임부의 연령에 따른 보완대체요법에 관한 인식 태도 경험 비교 연구

김연진,김지연,노경민,신혜리,유예지,이지민,장희조,정아인,최소정,강숙정,이향연,민혜영 이화여자대학교 간호과학대학 2016 이화간호학회지 Vol.- No.50

Purpose: This study aims to test if the age of pregnant women affects the perception, experience, and attitude towards complementary alternative therapy (CAT), by investigating the perception, experience, and attitude of pregnant women under the age of 35, and above 35 (Advanced Maternal Age). The study will 1) find the general characteristics of pregnant women under and over the age of 35 2) compare the perception, behavior, and experience of pregnant women under and over the age of 35, and 3) find the comparison of the perception, behavior, and experience according to the general characteristics of pregnant women under and over the age of 35. Method: The subjects of this study are composed of 44 women under the age of 35 and 44 women above the age of 35, totaling 88 pregnant women visiting midwiferies, obstetrics and gynecology, and baby fairs in Seoul and Gyeong-Gi area. Data for this study was collected from November 28, 2015 to January 6, 2016 for 40 days. The collected data analyzed mean, standard deviation, t test, ANOVA, and chi-square by using SPSS 23.0. Result Results show that there is a significant difference in the perception, attitude, and experience of the two-sample groups in the use of CAT. The question of “what is most necessary when applying CAT in a hospital clinical environment” for the perception criteria came out with the results of t=9.980, p<.05. For the attitude, results showed that the answers of pregnant women under the age of 35 displayed a more positive attitude towards CAT. (t=2.421, p<.05) Lastly, in the experience section, pregnant women under the age of 35 showed more CAT use than the other sample group. Conclusion Results have shown that there is a difference in the perception, behavior, and experience between the two sample groups. Therefore further research on the efficacy and the adverse effects of CAT needs to be done.

폐경전 여성에서 혈중 성호르몬결합글로불린 농도와 산화스트레스의 연관성

최영주,오지영,홍영선,성연아 대한내분비학회 2004 Endocrinology and metabolism Vol.19 No.1

연구배경: 여성에서 남성화의 간접적인 지표인 SHBG 농도는 인슐린저항성과 관련되며, 심혈관질환의 위험을 예측할 수 있는 지표로 보고되었다. 심혈관질환의 위험인자들이 산화스트레스의 증가와 관련되며, 최근 남성 호르몬의 증가와 인슐린저항성을 특징으로 하는 다낭성난소증후군 환자에서 성호르몬과 산화스트레스가 관련된다는 연구결과가 있다. 본 연구는 SHBG와 산화스트레스의 연관성을 규명하기 위하여 시행되었다. 방법: 당뇨병, 고혈압, 심혈관질환의 과거력 및 흡연력이 없는 폐경전 여성 46명을 대상으로 하여 방사 면역계수법으로 SHBG를 측정하였으며, ox-LDL은 효소면역측정법으로, TAS 및 MDA는 분광광도계로 측정하였고, SHBG와 산화스트레스를 나타내는 지표들간의 연관성을 관찰하였다. 결과: 1. 정상내당능군과 내당능장애군간에 SHBG와 MDA 농도는 유의한 차이가 없었으며, TAS는 내당능장애군에서 정상내당군에 비해 유의하게 높았다(1.41±0.15 mmol/L, 1.30±0.17 mmol/L, p=0.034). 2. SHBG 농도는 비만군에서 비비만군에 비해 유의하게 낮았다 (56.6±34.2 nmol/L, 76.0±23.8 nmol/L, p=0.036). 3. SHBG 농도는 체질량지수 (r=-0.394, p=0.007), 당부하후혈당(r=-0.326, p=0.027), 허리둘레(r=-0.323, p=0.029), 허리 대 허벅지둘레비 (r=-0.308, p=0.037), 공복인슐린 농도 (r=-0.387, p=0.008), 내장지방면적 (r=-0.339, p=0.021)과 유의한 음의 상관관계가 있었고, 인슐린 감수성지표와는 유의한 양의 상관관계(r=0.397, p=0.008)가 있었다. 4. SHBG 농도는 MDA 농도 (r=-0.357, p=0.015) 및 ox-LDL 농도 (r=-0.367, p=0.014)와 유의한 음의 상관관계가 있었다. 5. 다중회귀분석에서 연령, 체질량지수, 당부하후혈당, 허리둘레, 공복인슐린 농도, 수축기 혈압, 고밀도지 단백콜레스테롤, 중성지방을 보정한 후 SHBG 농도는 MDA 및 ox-LDL에 유의하게 독립적으로 영향을 주었다. TAS에 영항을 주는 인자로는 공복인슐린 농도와 당부하후 혈당이 통계학적으로 유의하였고, SHBG는 유의한 관련성이 없었다. 결론: 폐경전 여성에서 SHBG의 감소는 산화스트레스의 증가와 관련되어 심혈관질환의 위험을 예견할수 있는 지표로 생각된다. Background: Low levels of sex hormone-binding globulin (SHBG), an indirect index of androgenicity, are associated with insulin resistance and cardiovascular risk factors. The risk factors of the cardiovascular disease are known to be related to oxidative stress. In recent reports, sex hormones were associated with oxidative stress in women with polycystic ovarian syndrome (PCOS), which is characterized by increased androgenicity and insulin resistance. with NGT. Methods: To investigate the relationship between sex hormones and oxidative stress, we examined the association of malondialdehyde (MDA), total antioxidant status (TAS), oxidized low density lipoprotein cholesterol (ox-LDL), and SHBG in 46 Korean premenopausal women. Results: 1. SHBG and MDA levels were not significantly different among the women with NGT and IGT. But, TAS was significantly lower (p=0.034) in the subjects with IGT than in the subjects with NGT. 2. The SHBG level was significantly lower (p=0.036) in obese women than in non-obese women. 3. The SHBG level was significantly inversely correlated with BMI (r=-0.394, p=0.007), post challenge glucose (r=-0.326, p=0.027), waist size (r=-0.323, p=0.029), waist-to-thigh ratio (WTR) (r=-0.308, p=0.037), fasting insulin level (r=-0.387, p=0.008), visceral fat area (VFA)(r=-0.339, p=0.021), and was significantly positively correlated with SI (r=0.397, p=0.008). 4. The SHBG level was significantly inversely correlated with levels of MDA (r=-0.357, p=0.015) and ox-LDL (r=-0.367, p=0.014). 5. In a multiple linear regression analysis, the SHBG level was a significant and independent factor for both MDA and ox-LDL. For TAS, the fasting insulin level and post challenge glucose were significant and independent factors. Conclusion: Increased androgenicity assessed by the decrease in serum SHBG levels is associated with the increase in MDA and ox-LDL. These results suggest that increased androgenicity in premenopausal women can contribute to the development of cardiovascular diseases via increased oxidative stress (J Kor Soc Endocrinol 19:48∼57, 2004).

국내외 ‘영아’ 관련 연구물의 최근 동향 분석 : 2000년~2013년 발간 논문을 대상으로

이승연,권수현,권연정,김언경,나영이,유주연,최정아 이화여자대학교 교육과학연구소 2015 교육과학연구 Vol.46 No.3

The purpose of this study was to examine research trends in infant research published from 2000 to 2013, in order to understand overall aspects in research topics, methods, and subjects in infant research and to suggest directions for future infant research. A total of 2916 journal articles and theses/dissertations, both domestic and foreign, were selected for the analysis. The findings of this study were as follows: First, for the 14 year period, 737 domestic articles, 634 domestic theses/ dissertations, 1242 foreign articles, and 303 foreign dissertations on infant research were published, and there was a steady increase in the number of articles and theses/dissertations over the years. Second, in terms of research topics, different patterns were found between the domestic ones and the foreign ones; the topic of “education and teachers” in the domestic ones and “development” in the foreign ones occurred most frequently. Third, in terms of research methods, the domestic ones employed “survey” the most, and the foreign ones employed “experiment” the most among quantitative research methods; when analyzing the relation between methods and topics, the foreign ones showed clear matches between topics and research methods, while the domestic ones preferred “survey” regardless of the topics. Fourth, in terms of subjects/participants, “infants” were the most researched in both the domestic ones and the foreign ones, followed by “parent” and “teachers.” Among the infants, the domestic ones focused on 25~36-month olds the most, while the foreign ones focused most on 0~12-month olds. In addition, in all types of infant research, there were more single subject studies than multiple subject ones.

전신 발작을 동반한 갈색세포증 1예

안영미,최영아,박경원,전정현,이창배,홍은순,성연아,경난호 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.4·5

Inoue Balloon을 이용한 PMV의 장·단기 결과 분석

진은선,이연아,전숙,김현숙,정승묵,박상선,최락경,임달수,홍석근,황흥곤 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.11

Comparison of Oral versus Rectal Administration of Processed-Scutellaria baicalensis on Colonic Inflammation in Mice

( Yeon Ah Choi ),( Dae Ki Kim ),( Myung Kwan Chun ),( Hoo Kyun Choi ),( Young Mi Lee ) 한국약제학회 2009 Journal of Pharmaceutical Investigation Vol.39 No.5

Comparison of Oral versus Rectal Administration of Processed-Scutellaria baicalensis on Colonic Inflammation in Mice

Choi, Yeon-Ah,Kim, Dae-Ki,Chun, Myung-Kwan,Choi, Hoo-Kyun,Lee, Young-Mi The Korean Society of Pharmaceutical Sciences and 2009 Journal of Pharmaceutical Investigation Vol.39 No.5

We previously showed that the water extracts of rice wine-baked Scutellaria baicalensis Georgi (RWBS) ameliorated colonic inflammation more than crude Scutellaria baicalensis (CS) after oral administration. The aim of this study is to compare the effect of rectal and oral administration of RWBS in the experimental colitis. Experimental colitis was induced in mice by daily treatment with 5% dextran sulfate sodium (DSS) in the drinking water for 7 days. Water was used as vehicle of oral administration, while Carbopol/PEG mucoadhesive gel was used as vehicle of rectal administration. RWBS and RWBS gel (RWBSG) were administered once per day for 7 days. RWBS and RWBSG significantly attenuated the disease activity index (DAI) calculated as the sum of scores of body weight loss, stool consistency and rectal bleeding. Furthermore, RWBS and RWBSG reduced the mucosal myeloperoxidase activity and COX-2 (cyclooxygenase-2) expression in colon tissue. Anti-inflammatory effect of CS on colonic inflammation was increased by baking with rice wine in both oral and rectal administration. Moreover, anti-inflammatory effects of oral administration on colonic inflammation was greater than those of rectal administration. Further study would be required for the development of intra-rectal formulation.

Analysis of Active Ingredients as a Cosmetic Material of Glehenia littoralis Extract

Ah Reum Jo(조아름),Chul Joong Kim(김철중),Yea Ji Lee(이예지),Jea Hoo Choi(최재후),Yeong Seon Oh(오영선),Hye Lim Choi(최혜림),Seon Kang Choi(최선강),Chang Yeon Yu(유창연),Jae Geun Lee(이재근) 한국약용작물학회 2018 한국약용작물학회 학술대회논문집 Vol.2018 No.1

Enhanced oral bioavailability of morin administered in mixed micelle formulation with PluronicF127 and Tween80 in rats.

Choi, Yeon Ah,Yoon, You Hyun,Choi, Kwangik,Kwon, Mihwa,Goo, Soo Hyeon,Cha, Jin-Sun,Choi, Min-Koo,Lee, Hye Suk,Song, Im-Sook Pharmaceutical Society of Japan 2015 Biological & pharmaceutical bulletin Vol.38 No.2

<P>To overcome the low oral bioavailability of morin, a mixed micelle formulation with pharmaceutical excipients that facilitate solubilization and modulate P-glycoprotein (P-gp) was developed and evaluated in vitro and in vivo rats. Morin-loaded mixed micelle formulation with a morin-PluronicF127-Tween80 ratio of 1 : 10 : 0.02 (w/w/w) was prepared by a thin-film hydration method. The solubility, size distribution, drug encapsulation efficiency, and percent drug loading of the formulation were characterized. Subsequently, in vivo pharmacokinetic parameters of morin loaded in a PluronicF127 and Tween80 mixed-micelle formulation were investigated in rats. Absolute bioavailability of morin was dramatically increased by the oral administration of morin-loaded PluronicF127 and Tween80 mixed micelle from 0.4% to 11.2% without changing the systemic clearance and half-life. In Caco-2 cells, absorption permeability of morin from the novel formulation was increased 3.6-fold compared with that of morin alone. P-gp inhibition by cyclosporine A (CsA) increased absorptive permeability of morin 2.4-fold but decreased the efflux of morin by 52%, which was consistent with increased plasma concentration of morin in the pretreatment of CsA in rats. The morin formulation inhibited P-gp transport activity by 83.1% at 100 ?M as morin concentration. Moreover, morin formulation increased paracellular permeability of Lucifer yellow by 1.6-1.8 fold. In conclusion, enhanced oral bioavailability of morin from morin-loaded PluronicF127 and Tween80 mixed micelle formulation can be attributed to increased intestinal permeation of morin, which was mediated at least by P-gp inhibition and enhanced paracellular route.</P>

Ma'Book(마북) : 웹 스크랩북 만들기

최아연(Ah-Yeon Choi),안다빈(Da-Vin Ahn),박지유(Ji-Yoo Park),오용철(Yong-Chul Oh) 한국정보과학회 2012 한국정보과학회 학술발표논문집 Vol.39 No.2D