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A Case of Congenital Nephrogenic Diabetes Insipidus Confirmed by Gene Analysis
조은영,오진희,고대균 대한소아청소년과학회 2005 Clinical and Experimental Pediatrics (CEP) Vol.48 No.6
Nephrogenic diabetes insipidus (NDI) is a disorder in which the secretion of antidiuretic hormone is normal, but the response of the renal collecting tubules to vasopressin is impaired. Compared with acquired NDI (a-NDI), which is secondary to chronic bilateral incomplete urinary tract obstruction with hydronephrosis, congenital NDI (c-NDI) is a very rare heritable disorder that usually follows the X- linked recessive pattern. Clinical symptoms of c-NDI can be non specific, and often the disease ultimately results in failure to thrive, or mental retardation. Recently, the diagnosis can be confirmed by direct sequencing analysis of the peripheral blood specimens. The long-term results of treatment for c-NDI are not satisfactory. Reports on the follow up of c-NDI cases are rare and there is no report on the cases treated with combinations of three drugs. We report herein a case of severe c-NDI in an 8 year-old-boy with a severely dysconfigurated urinary tract system. The patient and his mother showed a frameshift mutation on the AVPR2 gene on chromosome Xq28:.847_851delTGCTG (p.C283fsX90). The patient showed normal growth and development by treatment with combinations of hydrochlorothiazide (65 mg/m2), amiloride (0.3 mg/kg/d) and indomethacin (100 mg/m2), yet after five years he needed adjuvant cystostomy to relieve him from the residual symptoms of urgency with polyuria. 유전자 분석검사로 확진된선천성 신성 요붕증 1례가톨릭대학교 의과대학 소아과학교실조은영·오진희·고대균신성 요붕증은 항이뇨호르몬의 정상적 분비에도 불구하고, 신장의 집합관의 항이뇨호르몬에 대한 반응이 저하되어 요농축능에 이상이 초래되는 질환이다. 특히 선천성 신성 요붕증은 대게 반성 열성 유전 양식을 따르는 유전 질환으로 매우 드물어 소아에서는 간헐적 보고만 있어 왔다. 어린 소아에서는 증상이 비특이적일 수 있고, 임상적 진단도 쉽지 않은데, 최근에는 항이뇨 호르몬 수용체 유전자의 돌연변이들이 확인되어 유전자 검사로 확진이 가능하게 되었다. 기존의 보고들은 선천성 신성 요붕증이 진단된 환아들에 대한 이뇨제나 비스테로이드성 항염증제 등을 포함한 치료가 이루어진 증례보고이었으나 이들의 치료 후 장기적 추적 결과 보고가 극히 드물며, 이들 약제에 의한 치료 효과는 낮은 것으로 알려져 있다. 저자들은 극심한 이뇨로 인한 이차적 요로기관의 변형이 초래되었던 8세 소아에서 환아와 엄마의 말초 혈액 유전자 분석 검사상 Xq28 염색체 부위의 AVPR2 유전자의 돌연변이가 확인되었고 hydrochlorothiazide, indomethacin 및 amiloride 병합 치료 후 배뇨량은 하루 12리터에서 4리터로 감소하였고, 성장 발육도 정상이었으나 더 이상의 호전이 없고 일상 생활에 불편함이 지속되어 보조적 방광루 형성술을 시행받은 후, 증상 호전 및 심리적 안정을 얻었던 심한 선천성 신성 요붕증 1례의 5년간의 추적 관찰 결과를 보고하는 바이다.
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조은영,김래영 이화여자대학교 교과교육연구소 2021 교과교육학연구 Vol.25 No.4
본 연구는 성인 수학교육의 개념화와 평생교육 현장의 수학교육 실태 파악을 바탕으로 향후 평생학습으로서의 수학교육에의 시사점을 제공하고자 한다. ‘성인’, ‘수학’, ‘literacy’ 또는 ‘numeracy’가 포함된 124개의 문헌과 주요문헌의 참고문헌, 평생교육 관련 기관 사이트의 프로그램을 조사·분석하는 체계적 문헌고찰(systematic review)을 하였다. 성인 수학교육은 수학소양, 직무수학, 생활수학이라는 세 개의 범주로 나뉘며, 하위영역으로는 직무수학에는 직업기초수학, 대학기초수학, 부모수학이, 생활수학에는 수리문해와 실버수학이 있다. 우리나라 성인 수학교육 현황을 분석한 결과 성인들의 수학적인 필요를 충분히 충족하지 못하는 것으로 나타났다. 따라서 성인의 전 생애주기 동안 수학적 필요를 견인할 수 있는 수학소양 규준 및 지표와 제도적인 뒷받침이 필요하며 이에 따른 함의와 시사점을 제시하였다. This study aims to define the concept of mathematics education for adults and to examine current status of mathematics education as lifelong learning. Based on systematic reviews on the literature, we classified it into numeracy, mathematics for work, and mathematics for life. Mathematics for work includes basic mathematics for work, university basic mathematics, and mathematics for parents, while mathematics for life includes quantitative literacy and silver mathematics. The current status of mathematics education programs for adults shows that they are not enough to strengthen adults’ mathematical competences. At the end, the further implication and suggestion are provided on the basis of the results from this study.
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釜山市所在のB大学の日本漢字授業の運営について ― 専攻選択教科目の「実用日本漢字」を事例として ―
趙恩英 한국일본어교육학회 2020 日本語敎育 Vol.0 No.92
The purpose of the present article is to consider the results after surveying the learners’ awareness for the learners’ activities & instructors’ feedbacks concerning the operation of the major elective of Japanese Kanji class. (1) The leaners who thought the activity① of expressing the event during a weekend in four key words to be helpful accounted for 84.5%. Through the activity①, it has been revealed that viewing an individual’s routine in Kanji was helpful to familiarization of Kanji providing an opportunity for familiarization with and review of the frequently-used Kanji and that comfortable access to Kanji was enabled. In addition, it was found to have become an opportunity for communication among the learners, allowing the learners to pleasantly learn and become proficient in Kanji with intimacy. (2) Concerning the activity② of using Kanji in a concentrated manner, 98.6% gave a positive rating. Unlike the expectation where the learners might feel the act of writing Kanji as a simple operation so as to have dissatisfaction or feel bothersome, it was discovered to be perceived as a meaningful activity for Kanji learning. (3) The learners considering the feedback time to be helpful for familiarization with Kanji accounted for 91.5%. It was learned that Japanese Kanji and Korean Chinese character became distinguishable after this time, Kanji susceptible to making a mistake along with precautions were recognized, and the time was provided for learning accurate usage of Kanji and living Kanji. In addition, his/her own Kanji capability could be seen objectively as the learners of the whole class get to recognize the use situations for Kanji, and it was shown to have been the time where the confidence in Kanji was connected with the desire for Kanji study.
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어머니의 양육 행동, 심리적 안정도, 결혼만족 및 아동특성이 유치원 아동의 애착행동과 사회성 발달에 미치는 영향
조은영,전경숙 미래유아교육학회 1997 미래유아교육학회지 Vol.4 No.1
The purposes of the present study were (1) to investigate influence of mothers' parenting behavior, psychological well-being, marital relationship and children's characteristics in relation to kindergarten on children's attachment and social development, (2) to examine the association between attachment and social development. Fifth-four children age 5 and 6 years and their mothers were observed and videotaped in a strange situation. Mothers completed questionnaires regarding mothers' parenting behavior, psychological well-being, marital satisfaction, parenting stresses and children's temperament. In addition, teachers rated children's social development using modified ISCS(Iowa Social Competency Scale: Preschool Form). The results showed that the most significant predictor of children's attachment and social development was reasoning guidance of parenting behavior. The secure attachment was associated positively with mother's reasoning guidance, involvement, intimacy and child's emotionality and negatively with parenting stress. The insecure attachment was associated positively with mother's limit setting, child's activity and emotionality and negatively with mother's reasoning guidance. Social development was associated positively with mother's reasoning guidance and negatively with parenting stress. Children's Insecure attachment were negative influence on their social development.
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Elastic Web Bend-buckling Analysis of Longitudinally Stiffened I-section Girders
조은영,신동구 한국강구조학회 2011 International Journal of Steel Structures Vol.11 No.3
The linear elastic web bend-buckling behavior of I-section girders with a longitudinal stiffener is investigated by a threedimensional finite element analysis in which the web, top and bottom flanges, and transverse and longitudinal stiffeners are modeled as thin shell elements. After obtaining the bend-buckling moment for an I-section girder by finite element analysis,the buckling stress and subsequently the buckling coefficient of a rectangular web panel with a longitudinal stiffener are calculated and compared with those obtained by AASHTO LRFD and Eurocode 3. To observe the effect of various parameters on the buckling behavior of an I-section girder under pure bending, the following aspects are considered: the non-symmetry of the cross-section, the location of the longitudinal stiffener, the boundary conditions along the transverse and longitudinal stiffeners and flanges, the flexural rigidity of the longitudinal stiffener, the spacing of the transverse web stiffeners, and the slenderness of the web. Based on the numerical results, new design equations for the bend-buckling coefficient of a longitudinally stiffened I-girder are proposed.
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