Interaction between Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Recent Negative Stressor in Harm Avoidance

Kim, Seog Ju,Cho, Seong-Jin,Jang, Ha Min,Shin, Jonghan,Park, Pil-Whan,Lee, Yu Jin,Cho, In Hee,Choi, Jung-Eun,Lee, Heon-Jeong S. Karger AG 2009 Neuropsychobiology Vol.61 No.1

<P>There have been controversial results regarding the association between brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and anxiety-related traits such as harm avoidance (HA). We aimed to investigate the interaction between <I>BDNF</I> Val66Met polymorphism and negative life stressors in HA. <I>BDNF</I> Val66Met polymorphism was genotyped in 391 community-dwelling Koreans (152 males, 239 females; 43.2 ± 14.1 years old). The Temperament and Character Inventory (TCI) and the Center for Epidemiological Studies for Depression Scale (CES-D) were self applied. The Structured Clinical Interview for DSM-IV axis I disorders and face-to-face interviews investigating negative life stressors within the last 6 months were also performed. There was no significant difference in TCI score, major depressive disorder prevalence and CES-D score among the 3 genotypes (94 Met/Met, 188 Val/Met and 109 Val/Val subjects). There was no significant difference in TCI scores between subjects with stressors and those without stressors, while more common major depressive episodes (p = 0.03) and higher CES-D scores (p < 0.001) were found in subjects with stressors. However, there was a significant interaction between the <I>BDNF</I> genotype and negative life stressors in HA (p = 0.02). Only subjects with the Val/Val genotype showed higher HA with recent negative stressors. Our finding suggests that <I>BDNF</I> Val66Met polymorphism might influence HA by interacting with recent negative stress experience.</P><P>Copyright © 2009 S. Karger AG, Basel</P>

난화를 이용한 자극제시 방법이 정신지체아의 언휘력 증가에 미치는 효과

장은정,권도하 한국언어치료학회 1997 言語治療硏究 Vol.6 No.1

The purpose of this study is to know the effects of two teaching methods using scribble with picture card and picture card only to increase vocabularies in the mentally retarded children. The subjects were four mentally retarded children who were between seven and eleven in chronological age. Each child was experimented with the two word lists using picture card and picture card with scribble. Scribble was used with the words spoken by the teacher. At that time the picture card of target word was presented. The results are as follows. 1. There was no difference in the mean time required for acquiring a single word between the two teaching methods. 2. The child who is the lowest IQ is the best learner with the scribble with picture card method than the rests of the subjects. 3. Even though there was no difference in the mean time in the two methods, the scribble with picture card method seems better than the card only in the respects of developing the learning attitudes. 4. The effects of improving and maintaining articulation observed in scribble plus picture method.

현대국어의 <뼈>명칭 분절구조의 연구 : <부위>를 중심으로

장은하 고려대학교 한국학연구소 2001 한국학연구 Vol.14 No.-

This study attempts to support the explanation of the word field nouns expressing 〈bye〉(bone)in modern Korean language. The explanation of word field related to feature analysis. The word related to body are composed of a proper language, and usually used frequently, and have important role in understanding vocabulary of system, visceral system, circulatory system, nervous system. Skeletal system is composed of bones. 〈bye〉(bone)is structurized by 〈part〉, 〈shape〉, 〈nature〉. and〈the subject〉. From those above investigations, word field nouns expressing 〈뼈: bye〉(bone)can be summarized as below. (1) 〈part〉is structurized by 〈skull〉,〈neck〉,〈trunk〉,〈arm〉and 〈leg〉. (2) 〈skull〉is structurized by 〈cranial part〉and 〈facial part〉. (3) 〈facial part〉is structurized by 〈eye〉, 〈nose〉, 〈cheek〉, 〈mouth〉, 〈chin〉and〈ear〉. (4) The word field nouns expressing 〈neck〉has relatively simple type compared to other word fields. (5) 〈trunk〉is stucturized by 〈breast〉, 〈back〉and 〈pelvis〉. (6) 〈arm, leg〉is structurized by 〈arm〉and〈leg〉.

MRTG를 활용한 네트워크 트래픽 분석

하은용,류장선 안양대학교 산업기술연구소 2004 自然科學硏究 Vol.11 No.1

본 논문에서는 MRTG와 SNMP, MIB를 이용하여 네트워크 트래픽을 모니터링하는 프로그램을 구현하여 안양대학교의 네트워크 상황과 트래픽을 분석했다. 분석 결과 안양대학교의 네트워크의 트래픽 상태는 매우 안정적으로 몇몇 포트를 제외하고는 2% 미만의 트래픽 IN, OUT을 타내난 것으로 확인됐다. 사용자가 많이 몰리는 수봉관 9층, 대신관 3층 같은 경우 10% 대의 트래픽 IN, OUT을 나타내었는데 전체 대역폭에 비하면 이 정도 수치 또한 매우 안정적이라고 판단된다. We implemented a network traffic monitoring system, which used MRTG, SNMP and MIB tools. With our monitoring system, we monitored and analyzed on Anyang University's campus networks. The results how that our campus network traffic is very low except for several network ports. Average network traffics of five network routers are under 2 % of network bandwidth. Specially, 9-th floor at Soobong and 4-th floor at Daeshin show 10% network traffic. These monitoring results show that our campus network is very statble in term of network traffic load.

自動車 塗料의 異同識別에 關한 硏究 : FT-Ingrared Microscopy에 關하여

長成吉,金恩浩,李京華,朴河宣 內務部 國立科學搜査硏究所 1996 國立 科學 搜査 硏究所 年報 Vol.28 No.-

야생효모, Wickerhamomyces anomalus HO9-2로부터 급성 폐손상 억제물질인 호중구 elastase 저해물질 생산 및 생산균주의 균학적 특성

장지은, 문정수, 김하근, 이종수 배재대학교 자연과학연구소 2023 自然科學論文集 Vol.34 No.1

This study was performed to produce acute lung injury-preventing neutrophil elastase inhibitor from non-pathogenic wild yeast and further determine enzyme activity and physiological functionality of the potent wild yeast. Culture supernatants and cell-free extracts of one hundred twenty five non-pathogenic wild yeast strains were prepared and their neutrophil elastase inhibitory activities were measured. The neutrophil elastase inhibitory activity of the cell-free extract from Wickerhamomyces anomalus HO9-2 showed the highest inhibitory activity of 38.4% and its elastase inhibitor was maximally produced(IC50,3.2㎎) when Wickerhamomyces anomalus HO 9-2 was cultured in pH 7.0 of malt extract medium at 20℃ for 24h. Wickerhamomyces anomalus HO9-2 was oval shape and did not form ascospore and pseudomycelium. The HO9-2 strain grew well in YPD and YM media and was halophilic yeast which grew well in YPD medium containing 15% NaCl. Cell-free extract of the HO9-2 strain were showed high 17.2U of glucoamylase activity and anti-diabetic α-glucosidase inhibitory activity of 87.5%. 본 연구는 급성 폐손상 예방(또는 치료)의약 소재를 개발하기 위하여 비병원성 야생효모들의 elastase 저해활성을 측정하여 우수 균주를 선발하였다. 또한 선발균주의 elastase 저해제 생산 조건을 최적화 하였으며 선발균주의 미생물학적 특성 등을 조사하였다. 비병원성 야생효모인 Wickerhamomyces anomalus HO9-2의 무세포추출물이 38.4%의 호중구 elastase 저해활성을 보여 우수균주로 선발하였고 이 균을 pH 7.0 의 malt extract 배지에서 20℃로 24시간 배양하였을 때 최고의 elastase 저해활성(IC50, 3.2mg)을 보였다. 또한 이 균은 난형으로 포자와 의균사를 형성하지 않았고 YPD와 YM배지에서 생육이 양호하였고 NaCl을 15% 함유한 배지에서도 생육하는 호염성 효모이었다.

우리 나라 보건관리대행서비스 평가 연구

하은희,조수헌,김선민,주영수,한상환,하미나,권호장,홍윤철,김창엽 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.1

Group occupational health service programme started in 1990 is one of the measures to cope with limited human and financial resources in occupational health. The programme has expanded rapidly to include 52 institutions, private as well as public, all over the country. In spite of its potential impact on health of employees and practice of occupational health in small and medium sized industries, comprehensive evaluation in terms of quality has not been tried. This study has aims to develop the criteria to assess the quality of newly developed group occupational health service programme, and to investigate the quality of institutions, and finally to develop policies for the quality improvement. 1) Criteria development : By defining occupational health services, in particular for small and medium sized industries, as one of the primary health care, followings are included as core elements of qualitative occupational health programme; accessibility, continuity, comprehensiveness, technical quality, intersectoral collaboration, emphasis on preventive services, community participation, and adequacy. Again each element is divided into five major components of national health system infrastructure developed by the World Health Organization; development of health resources, organized arrangement of resources, delivery of health care, economic support, and management. In turn, each component is categorized into three aspects of quality assessment, structure, process and outcome. Expert panel selected several criteria for each category to evaluate the programme. Criteria were modified according to each group of interviewees, to produce two sets of questionnaire, one for chief operating officer and another for nurses in the institutions, and the chief operating officer and workers in the workplace. 2) Subject : Of all 52 institutions, 25 voluntarily participated in the survey. At individual institution, chief operating officer and practicing nurses were interviewed in depth. After intensive education for interviewees, every interviewees, every interview was performed with standardized guideline and questionnaire. The quality of the 'Group occupational health service programme' was found to be lower than expected. Especially in continuity, comprehensiveness, technical quality, community participation and adequacy, lower quality in structural aspect was commonly identified throughout all the institutions,. Quality in terms of accessibility and continuity highly varied among institutions., To improve quality of the programme, more comprehensive and systematic programme such as accreditation has to be introduced. In addition, human resources, governmental fund and information systems for individual workers are to be developed. As a long range plan, integration of occupational health services into the national health systems and pooling of financial resources and planned allocation should be considered.

아크릴아미드 고정 구멍갈파래에 의한 중금속 Cd(Ⅱ), Pb(Ⅱ) 이온의 흡착특성 (Ⅰ)-Column법

박광하,권영두,정영진,장은경 한국공업화학회 2004 공업화학 Vol.15 No.1

본 연구에서는 동해안 해조류인 구멍갈파래를 아크릴아미드에 고정하여, Cd(Ⅱ) 및 Pb(Ⅱ) 중금속 이온의 흡착 특성을 살펴보았다. 수순한 Ulva pertusa 및 Si-Ulva pertusa 흡착제보다는 아크릴아미드에 고정화된 Ulva pertusa의 경우 많은 양의 중금속이 흡착되었으며, Pb(Ⅱ) 이온이 Cu(Ⅱ) 이온보다 더 잘 흡착되는 것으로 나타났다. 흡착제의 농도가 작은 경우 중금속 이온의 흡착량은 pH에 큰 영향이 없었으나, 흡착제의 농도가 클 경우 중금속 이온의 흡착량은 pH에 큰 영향을 받았다. pH에 따른 중금속 이온의 흡착량은 pH 10.5 > 8.5 > 7.0 > 5.5 > 3.5 순으로 나타났다. 아크릴아미드에 고정화된 Ulva pertusa의 단위 질량에 대해 Cd(Ⅱ) 및 Pb(Ⅱ) 이온의 최대 흡착량은 각각 최대 8.73 ㎎과 13.20 ㎎으로 나타났다. 또한 Cd(Ⅱ) 및 Pb(Ⅱ) 이온의 회수율은 pH에 따라 다소 차이가 있었으나, 각각 61.3~75.5% 및 61.4~54.1%로 나타났다. 중금속 이온의 회수에 있어서 산성 조건이 알칼리성 조건보다 효율적이었으며, 본 실험에 의한 중금속 이온의 흡착 특성은 Freundlich 흡착 특성과 잘 일치하는 것으로 나타났다. Adsoprtion characteristics of Cd(II) and Pb(II: heavy metal ions onto the Acrylamide-immobilized Ulva pertusa, and algae of the eastern coastal area. was examined in this work. Much amounts of heavy metal ions were adsorbed onto the Acrylamide-immobilized than either bare Ulva pertusa or Si-Ulva pertusa. It was also observed that Pb(II) was more readily adsorbed on the algae that Cu(II). The adsorption amounts of heavy metal ions showed no great dependence on the pH value at low adsorbent concentration, but those were high dependent on pH value at high adsorbent concentration. The adsorption amounts of heavy metal ions were in the following order; pH 10.5 > 8.5 > 7.0 > 5.5 > 3.5. The maximum adsorption amounts of Cd(II) and PB(II) onto Ig of Acrylamide-immobilized Ulva pertusa were 8.73 mg and 13.20 mg, respectively. It was found that recovery yields of Cd(II) and Pb(II) ions were in the range of 61.3∼75.5% and 61.4∼54.1% depending on the pH level. In the heavy metal recovery, acidic condition was more efficient that alkaline condition. The adsorption behavior of these heavy metal ions was well matched with the Freundlich adsorption isotherm.

법과학적 응용을 위한 섬유의 동일성에 관한 연구(Ⅰ) : FT-IR, PY-GC에 의한 섬유의 동일성에 관한 연구 A Study on the Identification of Textile by FT-IR & Py-GC

김은호,김명덕,김재균,박하선,장성길,박성우 內務部 國立科學搜査硏究所 2002 國立 科學 搜査 硏究所 年報 Vol.34 No.-

Gas Chromatography에 依한 潤滑油의 異同識別에 關한 연구(Ⅲ報)

金恩浩,李京華,朴河宣,長成吉 內務部 國立科學搜査硏究所 1996 國立 科學 搜査 硏究所 年報 Vol.28 No.-