癎疾患者에 있어서 toxoplasma 抗體價

殷洪培 전북대학교 의과학연구소 1982 全北醫大論文集 Vol.6 No.1

This study was undertaken to evaluate toxoplasma antibody prevalence by Sabin-Feldman dye-test in epileptics(n=51), schizophrenica(n=24), and normal persons(n=60). Fourfold serum dilutions were used, we considered tilters of 1:16 or more positive. The number and percentage of positive reaction in dye-test was shown as follows : 42(82.3%) of 51 epileptics, 13 (54.1%) of 60 normal persons. Toxoplasma antibody prevalence in epileptics was not significant according to duration of epileptic onset. There was significant difference in toxoplasma antibody prevalence by location, precentage of positive reaction showed 89.3% in rural compared to 69.6% in urban epileptics. This results suggested that epilepsy might be partially caused by toxoplasmosis.

개구리 식도의 섬모운동에 미치는 Morphine의 영향

은홍배,조규박 전북대학교 의과학연구소 1983 全北醫大論文集 Vol.7 No.1

The effect of morphine on the ciliary movement was studied in the frog esophagus to examine whether opiate receptor is present in the extra-neuronal site and whether change of electrolytes influences to the action of morphine on the ciliary movement. The activity of ciliary movement was measured by Hills method and the modified Krebs-Henseleit bicarbonate buffer solution was used in this study. Morphine elicited an dose-dependant delay of the ciliary movement. This inbibitory action of morphine was weakened or abolished in the presence of eserine, atropine or in the hemicholinium-treated preparation. In the atropine or hemicholinium-treated preparation, the speed of tobacco seed was rather increased. Increase of Ca^++ in the Ringer solution decreased the inhibitory action of morphine, while increased of Mg^++ potentiated the effect of morphine. From the above results, it is suggested that the inhibitory action of morphine on the ciliary movement is partly due to decreased release of acetylcholine mediated by opiate receptor drug interaction and that extra-and/or itnra-cellular concentration of electrolytes plays an important role of the effect of morphine.

電氣衝擊이 抗體形成에 미치는 影響

殷洪培 전북대학교 의과학연구소 1980 全北醫大論文集 Vol.4 No.1

This study was undertaken to evaluate the effects of the electro-convulsion on the immune response of rabbits to sheep red blood cells(SRBC). The experimental group of rabbits were treated with electro-convulsion for 7 days and immunized with SRBC. The control groups were only immunized without electro-convulsion at the same time with experimental group. Twenty-five days after primary immunization, rabbits were secondarily immunized for determining the antibody formation to SRBC. However, for the delayed-type hypersensitivity, rabbits were challenged 32 days after primary immunization. Delayed-type hypersensitivity was assayed by measuring the diameter of induration at 24, 48, and 72hrs after challenge, and antibody titers of the sera obtained from rabbits by various interval s were determined by quantitative microtitration method. Generally, both antibody formation and delayed-type hypersensitivity to SRBC were potentiated in the experimental group than the control group. Not only hemagglutinin but also hemolysin were increased in the experimental group before secondary immunization but after secondary immunization, only the hemolysin titers were slightly increased in the experimental group. The induration as well as the intensity of delayed-type hypersensitivity to SRBC were increased in experimental group compared to control group.

實驗的不眠에 의한 白鼠 小腦 Purkinje細胞內의 PAS : 陽性顆粒數의 變動에 對하여

殷洪培 大韓神經精神醫學會 1968 신경정신의학 Vol.7 No.1

Using the cerebellum of adult rats(220-24Cgm of body weight), PAS-positive granules such as ceroids and lipofuchsin in Purkinje cells was studied histochemically and statistically. 1. PAS-positive granules present in the rat cerebellum was resistant to saliva digestion and showed slight metachromatic reaction to the 0.5% toluidine blue aqueous solution. And no significant changes in size and number of the granules was observed, after pyridine extraction. These histochemical results may indicate that PAS-positive granules in Purkinje cells are composed mainly of carbohydrate-protein complex, mucopolysaccharide or mucoprotein. 2. Number of PAS-positive granules in a Purkinje cell of the experimental groups, which had sleeping disturbance by external stimulation for 7 days, are compared with those of control groups. Average number of PAS-positive granules in the cell of experimental groups was 6.7±0.4, whereas that of the control groups was 8.5±0.4. Difference of mean value calculated was statistically significant(p<0.01). These results were discussed in relation to the formation and accumulation of the granules in the cells during the experimental condition.

側腦室內 parathion의 家兎 腎臟機能에 미치는 影響

殷洪培,曺圭朴 전북대학교 의과학연구소 1979 全北醫大論文集 Vol.3 No.-

In this study the action of parathion give directly into the lateral ventricle on the renal function of the rabbit were investigated. 1. Intraventricular parathion in a dose of 100㎍ elicted diuresis following antidiuresis concomitant with changes of renal blood flow, glomerular filtration rate and electrolytes in the urine porportionally. 2. Diuretic effect of intraventricular parathion was inhibited by vagotomy, intravenous atropine or intraventriculal atropine. 3. Antidiuretic effect of intraventricular parathion was inhibited by intravenous or intraventricular regitine. From the above results, it seems most likely that renal effect induced by intraventricular parathion was brought about by renal hemodynamic changes as a result of parasympathetic and sympathetic stimulation, suggesting a possible involvement of the central cholinergic and adrenergic mechanism as well as the peripheral nerves.

精神分裂症患者에 있어서 兒童 胸腺細胞에 對한 抗體

殷洪培 전북대학교 의과학연구소 1978 全北醫大論文集 Vol.2 No.-

The sera from patients with schizophrenia and gealthy individuals were exzmined for cytotoxic antibodies against human child thymocyes of 3 years old. It was found that sera from schigophenics did not show higher cytotoxicity to child thymocyes than sera from normal controls.

精神病患에 있어서 胎兒胸腺細胞에 對한 抗體

殷洪培 전북대학교 의과학연구소 1977 全北醫大論文集 Vol.1 No.-

The sera from patients with mental disorders(chronic schizophrenia, paranoid psychosis, manic-depressve psychosis, psychoneurosis) and healthy individuals were examined for cyto toxic antibodies against human fetal thymocytes of 6 months in gestation. It was found that the mental disorders showed nonsignificant sytotoxicity to fetal thymocytes except one chronic schizophrenic when compared with normal controls. The cytotoxic index of one serum among 25 chronic schizophrenics was 4.

電氣刺戟이 家兎腦에 對한 自家抗體에 미치는 影響

殷洪培 전북대학교 의과학연구소 1979 全北醫大論文集 Vol.3 No.-

The sera from rabbits with electro-convulsion were examined for cytotoxic antibododies aganist thymocytes of young rabbit. It was found that rabbits with electro-convulsion showed higher serum cytotoxicity to rabbit thymocytes when compared with normal rabbits.

家兎腦 NAD Glycohydrolase에 對한 Hematin의 抑制作用

殷洪培 全南大醫大 1973 전남의대학술지 Vol.10 No.3

正常人과 精神症患者와의 免疫反應에 對한 硏究

殷洪培 전북대학교 의과학연구소 1981 全北醫大論文集 Vol.5 No.1

This study was undertaken to evaluate delayed-type hypersensitivity by sue of tuberculin test in schizoqhrenics (n=30), neurotics (n=17), and normal Person (n=20). All of the examined were injected intradermally by 1 TU of purified protein derivative (PPD). Delayed -type hypersitivity to PPD was assayed by measuring the mean size of induration at 5, 12, 24, and 48 hrs after injection of PPD. Number of persons showing negative reaction to tuberculin among persons vaccinated previously by BCG were assessed. 1. In number and percentage of positive reaction to PPD at 24 and 48 hrs after injection of PPD, schizophrenics and neurotics increased inconsistently in male and female according to interval of hours compared to normal persons. 2. In number of negative reaction to PPD among persons vaccinated previously by BCG, schizophrenics showed a small number compared to neurotics and normal persons. 3. Mean size of induration at 5, 12, 24, and 48 hrs after injection of PPD was not significant statistically in schizophrenics, neurotics and normal persons.