating depression in ACS. This study investigated the efficacy and safety of escitalopram in treating depressive disorders identified 2-14 weeks after a confirmed ACS episode.</P>
Park Gaeun,Jang Wooyoung Eric,Kim Seoyeon,Gonzales Edson Luck,Ji Jungeun,Choi Seunghwan,Kim Yujin,Park Ji Hwan,Mohammad Hazara Begum,Bang Geul,Kang Minkyung,Kim Soobin,Jeon Se Jin,Kim Jin Young,Kim Kw 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with impaired social behavior and communication, repetitive behaviors, and restricted interests. In addition to genetic factors, environmental factors such as prenatal drug exposure contribute to the development of ASD. However, how those prenatal factors induce behavioral deficits in the adult stage is not clear. To elucidate ASD pathogenesis at the molecular level, we performed a high-resolution mass spectrometry-based quantitative proteomic analysis on the prefrontal cortex (PFC) of mice exposed to valproic acid (VPA) in utero, a widely used animal model of ASD. Differentially expressed proteins (DEPs) in VPA-exposed mice showed significant overlap with ASD risk genes, including differentially expressed genes from the postmortem cortex of ASD patients. Functional annotations of the DEPs revealed significant enrichment in the Wnt/β-catenin signaling pathway, which is dysregulated by the upregulation of Rnf146 in VPA-exposed mice. Consistently, overexpressing Rnf146 in the PFC impaired social behaviors and altered the Wnt signaling pathway in adult mice. Furthermore, Rnf146-overexpressing PFC neurons showed increased excitatory synaptic transmission, which may underlie impaired social behavior. These results demonstrate that Rnf146 is critical for social behavior and that dysregulation of Rnf146 underlies social deficits in VPA-exposed mice.
머신러닝을 이용한 의사결정트리 기반의 식품교환표 구성 모델
김지윤 ( Jiyun Kim ),이상민 ( Sangmin Lee ),전형준 ( Hyeongjun Jeon ),김가은 ( Gaeun Kim ),김지현 ( Ji-hyun Kim ),박나은 ( Naeun Park ),진창균 ( Changgyun Jin ),권진영 ( Jin Young Kwon ),김종완 ( Jongwan Kim ) 한국정보처리학회 2020 한국정보처리학회 학술대회논문집 Vol.27 No.2
최근 국내에서는 식품에 대한 관심도가 높아짐에 따라 먹거리에 건강 환경 미래지향적 가치가 부여되고 있으며 식품 산업에서도 신규 식품 개발이 증가하는 추세이다. 식단을 구성할 때 기준이 되는 식품교환표는 개정과정에서 많은 인력과 시간이 소요되기 때문에 식품 섭취 변화를 신속하게 반영하기 어렵다. 본 논문에서는 식품교환표의 활용도를 높이기 위한 식품교환표 갱신 기법을 제안한다. 제안 기법은 의사결정트리 모델을 학습하여 새롭게 추가된 식품의 정보를 바탕으로 식품군을 분류하여 식품교환표를 갱신한다. 이는 영양 관리가 필요한 당뇨병 환자 등에게 실용적이며 기호성·다양성이 높은 식단을 구성하는 데 도움을 준다.
( Gaeun Kim ),( Kwang Yong Shim ),( Soon Koo Baik ) 대한소화기학회 2017 Gut and Liver Vol.11 No.1
Background/Aims: We identified reports in the literature regarding the diagnostic accuracy of hepatic vein arrival time (HVAT) measured by contrast-enhanced ultrasonography (CEUS) to assess hepatic fibrosis in cirrhosis. Methods: The Ovid MEDLINE, Embase, and Cochrane databases were searched for all studies published up to 23 July 2015 that evaluated liver status using CEUS and liver biopsy (LB). The QUADAS-II (quality assessment of diagnostic accuracy studies-II) was applied to assess the internal validity of the diagnostic studies. Selected studies were subjected to a meta-analysis with MetaDisc 1.4 and RevMan 5.3. Results: A total of 12 studies including 844 patients with chronic liver disease met our inclusion criteria. The overall summary sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of the HVAT measured by CEUS for the detection of cirrhosis compared to LB were 0.83 (95% confidence interval [CI], 0.77 to 0.89), 0.75 (95% CI, 0.69 to 0.79), 3.45 (95% CI, 1.60 to 7.43), and 0.28 (95% CI, 0.10 to 0.74), respectively. The summary diagnostic odds ratio (random effects model) was 15.23 (95% CI, 3.07 to 75.47), the summary receiver operator characteristics area under the curve was 0.74 (standard error [SE]=0.14), and the index Q was 0.69 (SE=0.11). Conclusions: Based on a systematic review, the measurement of HVAT by CEUS exhibited an increased accuracy and correlation for the detection of cirrhosis. (Gut Liver 2017;11:93-101)
Kim Gaeun,Jo Heejae,Kim Hyung-Sub,Kwon Minyoung,Son Yowhan 한국응용생명화학회 2022 Applied Biological Chemistry (Appl Biol Chem) Vol.65 No.6
Earthworms (Oligochaeta) are globally distributed soil-dwelling invertebrates that alter soil properties through feeding, casting, and burrowing behaviors. Soil physicochemical modification, which may directly influence the availability and dynamics of organic and inorganic nutrients in the soil, such as carbon and nitrogen, includes soil texture, porosity, and pH. Temperate forests produce year-round plant litter, the primary food source for earthworms, and litter processed by earthworms significantly contributes to soil organic material storage. In recent decades, studies on temperate forest ecosystems have attempted to elucidate and quantify the earthworm impact on soil organic material dynamics, mainly targeting carbon and nitrogen, using isotope analysis methods. This paper summarizes studies on the following topics: (1) effect of earthworm modification on soil property to understand these alterations’ interaction with carbon and nitrogen dynamics, and (2) isotope tracing method, used to elucidate the earthworm effect on carbon and nitrogen transformation and movements in temperate forests. The particular emphasis on the isotope method is based on its capability of time-adjusted quantification of organic materials in the ecosystem compartments. Also, isotopic labeling in biomass has a broad range of applications, such as tracing assimilated food sources, identifying trophic interactions in soil food webs, and addressing material dynamics in complex linkages between earthworms and their environment. In addition, we provide perspectives on other methodologies, such as chronology and population ecology, as feasible options to further assist the isotope tracing of earthworms’ impact on soil nutrient dynamics. Earthworms (Oligochaeta) are globally distributed soil-dwelling invertebrates that alter soil properties through feeding, casting, and burrowing behaviors. Soil physicochemical modification, which may directly influence the availability and dynamics of organic and inorganic nutrients in the soil, such as carbon and nitrogen, includes soil texture, porosity, and pH. Temperate forests produce year-round plant litter, the primary food source for earthworms, and litter processed by earthworms significantly contributes to soil organic material storage. In recent decades, studies on temperate forest ecosystems have attempted to elucidate and quantify the earthworm impact on soil organic material dynamics, mainly targeting carbon and nitrogen, using isotope analysis methods. This paper summarizes studies on the following topics: (1) effect of earthworm modification on soil property to understand these alterations’ interaction with carbon and nitrogen dynamics, and (2) isotope tracing method, used to elucidate the earthworm effect on carbon and nitrogen transformation and movements in temperate forests. The particular emphasis on the isotope method is based on its capability of time-adjusted quantification of organic materials in the ecosystem compartments. Also, isotopic labeling in biomass has a broad range of applications, such as tracing assimilated food sources, identifying trophic interactions in soil food webs, and addressing material dynamics in complex linkages between earthworms and their environment. In addition, we provide perspectives on other methodologies, such as chronology and population ecology, as feasible options to further assist the isotope tracing of earthworms’ impact on soil nutrient dynamics.
( Gaeun Kim ),( Moon Young Kim ),( Soon Koo Baik ) 대한간학회 2017 Clinical and Molecular Hepatology(대한간학회지) Vol.23 No.1
Background/Aims: Transient elastography (TE) has been proposed as a promising noninvasive alternative to hepatic venous pressure gradient (HVPG) for detecting portal hypertension (PH). However, previous studies have yielded conflicting results. We gathered evidence from literature on the clinical usefulness of TE versus HVPG for assessing PH. Methods: We conducted a systematic review by searching databases for relevant literature evaluating the clinical usefulness of non-invasive TE for assessing PH in patients with cirrhosis. A literature search in Ovid Medline, EMBASE and the Cochrane Library was performed for all studies published prior to December 30, 2015. Results: Eight studies (1,356 patients) met our inclusion criteria. For the detection of PH (HVPG ≥6 mmHg), the summary sensitivity and specificity were 0.88 (95% confidence interval [CI] 0.86-0.90) and 0.74 (95% CI 0.67-0.81), respectively. Regarding clinically significant PH (HVPG ≥10 mmHg), the summary sensitivity and specificity were 0.85 (95% CI 0.63-0.97) and 0.71 (95% CI 0.50-0.93), respectively. The overall correlation estimate of TE and HVPG was large (0.75, 95% CI: 0.65; 0.82, P<0.0001). Conclusions: TE showed high accuracy and correlation for detecting the severity of PH. Therefore, TE shows promise as a reliable and non-invasive procedure for the evaluation of PH that should be integrated into clinical practice. (Clin Mol Hepatol 2017;23:34-41)
Tackling Child Labor: Can Better Schools Prevent Children from Working?
Kim, Kyung-Won,Kim, Gaeun,Lee,Soo-Kyoung 계명대학교 간호과학연구소 2017 계명간호과학 Vol.21 No.1
Purpose: The purpose of this study was to investigate the conventional belief on the impact of child labor regulation and to identify related economic problems. Ultimately, the paper aimed to evaluate the successfulness of the United States’ Millennium Development Goals with particular focus on the issues of child labor, and provide policy suggestions for the development and implementation of the Sustainable Development Goals. Methods: Published articles on child labor were reviewed to identify the conventional logic of economics for child labor regulation as well as its problems. In addition, child labor regulations and failures were studied to address the important features of successful child labor regulations. Results: Whereas the conventional economic logic argues for stricter child labor regulation, studies revealed the risk of law enforcements that take place without considering the social and economic factors driving child labor participation. Considering primary education as an effective substitute of child labor, schools with better quality could serve as an alternate solution to child labor problems. However, whereas the nominal achievements of the Millennium Development Goals might be positive, thorough reviews on the quality issues of primary education are rather negative. Conclusion: The paper has shown the importance of primary education and its effectiveness in tackling child labor. However, as the Sustainable Development Goals proceed until 2030, the importance of the quality of education, as well as the quantity of schooling, should be well acknowledged.