체액 검체에서 톨루이딘 블루 염색의 유용성

이혜경,주명진,이광민,이은희,심상인,Lee, Hye-Kyung,Joo, Myung-Jin,Lee, Kwang-Min,Lee, Eun-Hee,Sim, Sang-In 대한세포병리학회 1999 대한세포병리학회지 Vol.10 No.1

We evaluated the availability of toluidine blue stain in body fluids, such as peritoneal and pleural fluid and urine. Nine hundreds specimens, i.e., 400 pleural and 400 peritoneal fluids and 100 urine samples, respectively, from Jan. 1995 to May 1996 were included. We obtained the result of high sensitivity and high specificity. In toluidine blue stained body fluid in comparison with Papanicolaou stained result. Additionally, we found the diagnostically important crystals in chylothorax and some urine samples, which can not be seen in routine Papanicolaou stain. We thought the toluidine blue stain in body fluid is one of very useful diagnostic methods.

스폰지 목욕에 대한 미숙아의 생리적상태 및 행동반응

이혜경,홍경자,남은숙,이영희,정은자,Lee Hae Kyung,Hong Kyung Ja,Nam Eun Sook,Lee Young Hee,Jung Eun Ja 한국아동간호학회 2000 Child Health Nursing Research Vol.6 No.1

A descriptive exploratory design was used in this study to evaluate the effects of sponge bathing on physiological(heart rate, heart period, vagal tone, oxygen saturation, respiration) and behavioral responses in newly born 40 preterm infants from intensive care unit of S University Hospital in Seoul. Data has been collected from October, 1997 to March, 1999. The infants were between 27-33 weeks gestational age at birth, and were free of congenital defects. The subjects entered the protocol when they were medically stable (determined by initiation of feeding and discontinuation of all respiratory support) but still receiving neonatal intensive care. The infants' physiologic parameters were recorded a 10 - minute before, during, and after bathing. Continuous heart rate data were recorded on a notebook computer from the infant's EKG monitor. The data were digitized off-line on software(developed by Lee and Chang in Wavelet program) which detected the peak of the R wave for each heart beat and quantified sequential R-R intervals in msec(i.e. heart periods). Heart period data were edited to remove movement artifact. Heart period data were quantified as : 1) mean heart period; 2) vagal tone. Vagal tone was quantitfied with a noninvasive measure developed by Porges(1985) in Mxedit software. To determine behavioral status, tools were developed by Scafidi et al(1990) were used. Collected data were analyzed with the SPSS program using paried t-test, ANOVA, and Pearson correlation. The result were as follow. 1. The results of the ANOVAs indicated that vagal tone were signifcantly lower during bathing than baseline and post-bathing. There were significant differences in heart period and heart rate levels across the bathing. But the mean oxygen saturations and respirations were no differences. Also, there were no significant differences on behavioral sign, motor activity, behavioral distress, weight changes, morbidity, and hospitalization period. 2. To evaluate the relation between vagal tone and subsequent parameters, the two groups (the high group had 19 subjects and low group had 21subjects) were divided by the mean baseline vagal tone. Vagal tone measured prior to bathing were significantly associated with respiration before bathing, vagal tone during bathing, and the magnitude of change in both vagal tone. But, other subsequent reactivities were no differences in two groups. 3. Correlations were also calculated between vagal tone and the subsequent physiological reactivities from baseline through after- bathing. Correlations were significant between baseline vagal tone and baseline heart rate, between baseline vagal tone and baseline heart period, between baseline vagal tone and oxygen saturation after bathing. In summary, the bathing in this study showed a stressful stimulus on premature infants through there was significance in the physiological parameters. In addition, our study represents the documentation that vagal tone reactivity in response to clearly defined external stimulation provides an index of infant's status.

Usefulness of Cytologic Study of Intraoperative Suction Fluid in Brain Tumors

이혜경,이형진,이은희,김희정,이일우,Lee, Hye-Kyung,Lee, Hyung-Jin,Lee, Eun-Hee,Kim, Hee-Jung,Lee, Il-Woo The Korean Society for Cytopathology 2002 대한세포병리학회지 Vol.13 No.2

In diagnosing a brain tumor, it is essential to obtain samples from many areas of the tumor. Although there are reports about the suitability of material obtained by cavitron ultrasonic surgical aspirator(CUSA), there is a paucity of reports regarding conventional intraoperative suction. This study was performed to evaluate the usefulness of the suction fluid and the effect of different hemolytic fixatives. Intraoperative suction fluid was obtained from 2 pituitary adenomas and 2 choroid plexus carcinomas. In two cases of mixed astro-oligodendroglioma, one of glioblastoma multiforme and 3 of meningioma, the fluid was collected by CUSA. Each sample was divided into four bottles for the different fixatives such as 0.1N HCI, 10% acetic acid, 95% alcohol, and no additive. All cases were evaluated by the both cytologic smear and cell block preparations, and were reviewed with concomitant histologic diagnosis. The result showed a good correlation between the cytologic study and the histologic diagnosis and 95% alcohol was found to be superior to other fixatives in ceil preservation.

자궁경부암의 방사선치료 후 자궁경부세포의 형태학적 변화

이혜경,이광민,정동규,김수곤,Lee, Hye-Kyung,Lee, Kwang-Min,Chung, Dong-Kyu,Kim, Soo-Kon 대한세포병리학회 1993 대한세포병리학회지 Vol.4 No.2

The effect of Roentgen rays on carcinoma of the cervix has long been of great interest to both radiologists and gynecologists. Since most cervical carcinomas are treated by irradiation, any additional knowledge either concerning the radiosensitivity of cervical tumors or their ultimate prognosis would be of value. The vaginal smear is considered to be one of convenient and rapid methods to study the effects of radiation on cervical malignancy. We observed morphologic changes in 297 cytologic preparations obtained from 60 patients who had underwent irradiation for cancer of the cervix. With the morphologic parameters such as cytoplasmic vacuolization, cytoplasmic basophilia, multinucleated giant cell formation, polymorphonuclear leucocytes (PMNL) sticking and postradiation dysplasia, we analyzed the findings in relation to the follow up time interval. The most common effect was the cytoplasmic vacuolization with basophilia of basaloid cells, which were noted in more than 90% of followed patients. The multinucleated giant ceil formation and PMNL stickering were noted in 38 cases(63%) and 48 cases(80% ) respectively. The differential diagnosis of postradiation dysplasia from recurrent or persistent carcinoma, reparative atypical cells, and regressing tumor cells was difficult and further study seems to be needed to clarify the more accurate morphologic features and biologic behavior.

폐암진단을 위한 객담세포검사 결과 - 16개월간의 전주 예수병원 객담세포검사 결과를 바탕으로 -

이혜경,이광민,정동규,강대송,김귀완,Lee, Hye-Kyung,Lee, Kwang-Min,Chung, Dong-Kyu,Kang, Dae-Song,Kim, Kwi-Wan 대한세포병리학회 1994 대한세포병리학회지 Vol.5 No.2

A prospective survey of sputum cytologic specimen was performed for 16 months from Jan. 1993 to Apr. 1994 in Presbyterian Medical Center. The purpose of this study is to find the positive rate of sputum cytology in the diagnosis of lung cancer and to correlate these results with tumor location and stage. Sputum cytologic specimen were received from 104 patients among 158 patients diagnosed as lung malignancy by histologic examination. Cytologic diagnosis of "suggestive of malignancy" was made in 61 patients (59%) and dysplasia in 9 patients(9%), atypia in 14 patients(13%), benign in 15 patients(14%) and inadequate specimen in 5 patients (5%), respectively. Among 84 patients beyond the cytologic diagnosis of atypia, 51 patients (61%) disclosed a central location, while 33 patients (39%) showed peripheral lesions. All 54 patients diagnosed as suggestive of non-small cell carcinoma were stage III or over, and all 7 patients diagnosed as suggestive of small cell carcinoma were in advanced stage. These results suggest that the cytologic examination of sputum seems to be an important tool in diagnosis of lung cancer.

대장암에서 장세척물의 세포학적 소견

이혜경,주명진,이광민,정동규,최용우,Lee, Hye-Kyung,Joo, Myung-Jin,Lee, Kwang-Min,Chung, Dong-Kyu,Choi, Yong-Woo 대한세포병리학회 1996 대한세포병리학회지 Vol.7 No.1

Although exfoliative colonic cytology for the diagnosis of colorectal cancer has been largely abandoned due to the widespread use of colonoscopy, some authors still insiston the usefulness of colon lavage fluid. We tried evaluating the diagnostic feasibility of colon lavage fluid cytology using an orally administered balanced electrolyte solution. We collected colon lavage fluids in 106 patients prior to colonoscopy and reviewed the slides. Cytologic examination revealed neoplastic cells in 7 of 16(44%) cases of endoscopically proven adenocarcinoma patients. Therefore, we thin cytologic study of colon lavage fluid may be considered as one of the noninvasive diagnostic tools in colorectal cancer.

우울 증상과 관련된 어려움 유무에 따른 집단 차이

이혜경,김준원,송열매,이건석,Lee, Hye-Kyung,Kim, Jun Won,Song, Yul-Mai,Lee, Kounseok 대한생물정신의학회 2013 생물정신의학 Vol.20 No.2

Objectives The purpose of this study was to examine the differences according to depressive symptom-related difficulty status. Methods 2828 participants were a divided into depressive symptom-related difficulty group (difficult group, n = 774), and a non-depressive symptom-related difficulty group (not difficult group, n = 2054). The psychological character of the participants were assessed using the Korean version of the Patient Health Questionnaire-9 (PHQ-9), Satisfaction with Life Scale (SWLS), the 12-item General Health Questionnaire (GHQ-12), and Conner-Davidson Resilience Scale (CD-RISC). Statistical analyses were done using t-test, chi-square, and analysis of covariance (ANCOVA). Results Compared with the no difficulty group, the difficulty group reported significantly higher score in all items of PHQ-9. The score of "feeling tired" was the highest and the score of "suicidal ideation" is the lowest in both groups. ANCOVA analysis that is adjusted with the total score of PHQ-9 showed the differences in SWLS, GHQ-12, and CD-RISC scores between the difficulty group and the no difficulty group. Conclusions The findings suggest that there are different characters on PHQ-9, SWLS, GHQ-12, and CD-RISC according to depressive symptom-related difficulty. Therefore, it is required not only to evaluate depressive symptoms in patients with depression, but also the depressive symptom-related difficulty to understand these differences.

간호대학생의 COVID-19에 대한 지식과 위험 인식이 COVID-19 예방행위에 미치는 영향

이혜경,강나경,김서현,김명서,남유나,노수현,이현동,정다움,주소현,최서린,Lee, Hyea-Kyung,Kang, Na-Gyeung,Kim, Seo-Hyun,Kim, Myeong-Seo,Nam, Yu-Na,Noh, Su-Hyeon,Lee, Hyeon-Dong,Jung, Da-Um,Joo, So-Hyeon,Choi, Seo-Rin 대한산업경영학회 2021 산업융합연구 Vol.19 No.5

The present study attempted to identify how the knowledge and risk perception of nursing students regarding COVID-19 impact COVID-19 preventive behaviors. This study collected data from May 1st to September 20th, 2021, using a self-reported questionnaire targeting 184 nursing students. The collected data were analyzed using Independent t-test, One-way ANOVA, and Multiple regression. The research results indicated that the knowledge(r=.15, p=.019) and risk perception(r=.13, p=.036) of nursing students regarding COVID-19 had a positive correlation with COVID-19 preventive behaviors. The factor that impacted the COVID-19 preventive behaviors of the subjects was COVID-19 knowledge, which had an explanatory power of 4%. Therefore, it is necessary to develop an educational intervention program that enables nursing students to obtain the correct knowledge regarding COVID-19 and improves preventive behaviors. 본 연구는 간호대학생의 COVID-19에 대한 지식과 위험인식이 COVID-19 예방행위에 미치는 영향을 파악하고자 시도되었다. 본 연구는 간호학과 학생 184명을 대상으로 자가 보고 설문지를 이용하여 2021년 5월 1일부터 9월 20일까지 자료를 수집하였다. 수집된 자료는 Independent t-test, One-way ANOVA, Multiple regression을 이용하여 분석하였다. 연구결과, 간호대학생의 COVID-19에 대한 지식(r=.15, p=.019), 위험인식(r=.13, p=.036)은 COVID-19 예방행위와 양의 상관관계가 있는 것으로 나타났다. 대상자의 COVID-19 예방행위에 영향을 미치는 요인은 COVID-19 지식이었으며 설명력은 4%였다. 따라서 간호대학생의 COVID-19에 올바른 지식을 습득하도록 하고 예방행위를 증진시키기 위한 교육중재 프로그램 개발이 필요하다.

남북한 보건의료인력의 통합방안 연구

이혜경,Lee, Hyekyoung 연세대학교 의과대학 2016 의학교육논단 Vol.18 No.1

In preparing for the unification of North and South Korea, rather than unilaterally over-writing the North's human resource training system with the South's health care human resource development system, it is important to understand the North's system and its ecology and to achieve a balance by seeking out aspects of each of the systems that could be consolidated with each other. The training period in both the North and South's health care human resource development systems is specified to be 6 years, but there is no system for internships or residencies in the North. South Korea introduced a 6-year system for pharmacist education in 2009, but North Korea has been using such a system since the 1970s (currently 5.5 years). In North Korea, training of health care personnel is conducted at various levels: at universities, at vocational schools, and at institutes for training health officials. Various types of training (daytime training, online, and ad hoc programs) are carried out. Also of interest is the North's licensure examination system. Rather than a state examination system as in South Korea, the North favors a graduation exam given by a national graduation examination committee composed of university professors, which awards both graduation certificates and 'permits,' that is, licenses for doctors and pharmacists. In working out a plan for the integration of the two Koreas' systems based on the study and analysis of the North's educational and testing system for doctors and pharmacists, this paper does not place exclusive focus on the distinctions between the systems or cling to negative views. Rather than claim that unification/integration is a practical impossibility, the paper focuses on the similarities between the two systems and maximizes them to uncover an approach for arriving at solutions. It is hoped that the practical data offered in this paper can contribute to the design of a forward-minded unification/integration model.

국내대학의 학술논문 연구업적평가기준 비교 분석

이혜경,양기덕,Lee, Hye-Kyung,Yang, Kiduk 한국도서관정보학회 2017 한국도서관정보학회지 Vol.48 No.2

본 연구는 보다 효율적이고 균일하게 교원의 연구업적을 평가하기 위한 기초 연구로서, 현재 국내 대학의 교원업적평가 기준과 한국연구재단의 연구업적평가기준, 그리고 여러 계량서지학 지표를 비교하여 국내의 교원연구업적평가 방식을 분석하였다. 본 연구를 진행하기 위하여 국내 대학 27곳의 교원업적평가기준과 한국연구재단 연구업적평가기준을 수집하였으며, 183명의 국내 문헌정보학과 교수의 2001년부터 2015년 사이 발표된 학술논문 3,863편과 16,978건의 인용을 수집하였다. 이를 토대로 우선 현재 시행중인 국내 대학의 연구업적평가지표들을 비교 한 후, 대학지표들과 저자기여도 산정식을 가중한 계량서지학적 지표들을 수집한 데이터에 적용하여 산출한 저자와 대학별 순위들을 분석하였다. 국내 대학의 연구업적평가지표는 연구업적의 생산성과 영향성을 고루 평가하고자 하였으나, h-index처럼 이와 유사한 계량서 지학 지표와 다른 평가 결과를 나타냄으로써, 평가지표가 평가결과에 각기 다른 영향을 미칠 수 있음을 발견하였다. As a first step in developing a more effective and robust approach to faculty research performance assessment, this study analyzed the existing faculty research assessment methods by comparing Korean universities' research evaluation standards, National Research Foundation of Korea's (KRF) standard for assessing research proposals, and various bibliometric measures. The study data included research evaluation standards of KRF along with 27 Korean universities with Library and Information Science (LIS) department, and the publication data of 183 LIS faculties in Korean universities from 2001 to 2015, which consisted of 3,863 papers 16,978 citations. After the comparative analysis of research evaluation standards, the study examined the rankings of institutions and faculty produced by applying the collected standards and bibliometric metrics to the publication data. The study showed that Korean university standards for research evaluation, which aim to consider both productivity and impact of faculty research, differ from similar bibliometric measures such as h-index, and the difference could significantly impact the assessment of faculty research performance.