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비정질 (Fe1-x Co x) 80 B20 합금의 결정화 과정에 대한 속도론적 연구
김택기,김윤배,오병현 대한금속재료학회(대한금속학회) 1985 대한금속·재료학회지 Vol.23 No.1
The thermal stability for the amorphous (Fe_(l-x)Co_x)_(80)B_(20) alloys has been studied systematically through DTA, X-ray diffraction pattern and the electrical resistance change response to temperature and time variations. The results obtained are as follows; 1) The crystallization temperature of amorphous (Fe_(l-x)Co_x)_(80)B_(20) alloy is independent of the concentration of Co and it is about 710˚K. 2) The crystallization process of amorphous (Fe_(l-x)Co_x)_(80)B_(20) alloy occurs in two steps; In the composition range of 0.1≤x≤0.5, amorphous (Fe_(l-x)Co_x)_(80)B_(20)→α phase (Fe, Co; bcc)+Fe₃B(bct) →α phase (Fe, Co; bcc)+Fe₂B(fct)+Co₂B(fct), and in the composition of x = 0.6 amorphous (Fe_(l-x)Co_x)_(80)B_(20)→α phase (Fe, Co; bcc) +Fe₃B(bct)+Co₃B(fct) →αphase (Fe, Co; bcc)+Fe₂B(fct)+Co₂B(fct), and in the composition of x = 0.7 amorphous (Fe_(l-x)Co_x)_(80)B_(20)→αphase (Fe, Co; bcc) +Co₃B(fco)→αphase (Fe, Co; bcc)+Fe₂B(fct)+Co₂B(fct) 3) The crystallization of amorphous (Fe_(l-x)Co_x)_(80)B_(20) is the diffusion-controlled nucleation and growth process, and the crystallization activation energy of amorphous (Fe_(l-x)Co_x)_(80)B_(20) alloy is independent of the composition of Co and it is about 70㎉/mole.
Kim, E-K,Seo, H-S,Chae, M-J,Jeon, I-S,Song, B-Y,Park, Y-J,Ahn, H M,Yun, C-O,Kang, C-Y Macmillan Publishers Limited 2014 Gene therapy Vol.21 No.1
For successful clinical tumor immunotherapy outcomes, strong immune responses against tumor antigens must be generated. Cell-based vaccines compromise one strategy with which to induce appropriate strong immune responses. Previously, we established a natural killer T-cell (NKT) ligand-loaded, adenoviral vector-transduced B-cell-based anticancer cellular vaccine. To enhance tumor antigen delivery to B cells, we established a modified adenoviral vector (Ad-k35) that encoded a truncated form of the breast cancer antigen Her2/neu (Ad-k35HM) in which fiber structure was substituted with adenovirus serotype 35. We observed increased tumor antigen expression with Ad-k35HM in both human and murine B cells. In addition, an Ad-k35HM-transduced B-cell vaccine elicited strong antigen-specific cellular and humoral immune responses that were further enhanced with the additional loading of soluble NKT ligand KBC009. An Ad-k35HM-transduced, KBC009-loaded B-cell vaccine efficiently suppressed the in vivo growth of established tumors in a mouse model. Moreover, the vaccine elicited human leukocyte antigen (HLA)-A2 epitope-specific cytotoxic T-cell responses in B6.Cg (CB)-Tg (HLA-A/H2-D) 2Enge/Jat mice. These findings indicated that the Ad-k35 could be appropriate for the preclinical and clinical development of B-cell-based anticancer immunotherapies.
Hur, H,Kim, N K,Kim, H G,Min, B S,Lee, K Y,Shin, S J,Cheon, J H,Choi, S H Nature Publishing Group 2012 The British journal of cancer Vol.106 No.1
<P><B>Background:</B></P><P>This study aims to evaluate the effectiveness of adenosine triphosphate-based chemotherapy response assay (ATP-CRA)-guided neoadjuvant chemotherapy for increasing resectability in patients with unresectable colorectal liver metastasis.</P><P><B>Patients and methods:</B></P><P>Patients were randomised into two groups: Group A was treated by conventional chemotherapy regimen and Group B was treated by chemotherapy regimen according to the ATP-CRA. Three chemotherapeutic agents (5-fluorouracil, oxaliplatin and irinotecan) were tested by ATP-CRA and more sensitive agents were selected. Either FOLFOX or FOLFIRI was administered. Between Group A and B, treatment response and resectability were compared.</P><P><B>Results:</B></P><P>Between November 2008 and October 2010, a total 63 patients were randomised to Group A (<I>N</I>=32) or Group B (<I>N</I>=31). FOLFOX was more preferred in Group A than in Group B (26 out of 32 (81.3%) <I>vs</I> 20 out of 31 (64.5%)). Group B showed better treatment response than Group A (48.4% <I>vs</I> 21.9%, <I>P</I>=0.027). The resectability of hepatic lesion was higher in Group B (35.5% <I>vs</I> 12.5%, <I>P</I>=0.032). Mean duration from chemotherapy onset to the time of liver resection was 11 cycles (range 4–12) in Group A and 8 cycles (range 8–16) in Group B.</P><P><B>Conclusion:</B></P><P>This study showed that tailored-chemotherapy based on ATP-CRA could improve the treatment response and resectability in initially unresectable colorectal liver metastasis.</P>
Hardening of Bi-Te based alloys by dispersing B<sub>4</sub>C nanoparticles
Jung, S.J.,Park, S.Y.,Kim, B.K.,Kwon, B.,Kim, S.K.,Park, H.H.,Kim, D.I.,Kim, J.Y.,Hyun, D.B.,Kim, J.S.,Baek, S.H. Elsevier Science 2015 Acta materialia Vol.97 No.-
Thermoelectric devices have attracted a great attention for renewable energy harvesters and solid-state coolers. For practical applications, the mechanical properties of thermoelectric materials become critical for the device reliability, a persistent performance with a long time and high operation cycles. Bi-Te based single-crystals, mostly used in commercial thermoelectric devices, are intrinsically brittle with weak van der Waals bonding, often leading to device failures such as crack and debonding during fabrication and operation. Thus, it is highly desirable to enhance the mechanical property of Bi-Te based alloys as well as the thermoelectric property. Here, we investigate the effect of B<SUB>4</SUB>C nanoparticles (less than 0.5wt%) dispersed in p-type Bi<SUB>0.4</SUB>Sb<SUB>1.6</SUB>Te<SUB>3</SUB> matrix on the mechanical properties. X-ray diffraction (XRD) result confirms that B<SUB>4</SUB>C-dispersed Bi<SUB>0.4</SUB>Sb<SUB>1.6</SUB>Te<SUB>3</SUB> has a single phase. We observe that the grain size of Bi<SUB>0.4</SUB>Sb<SUB>1.6</SUB>Te<SUB>3</SUB> becomes decreased with the B<SUB>4</SUB>C nanoparticle concentration by electron backscatter diffraction (EBSD) technique. Hardness, Young's modulus, and flexural strength of B<SUB>4</SUB>C-dispersed Bi<SUB>0.4</SUB>Sb<SUB>1.6</SUB>Te<SUB>3</SUB> are enhanced, compared to the B<SUB>4</SUB>C-free Bi<SUB>0.4</SUB>Sb<SUB>1.6</SUB>Te<SUB>3</SUB> polycrystals. On the other hand, the thermoelectric figure-of-merit of B<SUB>4</SUB>C-dispersed Bi<SUB>0.4</SUB>Sb<SUB>1.6</SUB>Te<SUB>3</SUB> is almost identical to that of the pure Bi<SUB>0.4</SUB>Sb<SUB>1.6</SUB>Te<SUB>3</SUB>. Such enhancements of the mechanical properties of the B<SUB>4</SUB>C-dispersed Bi<SUB>0.4</SUB>Sb<SUB>1.6</SUB>Te<SUB>3</SUB> are attributed to the grain boundary hardening and second-phase hardening. Beyond thermoelectric materials, our result implies that the grain refinement by nanoparticle dispersion is a simple and promising way to strengthen the mechanical properties of other brittle materials with layered structure.
Up regulation of GW112 Gene by NFκB promotes an antiapoptotic property in gastric cancer cells
Kim, Kee K.,Park, Key S.,Song, Seok B.,Kim, Kyoon E. Wiley Subscription Services, Inc., A Wiley Company 2010 Molecular carcinogenesis Vol.49 No.3
<P>To clarify the regulatory mechanism of GW112 gene expression, 5′-flanking region of the human GW112 gene was isolated and characterized in the present study. 5′-RACE analysis showed a single transcription start site, which is located 142 nucleotides upstream of the translation initiation site. Transient transfection studies with serial deletion constructs and close examination of the sequences identified a putative NFκB binding sequence between −442 and −430, which could be responsible for efficient expression of the GW112 gene. Indeed, GW112 gene was found to be regulated by NFκB signals including overexpressed p65 and IκBα, IKK inhibitor, and proteasome inhibitor. Binding of NFκB to its putative site was confirmed by EMSA and ChIP assays. These results suggest that NFκB is an essential regulatory factor for GW112 transcription. Based on this finding, we next confirmed that inhibition of GW112 expression could induce apoptosis in the presence of cytotoxic agent in gastric cancer cells. Furthermore, knocking-down or overexpression of GW112 gene in gastric cancer cells demonstrated that GW112 has an antiapoptotic property against the cytotoxic agents-induced apoptosis. Taken together, these results suggest that GW112 could be an important mediator in NFκB-dependent tumorigenesis of digestive tract tissues. © 2009 Wiley-Liss, Inc.</P>