http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Helicobacter pylori 감염에서 CagA 및 VacA 발현과 위 상피세포 증식과의 관계
김남일(Nam Il Kim),이중현(Jung Hyun Lee),이영실(Yeoung Sil Lee),이재욱(Jae Uk Lee),이구(Goo Lee),서정일(Jeong Ill Suh),양창현(Chang Heon Yang),이창우(Chang Woo Lee),윤환중(Hwan Jung Yun),장태정(Tae Jung Jang),김정란(Jung Ran Kim),하경 대한내과학회 2000 대한내과학회지 Vol.58 No.5
N/A Background : Infection with Helicobacter pylori (H. pylori) has been associated with an increased risk for developing gastric cancer. This risk is further enhanced with CagA positive H. pylori strains. Increased epithelial cell proliferation is associated with an increased risk for gastric cancer. The aim of the study was to investigate whether the gastric epithelial cell proliferation was related to the expression of CagA and VacA in H. pylori infection. Methods : The subjects were 77 patients who had undergone diagnostic esophagogastroduodenoscopy with biopsy; 18 gastritis, 18 gastric ulcer, 17 duodenal ulcer and 24 gastric cancer. The expression of cytotoxic genes was determined indirectly by assaying serum IgG antibodies to specific antigens of H. pylori. Gastric epithelial cell proliferation was assessed using immunohistochemical method using Ki-67 monoclonal antibody. Acute and chronic inflammation, intestinal metaplasia and glandular atrophy were scored according to the updated Sydney system. Results : Ki-67 labeling index, acute and chronic inflammation were significantly higher in H. pylori infected persons (n=70, 90.9%) than in uninfected persons (n=7, 9.1%) (p<0.05), but the difference in intestinal metaplasia and glandular atrophy between the two groups was not statistically significant. Ki-67 labeling indices in persons infected with CagA positive strains (n=56, 80.0%) were significantly higher than in persons infected with CagA negative strains (n=14, 20%) (0.55±0.13 vs 0.37±0.17, p<0.05), but the differences in acute and chronic inflammation, intestinal metaplasia and glandular atrophy between the two groups were not statistically significant. No significant difference was found in Ki-67 labeling index, acute and chronic inflammation, intestinal metaplasia and glandular atrophy according to expression of VacA. Conclusion : Gastric mucosal cell proliferation, which might be closely involved in the pathogenesis of gastric carcinoma, was significantly higher in CagA positive H. pylori infected persons.(Korean J Med 58:516-525, 2000)
Propofol을 이용한 수면유도 상부 위장관 내시경의 효과연구
최우혁 ( Woo Hyuk Choi ),김성욱 ( Sung Wook Kim ),이영실 ( Yeoung Sil Lee ),박윤선 ( Youn Sun Park ),도윤정 ( Yun Jeong Doh ),박재석 ( Jae Suek Park ),손석만 ( Sug Man Son ),김준형 ( Joon Hyung Kim ),정소연 ( So Yean Jung ),김남일 대한내과학회 2003 대한내과학회지 Vol.64 No.5
목적 : Propofol (2,6-diisopropylphenol)은 페놀계 화합물로 내시경 검사, 수술 등에서 진정, 마취 유도 및 유지를 위해 사용되며 benzodiazepine 계통의 midazolam에 비해 비슷한 진정작용과 기억상실 효과를 가지면서도 짧은 반감기로 인한 빠른 의식 회복으로 외래방문 환자를 대상으로 사용하기에 적절한 약제로 알려져 있다. 저자 등은 propofol로 수면 유도를 하여 그 효과를 혈역학적 변화와 만족도, 순응도 등을 Background : Propofol can be used to provide general anesthesia or sedation. The objectives of this study were to assess propofol as sedative agents for outpatient GI endoscopy, amnestic effects, hemodynamic state and oxygenation during the procedure. Met