충남지역 석불의 암석학적 풍화특성에 관한 연구

최석원,채상정,이효민 공주대학교 문화재보존과학연구소 2003 문화재과학기술 Vol.2 No.1

충청남도내의 중요문화재로 지정된 석불 중 역사적 중요성을 가지고 구조적으로 보아 위험성이 있는 것으로 판단되는 석불 31개를 대상으로 암석학적 특징, 풍화에 의한 암석의 조직 및 광물학적 변화, 풍화에 따른 물성 변화 등, 석불을 이루고 있는 암석의 풍화특성을 파악하였다. 석불을 이루고 있는 암석은 대부분이 중립 내지 조립질의 화강암류이며, 소수 석불만이 편마암으로 이루어져 있다. 시료채취가 가능한 12개 화강암류 석불의 모드분석 결과, 흑운모화강암 8개, 반상화강섬록암 3개, 화강섬록암 1개로 분류되었다. 이것들은 암석자체에 많은 절리, 박리조직과 심한변색을 보이고 있다. 편광현미경하에서의 관찰 결과, 장석류는 견운모화작용이 심하고, 흑운모는 녹니석화작용으로 주변광물을 변색시키며, 석영은 일정한 방향으로 균열이 발생하는 등의 조직변화가 일어나고 있다. 석불을 구성하고 있는 암석은 풍화가 많이 진행되어 카올리나이트화 되었으며. 풍화등급은 MW에서 HW에 속한다. 따라서 대부분의 석불들은 풍화를 많이 받은 상태이고, 각 석불의 풍화특성을 고려하여 과학적이고 비파괴적인 보존방법이 연구되어야 할 것이다. This study was carried out the survey of the petrological weathering characteristics as the petrological texture and the mineralogical alteration and the change of rock physical properties by weathering for 31 Stone-Buddhist images designed as important cultural property in Chungnam province. Most rocks composing Stone-Buddhas are classified into granite which is medium to coarse, but some Stone-Buddhist images comprise in gneiss. As the result of modal composition for 12 Stone-Buddhist images being possible to take samples, they are classified into 8 biotite granite, 3 porphyritic granodiorite and 1 granodiorite, which are showed with many joints, exfoliation and intensive discoloration. Referring to the result of observation under the polarizing microscope, some feldspar are being sericitizated and some biotite are being changed to chlorite Under the observation with SEM, some feldspar are changed into lamella-kaolinite by the weathering. Most rocks composing the stone Buddhist images are being weathered much and kaolinited, and its weathering level is classified into MW to HW referring to the result of these studies. Accordingly it is required studying scientific and undestructive method considering the weathering distinction of Stone-Buddhist images.

Symplastic glomus tumor 1예

이원채,장윤환,김효진,이석종,정상립,이수경,배한익 대한피부과학회 2003 대한피부과학회지 Vol.41 No.8

Glomus tumor is a benign lesion characterized by vessels and glomus cells in the varying proportion and it classically presents as a solitary, painful papule or nodule. Occasionally it displays unusual histopathologic features diagnosed as "atypical" glomus tumor, including malignant glomus tumor, glomus tumor of uncertain malignant potential, glomangiomatosis, and symplastic glomus tumor. Glomangiomatosis and symplastic glomus tumor reveal benign biologic behavior. We report herein a typical case of symplastic glomus tumor showing marked nuclear atypia, its only unusual feature comparing with classical one, in addition to the typical clinical and pathological features. (Korean J Dermatol 2003;41(8) : 1118~1120)

항공레이저 측량 자료의 해상도에 따른 DEM 오차 비교평가 연구

이근상,고덕구,채효석,신영호 한국지리정보학회 2003 한국지리정보학회지 Vol.6 No.3

최근 높은 수직정확도를 갖는 항공레이저측량 기술이 개발됨에 따라 이를 이용한 DEM(digital elevation model) 생성, 건물추출, 홍수위험지도 제작, 3차원 도시모델 구축 등의 다양한 연구가 활발하게 수행되고 있다. 본 연구에서는 항공레이저측량으로부터 취득한 원시자료로부터 생성한 해상도별 DEM의 표준편차를 계산하기 위해 점비교법, 등고선비교법 그리고 1/5,000 수치지형도를 활용하였다. 비교결과 점비교법이 등고선비교법보다 낮은 DEM 표준오차를 나타냈으며, 이것은 등고선비교법이 점비교법에 비해 조밀한 격자 연산이 이루어지지 않은 것이 원인으로 파악되었다. 또한 1/5,000 수치지형도는 평균수평거리인 25.4m 이하에서는 점비교법과 등고선비교법에 비해 높은 오차를 보였으며, 25.4m 이상에서는 등고선비교법과 유사한 결과를 나타냄을 알 수 있었다. As airborne laser scanning technique is developed with high vertical accuracy recently, there come many studies on DEM(digital elevation model creation, building extraction, flood risk mapping and 3D virtual city modeling. This study applied point comparative method, contour comparative method and digital map with scale 1/5,000 to calculate RMSE of DEM in according to resolution that was constructed using rawdata being acquired by airborne laser scanning. As a result, point comparative method showed lower DEM standard error than contour comparative method, it is a reason that contour comparative method was not carried out detailed grid calculation for point comparative method. Also, digital map with scale 1/5,000 showed higher DEM standard error than point comparative method and contour method in below 25.4m that is average horizontal distance among contour line, and showed similar result with contour comparative method in over 25.4m.

Alcoholic hepatotoxicity inhibitory effect using heat killed lactic acid bacteria

Hyo-Seok Chae,Hyang Hyun Cho,Woo Seung Song,Min Jung Ryu,Kwontack Hwang 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

The effect of heat-sterilized lactic acid bacteria on acute alcoholic liver disease and alcoholic hangover was investigated. In the case of AST activity, an indicator of liver damage, a significant decrease was observed in the HLPH group (p<0.001) together with the control group, and ALT activity was also inhibited in the HLPH group (p<0.01) together with the ethanol control group. On the other hand, in cytokine expression, IL-1β mRNA expression was significantly suppressed at the (p<0.001) level in all treatment groups, but IL-6 was suppressed only in the heat-sterilized lactic acid bacteria group (p<0.05). In the change of the amount of ethanol and acetaldehyde before and after ethanol administration, the ethanol reduction effect before and after ethanol administration was decreased in the heat-treated sterilized lactic acid bacteria group (p<0.001). Regardless, it was confirmed that it was significantly increased in the heat-sterilized lactic acid bacteria group (p<0.001).

Investigation of immune cytotoxicity and immune activity of prebiotic materials (oat, pork potato, seoritae, wheat sprout, yacon)

Hyo-Seok Chae,Hyang Hyun Cho,Woo Seung Song,Min Jung Ryu,Kwontack Hwang 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

Cytotoxicity and immunological activity of prebiotic materials (oats, pork potato, seoritae, wheat sprout, yacon) were measured. As a result of evaluating the cytotoxicity of probiotic materials in macrophages, the simultaneous treatment of 10 ng/mL LPS and each of 5 prebiotics (oat, pork potato, seoritae, wheat sprout, yacon) 1, 2, 4% was all treatment. There was no significant cytotoxicity in the group. LPS-induced NO production inhibitory effect was shown (P<0.05), and oats, wheat sprouts, and yacon except for pork potato and seoritae showed a treatment concentration-dependent inhibitory effect on NO production. Among them, yacon and wheat sprout showed the highest NO production inhibitory effect. In the case of IL-6 production inhibitory effect, oat, pork potato, and seoritae showed significant IL-6 production inhibitory effect from 2%, and yacon and wheat sprout showed significant IL-6 production inhibitory effect from 1%. In the case of TNF-a production inhibitory effect, all five types of prebiotic materials showed an inhibitory effect on TNF-α production, and yacon, wheat sprout and seoritae showed a clear production inhibitory effect. In the case of IL-1β production inhibitory effect, all 5 types of prebiotic materials showed IL-1β production inhibitory effect, and wheatgrass, seoritae and yacon showed superior production inhibitory effect.

열처리 살균 유산균을 이용한 알코올성 간독성 억제 효과

채효석(Hyo-Seok Chae),조향현(Hyang Hyun Cho),송우승(Woo Seung Song),황권택(Kwontack Hwang) 한국식품영양과학회 2021 한국식품영양과학회지 Vol.50 No.12

사균 유산균의 알코올성 급성 간 질환과 알코올성 숙취해소에 대한 효과를 확인하고자 하였다. 조직학적 조사에서 EtOH 처리군 이외에 변화는 없었으나, 간세포에서 지방립의 변화에서 EtOH와 사균 유산균분말 고농도투여군(P< 0.01)에서 유의성을 보였다. 그리고 간모세혈관확장 score에서도 유사하게 양성대조군(P<0.01)과 EtOH와 사균 유산균분말 고농도투여군(P<0.05)에서 유의적인 완화를 보였다. 간 손상의 지표인 AST 활성의 경우 EtOH와 함께 사균 유산균 분말 고농도투여군(P<0.001)에서 유의적인 감소를 보였고, ALT의 활성에서도 EtOH와 함께 사균 유산균 분말고농도투여군(P<0.01)에서 억제시켰다. 한편 염증지표로서 cytokine 발현을 보았는데, IL-1β mRNA 발현이 모든 처리군에서(P<0.001) 매우 유의하게 억제되었지만 IL-6는 사균 유산균군(P<0.05)에서만 억제되었다. EtOH 투여 전후의 EtOH와 acetaldehyde양의 변화에서 EtOH 투여 전후 EtOH 감소 효과가 사균 유산균군에서 감소 효과를 보였다(P<0.001). 한편 ADH와 ALDH 활성은 EtOH 투여와 상관없이 사균 유산균군에서 매우 유의하게 증가시키는 것을 확인하였다(P<0.001). 따라서 사균 유산균이 알코올성 급성간 질환들에 유의한 효과를 나타내는 것을 알 수 있었다. The purpose of this study was to examine the effects of heat-killed lactic acid bacteria on acute alcoholic liver disease and alcoholic hangover. Histologic analysis exhibited no change except in the ethanol-treated group, but the EtOH+heat-killed Lactobacillus plantarum high dose-treated group (P<0.01) showed a significant change in the fatty granules in hepatocytes. Similarly, the positive control group (P<0.01) and the EtOH+HLPH (heat-killed L. plantarum high dose) group (P<0.05) showed significant difference in the hepatic telangiectasis score. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities were significantly decreased in the EtOH+HLPH group (P<0.001 and P<0.01 respectively). Inhibition of inflammation was assessed through cytokine expression. IL-1β mRNA expression was significantly inhibited in all treatment groups, but IL-6 was inhibited only in the heat-sterilized lactic acid bacteria group (P<0.05). While measuring the changes in the amount of ethanol and acetaldehyde in the blood before and after ethanol administration, it was observed that the heat-killed lactic acid bacteria group effectively decreased after ethanol administration (P<0.001). In addition, it was confirmed that alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities were significantly increased in the heat-killed lactic acid bacteria group (P<0.001). Therefore, it was observed that heat-treated and sterilized lactic acid bacteria like live bacteria had a significant effect on acute alcoholic liver disease.

상부위장관암 환자의 난치성 복통에 대한 흉강경적 내장신경절제술(Thoracoscopic Splanchnicectomy)

채윤석(Yoon-Seok Chae),이우정(Woo-Jung Lee),백효채(Hyo-Chae Paik),이종훈(Jong-Hoon Lee),김경식(Kyung-Sik Kim),김병로(Byong-Ro Kim) 대한외과학회 2001 Annals of Surgical Treatment and Research Vol.60 No.1

Using Femtosecond Laser Irradiation to Enhance the Vertical Electrical Properties and Tailor the Morphology of a Conducting Polymer Blend Film

Chae, Sangmin,Yi, Ahra,Park, Cheolmin,Chang, Won Seok,Lee, Hyun Hwi,Choi, Jiyeon,Kim, Hyo Jung American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.29

<P>We report femtosecond infrared laser-induced selective tailoring of carrier transport as well as surface morphology on a conducting polymer blend thin film. Maximal 2.4 times enhancement on vertical current transport in poly(3-hexylthiophene):phenyl-C61-butyric acid methyl ester, was achieved by this irradiation. The laser irradiation induced a photo expansion without deteriorating its molecular structure and the film morphology could be customized in the micron scale by adjusting the laser writing parameters. In the photoexpanded region, the face-on populations were about 2.2 times larger in comparison with the pristine region, which was a major contributor to the enhanced carrier transport.</P>

만성 B형 간염 환자에서 자발성 급성 악화의 원인 및 임상 경과

채명종,김병호,정경환,김남훈,동석호,김효종,장영운,이정일,장린 대한간학회 2004 Clinical and Molecular Hepatology(대한간학회지) Vol.10 No.2

목적: 저자 등은 만성 B형 간염 경과 중 급성 악화가 심하게 발생한 환자에서 그 원인을 조사하고, 자발적 악화시 HBeAg 혈청전환 및 임상 경과에 대하여 알아보고자 하였다. 대상과 방법: 1992년 1월부터 2001년 12월까지 만성 B형 간염의 급성 악화로 입원하였던 환자를 대상으로 하였다. 중증 급성 악화의 정의는 AST/ALT가 정상 상한치의 10배 이상 증가한 경우로 하였다. 후향적으로 의무기록을 조사하여 성별, 연령, 원인, 간기능검사, 혈청학적 검사 및 생존 등에 대하여 성별 및 연령이 유사한 대조 환자군과 비교 분석하였다. 결과: 중증 급성 악화 환자는 남자 29명, 여자 15명 등 44명으로 평균 38.6±0.1세였다. 급성 악화 원인으로는 자발적 악화가 34예(77%), 약물 복용 7예(16%), 음주 2예(5%), HCV 중복감염 1예(2%)였다. 혈액검사에서 총 빌리루빈은 8.3±8.3 ㎎/dL, 알부민 3.6±0.7 g/dL, ALT 924±597 IU/L, 프로트롬빈 시간 1.58±1.29 (INR), α PF 108±163 ng/mL이었다. 자발적 급성 악화 34예 중 HBeAg 양성인 경우는 27예(79%)였으며, 추적 기간(579±459일) 동안 51.9%에서 HBeAg 혈청전환이 일어났으나, 3개월째 혈청전환율은 15%에 불과하였으며, 12개월 및 24개월째는 각각 18.5%, 48.1%였다. 한편 ALT가 199 IU/L 이하인 대조 환자의 경우는 같은 기간의 혈청전환율이 각각 4.3%, 10.9%로 낮았으며, 기저 ALT치에 따른 누적 혈청전환율도 200 IU/L을 중심으로 유의한 차이가 있었다(P<0.05). 간경변으로의 진행은 대조 환자군에 비하여 높은 경향을 보였으며(17.6% vs. 5.5%, P<0.08), 사망한 경우는 급성 악화군에서만 1예(2%) 있었다. 결론: 만성 B형 간염 환자 중 중증의 급성 악화는 자발적 악화가 가장 흔하였으며, 약 반수에서 2년내 HBeAg 혈청전환되었고 18% 정도에서 간경변으로 진행되었다. 그러나 3개월 이내의 조기 혈청전환은 15%로 낮았으며, 전반적인 혈청전환율도 외국의 보고에 비하여 다소 낮았다. Background/Aims: Acute exacerbation (AE) of chronic hepatitis B (CHB) can occur spontaneously, and may be followed by HBeAg clearance. HBeAg seroconversion often coincides with the normalization of liver biochemical tests and clinical remission. The purpose of this study was to identify the etiology and the clinical consequence of severe AE in Korean patients with CHB. Methods: The medical records of CHB patients with severe AE (defined by the sudden increase of ALT above 400 IU/L) who were admitted to Kyung Hee University Hospital between January 1992 and December 2001, were reviewed retrospectively. Forty-four patients were included in the severe AE group. Results: The most common etiology of severe AE was spontaneous exacerbation (77%). Drugs (16%), alcohol (5%), and HCV coinfection (2%) were suspected of causing AE in the remaining patients. HBeAg seroconversion at 12, 18, and 24 months following severe spontaneous AE was 18.5%, 40.7%, and 48.1%, respectively. These were significantly higher compared to CHB patients without AE (4.3%, 4.3%, and 10.9%, respectively). Seroconversion within 3 months, however, occurred in only 15% of CHB patients with AE. There was a tendency to progress to liver cirrhosis more frequently in the patients with AE as compared to the patients without AE (17.6% vs. 5.5%, P<0.08). Conclusions: Severe AE in patients with CHB is mainly caused by spontaneous exacerbation. Although HBeAg seroconversion occurs frequently in these patients, the rates are relatively low compared to those reported in other countries and early seroconversion is expected only in a small proportion. Further studies will be warranted to determine the efficacy of the early use of antiviral agents at the time of AE.(Korean J Hepatol 2004;10:99-107)

Clinical effects of conservatively used dienogest in patients with ovarian endometrioma instead of surgical treatment

( Chae Hee Sim ),( De Hee Kim ),( Hyo Sook Bae ),( Mi Kyoung Kim ),( Yong Wook Jung ),( Bo Seong Yun ),( Seok Ju Seong ),( Mi La Kim ) 대한산부인과학회 2015 대한산부인과학회 학술대회 Vol.101 No.-