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      • Slide Session : OS-IFD-07 ; Infectious Disease : In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus

        ( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

        In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.

      • KCI등재후보

        비복신경이식을 이용한 긴 거리의 말초신경 결손부 수복

        이종호,이세영,김명진,이은진,안강민,김성민,최원재,명훈,황순정,서병무,최진영,정필훈 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.2

        The surgery of oral and maxillofacial area poses the risk of cranial nerve damage such as trigeminal nerve or facial nerve. Inferior alveolar nerve is prone to damage in the third molar extraction, implant installation, orthognathic surgery, open reduction and rigid fixation, and tumor ablation surgery. On the other hands,facial nerve is likely to be damaged or sacrificed with trauma or parotidectomy. In case of inferior alveolar nerve injury, the incidence is reported to be about 1.3%. The nerve function will almost recover in minimal damage, but it won't recover at last in total damage of a part of nerve unit. In latter cases, nerve regeneration in intended by allograft as nerve substitute or various route of merve condit. But the recovery with autograft is believed to be most relialbe mrthod in the rapair of long-span(longer than 15㎜)nerve defect. We have performed autologous sural nerve graft in the repair of nerve defect, which is caused by resection of benign or malignant tumor. Hereby we report the method of nerve harvesting, recovery of defected peripheral nerve and the complications of donor site with the discussion of sural nerve anatomy.

      • 飽和度에 따른 三軸壓縮强度의 特性 硏究

        최명진,고영현,상현규,김팔규 忠南大學校 産業技術硏究所 1999 산업기술연구논문집 Vol.14 No.1

        Lately,the study of the soil behavior and mainly related to the degree of saturation. But most soils in the ground actually exist not in the saturated condition but in the unsaturated one. The foundation bases adn the soils used for construction material are almost such unsaturated soil as granite soil in Korea. The griaxial test are used in order to examine the strength characters of the unsaturated soil in this research, reappeared in-situ field condition for the undaturated soil through the UU-test in the laboratory and examined strength character. The variation of shear strength accrding to the increase of the degree of saturation is measured as the result and the proposed formula are suggested

      • 초기 인장력을 고려한 유체 유동 굴곡 파이프의 고유 진동수 해석

        최명진 慶熙大學校 材料科學技術硏究所 1999 材料科學技術硏究論集 Vol.12 No.-

        Using finite elements, a simulation is performed for pipe systems to investigate free vibrational characteristics, that is natural frequencies, considering the initial tension due to the velocity and the pressure of the inside fluid flow. To confirm the program developed in this study, the results are compared with the results of commercial software ANSYS. When the initial tension is neglected in curved pipes, the natural frequencies are reduced as flow velocity increases, and the rapid decrease of the natural frequencies took place. However, when the initial tension is taken into account, the natural frequencies are not changed with the change of the flow velocity. In free vibrational simulation of pipe systems, it is necessary to calculate the initial state force due to the velocity and the pressure of the fluid flow from the equilibrium first, then the force should be included in the equation of motion of the systems to get more accurate natural frequencies. The angles of elbows do not affect the change of the fundamental natural frequency, but affect the change of the third or higher natural frequencies.

      • 유속과 곡관부의 형상 변화를 고려한 파이프 계의 자유진동 해석

        최명진,임경식,이동명 경희대학교 산학협력기술연구원 2000 산학협력기술연구논문집 Vol.6 No.-

        A simulation is performed to study the change of the natural frequencies of curved pipe systems containing fluid flow, for different angles and geometry of the pipe systems. Based upon the Hamilton's principle, the equations of motions are derived. This paper consider an initially deformed state caused by the fluid flowing through the pipe at a constant velocity. This deformed state gives rise to initially tension force in the pipe. When the initial force is neglected in cured pipes, the natural frequencies are reduced as flow velocity increases. However, when the initial force is considered, the natural frequencies changed a little with the change of the flow velocity for changing shape(curvature, angle) of curved pipes. In free vibrational simulation of pipe systems, it is necessary to consider the initial force due to the flow velocity and the geometric shape of pipes. Like this, the initial force should be included in the equation of motion of the systems to get more accurate natural frequencies and the change of shape of curved pipes should be considered.

      • KCI등재후보

        의류 중의 미생물에 대한 소비자의 지식과 세탁습관 실태조사 분석

        최해운,정찬진,박명자 服飾文化學會 2002 服飾文化硏究 Vol.10 No.6

        Microorganisms living in clothing cause damage to fabric as well as unhygienic conditions with unpleasant odor for wearers. Removal or growth of microorganisms are affected by the conditions during washing and storage. The purpose of this research was to study the consumer's knowledge and habits in laundering with respect to microorganisms in clothing. For survey method, questionnaires were administered to 580 housewives, age of 20~60s living in Seoul. Employing 479 respondents, the data were analyzed by using deseriptive statistics. The results are as follows; The level of knowledge about microorganisms of clothing was high in general, but wasn't expert level. Many people had experienced damages of textiles, clothing and unpleasant odor due to microorganisms. Fabric softeners and bleaches were rarely used for disinfection but usually used for antistatic. whitening or removal of stains. There was no relationship between laundering habits the knowledge of microorganism, and experience of clothing damage by microorganism

      • 감쇠와 강성이 오토바이 헬멧의 충격응답에 미치는 영향

        최명진,이동명 慶熙大學校 材料科學技術硏究所 1998 材料科學技術硏究論集 Vol.11 No.-

        Using the finite element analysis, a simulation is performed to find the impulsive response of a motorcycle helmet, and equivalent one degree of freedom vibrational model is adapted. Using the model, transient responses due to impulse of drop are analysed to investigate the impulsive responses with respect to the damping and the stiffness of motorcycle helmets, respectively. The she-me and results can be utilized in the design of high quality motorcycle helmets to control the design parameters.

      • 내부 유체 유동속도와 지지점 변화에 따른 굴곡파이프의 고유진동수

        최명진 경희대학교 산학협력기술연구원 1998 산학협력기술연구논문집 Vol.4 No.-

        Based upon the Hamiton's principle, the equations of motions are derived, and the finite element equation is constructed to solve the eigenvalue problem for curved pipe structures. To confirm the scheme used in this study, the results are compared with the results of commercial software ANSYS. When the initial tension is neglected in cured pipes, the natural frequencies took place. However, when the initial tension taked into account, the natural frequencies are not changed with the change o the flow velocity. In free vibrational simulation of pipe systems, it is necessary to calculate the initial state force due to the velocity and the pressure of the fluid flow from the equilibrium, then the force should be included in the equation of motion of the systems to get more accurate natural frequencies. The mechanical properties like stiffness or the location of pipe supports are need to be changed to avoid resonance. The natural frequencies are to be isolated from the frequency range of dominant vibration modes. The angles of elbows do not affect the change of the fundamental natural frequency, but affect the change of the third or higher natural frequencies.

      • 중소기업형 CIM시스템 구축을 위한 생산계획수립 및 실적파악 모듈

        최후곤,신완선,장중순,서준성,여명구,안동근,김진봉 成均館大學校 科學技術硏究所 1996 論文集 Vol.47 No.2

        This study Focuses on developing several modules involved in an integrated production information system for medium- or small-sized industries. The modules of order management, quality control, production scheduling, and shop management are executed for an example case industry. The potential values of this research includes that the major information modules to collect, analysis, and display production data and shop data for constructing the computer integrated manufacturing system(CIMS) are programmed with various features of medium- or small-sized industries

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