77K에서 SC(NH₂)₂의 ¹⁴N 핵사중극 공명연구

최숙자,박영민,박현진,전인,송승기,서용문 명지대학교 자연과학연구소 1997 자연과학논문집 Vol.16 No.-

강유전체 질소화합물 thiourea [SC(NH₂)₂]분말시료의 ??plused NQR 실험을 77K 에서 실행하여 공명진동수와 핵사중극 결합상수, 비대칭인자, 완화시간등을 측정했으며, 4개의 공명선이 관측되었다. 결정내에는 주위 환경이 다른 두 종류의 질소 N₁,N₂가 존재함을 알 수 있었다. N₁에 관한 공명진동수는 ??(1)=2.6487㎒, ??(1)=2.032㎒, N₂에 대하여는 ??(2)=3.1852㎑, ??(2)=2.0183㎒이고, 공명선폭은 ??(1)=2.6752㎑, ??(1)=3.1852㎑, ??(2)=3.2618㎑, ??(2)=3.5448㎑ 임을 보였다. 한편 e²qQ/h의 값은 ν(1)에서 3.1205㎒, η는 0.3953이었으며, ν(2)에서는 3.0279㎒, 0.3939이었다. 이는 이미 보고된 결과와 일치하였다. 그리고, FID(Free Induction Decay)와 spin-echo실험을 통하여 얻은 스핀-격자 완화시간 T₁은 ??(1)에서 7.143 s, ??(2)에서 5.88 s이었으며, 스핀-스핀 완화시간 T₂는 ??(1)에서 25㎳, ??(2)에서 33.3㎳, ??(2)에서 33.3㎳의 값을 얻었다. We have measured ??N NQR frequencies, nuclear quadroupole coupling constants, asymmetric parameters and relaxation times in ferroelectric nitrogen thiourea [SC(NH2)2] at 77K, and four NQR resonance lines were observed. The results of measurements show that there are two kinds of nitrogen site, N1 and N2, with different environments in the crystal. The resonance frequencies were found to be ν+(l)=2.64 87MHz, ν_(1)=2.032 MHz for N1 and ν+(2)=2.6285MHz, ν_(2) =2.0183MHz for N2 respectively. The corresponding linewidths were ν+(1)= 2.6752kHz, Δν_(l) =3.1852kHz, ν+(2) =3.2618kHz and Δν_(2) =3.5448kHz, respectively. For N1, e2Q/h is 3.1205 MHz and η is 0.3953, and for N2, these are 3.0979MHz and 0.3939. These results are in agreement with those reported previously. The spin-lattice relaxation time (Ti) and the spin-spin relaxation time (T2) by FID and spin-echo experiments are as follows : T1(ν+(1)) is 7.143 s and T1(ν+(2)) is 5.88 s. T2(ν+(1)) is 25 ms, T2(ν_(1)) is 25 ms, T2(ν+(2)) is 33.3 ms and T2(ν_(2)) is 33.3 ms.

성인 천식환자에서 도메난(염산 오자그렐)의 임상적 효과와 안전성

최인선,고영일,임호,명보현,홍서나,오봉석,이삼용 최신의학사 2000 最新醫學 Vol.43 No.9-10

冬蟲夏草의 抗轉移와 免疫增進에 關한 硏究

최우진,유화승,이용연,서상훈,조정효,이연월,손창규,조종관 대전대학교 한방병원 2000 惠和醫學 Vol.9 No.2

This experimental study was carried out to evaluate the effects of Cordiceps sinensis on the antimetastasis and immune activity. In order to investigate the effect of Cordiceps sinensis, the followings were performed; Cytotoxicity, inhibition of MMP-2 & MMP-9 gene expression, fraction of CD4+, CD8+, CD19+ in splenic cell, the moprphological change of splenic cells, gene expression of IL-12(p35), IL-12(p40), IFN-?? and splenic cell proliferation by CS-E. The results were obtained as follows. 1. CS-E did not present cytotoxic effect on L+14, B16-F10 melanoma cells and HMCB. 2. CS-E inhibited MMP-2 and MMP-9 gene expression more effectively compared with control group. 3. CS-E inhibited invasion of B16-F10 melanoma cells more effectively compared with control group. 4. CS-E helped CD4+, CD8+, CD19+ expression more effectively compared with control group. 5. CS-E activated phagocytic cells in spleen more effectively compared with control group. 6. CS-E helped IL-12(p35), IL-12(p40), IFN-?? gene expression in splenic cell more effectively compared with control group. 7. CS-E activated splenic cell proliferation more effectively compared with control group. From above findings, it is suggested that CS-E is able to inhibit metastasis of cancer and activate immune response system.

Plasminogen kringle (angiostatin) 분획의 유효부분 분석

최영기,서원덕,이종수,신광순,김철중 충남대학교 수의과대학 동물의과학연구소 1998 動物醫科學硏究誌 Vol.6 No.-

In order to inhibit the growth of the malignant tumor, the development of various drugs against the malignant tumors has been archived. The combination of these drugs made the tumor therapy possible, but in many cases, secondary matastasis of the tumor to the other organs after its removal has been frequently reported. The angiostain, recently purified and cloned, not only promtes the angiogenesis of the tumor itself in the primary tumor but also inhibits the angiogenesis and metastasis of the secondary tumors. In this study, the nucleic acid sequences of the angiostatin was investigated. And the angiostain gene was expressed in a prokayotic expression system(E. coli) and a eukayotic expression system(Pichia pastoris). The angiostain gene was futher subcloned into 6 clones to characterize its biological activity. In the near future the biological activity and the biochemical property of the protein encoded by each clone will be elucidated.

지능화 진단 시스템개발을 위한 광바이오 텔레미트리 칩 제작

서희돈,박차훈,배용욱,최세곤 嶺南大學校 工業技術硏究所 1997 工業技術硏究所論文集 Vol.25 No.1

In this paper, we fabricated optical telemetry IC chip using CMOS process. The telemetering IC with the size of 4 ×4㎟ has the following functions: receiving of command signals, initialization of internal state of all functional blocks, decoding of subject-selection signal, time multiplexing of 4-channel modulated physiological signals, transmission of telemetry signal to extemal system, and auto power down control. The designed synchronous oscillator with low supply voltage dependence operates at a supply voltage from 4.6V-6.0V. And the nonlinearity error of PIM modulator was less than 1.2%FS. In order to demonstrate the principle operations of the implemented CMOSIC chip, the experiments of biotelemetry was performed by telemeter unit and external unit. Main features of this system are to select one of the 4 subjects, to enable measurement of biological signals using the same optical signal, and transmit them back to the extemal unit.

非晶質滋性合金薄帶의 滋歪測定에 관한 硏究

崔熙太,愼鏞璡,徐康壽 明知大學校 産業技術硏究所 1989 産業技術硏究所論文集 Vol.8 No.-

This paper is studied on the measurement of magnetostriction of an alloy ribbons tensile force, via measuring the response ar the double frequency of the driving field frequency. The experiments with both crystalline magnetic material,(??)-Fe and amorphous magnetic material. ??, proved that the possibility in this paper can measure magnetostriction with ease and high accuracy.

스쿠알렌 합성 유전자를 도입한 형질전환 가시오가피

서진욱,정재훈,최용의,이학성,신차균 중앙대학교 유전공학연구소 2003 遺傳工學硏究論集 Vol.16 No.1

The enzyme, squalene synthase, represents a branch point in the isoprenoid pathway capable of diverting carbon flow specifically to the biosynthesis of phytosterol and Triterpenoid. Transgenic Eleutherococcus senticosus plants were prepared by introducing the genes for squalene synthase derived from Panax ginseng (PgSS1), hygromycin phosphotransferase (HPT) and green fluorescent protein (GFP) through Agrobacterium-mediated transformation. Establishment of transgenic plantlets were confirmed by the presence of PgSS1 and HPT bands in the genomic DNA preparation using a PCR method and a Southern blotting. In addition, expression of the introduced GFP DNA was confirmed by observing green fluorescence of GFP from the embroyos. In the in vitro analysis of the PgSS1 enzymatic activities the transgenic plants showed to have 1.5 to 3 times higher than wild type plant, indicating that the PgSS1 genes was well over-expressed in the transgenic plants. Especially the PgSS1 acivities of embroyogenic cell was 120 times higher than those of plantlet.

蒼耳子의 IC - 2 細胞에 대한 抗알러지 效果에 關한 硏究 ( 2 )

徐榮培,崔永奉,李龍求,李永喆 대한본초학회 2002 大韓本草學會誌 Vol.17 No.1

This study was carried out for the purpose of knowing the effect from anti-allergic action of B cells and the IC-2 mast cells the extraction from Xanthii Fructus(EXF). In order to know the effect of the cytotoxicity from extraction of Xanthii Fructus, we had to examine the safe density of EXF on lung fibroblast cells of the mouse (mLPCs). We also attempted to resolve the relationship cytotoxicity. The effect was on the organization of cytokine gene expression from the increas and divorce of the B cells and allergic acting by EXF, we found it necessary to examine the IC-2 cells and B cells. We examined the histamine release of IC-2 cells by ELISA method, we also examined the effect of EXF on the increase and divorce of the B cells by ^3H-thymidine uptake method. We then analyzed the release of IL-4, IgE and nitric oxide (NO). The results are as follows : 1. EXF did not show cytotoxicity against mLFCs. 2. According to the inspection on the effect on IC-2 cells gene expression by EXF, we found out the following results: EXF reduced IL-4, IL-6, GM-CSF, TNF-α gene expression and histamine release of IC-2 cells. The EXF inhibited signs of inflammation IC-2 cells.

관상동맥 누공에 의한 급성 심근 경색 1예

서유승,최재웅,송창섭,조용범,양진수,박준섭,정인수 대한내과학회 2003 대한내과학회지 Vol.65 No.2

관상동맥 동정맥루 기형은 매우 드문 질환으로 치료가 불필요한 경우가 대부분이나 coronary steal 현상으로 인해 증상이 발생하거나 합병증이 발생한 환자에 대해선 치료를 요한다. 최근에는 시술에 적합한 누공을 가진 선택된 환자군을 대상으로 카테터를 이용한 중재적 시술이 시행되어 수술적 치료와 유사한 결과를 얻고 있다. 저자들은 젊은 남자에서 관상동맥 동정맥루 기형과 동반된 급성 심근 경색증을 진단하여 비 수술적 방법인 카테타 코일 색전술로 성공적 치료 후 증상 및 심근 재관류에 호전을 보인 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. We report a case of coronary fistula between the left anterior descending and main pulmonary artery complicating acute non-Q wave myocardial infarction. A 27-year-old man visited emergency department because of severe chest pain lasting two hours. The electrocardiogram showed ST segment elevation in precordial leads V3~6. Cardiac enzymes were as follows;CK-MB:36.44 IU/L T-T:0.489 ng/mL, CPK:542 IU/L, and LDH:475 IU/L. The thallium-201 dipyridamole stress perfusion scan showed perfusion defect and reversed redistribution in the anteroseptal wall. The coronary angiogram revealed coronary artery fistula between the proximal left anterior descending artery and main pulmonary artery without significant stenoses of coronary arteries. The result of ergonovine test was negative. After micro-coil embolization to the coronary fistula, symptoms were improved. Follow-up thallium-201 scan showed normalized blood flow in the left anteroseptal wall.

요로손상의 예방과 대책

최유덕,이서용,김자영,곽인호 대한가정의학회 1988 Korean Journal of Family Medicine Vol.9 No.3