1,559례의 소아 신생검에 대한 고찰 : 단일기관 연구

최용성,김선경,김성도,조병수,Choi, Yong-Sung,Kim, Sun-Kyoung,Kim, Sung-Do,Cho, Byoung-Soo 대한소아신장학회 2006 Childhood kidney diseases Vol.10 No.2

Purpose : To analyse the results of the renal biopsies and the clinical diagnoses of patients who had undergone percutaneous kidney biopsies in the department of pediatrics at Kyunghee University Hospital for 22 years from 1984 to 2005. Methods : We retrospectively reviewed the medical records of 1559 patients and analyzed the chief complaints that led to a renal biopsy, age, sex, histopathologic findings and diagnosis. Routine kidney biopsies were performed by automated gun biopsy guided by real time ultrasonography. The diagnoses were made based on the specimen's light microscopy, immunofluorescence microscopy and electron microscopy findings and clinical symptoms and signs. Results : The mean age of the patients was 10 years with the male to female ratio being 1.3:1. The chief complaints that led to a renal biopsy included hematuria only(753 cases, 48.3%), proteinuria only(125 cases, 8.0%) and hematuria combined with proteinuria(537 cases, 34.4%). The most frequent histopathological finding was primary glomerular disease(75.4%) which included IgA nephropathy(30.1%) and mesangial proliferative glomerulonephritis(27.6 %). Systemic disease comprised 11.4% which included Henoch-$Sch\ddot{o}nlein$ nephritis(10.5%) and lupus nephritis(0.8%). Alport syndrome was found in 1.1% of cases which was attributed to hereditary causes. 628 children(40.3%) visited the clinic due to abnormal school urine screening abnormalities and among these, 237 children had mesangial proliferative glomerulonephritis and 234 children who had IgA nephropathy were managed thereafter. Conclusion : IgA nephropathy and mesangial proliferative glomerulonephritis were the two major forms of primary glomerulonephritis found in Korean children who had kidney biopsies from 1984 to 2005.

초전도 벌크를 이용한 베어링기술

최용성,이상헌,Choi, Yong-Seong,Lee, Sang-Heon 한국전기전자재료학회 2006 전기전자재료 Vol.19 No.12

자기력과 Random Fluidic Self-assembly에 의한 신규 바이오칩의 개발

최용성,권영수,박대희,Choi, Yong-Sung,Kwon, Young-Soo,Park, Dae-Hee 한국전기전자재료학회 2004 전기전자재료학회논문지 Vol.17 No.6

This paper describes a new constructing method of multifunctional biosensor using many kinds of biomaterials. A metal particle and an array was fabricated by photolithographic. Biomaterials were immobilized on the metal particle. The array and the particles were mixed in a buffer solution, and were arranged by magnetic force interaction and random fluidic self-assembly. A quarter of total Ni dots were covered by the particles. The binding direction of the particles was controllable, and condition of particles was almost with Au surface on top. The particles were successfully arranged on the array. The biomaterial activities were detected by chemiluminescence and electrochemical methods.

전기화학적 방법에 의한 유전자의 검출

최용성,이경섭,박대희,Choi, Yong-Sung,Lee, Kyung-Sup,Park, Dae-Hee 한국전기전자재료학회 2005 전기전자재료학회논문지 Vol.18 No.6

In this paper, a microelectrode away DNA chip was fabricated on glass slide using photolithography technology. Several probe DNAs consisting of mercaptohexyl moiety at their 5' end were immobilized on the gold electrodes by DNA arrayer utilizing the affinity between gold and sulfu. Then target DNAs were hybridized and reacted with Hoechst 33258, which is a DNA minor groove binder and electrochemically active dye. Cyclic voltammetry in 5mA ferricyanide/ferrocyanide solution at 100 mV/s confirmed the immobilization of probe DNA on the gold electrodes. Linear sweep voltammetry or cyclic voltammetry showed a difference between target DNA and control DNA in the anodic peak current values. It was derived from Hoechst 33258 concentrated at the electrode surface through association with formed hybrid. It suggested that this DNA chip could recognize the sequence specific genes. It suggested that multichannel electrochemical DNA microarray is useful to develop a portable device for clinical gene diagnostic system.

유기박막의 전기적 특성 연구

최용성,송진원,문종대,이경섭,Choi Yong-Sung,Song Jin-Won,Moon Jong-Dae,Lee Kyung-Sup 한국전기전자재료학회 2006 전기전자재료학회논문지 Vol.19 No.10

Langmuir-Blodgett(LB)layers of Arachidic acid deposited by LB method were deposited onto slide glass as Y-type film. The structure of manufactured device is Au/arachidic acid/Al, the number of accumulated layers are $9{\sim}21$. Also, we then examined of the Metal-Insulator-Metal(MIM) device by means of I-V. The I-V characteristics of the device are measured from -3 to +3 V. The insulation property of a thin film is better as the distance between electrodes is larger.

재발성 호흡기 감염과 성장 부전을 보인 IgG 아형 결핍증 1례

최용성,홍정미,나영호,차성호,Choi, Yong-Sung,Hong, Jung-Mi,Rha, Young-Ho,Cha, Sung-Ho 대한소아감염학회 2006 Pediatric Infection and Vaccine Vol.13 No.2

원발성 면역 결핍증에는 항체형성에 영향을 주는 질환이 가장 흔하고 그중 선택적으로 분비성 IgA 결핍이 많으나 IgG 농도가 정상 혹은 증가되어 있는 어떤 환자에서는 4가지의 IgG 아형 중에서 한 두 개 이상의 결핍이 발견된다. 대부분의 환자, 특히 IgG4 결핍증 환자에서 폐구균, 포도구균, 헤모필루스균 등에 의한 부비동염, 중이염, 폐렴 등이 반복된다. 상기 10세 여아는 평소에 잦은 상기도 감염을 앓아 왔고, 결핵성 림프절염으로 약물요법을 시행한 병력이 있으며, 매년 2~3차례 폐렴으로 입원치료를 받아왔다. 키와 몸무게가 모두 3백분위수 미만으로 성장부전(growth failure)가 지속되었다. 2003년 9월 심한 폐렴으로 입원 치료 중에 면역결핍 검사를 시행하였다. IgG, IgM level은 정상이었으나 IgG subclass 2, 3, 4에서 모두 감소된 수치를 보여 IgG 아형 결핍을 보였다. 저자들은 반복적인 호흡기 질환을 앓는 환아에서 성장부전이 동반된 IgG 아형 결핍 1례를 보고하는 바이다. Immunodeficiency affected by antibody formation is most common among primary immuno-deficiencies. Selective IgA deficiency is more common but, one or more IgG subclass level is low or deficient in some patients. Patients with antibody production deficiency are vulnerable to pneumococci, staphylococci and H.influenzae leading to sinusitis, otitis media and pneumonia. A 10-year-old girl had suffered from frequent upper respiratory infections, a history of tuberculous lymphadenitis tuberculosis medication, and frequent pneumonia that requires hospital adimission. Her height and weight were below 3 percentile normal growth as a manifestation of failure to thrive. When she had another severe pneumonia, all the immunologic test was normal at first, and then we checked the IgG subclass levels. Her IgG1 was within normal, IgG2 was very low, IgG3 and IgG4 was not detected. We report a case of IgG subclass deficiency in frequent upper respiratory infection and failure to thrive.

경계인으로서 북한이탈주민의 윤리적 주체성 형성 연구: 한나 아렌트의『정신의 삶』을 중심으로

최병학(Choi, Byunghak),최용성Choi, Yongsung천명주(Chun, Myungju),강순규(Kang, Soongyu) 순천향대학교 인문학연구소 2021 순천향 인문과학논총 Vol.40 No.1

이 논문은 북한이탈주민이 남한 사회의 일원으로서 어떻게 윤리적 주체성을 형성해야 하는지에 관한 연구이다. 이를 위해 정치 철학자 한나 아렌트의 『정신의 삶』에 나타난 사유에 기초하여, 북한이탈주민이 남한 사회의 일원으로서 윤리적 주체성을 형성할 수 있도록 ‘법적 주체로 사유하기’, ‘도덕적 주체로 의지하기’, ‘인륜적 주체로 판단하기’를 제시하고, 결론으로 ‘서로-주체성’의 보편주의를 북한이탈주민은 물론 남쪽 국민의 윤리적 주체성으로 제안하고자 한다. ‘서로-주체성’을 통한 남과 북의 정체성 변화 및 강화는 마음의 통일로 이어져, 경제, 문화, 정치의 통일을 앞당기는 계기가 될 것이다. This paper is a study of how North Korean defectors should form ethical subjectivity as members of South Korean society. To this end, this paper was helped by the ideas that appeared in the political philosopher Hannah Arendt’s The Life of the Mind. Based on Arendt’s idea, I suggest ‘thinking as a Legal-Subject’, ‘relying as a Moral-Subject’, and ‘judging as a Human-Subject’. And as a conclusion, I would like to propose the universalism of ‘One Another-Subjectivity’ as an ethical subject of not only North Korean defectors but also the South Korean people. The change and strengthening of the identity of the South and the North through “subject to each other” will lead to unification of the mind, and will accelerate the unification of the economy, culture and politics.

사이버 공간에서의 도덕심리와 레스트의 4구성요소에 따른 정보윤리교육적 교수전략에 관한 연구

최용성 ( Yong Seong Choi ) 한국윤리학회 2014 倫理硏究 Vol.94 No.1

이 연구는 레스트의 도덕성의 4-구성요소 모형을 정보윤리교육이란 차원에서 분석해 보고, 4가지 구성요소에 영향을 주는 요인들을 살피고자 하는 것이다. 디지털 기술과 환경의 영향은 사이버 공간의 도덕심리에 영향을 주어서 도덕적 감수성을 떨어지게 하고 도덕적 판단력을 더욱 자아중심적이게 할 수 있으며 도덕적 동기화와 품성화를 약화시킬 수 있다. 반면에 정보윤리교육적 교수전략을 도덕성의 4구성요소에 맞추어 적절하게 수행한다면 개인의 도덕성의 발달을 도모할 수 있다 고 보았다. 그러므로 레스트의 4-구성요소 모형에 기반하여 핵심적인 정보윤리교육적 교수전략을 발문과 함께 제시해 보고자 하였다. The goal of this study is to explore the different effect element to hinder and develop four information ethics component model. The four information ethics component model is related with the four moral component model with J.Rest suggested. I will research the ways in which moral psychology can inform information ethics. A “Four Component Model” of moral behavior is described involving the synergistic influences of key factors including sensitivity, judgment, motivation, and action. These components are not personality traits or virtues; rather, they are major units of analysis used to trace how a person responds in a particular social situation. This fourth component, then, is dependent both on having the requisite skills and on persisting in the face of any obstacles or challenges to the action that may arise. I explored to illustrate how technology can impact each of the four components believed to underlie moral behavior. It is argued that technology can create a kind of “psychological distance” between those who use technology. This distance potentially impacts all four components of moral behavior in such a way that the usual social or moral constraints operative under normal circumstances. Recognition of the potential deleterious impact of technology on each of the four components leads to a better understanding of how specific educational interventions can be devised to strengthen personal morality. So, I explored to illustrate how we can impact each of the four moralcomponent model within the context of our increasingly digital world. And Iexplored how we can develop information ethics education``s teaching strategies within four moral component model.

무작위 액중 상호 작용에 의한 단백질칩의 개발

최용성(Yong-Sung Choi),권영수(Young-Soo Kwon),박대희(Dae-Hee Park) 대한전기학회 2003 대한전기학회 학술대회 논문집 Vol.2003 No.10

인공적 도덕 행위자에 관한 도덕철학·심리학적 성찰

최용성 ( Choi Yong-seong ),천명주 ( Chun Myung-ju ) 한국윤리교육학회 2017 윤리교육연구 Vol.0 No.46

본 연구의 목적은 인공적 도덕 행위자의 개발에 있어서 도덕철학적·도덕심리학적 성찰을 제공하는 것이다. 도덕적 인공지능의 개발이 제기하는 도덕성 문제가 무엇인지를 밝혀냄과 동시에 도덕적 인공지능의 개발과정에서 제기되는 여러 문제들을 성찰해 보고자 하는 것이다. 우선 전통적인 공리주의나 의무론적 윤리이론에 기반을 둔 하향식 접근, 발달적·발전적·진화적 접근을 추구하는 상향식 접근, 그리고 이 두 접근을 융합하려는 혼합식 접근을 살펴보았다. 또한 도덕적 정서를 고려하는 접근이 보완적으로 왜 필요한지를 살피고자 하였다. 특별히 최근의 신경과학이나 도덕심리학적 입장은 이성과 사고하는 능력 중심의 기존 관점에서 벗어나 감정이나 직관의 중요성을 더욱 강조하는 경향성을 가지기에 이성과 직관·정서의 상호보완적 접근을 추구하는 AMA의 도덕성 구축이 필요함을 제시하였다. 여러 접근에서 모두 한계점과 문제점을 가지고 있지만 이것을 도덕철학적으로 또 도덕심리학·신경과학·신경윤리학적으로 살펴봄으로써 반성적 성찰을 제공하고자 하였다. The moral decision-making abilities in AI is necessary. Robots with the ability to make moral judgments on its own is called AMA. In this paper I research that in certain circumstances AMA can be seen as real moral agents. For this, I will suggest four approaches when it comes to establishing an ethics for the AMA. First, the top-down approach makes use of the traditional ethical theories such as utilitarian or deontological theories. The role of the ethical theory in this approach is to provide the AMA with rules to follow in morally complex situations. Second, the bottom-up approach follows the central ideas proposed by developing various machine-learning methods for the AMA to learn ethical reasoning without giving it any available rules at hand. The basic idea for this approach is to regard the AMA as a human child who has the potential of obtaining moral reasoning as the child grows up according to proper developmental stages of morality. Third, the hybrid approach is an attempt to unite the top-down and the bottom-up approaches. Fourth, I argue that emotions, intuitions, and feelings are very important for AMA to be truly ethical. From a neuroscientific perspective and moral psychology, moral emotions have a scientific basis worthy of consideration. After all, I wish to provide some direction for AMA by outlining the value and limitations inherent in each of these approaches.