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인슐린 비의존형 당뇨병 환자에서 24시간 혈압 변동 및 요중 알부민 배설량에 관한 연구
주기산,안기완,정종훈,배학연,홍순표 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1
Recently, blood pressure(BP) starts to increase in close relationship to development of persistent microalbuminuria in diabetes. Thus, author studied 24-hour BP changes in diabetics compared to the those in nondiabetics and the changes of urinary albumin excretion (UAE) according to 24-hour BP changes in diabetics with microalbuminuria. Twenty-four-hour ambulatory blood pressure monitoring(ABPPM) was performed in 38 NIDDM patients(18 normotensives and 20 hypertensives) and in 37 control subjects without diabetes(18 normotensives and 19 hypertensives) . Also 24-hour ABPM was performed in 38 diabetics (20 microalbuminurit and 18 normoalbuminuric). The analysis of individual recordings allowed us to detect an impaired circadian pattern(the disappearance of the nocturnal BP decrease or a paradoxical BP increase) in 30% of the normotensive and 31% of the hypertensive diabetics. Twenty-four-hour ABPM(night systolic/diastolic ±SD mmHg) was significantly higher in microabluminuric(124.2 ±11.4/75.1±8.2 mmHg) than in normoalbuminuric subject, (114.0±7.6/64.6±6.6 mmHg, p<0.05). This study suggests that not only awaking BP but also especially day-night minimum SBP decrease are highly responsible for the renal impairment in NIDDM patients, unrelation to hypertension. Thus. ABPM reflects the association between UAE and blood pressure in diabetics more precisely than clinical measurements. and a significant correlation exists between rate of increase in Urinary albumin excretion and blood pressure in diabetics.
주기산,임현성,김미자,양태영,허경,김완중,박유환,정춘해 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1
Essential thrombocythemia is a chronic myeloproliferative disorder of unknown origin, charcterized by excessive number of morphologically and functionally abnormal platelet in peripheral blood and abnormal proliferation of megakaryocytes in bone marrow. Its main clinical manifestations are hemorrhages and thromboses. The aim of therapy is suppression of the excessive bone marrow activity, which can be achieved by radioactive phosphorus, alkylating agent, hydroxyurea and interferon. Two cases were diagnosed at our hospital which had laboratory and clinical features compatible with this disease. We have successfully treated patient with hydroxyurea and platelet antiaggregating agent.
김용화,주기산,서영환,조경상,김상도,정춘해 朝鮮大學校 附設 醫學硏究所 1992 The Medical Journal of Chosun University Vol.17 No.2
Pleural effusion in a patient with multiple myeloma due to plasma cell involvement of the pleura has been reported infrequently. We report a case of multiple myeloma with pleural involvement presenting bone pain and dyspnea in a 69-year-o1d woman. On the physical examination, the patient looked chronically ill with bedridden state. There was a palpable mass on the left posterior lower chest, firm but not tender and decreased breathing sound in the left lower lung. Laboratory finding revealed amemia, elevation of ESR, globulin, and calcium. X-ray of the chest showed pleural effusion in the left lower lung, and multiple pathologic fractures in the both ribs. X-ray of the skull, and pelvis revealed multiple punched-out osteolytic fractures in the both ribs. X-ray of the skull, and pelvis revealed multiple punched-out osteolytic lesion, and compression fracture in the lumber spine. Serum and urine electrophoresis revealed a M-spike. Serum and urine immunoelectrophoresis demonstrated an IgA-kappa monoclonal protein. Thoracentesis revealed serosanguinous fluid but not containing atypical plasma cells. Bone marrow examination showed 16.7% of immature plasma cells. With first cycle of melphalan, prednisone chemotherapy, improvement of pain and disappearance of pleural effusion was observed.
간 낭종을 동반한 성인 다낭신 환자에서 간 낭종의 감염 1예
정규성,서정철,주기산,김원식,임영국,정종훈,문철웅 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1
Adult polycystic kidney disease(APKD) usually accompanies with renal and extrarenal manifestations and liver cysts are present in aproximately 30% of patients with APKD. Kidney cysts often accompany with hemorrhage, rupture, infection, however, liver cysts are usually asymptomatic and do not impair liver function. Rare complication of liver cysts in patient with APKD include portal hypertension with bleeding esophageal varices and hepatic failure with encephalopathy. But, in APKD patient, infection of liver cysts without infection of renal cysts is extremely rare. We report a case of infected liver cyst in a patient with APKD who has complained generalized abdominal pain and high fever which was confirmed by ultrasound and aspiration. The patient was treated successfully with repeated aspiration and systemic antibiotics.
간담도내 Calcium - bilirubinate 결석을 갖는 환자에서 간흡충증의 유병율에 관한 연구
양태영(Tae Young Yang),서정철(Jeong Cheol Seo),김미자(Mi Ja Kim),정규성(Kyu Sung Chung),주기산(Gi San Ju),김태원(Tae Weon Kim),박찬국(Chan Gook Park),김만우(Man Woo Kim),김석일(Suk Il Kim) 대한내과학회 1996 대한내과학회지 Vol.50 No.1
N/A Objectives: Clonorchiasis is very common in the Far East and nation-wide in our country. Hepatobiliary stones is not rare in the group of hepatobiliary disease. Some debates has been made in the point of the relationship between clonorchiasis and calcium-bilirubiante stone. The object of the study is to evaluate the prevalence of clonorchiasis in the hepatobiliary stone patients. Methods: Ultrasonographic survey were made of 72 patients in Chosun University in Kwang-ju from August 1993 to July 1994. The ultrasonogram was Aloka model SSD 680(Tokyo, Japan). The hepatobiliary stones were classified based on their sonographic characteristics by modified Tsuchiya method. The stoo1 examination was carried out using the cellulous thick smear and the anti-C. sinensis IgG was measured by enzyme-linked immunosorbent assay. Results: The ultrasonographic analysis of stones showed that type 1 mainly composed of cholesterol stone was 45 cases(62.5%) and type 3 mainly composed of calcium-bilirubiante stone was 23 cases (31.9%). The prevalence of clonorchiasis in 72 cases of hepatobiliary stone patients, in 23 cases of calcium-bilirubinate stones, and in 49 cases of non calcium-bilirubinate stones were 18 cases(25%), 10 cases (43.5%), and 8 cases(16.3%) respectively. Conclusion: The relationship between Clonorchiasis and calcium-bilirubinate stone was statistically significant(p<0.01)
간담도내 Calcium - bilirubinate 결석을 갖는 한자에서 간흡축증의 유병율에 관한 연구
양태영(Tae Young Yang),서정철(Jeong Cheol Seo),김미자(Mi Ja Kim),정규성(Kyu Sung Chung),주기산(Gi San Ju),박찬국(Chan Gook Park),김만우(Man Woo Kim),김석일(Suk Il Kim) 대한내과학회 1995 대한내과학회지 Vol.49 No.5
N/A graphic characteristics by modified Tsuchiya method. The stool examination was carried out using the cellulous thick smear and the anti-C, sinensis IgG was measured by enzyme-linked immunosorbent assay. Results: The ultrasonographic analysis of stones showed that type 1mainly composed of cholesterol stone was 45cases(62.5%) and type 3 mainly composed of calcium-bilirubinate stone was 23cases (31.9%). The prevalence of clonorchiasis in 72cases of hepatobiliary stone patients, in 23cases of calciumbilirubinate stones, and in 49cases of non calciumbilirubinate stones were 18cases(25%), 10cases (43.5%), and 8cases(16.3%) respectively. Conclusion: The relationship between Clonorchiasis and calcium-bilirubinate stone was statistically significant(p<0.01).