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오도연 ( Do Yeun Oh ) 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.2(S)
Patients with chronic liver disease frequently show hemostatic abnormalities with complex mechanism. Patients with chronic liver disease may be in hemostatic rebalance by concomitant changes in prohemostatic and antihemostatic pathways. Because the rebalanced hemostatic conditions in patients with chronic liver disease can be only detected by sophisticated tests, results from current routine laboratory tests do not well correlated with clinical findings in patients with chronic liver disease. More studies are required for proper management of hemostatic abnormalities in patients with chronic liver disease.
Double primary lung adenocarcinoma diagnosed by epidermal growth factor receptor mutation status
( Oh Jung Kwon ),( Min Hyeok Lee ),( Sung Ju Kang ),( Seul Gi Kim ),( In Beom Jeong ),( Ji Yun Jeong ),( Eun Jung Cha ),( Do Yeun Cho ),( Young Jin Kim ),( Ji Woong Son ) 영남대학교 의과대학 2017 Yeungnam University Journal of Medicine Vol.34 No.2
A nodular density was detected on a chest radiograph taken from a 57-year-old Korean woman who was visiting a hospital for a routine check. Chest computed tomography revealed a 4.8 cm lobulated mass in the right lung and another focal nodular lesion in the left lung; biopsies of both lungs revealed adenocarcinoma. We conducted DNA sequencing and peptide nucleic acid clamping to investigate the potential double primary lung cancer. The results verified that the mass in the right lung had a mutation in the epidermal growth factor receptor, whereas the nodule in the left lung had a wild-type sequence, showing that these two were genetically different cancers from one another. Thus, we demonstrate that genetic testing is useful in determining double primary lung cancer, and we herein report on this case.
S-341 Double primary lung cancer diagnosed by epidermal growth factor receptor mutation status
( Oh Jung Kwon ),( Min Hyuk Lee ),( Sung Ju Kang ),( Seul Gi Kim ),( In Beom Jeong ),( Eun Jung Cha ),( Do Yeun Cho ),( Young Jin Kim ),( Ji Woong Son ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
A nodular density was detected in a chest radiograph in a 57-year-old Korean woman who was visiting a hospital for a routine check. Chest computed tomography revealed a 4.8 cm lobulated mass in the right lung and another focal nodular lesion in the left lung, and biopsy of both lungs revealed adenocarcinoma. We conducted DNA sequencing and peptide nucleic acid clamping discern double primary lung cancer. The results verified that the right lung had a mutation of the epidermal growth factor receptor whereas the left one had a wild-type sequence, showing that these were genetically different cancers. Thus, we came to be sure that genetic testing was useful in discerning double primary lung cancer, and we here report on this case.
Double primary lung adenocarcinoma diagnosed by epidermal growth factor receptor mutation status
Kwon, Oh Jung,Lee, Min Hyeok,Kang, Sung Ju,Kim, Seul Gi,Jeong, In Beom,Jeong, Ji Yun,Cha, Eun Jung,Cho, Do Yeun,Kim, Young Jin,Son, Ji Woong Yeungnam University College of Medicine 2017 Yeungnam University Journal of Medicine Vol.34 No.2
A nodular density was detected on a chest radiograph taken from a 57-year-old Korean woman who was visiting a hospital for a routine check. Chest computed tomography revealed a 4.8 cm lobulated mass in the right lung and another focal nodular lesion in the left lung; biopsies of both lungs revealed adenocarcinoma. We conducted DNA sequencing and peptide nucleic acid clamping to investigate the potential double primary lung cancer. The results verified that the mass in the right lung had a mutation in the epidermal growth factor receptor, whereas the nodule in the left lung had a wild-type sequence, showing that these two were genetically different cancers from one another. Thus, we demonstrate that genetic testing is useful in determining double primary lung cancer, and we herein report on this case.
연쇄알구균 감염에 의한 급성 인후염 후 반응성 관절염 1예
박은하,도연실,양정채,강미라,서현주,정숙인,손준성,기현균,오원섭,백경란,송재훈 대한감염학회 2004 감염과 화학요법 Vol.36 No.6
연쇄알구균에 의한 급성 인후염 후 발생한 반응성 관절염은 급성 류마티스열의 개정된 진단기준을 충족하지 못하면서, 지속적 혹은 재발성의 비이동성 관절염과 발열, 홍반성 결절, 일시적 간기능 이상 등을 보이면서 심장염과 무도증을 드물게 동반하는 질환이다. 따라서, 발열을 동반한 급성 관절염 환자에서 감별해야 할 질환 중의 하나이며, 심근염 예방을 위한 페니실린 요법의 적응증 및 기간에 대해서는 아직 이론이 많은 상황으로, 보다 광범위한 연구가 필요하다. 저자들은 연쇄알구균에 의한 급성 인후염 1주 후에 발생한 하지의 다발성 비이동성 관절염과 함께 결절홍반 및 일시적 간기능 이상을 보인 환자에서 PSRA로 진단하고 비스테로이드성 항염증제 및 스테로이드로 성공적인 치료를 하였기에 이를 문헌 고찰과 함께 보고하는 바이다. Poststreptococcal reactive arthritis (PSRA) is associated with recent streptococcal infections. However, PSRA is distinct from acute rheumatic fever by its clinical manifestations: non-migrating arthritis, erythema nodosum or erythema multiforme, and transient elevation of serum transaminases. We experienced a 33-year-old man who presented with fever, arthritis of both knees and ankles, and erythema nodosums on extensor surfaces of lower legs which developed 6 days after the onset of pharyngitis symptoms. Blood and urine cultures were negative. Throat culture was negative for group A β-hemolytic streptococcus. The ASO titers increased up to 2080 IU/mL in sequential monitoring. The result of bone scan was compatible to arthritis of both knees and ankles. There were no signs or symptom of carditis. He showed clinical improvement with anti-inflammatory drugs (naproxen 1,000 mg/day and prednisolone 7.5 mg/d). PSRA should be included in the differential diagnosis of patients presenting with arthritis combined with fever.