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정은나 ( Eun Na Chung ),김상헌 ( Sang Heon Kim ),권재현 ( Jae Hyun Kwon ),정민섭 ( Min Sub Jung ),박인수 ( In Su Park ),고영건 ( Young Gun Ko ),한성식 ( Sung Sik Han ),김영하 ( Young Ha Kim ),김수현 ( Soo Hyun Kim ) 한국조직공학과 재생의학회 2006 조직공학과 재생의학 Vol.3 No.1
We developed a biodegradable porous scaffold fabricated by a gel spinning method using a biodegradable and elastic polymer, poly(L-lactide-co-ε-caprolactone) (PLCL) (50:50) for vascular grafts application. To characterize the scaffold, we tested fiber thickness, SEM, cell seeding efficiency, tensile properties, and elasticity. In seeding test, we used bone marrow mononuclear cells isolated from rabbit. Furthermore, we examined tissue ingrowth activities for the scaffolds implanted in nude mice. The fiber thickness of the gel-spun scaffolds increased as the concentration of polymer solution increased. In mechanical properties such as tensile strength and elasticity, the gel-spun scaffolds were superior to scaffolds fabricated by a extrusion technique. In addition, the cell seeding efficiency of the scaffolds was higher than that of other scaffolds fabricated by compared methods. In implantation experiments, the scaffolds showed a good tissue ingrowth through open spaces between micro fibers. In conclusion, gel-spun tubular scaffolds can be a good candidate as scaffolds for cardiovascular tissue engineering.
NaBr 및 NaF 용액에 대한 Sn-3.0Ag-0.5Cu 솔더 합금의 Electrochemical Migration 특성
정자영,장은정,유영란,이신복,김영식,주영창,정태주,이규환,박영배,Jung, Ja-Young,Jang, Eun-Jung,Yoo, Young-Ran,Lee, Shin-Bok,Kim, Young-Sik,Joo, Young-Chang,Chung, Tai-Joo,Lee, Kyu-Hwan,Park, Young-Bae 대한용접접합학회 2007 대한용접·접합학회지 Vol.25 No.3
Electrochemical migration characteristics of Pb-free solder alloys are quantitatively correlated with corrosion characteristics in harsh environment conditions. In-situ water drop test and corrosion resistance test for Sn-3.0Ag-0.5Cu solder alloys were carried out in NaBr and NaF solutions to obtain the electrochemical migration lifetime and pitting potential, respectively. Sn-3.0Ag-0.5Cu solder alloy shows similar ionization and electrochemical migration behavior with pure Sn because of Ag and Cu do not migrate due to the formation of resistant intermetallic compounds inside solder itself. Electrochemical migration lifetime in NaBr is longer than in NaF, which seems to be closely related to higher pitting potential in NaBr than NaF solution. Therefore, it was revealed that electrochemical migration lifetime of Sn-3.0Ag-0.5Cu solder alloys showed good correlation to the corrosion resistance, and also the initial ionization step at anode side is believed to be the rate-determining step during electrochemical migration of Pb-free solders in these environments.
고농도 과산화수소와 플라즈마 아크를 이용한 미백 치료에 있어서 불소의 효과
정선영 ( Sun Young Chung ),이영은 ( Young Eun Lee ),안상헌 ( Sang Hun Ahn ),양해영 ( Hae Young Yang ),전은숙 ( Eun Suk Jeon ),최연희 ( Youn Hee Choi ),송근배 ( Keun Bae Song ) 한국치위생과학회 2011 치위생과학회지 Vol.11 No.4
This study evaluated whether fluoride treatment can affect recovery of the irregularity of enamel surface after tooth whitening with a high concentration of hydrogen peroxide (HP) activated by plasma arc light. A total of 36 bovine teeth stained with coke were used in this experiment. The specimens were classified into following three groups (two different commercial plasma arc groups and a control group without light curing source): (1) 35% HP gel only, (2): 35% HP gel and Plasma arc A, and (3) 35% HP gel and Plasma arc B. To measure color changes and surface morphologies before and after the bleaching, colorimeter and scanning electron microscopy were used, respectively. When the specimens were bleached with hydrogen peroxide and plasma arc lights, the bleaching effect was greater than when only hydrogen peroxide gels were used (Kruskal-Wallis test, p<0.05). In addition, plasma arc B showed the more color changes than plasma arc A (Bonferroni post-hoc test, p<0.05). The surfaces of the teeth treated with fluoride gel after the whitening treatment came to be smooth. Therefore, the results of this study suggested that the fluoride application for patients who got tooth whitening therapy with a high concentration of hydrogen peroxide gels activated by plasma arc light will be effective to recover rough enamel surfaces.
젊은 남성에게서 재발한 다발성 간 내 국소 결절성 과형성 1예
정은 ( Eun Chung ),박정화 ( Chung Hwa Park ),김진아 ( Jean A Kim ),한남익 ( Nam Ik Han ),이영석 ( Young Sok Lee ),최호중 ( Ho Joong Choi ),배시현 ( Si Hyun Bae ),박일영 ( Il Young Park ) 대한소화기학회 2014 대한소화기학회지 Vol.64 No.1
Focal nodular hyperplasia (FNH) is the second most common benign hepatic tumor that is usually found in women. Diagnosis of FNH mainly depends on imaging studies such as color Doppler flow imaging, computed tomography, and magnetic resonance imaging. It is characterized by the presence of stellate central scar and is nowadays incidentally diagnosed with increasing frequency due to advances in radiologic imaging technique. FNH typically presents as a single lesion in 70% of cases and generally does not progress to malignancy or recur after resection. Herein, we report a case of a young male patient with recurrent multiple FNH who underwent surgical resection for presumed hepatic adenoma on computed tomography. (Korean J Gastroenterol 2014;64:49-53)
한국에서의 후천성 면역 결핍증 환자에서 위장관을 침범한 카포시 육종의 증례발표 및 문헌고찰
정조윤 ( Cho Yun Chung ),박상우 ( Sang Woo Park ),명은 ( Eun Myung ),조동근 ( Dong Keun Cho ),송영아 ( Young A Song ),박강진 ( Kang Jin Park,),장희창 ( Hee Chang Jang ),주영은 ( Young Eun Joo ) 대한소화기학회 2012 대한소화기학회지 Vol.60 No.3
Kaposi sarcoma (KS) is a vascular neoplasm, which is fairly prevalent in acquired immunodeficiency syndrome (AIDS) patients. Mucocutaneous and lymph node involvements are characteristic features of KS in AIDS patients. The involvement of gastrointestinal tract occurs in 40% of KS patients and leads to significant morbidity and mortality. In the highly active antiretroviral therapy (HAART) era, the rate of AIDS related KS has fallen with control of human immunodeficiency virus (HIV) viremia. However, it is still recognized as the primary AIDS-defining illness, and the proportion of AIDS diagnoses made due to KS ranged from 4.1% to 7.5%. In Korea, AIDS-related KS has been report in low rate incidence. Its gastrointestinal involvements are rarely reported. To date, five cases have been recorded in Korea. Herein, we present an additional case of gastrointestinal KS as the AIDS-defining illness and review of the Korean medical literature. (Korean J Gastroenterol 2012;60:166-171)
다양한 탄수화물 함유 배지 사용에 따른 자일리톨 감성 및 내성 Streptococcus mutans의 독력 비교
정선영 ( Sun Young Chung ),이영은 ( Young Eun Lee ),안상헌 ( Sang Hun Ahn ),김혜영 ( Hye Young Kim ),최연희 ( Youn Hee Choi ),송근배 ( Keun Bae Song ) 대한예방치과·구강보건학회 2011 大韓口腔保健學會誌 Vol.35 No.4
연구목적. Streptococcus mutans ( S. mutans)는 치아 우식의 중요한 병인 중 하나로, S. mutans가 자일리톨에 장기간 노출되었을때 자일리톨에 대한 감수성을 잃고 자일리톨에 의한 성장 억제를 보이지 않는 자일리톨 내성균주가 형성된다고 보고된 바 있다. 본 연구는 자일리톨 내성균주와 자일리톨 감성균주가 다양한 탄수화물 조건에서 배양되었을 때의 독력 인자 발현 양상을 비교하고자 하였다. 연구방법. S. mutans KCTC3065를 포도당이 포함된 TYE 배지에 1% 자일리톨을 처리하여 자일리톨 내성균주를 형성한 후, 자일리톨 감성균주와 함께 포도당 단독 및 포도당에 자당, 과당, 엿당이 각각 포함된 배지에서 배양하였다. S. mutans의 독력과 관련이 있는 성장과 산생성, 글루칸 합성 관련 유전자 발현 및 세포외 다당류 합성을 살펴보았다. 연구결과. 자일리톨 내성규주는 감성균주와 비교하여 pH의 차이 없이 최종 성장, 글루칸 합성 관련 유전자 발현 및 세포외 다당류 합성이 모두 저하된 양상을 나타내었다. 탄수화물 종류별 특성을 살펴보면, 자일리톨 감성균주와 내성균주 모두 포도당과 비교하여 포도당과 엿당이 혼합된 배지에서 최종 성장이 증가한 반면, gtfB와 gtfD의 발현은 감소하였다. 또한 포도당과자당 그리고 포도당과 과당이 혼합된 배지에서 최종 성장이 감소한 반면, gtfB와 gtfD의 발현은 증가하였다. 그러나 감성균주와 내성균주 모두 배양 조건과 관계없이 산생성에서는 차이를 보이지 않았다. 투과전자현미경 관찰 결과, 포도당과 엿당이 혼합된 배지에서 특히 자일리톨 내성균주의 세포외 다당류 합성이 저하된 것을 확인할 수 있었다. 결론. 자일리톨 내성균주는 감성균주에 비해 우식원성이 저하되어 있으며, 탄수화물 종류에 따라 자일리톨 내성균주와 감성균주의 독력인자가 다르게 발현되었다.
덱스트로메토르판에 대한 한국인의 표현헝 및 유전자헝 분석
정희선(Hee Sun Chung),양원경(Won Kyung Yang),최화경(Hwa Kyung Choi),양영근(Young Keun Yang),한은영(Eun Young Han),정운계(Wun Kye Chung),유영찬(Young Chan Yoo) 大韓藥學會 2002 약학회지 Vol.46 No.3
The abuse of dextromethorphan has been prevalent for 15 years in Korea and its fatal cases were reported even though it has proved to be very safe. In this study; to investigate the safety and tolerance assessment of deitromethorphan, the metabolic phenotyping and genotype of dextromethorphan were studied. After a single 30 mg of dextromethorphan oral administration to 74 volunteers, concentration of dextromethorphan and its metabolites, dextrorphan, hydroxymorphinan and methoxymorphinan were measured in urine which collected during 8hrs after the drug administration. CYP2D6 phenotype was determined from the ratio of dextromethorphan to dextrorphan. GC/MS was used to quantify dextromethorphan and its metabolites. For genotyping, mutant alleles of the CYP2D6 gene were identified.24 subjects (32.4%) were homozygous for CYP2D6*10B, 29 subjects (39.2%) were heterozygous for thIns allele, while in 21 subjects (28.4%) no exon 1 mutation could be found. The frequency of CYP2D6*10B-allele containing the 188C T mutation was 54% of total subjects studied.
초등학교 고학년 아동의 컴퓨터 게임 양상과 정서 및 행동 특성
이자영,박태원,이문숙,조은정,정영철,황익근,양종철,정상근,정애자,은홍배,Lee, Ja-Yeong,Park, Tae-Won,Lee, Moon-Sook,Cho, Eun-Cheong,Chung, Young-Chul,Hwang, Ik-Keun,Yang, Jong-Chul,Chung, Sang-Keun,Jung, Ae-Ja,Eun, Hong-Bae 대한불안의학회 2008 대한불안의학회지 Vol.4 No.2
Objective : The purpose of this study was to investigate the relationship between the pattern of computer game play and emotional and behavioral characteristics of 5th and 6th grade elementary school children in Jeonju city. Methods : Fifth and sixth graders from two elementary schools (N=413, M=214, F=199) were chosen to participate in this study. The participants completed self-report questionnaires designed by the authors, and were also evaluated based on a computer game addiction scale, state-trait anxiety inventory for children, children's depression inventory and Piers-Harris children's self-esteem scale. The parents of the participants determined the disruptive behavior rating scale of the participants. Results : Positive links were reported between the pattern of computer game play (years of computer game experience, average length of each computer game play session, average time spent on computer game play per day, and average frequency of computer game play per week) and scores of computer game addiction scale. In addition, significant correlation was found between the internalized problems of children (trait anxiety, state anxiety, depression, and self-esteem), and computer game addiction scale score, among both sexes (p<0.01). There were significant correlations between game addiction scale score and inattention (p<0.01) as well as total attention deficit hyperactivity disorder (ADHD) score (p<0.05) in girls. Conclusion : Our findings suggest that computer game addiction is related to symptoms of internalizing, particularly to the trait anxiety. Significant positive correlations between game addiction scale score and externalized behavioral problems were found only in girls.