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부추 당침액의 유산균 발효에 따른 항산화 및 ACE저해활성
이중복(Jung-Bok Lee),배정식(Jung-Shik Bae),손일권(Il-Kwon Son),전춘표(Chun-Pyou Jeon),이은호(Eun-Ho Lee),주우홍(Woo-Hong Joo),권기석(Gi-Seok Kwon) 한국생명과학회 2014 생명과학회지 Vol.24 No.6
본 연구는 최근 국민들이 많은 관심을 갖는 식물발효 효소액 중 부추 당침액(부추:설탕 1:3)을 유산균(Lactobacillus acidophilus AML 0422, Lactobacillus brevis HLJ 59, Lactobacillus helveticus AML0410, Lactobacillus plantarum KCTC 13093) 발효를 통해 발효 부추액의 항균활성 및 항산화활성과 항고혈압활성 등의 기능성을 발효 전 후의 유효 특성을 조사하였다. 유산균을 이용하여 발효한 발효 부추액은 S. aureus KCTC 1916에 대해 31.43 mm의 높은 항균력을 보이는 것으로 조사되었으며, 총 폴리페놀함량, 총 플라보노이드 함량과 DPPH 활성 소거능이 160.8-178 mg/ml, 100-108 mg/ml, 82.8-93.5%로 각각 조사되었다. DPPH 활성 소거능에 있어서는 Vitamin C 50 ppm과 유사한 활성을 보이는 것으로 나타났다. 심혈관질환 및 뇌혈관질환 등 고혈압과 관련이 깊은 ACE 저해활성은 유산균의 종류에 따라 50.4-67%로 발효전인 32.6%보다 좋은 활성을 보이는 것으로 조사되었다. 이상의 결과를 종합하였을 때 유용 유산균을 이용한 부추 당침액의 발효산물은 항균활성, 항산화활성과 ACE 저해활성 등 우수한 생리활성 효과를 나타내는 것으로 조사되었다. In recent years, the growing interest in the health care benefits of sugared-plant fermented enzymes has led to increased consumption. This study investigated the fermentation of sugared-buchu (Leek:sugar, 1:3) by lactic acid bacteria (Lactobacillus acidophilus AML 0422, Lactobacillus brevis HLJ 59, Lactobacillus helveticus AML0410, Lactobacillus plantarium KCTC 13093) and the antibacterial activity, antioxidant activity, and functionality (e.g., anti-hypertensive activity) of the fermented product. The fermented sugared-buchu showed high antibacterial activity against Staphylococcus aureus KCTC 1916, at 31.43 mm, and its total polyphenols, total flavonoid content, and DPPH scavenging activity were 160.8-178 mg/ml, 100-108 mg/ml, and 51.4-58.1%, respectively. DPPH scavenging activity was to that of vitamin C (50 ppm). ACE inhibitory activity was 50.4-67%, depending on the strain of lactic acid bacteria, and the control of sugared-buchu activity was higher than 32.6%. These results suggest that sugared-buchu fermented with lactic acid bacteria has strong antibacterial, antioxidant, and ACE inhibitory activities.
정수장 슬러지를 이용한 무기질 비료의 제조에 관한 연구
이중기(Jung-Ki Lee),백순기(Sun-Gi Beak),김조천(Zo-Cheon Kim),이정일(Jeong-Il Lee),표병식(Byoung-Seok Pyo),최종건(Jong-Guen Choi),김판채(Pan-Chae Kim),박귀환(Gui-Hwan Park) 유기성자원학회 2000 유기물자원화 Vol.8 No.1
As it is forbidden to landfill the organic sludge generatεd in water treaanent plant fÌom 2001, disposal coast of the sludge will be highly incersed. Therεfore, Th.is Srudy was conducred to recyle the sludge of water supply planr as inorganic fertilizer for agriculrural areas and forests using the Chemical and the Hydrothermal methods. As the result, we could manufacture sutiable inorganic ferrilizer, removing organics and harmful heavy metals by the Chemical and the Hydrothermal method. 2001년부터 정수장에서 발생하는유기성오니의 직매립이 금지됨에 따라이의 처리비용이 매우증가할것으로판단 되어 본 연구에서는 정수장 슬러지를 Chemical 및 Hydrothermal 법을사용하여 농업 및 임업용 비료로 재활용 할 수 있는 방법을찾고자진행하였고,그결과두방법 모두유기물및 유해 중금속을제거할수있었으며 안정화된 무기질 비료를 제조할수있었다.
Helicobacter pylori 감염에서 CagA 및 VacA 발현과 위 상피세포 증식과의 관계
김남일(Nam Il Kim),이중현(Jung Hyun Lee),이영실(Yeoung Sil Lee),이재욱(Jae Uk Lee),이구(Goo Lee),서정일(Jeong Ill Suh),양창현(Chang Heon Yang),이창우(Chang Woo Lee),윤환중(Hwan Jung Yun),장태정(Tae Jung Jang),김정란(Jung Ran Kim),하경 대한내과학회 2000 대한내과학회지 Vol.58 No.5
N/A Background : Infection with Helicobacter pylori (H. pylori) has been associated with an increased risk for developing gastric cancer. This risk is further enhanced with CagA positive H. pylori strains. Increased epithelial cell proliferation is associated with an increased risk for gastric cancer. The aim of the study was to investigate whether the gastric epithelial cell proliferation was related to the expression of CagA and VacA in H. pylori infection. Methods : The subjects were 77 patients who had undergone diagnostic esophagogastroduodenoscopy with biopsy; 18 gastritis, 18 gastric ulcer, 17 duodenal ulcer and 24 gastric cancer. The expression of cytotoxic genes was determined indirectly by assaying serum IgG antibodies to specific antigens of H. pylori. Gastric epithelial cell proliferation was assessed using immunohistochemical method using Ki-67 monoclonal antibody. Acute and chronic inflammation, intestinal metaplasia and glandular atrophy were scored according to the updated Sydney system. Results : Ki-67 labeling index, acute and chronic inflammation were significantly higher in H. pylori infected persons (n=70, 90.9%) than in uninfected persons (n=7, 9.1%) (p<0.05), but the difference in intestinal metaplasia and glandular atrophy between the two groups was not statistically significant. Ki-67 labeling indices in persons infected with CagA positive strains (n=56, 80.0%) were significantly higher than in persons infected with CagA negative strains (n=14, 20%) (0.55±0.13 vs 0.37±0.17, p<0.05), but the differences in acute and chronic inflammation, intestinal metaplasia and glandular atrophy between the two groups were not statistically significant. No significant difference was found in Ki-67 labeling index, acute and chronic inflammation, intestinal metaplasia and glandular atrophy according to expression of VacA. Conclusion : Gastric mucosal cell proliferation, which might be closely involved in the pathogenesis of gastric carcinoma, was significantly higher in CagA positive H. pylori infected persons.(Korean J Med 58:516-525, 2000)
Antipsychotic Effects of Quetiapine in Naturalistic Long Term Follow Up Study
이중선,안중호,김도훈,Jong-Jin Kim,Tae-Young Kim,유소영,Dong-Geun Lee,이상혁,임세원,임원정,Il-Kyung Jung,Hae-Kyung Jung,Dong-Hwan Cho,조인희,김창윤 대한신경정신의학회 2010 PSYCHIATRY INVESTIGATION Vol.7 No.2
ObjectiveaaThis study aimed to examine the effectiveness of quetiapine and the effects of dosage relates to its effectiveness on schizophrenia and schizoaffective disorder in a naturalistic setting in Korean people. MethodsaaThis study was a 24-week, open-label, non-comparative, naturalistic study of quetiapine in patients diagnosed with schizophrenia and schizoaffective disorder according to DSM-IV. We stratified the patients into mild [(clinical global impression severity (CGI-S)<4 at baseline)] and severe groups (CGI-S ≥4 at baseline). We investigated the response rate, defined as clinical global impression improvement (CGI-I) ≤2, in the severe group and the aggravation rate in the mild group using the last-observation-carried-forward (LOCF) and the Kaplan-Meier method (K-M). ResultsaaDuring the 24 weeks, 151 (18.4%) of the participants dropped out of the study. There was a significant decrease in the mean CGI-S score, from 4.5±1.1 at baseline to 2.8±1.1 at 24 weeks. The response rate of severe group was 54.5% (estimated by LOCF) and 73.3%(K-M estimated) at 24 weeks. All patients who completed the study had taken a mean quetiapine dosage of 507.9±245.9 mg daily. The decrease of CGI-S score in high-dose group (the maximum dose was 750 mg/d or above) was statistically significant than that in recommendeddose group (the maximum dose was less than 750 mg/d). ConclusionaaThis study demonstrated the long-term effectiveness of quetiapine in the treatment of schizophrenia and schizoaffective disorder in a naturalistic setting in Korean people. This study suggests that higher than recommended quetiapine dosages could be more effective in some patients.
유한요소법과 프라이자흐모델이 결합된 해석기법을 이용한 PMASynRM과 SynRM의 효율특성 비교
이일교(Il Kyo Lee),전아람(Ah Ram Jeon),이중호(Jung Ho Lee) 대한전기학회 2010 대한전기학회 학술대회 논문집 Vol.2010 No.7
This paper deals with the efficiency evaluations in a synchronous reluctance motor (SynRM) versus a permanent magnet assisted SynRM (PMASynRM) using a coupled transient finite element method (FEM) and Preisach modeling, which is presented to analyze the characteristics under the effect of saturation and hysteresis loss. We are focusing on the efficiency evaluation relative to hysteresis loss, copper loss, etc. on the basis of load condition in a SynRM and PMASynRM. Computer simulation and experimental results for the efficiency using dynamometer show the propriety of the proposed method and the high performance of PMASynRM.
유한 요소법과 반응표면법이 결합된 동기형 릴럭턴스 전동기의 특성해석 및 이방성 회전자 설계
이일교(Il Kyo Lee),조용현(Young Hyun Cho),이중호(Jung Ho Lee) 대한전기학회 2009 대한전기학회 학술대회 논문집 Vol.2009 No.7
This paper deals with the characteristics analysis & optimum design of Synchronous Reluctance Motor (SynRM) with anisotropy rotor using a coupled Finite Element Method (FEM) & Response Surface Methodology (RSM). The focus of this paper is the characteristics analysis & optimum design relative to the output power on the basis of rotor materials of a SynRM. The coupled Finite Elements Analysis (FEA) & Preisach model have been used to evaluate nonlinear solutions. Comparisons are given with characteristics of normal synchronous reluctance motor and those of anisotropy rotor SynRM (ANISO-SynRM), respectively. The feasibility of using RSM with FEM in practical engineering problem is investigated with computational examples and comparison between the fitted response and the results obtained from an analytical solution according to the design variables of rotor in anisotropy rotor SynRM.
북한 한글 순서를 지원하는 EUC-KR 기반의 로캘과 응용 프로그램 개발
정일동,이중화,김용호,김경석,Jung Il-dong,Lee Jung-hwa,Kim Yong-ho,Kim Kyongsok 한국정보처리학회 2004 정보처리학회논문지B Vol.11 No.7
UCS(=ISO/BC 10646, =Unicode)는 국제화에 따라 앞으로 점점 더 많이 쓰게 될 것이고, 일단 정착되고 나면 한참 동안 쓸 것으로 예상하고 있다. 하지만, UCS로는 남한과 북한의 같은 글자를 쓰면서도 다른 사전 순서로 쓰는 상황을 해결할 수 없다. 국제 표준 ISO/IEC 14651:2000(International String Ordering)은 여러 나라 글자계(script)가 섞여 있을 때, 모든 글자의 차례를 정하고 간추리는 틀에 관한 표준이다. ISO/IEC 14651을 이용하면 간추리는 차례가 공통 틀 표(Common Template Table)에 들어 있기 때문에 글자의 간추리는 차례를 쉽게 바꿀 수 있으며, 남한과 북한의 가나다 차례를 통일하지 않고 글자 순서가 다른 문제를 해결할 수 있다. ISO/IEC 14651 관련 함수는 리눅스와 솔라리스, FreeBSD와 같은 유닉스 기반 운영체제의 최신 라이브러리에 포함되어 있다. 본 논문에서는 북쪽의 한글 가나다 차례를 남쪽에서 활용할 수 있도록 하기 위해서 북쪽의 한글 가나다 차례를 포함하는 북쪽 로캘을 리눅스 시스템에서 만들고, 입력된 문자열(=글자떼)을 남쪽 혹은 북쪽의 한글 가나다 차례에 따라 간추리기 할 수 있는 프로그램을 개발하였다. UCS (=ISO/IEC 10646, =Unicode) will be used widely as globalization. If UCS is used for official purpose in Koreas, UCS solves a Problem in different hangeul code between South and North Korea. But, UCS is not a solution for problems in unequal order with the same character. IS0/1EC 146sl : 2000 (International String Ordering), which is a international standard for string ordering, defines a framework sorting all char-acter strings consisting multi-national scripts. Because the Common Template Table in ISO/IEC 14651 defines orders of characters, we can change orders of characters without changes of characters sequences in programs. Therefore, we can solve a ordering problem without unifying order of hangeul in South and North Korea. Functions related ISO/IEC 14651 are contained by system librarys in unix-based operating system such as Linux, Solaris and FreeBSD. We implement EUC-KR-based North Korean locale, which includes North Korean hangeul order, in Linux in order to use North Korean locale in South Korea. And we develop a program ordering strings with South and North Korean hangout order.