선천성 고혈압 흰쥐에서 두릅 에탄올 추출물의 항고혈압 효과

진주연,박은혜,전윤아,이영재,Jin, Ju-Youn,Park, Eun-Hye,Jeon, Yoon-A,Lee, Young-Jae 대한수의학회 2017 大韓獸醫學會誌 Vol.57 No.3

Antihypertensive effects of ethanol extracts of Aralia elata (Miq.) Seem. (AE) were investigated in spontaneously hypertensive rats (SHR). SHR aged 14 weeks were treated for 8 weeks with AE (10 or 50 mg/kg/day) or amlodipine besylate (Am; 10 mg/kg/day) orally. Hypertension results in injury to several organs and can produce a significant increase in malondialdehyde (MDA) content as a result of lipid peroxidation and endothelial dysfunction. In this study, oral administration of AE and Am significantly reduced systolic blood pressure, organ weight index, and MDA content in tissues but increased significantly the plasma nitrite and nitrate concentrations. The endothelium-dependent relaxant activities of acetylcholine ($10^{-10}-10^{-3}M$) in norepinephrine (NE)-precontracted aorta were increased in AE- and Am-treated rats. Particularly strong endothelium-dependent relaxant activities were observed in AE-treated (50 mg/kg) rats. The endothelium-independent relaxant activities of sodium nitroprusside ($10^{-10}-10^{-3}M$) in NE-precontracted aorta were not changed. The results of this study suggest that AE has both antihypertensive and end-organ protective effects in SHR.

상장간막동맥증후군처럼 보이는 위날문막힘이 있는 소아의 호산구성 위장관염

진주연,황숙민,김정원,조기영 대한 소아알레르기 호흡기학회 2020 Allergy Asthma & Respiratory Disease Vol.8 No.4

Eosinophilic gastroenteritis (EGE) is known to have a low incidence among the pediatric population, but it can result in serious complications, such as gastric outlet obstruction. In previously published EGE cases with the obstruction in adults, surgeries were often performed. In this report, we present a 14-year-old girl who came to our facility with severe abdominal pain and vomiting. On the initial abdominal physical examination, diffuse tenderness and severe epigastric pain were noted. Computed tomography scan of the abdomen showed the findings of superior mesenteric artery (SMA) syndrome. However, she had no history of recent weight loss, and the medical history was inconsistent with SMA syndrome. We planned upper gastrointestinal series with barium, and then verified gastric outlet obstruction. We performed esophagogastroduodenoscopy and obtained a final diagnosis of EGE through mucosal biopsy specimen. Corticosteroids and anti-inflammatory medications were administered. Dietary modification and education were done as well. The symptoms resolved, and the follow-up esophagogastroduodenoscopy and ultrasonography showed improvements in the obstruction. Our case emphasizes that gastric outlet obstruction due to EGE must be carefully differentiated from SMA syndrome because of their similarities in clinical features and radiologic images. In doing so, we can avoid surgical intervention and perform medical/dietary treatment for gastric outlet obstruction. .

국내 통합체육 연구의 동향: 텍스트 마이닝 분석

진주연,이후경,김지안,최서언 한국특수체육학회 2022 한국특수체육학회지 Vol.30 No.1

The purpose of this study was to understand the research trends of inclusive physical activity in Korea. A total of 209 papers published in Korean academic journals from 1991 to 2021 were analysed. For objective and systematic analysis, text mining using keyword analysis, topic modeling, and semantic network analysis were used. In addition, time-series analysis was used to reveal the 10-year-patterns of research topics. As a result, many domestic journals(n=47) published studies regarding inclusive physical activity, but similar amounts of research have been published since 2005. For keyword analysis, N-gram analysis showed that‘inclusive physical activity’ and ‘attitude’ had the highest frequency, and ‘inclusive physical activity classes’, ‘students with disability’, and ‘inclusive physical activity’, were sorted in the order of high weight of TF-IDF. For topic modeling analysis, ‘teaching method’, ‘inclusive physical activity environment’, ‘value of inclusive physical activity’, ‘role of physical education teacher’, and ‘inclusive physical activity program’were clearly categorized without overlapping when classified into five topics. For the analysis of degree centrality and betweenness centrality of the semantic network analysis, the number of links with other nodes appeared in the order of ‘inclusive physical activity', ‘inclusive physical activity class’, and ‘inclusive physical activity education'. Closeness centrality analysis revealed that‘physical self-concept' and ‘physical environment' were the most influential nodes in the entire network. Time series analysis demonstrated no noticeable change although there was a 10-year-pattern of inclusive physical education adopted from special education-importance of a teacher and an independent role of inclusive physical education-an extension of the study topics considering inclusive physical activity environment. Compared to the past, IPA research in Korea still do not have significant changes in both quantity and quality. Future researchers may extend the research scope from school to community settings and consider a variety of factors for better understanding complicated mechanism of IPA and for successful IPA implementation in practice. 본 연구는 성공적인 통합체육의 실행을 위한 연구동향의 분석을 위해 1991년부터 2021년까지 국내 학술지에 게재된 논문 중 통합체육을 주제로 진행된 논문 209편을 분석하였다. 국내 통합체육 관련 연구를 객관적이고 체계적으로 분석하기 위해 키워드 분석, 토픽모델링, 의미연결망 분석을 이용한 텍스트 마이닝 기법을 활용하여 지난 30년간 국내에서 수행된 연구의 흐름을 종합적으로 파악하였다. 또한, 시계열 분석을 통해 1990년대를 시작으로 10년 단위의 구분을 적용하여 연구주제의 변화 과정을 구체적으로 파악하였다. 연구 결과, 국내 많은 학술지(n=47)에서 통합체육 관련 연구를 출판한 것으로 나타났지만, 출판된 논문의 수는 2005년 급격한 증가한 이후 큰 폭의 변화 없이 비슷한 양의 논문이 매년 출판되고 있었다. 키워드 분석 결과, N-gram 분석에서는 ‘통합체육’과 ‘태도’의 연속 출연 빈도가 가장 높은 것으로 나타났고, ‘통합체육수업’, ‘장애학생’, ‘통합체육’이 TF-IDF의 가중치가 높은 순으로 정렬되었다. 토픽모델링 분석 결과, ‘교수방법’, ‘통합체육 환경’, ‘통합체육의 가치’, ‘체육교사의 역할’, ‘통합체육 프로그램’ 5개의 토픽으로 분류되었을 때 서로 겹치지 않고 명확하게 범주화되는 것으로 확인되었다. 의미연결망의 연결중심성과 매개중심성 분석 결과, ‘통합체육’, ‘통합체육수업’, ‘통합체육교육’ 순으로 다른 노드와의 링크수가 많이 나타나고 네트워크 내 중재 역할을 하였으며, 근접중심성 분석 결과, ‘신체적자기개념’과 ‘물리적환경’이 전체 네트워크에서 가장 영향력을 갖는 노드로 밝혀졌다. 시계열 분석 결과, 1구간(1991~2000)은 특수교육과 연계된 ‘통합체육 개념 도입’, 2구간(2001~2010)은 교사의 중요성과 독립적인 영역으로써 ‘통합체육 가치 확산’, 3구간(2011~2021)은 일부 ‘통합체육 환경’을 고려한 연구주제의 확장으로 이어지며 10년 단위로 변화를 보이긴 했으나 눈에 띄는 명확한 변화는 찾아볼 수 없었다. 본 연구를 통해 과거와 비교했을 때 여전히 국내 통합체육 연구는 양적, 질적 모두 변화의 폭이 크지 않은 것을 파악할 수 있었다. 따라서 앞으로 통합체육 연구는 전 연령을 대상으로 학교뿐만 아니라 지역사회 환경 안에서 광범위한 연구의 범위를 설정하고, 다양한 변인을 연구할 필요가 있다고 생각된다.

토픽모델링 및 의미연결망을 활용한 지적장애인 대상 특수체육 연구의 동향 분석

진주연 ( Jooyeon Jin ),김은혜 ( Eunhye Kim ),윤지은 ( Ji Eun Yun ),김지안 ( Jian Kim ) 한국특수체육학회 2021 한국특수체육학회지 Vol.29 No.1

본 연구는 지적장애인을 대상으로 수행된 특수체육에 관한 연구의 주요 주제와 흐름을 토대로 종합적인 연구 동향을 파악하였다. 먼저, 지난 20년간의 국내·외 지적장애인 대상 특수체육 관련 연구를 추출하고자 ‘지적장애’. ‘정신지체’, ‘체육’, ‘,신체활동’, ‘스포츠’, ‘운동’, ‘무용’ 등의 주요어들을 교차 적용하였다. 국내·외 특수체육 연구 관련 학술지들을 대상으로 Phython 3.7 Package를 이용한 LDA 알고리즘 기반토픽모델링 분석과 R프로그램 KoNLP와 UCINET 프로그램을 이용한 의미연결망 분석을 수행하였다. 토픽모델링 분석 결과, 국내·외 각각 9개의 토픽이 도출되었다. 국내 연구의 토픽은 ‘교육적 접근’, ‘운동수행능력’, ‘유산소운동’, ‘중재와 평가’, ‘참여대상별 유형’, ‘신체활동 참여’, ‘적응행동기술’, ‘인지능력’, ‘신체조성과 복합운동’이며, 국외 연구 토픽은 ‘비만 예방을 위한 심리요인과 체력’, ‘신체활동 결정요인과 중재’, ‘운동 발달’, ‘운동의 효과’, ‘운동능력 측정’, ‘참여대상별 유형’, ‘운동 프로그램 참여’, ‘체력증진’, ‘심동, 인지, 정의적 특성’으로 명명하였다. 의미연결망 분석 결과, 국내·외 연구 모두 ‘아동’, ‘청소년’, ‘성인’을 중심으로 ‘건강관련체력’, ‘신체조성’, ‘운동수행능력’, ‘운동기술’의 연결망 구조를 이루고 있었다. 특히, 국내 연구에서는 뇌파훈련, 연산운동과 같은 인지기능 관련 노드가 프로그램에 연결되어있었고, 국외 연구의 경우 스페셜올림픽 참여, 통합스포츠, 훈련과 같은 스페셜올림픽 관련 노드가 프로그램에 연결되어 있어 국내·외 연구 주제와 흐름, 경향의 차이점을 보였다. 이러한 결과는 지적장애인의 연령에 따라 다양한 특수체육에 관한 연구 주제와 흐름, 지식의 연결구조가 어떻게 국내·외 문헌에서 집적되었는지 체계적으로 분석하고 정리했다는 점에서 의의가 있다. 본 연구의 결과를 바탕으로 국제적인 연구 동향을 참고하여 지적장애인의 신체활동 촉진과 건강증진을 위한 후속 연구의 노력이 국내에서 더욱 필요할 것으로 사료된다. The purpose of this study was to comprehensively explore research trends in adapted physical activity(APA) for individuals with an intellectual disability(ID). We extracted domestic and foreign research in APA for people with ID over the past 20 years, and key words such as ‘intellectual disability’, ‘mental retardation’, ‘physical education’, ‘physical activity’, ‘sports’, ‘exercise’ and ‘dance’ were cross-applied. A topic modeling analysis based on the LDA algorithm using Python 3.7 Package and a semantic network analysis using the R based KoNLP and UCINET programs were conducted for domestic and foreign journals related to APA research. As a result, nine domestic and nine foreign topics were extracted respectively. Domestic topics included ‘educational approach’, ‘exercise performance ability’, ‘aerobic activity’, ‘mediation and evaluation’, ‘type of participants’, ‘participation in physical activities’, ‘adaptive action skills’, ‘cognitive ability’, and ‘body composition and combined exercise’. Foreign topics contained ‘psychological and physical fitness for prevention of obesity’, ‘determinants and meditations of physical activity’, ‘exercise development’, ‘effects of exercise’, ‘measurement of motor skills’, ‘type of participants’, ‘participation in physical activity’, ‘physical improvement’, ‘characteristics of psychokinetic, cognitive affective’. Both domestic and foreign studies formed a network of “health-related fitness”, “body composition”, “exercise performance ability”, and “motor skill”, focusing on “children,” “youth” and “adult”. In particular, domestic studies showed nodes related to cognitive functions, such as brainwave training and computational practice, were connected to the program, and foreign studies revealed that nodes related to Special Olympics, such as Special Olympics participations, unified sports, and training were connected to the program. This shows differences in domestic and foreign research topics and trends. These results are meaningful in that we systematically analyzed and summarized how the research topics, flows, and connections of knowledge in the field of APA, considering age of people with an intellectual disability, were aggregated in domestic and foreign literature. Based on the results of this study, it is expected that researchers in Korea make further efforts to promote physical activity and improve health of individuals with ID.

랫드에서 두릅 추출물의 4주 반복투여 독성시험

진주연(Ju Youn Jin),양희경(Hee Kyoung Yang),김지민(Ji Min Kim),고문수(Mun Su Ko),홍현주(Hyun Ju Hong),진영건(Young Gun Jin),김동건(Dong Gun Kim),김상철(Sang Chul Kim),이일(Il Lee),현민경(Min Kyong Hyon),강상철(Sang Chul Kang),김재훈(Ja 한국독성학회 2006 Toxicological Research Vol.22 No.4

Aralia elata, a common medicinal and culinary herb, has been consumed for centuries without any reported adverse effects. However, due to its limited safety information, we decided to investigate the repeated-dose toxicity of ethanolic extract of Aralia elata. The test was administered once daily by the gavage to male and female rats at doses of 0, 250, 500 and 1,000 ㎎/㎏/day for four weeks. Throughout the study, no treatment-related deaths or clinical signs were observed. Also, no apparent changes were detected in ophthalmoscopy, urinalysis, serum biochemistry, hematology and gross necropsy. The test result showed a significant decrease in body and heart weight of males treated with 250 ㎎/㎏ of extract of Aralia elata compared to normal control, a significant increase in relative brain weight and adrenal weight in females treated with 250 ㎎/㎏ of extract compared to normal control. However, all these changes were not considered toxicologically important due to irrelevant dose-response relationship to gross and microscopic findings. Histopathologically, abnormal changes were not observed in any target organs. On the basis of these results, the NOAEL of extract of Aralia elata was estimated to be more than 1,000 ㎎/㎏/day under the tested conditions.

Development and Evaluation of the Evidence-based Practice Instrument for Physical Educators Teaching Students with Disabilities

진주연(Joo Yeon Jin),윤준구(Joon Koo Yun) 한국체육측정평가학회 2014 한국체육측정평가학회지 Vol.16 No.2

본 연구의 목적은 범이론적 모델을 바탕으로, 장애 학생들에게 근거에 입각한 수업을 진행하기 위한 체육교사의 의 지와 교수법을 측정할 수 있는 측정도구를 개발하고 검증하는 데 있다. 미국 북서부 지역 초.중등학교에서 근무하는 148명의 체육교사들이 본 연구에 참여하였다. 범이론적 모델의 세 가지 개념(자기효능감, 의사결정균형, 변화과정)을 측정하는 문항들의 판별기능을 평가하기 위해 문항분석이 사용되었고, 그 이론적 구조는 확인요인분석을 통해 평가되 었다. 범이론적 모델의 핵심개념인 변화의 단계는 일원분산분석과 다변량분산분석을 사용하여 위의 세 개념들과 비교 되었다. 평가도구의 모든 항목들에 대한 문항판별값과 내적 일치도 값은 우수하거나 매우 우수하게 나타났고, 합당한 설명량(다중상관자승)과 요인적재치를 보였다. 범이론적 모델의 자기효능감, 의사결정균형, 변화과정 구조모형은 부분 적인 타당도가 수립되었다. 향후 본 측정도구의 타당도를 높이기 위해, 큰 표본을 이용한 교차검증법이 유망할 것이다. The purpose of this study was to develop and validate an instrument based on the Transtheoretical Model (TTM) for assessing physical educators’ intentions and teaching behavior to implement evidence-based practice for students with disabilities. Study participants were 148 physical education teachers who were recruited from both elementary and secondary schools in Northwest regions of the U.S. Item analysis was conducted to evaluate appropriate discriminate functions for items measuring three TTM constructs (self-efficacy [SE], decisional balance [DB], and processes of change [POC]). Internal structures of the TTM items were examined by confirmatory factor analyses. The responses from stage of change were compared to the three TTM constructs. Separate one-way analyses of variance and multiple analyses of variance on each construct by stage were conducted to assess differences among the stages of change. Item discrimination values for all items were good to very good, except for two negative DB items that were deleted. Internal consistencies of SE, DB, and POC were found to be good to excellent. Confirmatory factor analyses showed reasonable squared multiple correlation and factor loading estimates. Three structural models were partially supported by goodness of fit indices. Cross-validation with a large sample size will be desirable to refine this measurement system in the future studies.

시설이용 치매노인의 인지기능, 불안 및 삶의 질 비교연구

진주연(Jin Joo Youn),강지숙(Kang Ji Sook) 한국성인간호학회 2009 성인간호학회지 Vol.21 No.3

Predicting Adolescents’ Physical Activity in Physical Education using an Extended Theory of Planned Behavior

진주연(Joo yeon Jin),윤준구(Joon koo Yun) 학습자중심교과교육학회 2018 학습자중심교과교육연구 Vol.18 No.3

본연구의 목적은 중학교 체육수업에 참여하는 청소년의 신체활동의지와 신체활동량을 예측하기 위해 확장된 계획행동이론의 유용성을 검증 하는 것이다. 2011년도 가을, 서울과 경기도에 위치한 8개 중학교에서 모집된 553명의 중학생들이 연구에 참여하였다. 확장이론의 예측유용도와 (predictive utility: 가설 1) 목표의지와 신체활동 사이에서 실행의지의 매개효과 (medication effect: 가설 2)를 검증하기 위해 구조방정식이 사용되었다. 참가자의 태도, 사회적규범과 장애효능감은 목표의지를 유의미하게 예측했고 (R2=.68, p<.001), 실행의지와 임무효능감은 신체활동의 유의미한 예측요인이었다 (R2=.13, p<.001). 또한, 실행의지는 완벽하게 목표의지와 신체활동의 관계를 매개했다 (β=.12, p<.001). 전체적으로, 확장이론은 중학교 체육수업에서 학생들의 신체활동을 예측하는데 효과적인 것으로 나타났다. 후속 연구자들이 학교체육수업 참여하는 학생들의 신체활동증진을 위한 교수법을 개발할 때 본 확장이론에서 검증된 심리. 사회적 요인들을 고려해야 할 것으로 생각된다. The purpose of this study was to investigate the utility of an extended theory of planned behavior to predict physical activity (PA) intentions and behavior of adolescents in middle school physical education classes. A total of 553 students from 8 middle schools in Seoul and the suburbs of Korea participated in this study during fall of 2011. Structural equation modeling using robust maximum likelihood estimator was used to examine the predictive utility of the integrative model (hypothesis 1) and the mediation effect of implementation intention between goal intention and PA (hypothesis 2). Participants’ attitudes, subjective norms, and barrier-efficacy significantly predicted students’ goal intentions (R2=.68, p<.001), and their implementation intentions and task-efficacy were significant PA predictors (R2=.13, p<.001). In addition, implementation intentions completely mediated the relationship between goal intentions and PA (β=.12, p<.001). Findings suggest that the integrative model is useful to effectively predict adolescents’ PA in middle school physical education settings. Future studies should consider the psychosocial factors to effectively develop instructional strategies that promote adolescents’ PA in physical education classes.

C57BL6 마우스에서 복합생약제인 황금궁의 육모 효과

허진주(Jin Joo Hue),리란(Lan Li),유설혜(Sul Hye Lyu),백인정(In Jeoung Baek),연정민(Jung Min Yon),남상윤(Sang Yoon Nam),윤영원(Young Won Yun),황석연(Seock Yeon Hwang),홍진태(Jin Tae Hong),이범준(Beom Jun Lee) 대한약학회 2005 약학회지 Vol.49 No.6

Hwanggumgung (HGG) is a hair-care product which is composed of several plant extracts used in oriental medicine. This study was carried out to investigate effect of HGG on hair regrowth in a shaving model of C57BL6 mice. Five-week-old mice were acclimated for 1 week under 23±3℃, 50±10% relative humidity, and 12h of a light/dark cycle before beginning experiment. There were four experimental groups including distilled water (D.W., control), 10% ethanol (EtOH, vehicle control), a positive control of 3% minoxidil (MXD), and HGG for female and male mice, respectively. Six-weeks old mice were trimmed by electric clippers so as not to damage the skin. The next day, mice without visible scraches were selected, randomized and separated in groups of 11 mice. The test compounds were topically treated with 0.15㎖ per mouse per day for 21 days. The hair regrowth was photographically and histologically determined during the experimental period of 21 days. Enzyme activities of γ-glutamyl transpeptidase and alkaline phosphatase were also determined using a rate assay method. There were no clinical signs in all experimental groups. The topical application of 3% MXD and HGG in female mice promoted hair regrowth earlier and faster than the control groups. In male mice, the topical application of 3% MXD and HGG also accelerated hair growth compared with the controls. Ten percent ethanol also promoted hair growth faster than D.W group. The histology of hair growth in experimental groups was strongly associated with the hair regrowth. 3% MXD and HGG promoted elongation of hair follicles compared with the controls in both female and male mice. Activities of alkaline phosphatase and γ-glutamyl transpeptidase, enzymes related to hair growth, significantly increased after treatments of 3% MXD and HGG for 2 weeks in both female and male mice (p<0.05). These results suggest that HGG has hair growth promoting activities and it can be for treatment for alopecia.

Development of a simple HPLC method for simultaneous determination of medimin E and α-tocopherol in swine serum

Choi, Soo Youn,Jin, Ju Youn,Lee, Young Jae 濟州大學校亞熱帶農業硏究所 2004 아열대농업생명과학연구지 Vol.20 No.1

A rapid and simple HPLC method has been developed for simultaneous determination of medimin E. a new a -tocopherol derivate and atocopherol in swine serum. The analytes were extracted with ethanol from 0.2 ml of swine serum and separated by HPLC on a C_(18) reversed-phase column using methanol as a mobile phase and UV detection a t 285 nm. The method was validated over a concentration range of 2-100 μg/ml with a correlation coefficient of 0.998 for medimin E and 0.2-10 μg/ml with 0.996 for a -tocopherol. The lower limit of quantification (LOQ) in serum were 2μg/ml for medimin and 0.2 μg/ml for a-tocopherol: intra- and interday coefficients of variation were ≤13.0% except for LOQ. Advantages of this validated assay include small samples volume. simplified serum extraction, excellent extraction recovery and fast run time. This method can be applied to analysis of medimin E and a-tocopherol in clinical pharma-cokinetics and biological activities studies.