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이윤하(Lee, Youn-Ha),이지수(Lee, Ji-Soo),홍원화(Hong, won-hwa) 한국주거학회 2016 한국주거학회 학술대회논문집 Vol.2016 No.4
Recently, fire or due to the emergence of new risks that can lead to disaster and accident risk that the environment is gradually increasing. Nevertheless, the ability of fire fighting organizations that can beat these disaster situation that did not evolved significantly. Fire function has for its object to protect the value of the altitude and human life, body, dignity. So it can not seek only to pursue the maximum efficiency calculation of limited resources. But efforts to ensure the timeliness and adequacy of response scale of the disaster response is needed for effective emergency response because of the government and local government resources are limited. In this study, to investigate the problem of current to fire service deployment standard in korea and suggests the need for effective development of fire service deployment standard.
이윤하(Lee, Youn-Ha),이호영(Lee, Ho-Young),최준호(Choi, Jun-Ho),홍원화(Hong, Won-Hwa) 한국화재소방학회 2011 한국화재소방학회 학술대회 논문집 Vol.2011 No.추계
장애학생들이 생활하는 특수학교의 경우 화재 발생빈도는 낮지만, 장애인은 초기 대응능력과 피난능력이 현저히 부족하므로 화재 발생 시 막대한 인명피해를 초래할 수 있다. 장애인의 안전한 피난을 위해서는 초기 소화설비와 피난에 필요한 경보설비, 피난설비의 설치 및 운영 그리고 피난보조자의 역할과 책임이 중요하기 때문에 특수학교를 대상으로 하여 소방시설의 설치 및 운영, 피난보조자의 화재안전의식에 대해 조사하였다. 그 결과 Fail-safe 원칙에 따라 2방향 이상의 피난이 가능해야 하지만 6개교 중 5개교가 평상시 안전을 이유로 비상구에 자물쇠를 채워 통행이 불가능하였고, 특수학교 교사들 중 피난시 교사들의 역할분담에 대해 54.2%가 모르고 있었으며, 피난보조자에 대해서도 64.5%가 모른다고 답하였다. 또한 소화기와 옥내소화전을 실제 사용해 본적 있는 교사는 각각 32.2%, 7.9%로 조사되어 화재발생시 초기소화를 담당해야 하는 교사들의 소화설비의 사용 경험이 부족한 것으로 나타났다.
이혜경(Lee, Hye-Kyoung),홍원화(Hong, Won-Hwa),이윤하(Lee, Youn-Ha) 대한건축학회 2016 대한건축학회논문집 Vol.32 No.3
For the last ten years, 270 deaths, 206,509 victims were caused by flooding. In order to reduce the casualties, flooding patterns, prediction of the danger flooded areas, standard of the safe evacuation environment it is important. In addition evacuation routes and shelters does not reflect the characteristics of a natural disaster and measurement capabilities of the refuge person is also not made much yet. The purpose of this study is to provide the standard of the safe evacuation environment through the evacuation simulation experiment to measure change in speed due to the water depth and to analyze speed difference in movement form, physical condition, distance. Evacuation simulation experiment was conducted with 20 people male of 20’s-30’s. The results was that 1] The speed is decreased as the water depth deepen but not a big difference in the running and walking. 2] The speed is more influenced by exercise capacity than the physical condition. 3] It showed a large speed reduction ratio lower than the deeper depths and running than walking in the speed according to the distance. This experimental data and the results of this study can be used as a basis to set the standard of safe evacuation plan for flood. Ultimately, expected to reduce the loss of life due to flooding.
간 스캔상 공간점유병소의 소견을 보인 Budd-Chiari 증후군
이정해,이윤하,서대원,장태종,황인섭,김영중,김소연,이권전 ( Jeong Hae Lee,Youn Ha Lee,Dae Won Seo,Tae Jong Jang,In Shup Hwang,Young Jung Kim,So Yon Kim,Gwon Jun Lee ) 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.3
A twenty-one-year old man visited our hospital due to abdominal distension for a month. On the physical examination, there was severe abdominal distension with fluctuation and shifting dullness. The routine laboratory results were within normal range. On the Magnetic Resonace angiography, there wasnt any blood flow within the right and middle hepatic vein. So we concluded that the etiologic disease was Budd Chiari syndrome. On the Iiver scan, there was cold area(absence of radiouptake) on entire right lobe of the liver, increased uptake on the bone marrow and showed spienomegaly. This finding was similar to the liver mass occupying right lobe with underlying chronic liver disease. On the previous reports, it is quite uncommon finding that Budd-Chirari syndrome shows lesion like space occupying one on the liver scan. So we report this case with a review of the lit.erature.
경구투여한 V. vulnificus 백신의 면역원성 및 감염방어효능
이나경(Na Gyong Lee),정상보(Sang Bo Jung),안보영(Bo Young Ahn),김영지(Young Gi Kim),이윤하(Youn Ha Lee),전영중(Young Joong Jeon),박완제(Wan Je Park) 한국응용약물학회 1998 Biomolecules & Therapeutics(구 응용약물학회지) Vol.6 No.2
Vibrion vulnificus is an estuarine gram0negative human pathogen that affects people with chronic hepatitis, alcoholic cirrhosis, diabetes mellitus or other underlying diseases, V. vulnificus infection is mediated primarily by consumption of raw fish or by exposure of pre-existing wounds to seawater, causing permanent tissue damages or fatal septic shock. We have been developing a vaccine against V. vulnificus composed of whole cell lysate of a V. vulnificus O-antigen serotype 4 strain. Oral administration of the V. vulnificus vaccine elicited a high serum antibody response in rabbits. The induced antibodies were reactive not only to the homologous strain but also to heterologous O-antigen serotype strains, indicating cross-reactivities among serotypes. Western blot analysis revealed that the antibodies are mainly specific for outer membrane proteins (OMPs) and reacted equally well with OPMs purified from 9 O-antigen serotypes The rabbit antisera showed opsonophagocytic killing activity against heterologous strains as well as the homologous strain. Passively transferred rabbit antisera into mice were protective against a lethal V. vulnificus infection. These data demonstrate that oral administration of the V. vulnificus infections, suggesting that this vaccine preparation could be used to develop an oral vaccine against V. vulnificus. Keywords □ V. vulnificus. oral vaccine, immunogenicity, protective efficacy
골수염 치료제인 항생제비드 ( CJ-40003 ) 유효성분의 일반약리작용
김영훈(Young Hoon Kim),최재묵(Jae Mook Choi),온윤성(Yoon Seong On),연규정(Kyu Jeong Yeon),이윤하(Youn Ha Lee),김제학(Je Hak Kim),이영수(Young Soo Lee) 한국응용약물학회 1999 Biomolecules & Therapeutics(구 응용약물학회지) Vol.7 No.1
A new antibiotic bead, CJ-40003 is a combination of three antibiotics, tobramycin, vancomycin and cefazolin embedded in bone cement, for the treatment of osteomyelitis. To evaluate the general pharmacological properties of CJ-40003, the effects of its active ingredients were investigated in mice, rats, dogs and isolated guinea pig ileum. The combination of three antibiotics (CA) did not affect general behavior, central nervous system, smooth muscles, gastrointestinal system, cardiovascular and respiratory system and water and electrolytes excretion when administered intravenously at the doses of 0.3, 1 and 3 mg/kg, respectively, into experimental animals. The CA had no effect on the contractile response of the isolated guinea pig ileum to various spasmogen at concentrations of 1, 3 and 10 ㎍/ml, respectively. In conclusion, the active ingredients of CJ-40003 showed no pharmacological effect in these studies.
Vibrio vulnipcus 에 대한 경구용백신 CJ-50002 의 일반약리작용
박완제(Wan Je Park),김영훈(Young Hoon Kim),정성목(Seong Mok Jeong),이영수(Young Soo Lee),신재규(Jae Kyu Shin),최재묵(Jae Mook Choi),이나경(Na Gyong Lee),이윤하(Youn Ha Lee) 한국응용약물학회 1999 Biomolecules & Therapeutics(구 응용약물학회지) Vol.7 No.1
CJ-50002 is an oral vaccine against V. vulnificus infection composed of whole cell lysate of V. vulnificus. The general pharmacological properties of CJ-50002 were evaluated in various animals and in vitro system. CJ-50002 at oral doses of 0.2, 2 and 20 mg/kg had no effect on general behavior in mice, chemoand electro-convulsions in mice, writhing syndrome induced by acetic acid in mice, body temperature in rats, charcoal meal propulsion in mice and urine and electrolytes excretion in rats. However, oral administration of CJ-50002 at dose of 20 mg/kg prolonged the hexobarbital-inuced sleeping inducing time in mice. In anesthetized dogs, CJ-50002 showed no effect on blood pressure, heart rate and ECG but decreased the respiratory rate and femoral blood flow at dose of 20 mg/kg. p.o. CJ-50002 had no effect on the contractile response of the isolated guinea pig ileum to various spasmogen at concentrations of 0.2, 2 and 20 ㎍/ml, respectively. Since these pharmacological effects of CJ-50002 were observed at dose much greater than those in clinical use (approximately 0.16 mg/kg, p.o.), it is likely that this vaccine may be relatively free of undesirable effects in clinical practice.
김영중,유광현,김용일,이윤하,김소연,황인섭,차경석,최병진,조민구 대한내과학회 1996 대한내과학회지 Vol.50 No.3
Focal nodular hyperplasia(FNH) is a rare benign hepatic tumor usually discovered serendipitous]y by an imaging procedure performed for some other reason. FNH is typically asymptomatic, and invariably follows a benign course. Accordingly, the preferred management is conservative, and excision is reserved for large symptomatic and complicated lesion, or when the diagnosis remains uncertain. Although many cases of FNH has been described to date in other countries, only two cases of FNH has been reported in Korean literature. But biopsy proven case have not been reported in Korea. In the present report we describe a 15 cm sized symptomatic lesion of FNH in a 29-year-old woman, that was disclosed by various kinds of imaging procedure. A left lateral segmentectomy was performed. The mass was firm and showed areas of localized growth of mature hepatocytes and septal fibrosis accompanied with marginal ductal proliferation, consistent with FNH. It also displayed an incomplete stellate architectural configuration consisted of a central fibrous scar. We report a case of FNH with a review of the literature.