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        AntiHBc 단독양성인 검진자에서 혈청 GOT , GPT 치의 변화

        김영조(Young Jo Kim),이헌주(Heon Ju Lee),정문관(Moon Kwan Chung),이영현(Young Hyun Lee),양창현(Chang Heon Yang),김종설(Chong Cuhl Kim) 대한소화기학회 1985 대한소화기학회지 Vol.17 No.1

        N/A It is well known that Anti HBc may be causative agent of HBU infection and means viral replication. To evaluate the clinical significance of anti-HBc, serum transaminases was checked and screening test for hepatitis B surface antigen(HBsAg), antihody to hepatitis core antigen(anti-HBc) and antibody to hepatitis B surface antigen(anti-HBs) was made by radioimmunoassay technique in 419 consecutive subjects. Both groups were healthy clinically and had neither past history of liver diseases nor other causes that may change the level of serum transaminases. Followings are results of authors observation of present series; 1) The difference in incidence of elevated serum transaminases between control and anti- HBc(+) groups statistically was not significant. 2) The incidence of elevated serum transaminases among male was higher than among female in anti -HBc(+) group. 3) The incidence of elevated serum transaminases tended to be higher as ages progress in both groups. 4) The values of elevated serum transaminases in both groups were generally within the two fold upper normal values.

      • KCI등재후보

        Helicobacter pylori 감염에서 CagA 및 VacA 발현과 위 상피세포 증식과의 관계

        김남일(Nam Il Kim),이중현(Jung Hyun Lee),이영실(Yeoung Sil Lee),이재욱(Jae Uk Lee),이구(Goo Lee),서정일(Jeong Ill Suh),양창현(Chang Heon Yang),이창우(Chang Woo Lee),윤환중(Hwan Jung Yun),장태정(Tae Jung Jang),김정란(Jung Ran Kim),하경 대한내과학회 2000 대한내과학회지 Vol.58 No.5

        N/A Background : Infection with Helicobacter pylori (H. pylori) has been associated with an increased risk for developing gastric cancer. This risk is further enhanced with CagA positive H. pylori strains. Increased epithelial cell proliferation is associated with an increased risk for gastric cancer. The aim of the study was to investigate whether the gastric epithelial cell proliferation was related to the expression of CagA and VacA in H. pylori infection. Methods : The subjects were 77 patients who had undergone diagnostic esophagogastroduodenoscopy with biopsy; 18 gastritis, 18 gastric ulcer, 17 duodenal ulcer and 24 gastric cancer. The expression of cytotoxic genes was determined indirectly by assaying serum IgG antibodies to specific antigens of H. pylori. Gastric epithelial cell proliferation was assessed using immunohistochemical method using Ki-67 monoclonal antibody. Acute and chronic inflammation, intestinal metaplasia and glandular atrophy were scored according to the updated Sydney system. Results : Ki-67 labeling index, acute and chronic inflammation were significantly higher in H. pylori infected persons (n=70, 90.9%) than in uninfected persons (n=7, 9.1%) (p<0.05), but the difference in intestinal metaplasia and glandular atrophy between the two groups was not statistically significant. Ki-67 labeling indices in persons infected with CagA positive strains (n=56, 80.0%) were significantly higher than in persons infected with CagA negative strains (n=14, 20%) (0.55±0.13 vs 0.37±0.17, p<0.05), but the differences in acute and chronic inflammation, intestinal metaplasia and glandular atrophy between the two groups were not statistically significant. No significant difference was found in Ki-67 labeling index, acute and chronic inflammation, intestinal metaplasia and glandular atrophy according to expression of VacA. Conclusion : Gastric mucosal cell proliferation, which might be closely involved in the pathogenesis of gastric carcinoma, was significantly higher in CagA positive H. pylori infected persons.(Korean J Med 58:516-525, 2000)

      • 췌장염에 의한 가성낭종내에 생긴 가성동맥류 : 1례 보고

        오연희,이채경,김승현,이성우,양창현,이정호,이영현 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

        만성 췌장염의 합병증으로 생긴 가성동맥류는 드문질환으로, 반복적으로 다량의 출혈을 일으킬 수 있으며, 치료를 하지 않을 경우 사망율이 높기 때문에, 조기 진단과 치료가 필수적이다. 저자들은 38세 남자 환자에서 췌장염의 합병증으로 생긴 가성낭종내에서 발생한 가성동맥류 1예를 경험하였기에 보고하는 바이다. 가성 동맥류의 색혈류도플러상 낭종내에 양방향 흐름의 와류를 볼 수 있었다. Pancreatic Pseudoaneurysm within Pseudocyst from Pancreatitis: 1 Case Department of Diagnostic Radiology and Internal Medicine, College of Medicine,DongGuk University Yeon Hee OH M.D., Chae Kyeong Lee M.D., Seoung Hyeon Kim M.D., Sung Woo Lee M.D., Chang Heon Yang M.D., Jung Ho Lee M.D., Young Hyun Lee M.D. Pseudoaneurysm from pancreatitis is uncommon, but it can cause recurrent and massive hemorrhage. Because of high morbidity and mortality, early detection and treatment of the pseudoaneurysm is needed. We report a case of pseudoaneurysm within pseudocyst from pancreatitis. Color-flow Doppler sonography shows bidirectional flow and turbulent arterial flow, within anechoic mass.

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