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원발성 경화성 담관염, 궤양성 대장염 및 담관암종이 병발해 나타난 1예
김경현,김창민,정숙향,정진행,김연경,김유철,이병희,양정훈,최병국,최택희 대한소화기학회 1999 대한소화기학회지 Vol.34 No.2
Primary sclerosing cholangitis (PSC) is a progressive, inflammatory disease affecting extra- and intra- hepatic bile ducts with characteristic radiologic and histologic findings. PSC is frequently associated with ulcerative colitis (UC) and the incidence of cholangiocarcinoma is increased in those patients with PSC and UC. We experienced a case in which primary sclerosing cholangitis, ulcerative colitis, and peripheral cholangiocarcinoma were combined. The patient was a 37-year-old female and complained of jaundice. To our knowledge, this is the first report which has presented the association of three disease entities in Korea.
간세포암종 환자의 종양 조직 내 P-glycoprotein 및 p53 단백의 발현이 항암화학요법의 반응률에 미치는 영향
김영호,정진모,조광희,조현호,정진행,이승숙,이진오,한철주,김유철,정숙향,이진혁,최대현,조상형 대한간학회 2001 Clinical and Molecular Hepatology(대한간학회지) Vol.7 No.4
Background / Aims : Hepatocellular carcinoma(HCC) is a drug -resistant tumor. The expression of a multidrug resistant gene, P-glycoprotein(P-gp) is a major mechanism of drug resistance. The aims of our study were, firstly, to observe the expression rate of P-gp in HCC tissue obtained by percutaneous fine needle aspiration(PCNA) from stage IV HCC patients; secondly to examine the association between P-gp and chemotherapeutic response ; and finally to investigate the correlation between p53 protein expression and P-gp expression. Subjects and Methods : We studied 29 cases of stage IV HCC treated by systemic chemotherapy. Expression of P-gp and p53 were evaluated by immunohistochmical staining of HCC tissue with human monoclonal anti body, JSB-1(Anti P-gp ) and DO-7(Anti p53), respectively. We analyzes the results of immunohistochmical staining of HCC tissues of the patients in relation to chemotherapeutic response and other clinical charateristics. Results : The expression rate of P-gp was 27.5%. Partial response to anti-cancar chemotherapy was observed in 16.7% of the to chemotherapeutic response, none of the response to anti-caner chemotherapy was observed in 16.7% of the patients. Although we could not see a statisrically significant association between to chemotherapeutic response expression and chemotherapeutic response , none of the response patients showed chemotherapeutic response P-gp expression. p 53 protein expression was found in 45% of the patients. There was no significant correlation between p 53 protein expression and P-gp expression. Conclusions : Although the number of our study subjects was small, chemotherapy- responsive patients didn't show P-gp expression. P-gp expression might be used as a predictor of response to potentially toxic anti-cancer chemotherapy in HCC patients. Futher study is warranted to confirm our results.