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김재균,배지훈,조원태,임홍철 대한정형외과학회 2015 Clinics in Orthopedic Surgery Vol.7 No.1
Background: The aims of our study were to evaluate the success rate of irrigation and debridement with component retention(IDCR) for acutely infected total knee arthroplasty (TKA) (< 4 weeks of symptom duration) and to analyze the factors affecting prognosisof IDCR. Methods: We retrospectively reviewed 28 knees treated by IDCR for acutely infected TKA from 2003 to 2012. We evaluated thesuccess rate of IDCR. All variables were compared between the success and failure groups. Multivariable logistic regression analysiswas also used to examine the relative contribution of these parameters to the success of IDCR. Results: Seventeen knees (60.7%) were successfully treated. Between the success and failure groups, there were significant differencesin the time from primary TKA to IDCR (p = 0.021), the preoperative erythrocyte sedimentation rate (ESR; p = 0.021), microorganism(p = 0.006), and polyethylene liner exchange (p = 0.017). Multivariable logistic regression analysis of parameters affectingthe success of IDCR demonstrated that preoperative ESR (odds ratio [OR], 1.02; p = 0.041), microorganism (OR, 12.4; p = 0.006),and polyethylene liner exchange (OR, 0.07; p = 0.021) were significant parameters. Conclusions: The results show that 60.7% of the cases were successfully treated by IDCR for acutely infected TKA. The preoperativeESR, microorganism, and polyethylene liner exchange were factors that affected the success of IDCR in acutely infectedTKA.
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비소세포폐암종에서 CD44s, CD44v5 및 CD44v6 발현의 임상병리학적 의의
김재균,이창훈,이경민,송진미 대한병리학회 2004 Journal of Pathology and Translational Medicine Vol.38 No.2
Background : CD44 is a polymorphic family of transmembrane glycoproteins generated by alternative splicing of messenger RNA and is involved in the mechanism of tumor invasion and metastasis. Methods : The expression of selected CD44 molecules (CD44s, CD44v5, and CD44v6) was determined immunohistochemically in 84 cases of non small cell lung carcinomas (NSCLCs). The results were compared with PCNA index, microvessel density (MVD), and clinicopathological parameters including patient’s survival. Results : CD44s showed a positive reaction in 61.9% (52/84) of NSCLCs, CD44v5 in 73.8% (62/84), and CD44v6 in 39.3% (33/84). Squamous cell carcinomas (SCCs) displayed preferential expression of all CD44 molecules in comparison with adenocarcinomas (ACs) (p<0.001). As a whole, the expression of CD44 molecules was not correlated with clinical parameters (stage, TNM-T, and TNM-N), PCNA index, or MVD. For ACs only, however, CD44v5 expression was negatively correlated with PCNA index (p<0.05). Poor survival was correlated with CD44v5 expression in ACs and CD44v6 in SCCs (both, p<0.05). Conclusions : These findings suggest that CD44 molecule in NSCLC could be a distinctive phenotypic marker for SCC, and the possibility that CD44v5 and CD44v6 are in some way instrumental in conditioning the biologic behavior of NSCLC according to major histologic types.
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