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유희진(Hee Jin Yu),이기택(Ki Teak Lee),이규희(Gyu Hee Lee),오만진(Man Jin Oh) 한국식품영양과학회 2006 한국식품영양과학회지 Vol.35 No.10
Structured lipid (SL) containing conjugated linoleic and caproic acid was produced from soybean oil through lipase-catalyzed reaction, and its oxidative stability was compared. When heated at 60℃ or 150℃, soybean oil as control was more susceptible to oxidation than SL. When the antioxidants, such as ascorbyl palmitate, tea polyphenol, alpha-tocopherol, and rosemary extract, were added in SL, the induction periods of each antioxidant treats in SL were increased. The tea polyphenol showed the most effective antioxidant activity among them. When the emulsion form with SL was heated from oxidation, its oxidation stability was reduced compared to SL. The oxidation stability were also observed in photooxidation of SL.
Array comparative genomic hybridization analysis of cervical intraepithelial neoplasia and cancer
유희정 ( Hee Jeong Yu ),( Jeong Hoon Bae ),( Hae Nam Lee ),( Yong Wook Kim ),( Guo Hwa Ding ),( Su Mi Bae ),( Yong Wan Kim ),( Tae Chul Park ),( Jang Heub Kim ),( Joon Mo Lee ),( Sung Eun Namkoong ),( Wo 대한산부인과학회 2006 대한산부인과학회 학술대회 Vol.92 No.-
Development of anticancer gene vaccine interact with HPV oncoprotein inhibition
유희정 ( Hee Jung Yoo ),( Ok Kyung Kim ),( Suk Woo Lee ),( Su Mi Bae ),( Byung Hoon Kim ),( Eun Kyung Park ),( Hae Nam Kim ),( Young Wook Kim ),( Jun Mo Lee ),( Sung Eun Namkoong ),( Chong Kook Kim ),( J 대한산부인과학회 2004 대한산부인과학회 학술대회 Vol.90 No.-
관광계열 전공 대학생의 진로장벽과 진로적응성의 관계에서 성격강점의 매개효과
이정희 ( Lee Jung-hee ),유희정 ( Yu Hee-jung ) 한국컨벤션학회 2016 MICE관광연구 Vol.16 No.3
The purpose of this research was to evaluate the mediating effect of character strength in the influence of Tourism Related Student’s Career Barrier on Career Adaptability. Data was collected from 238 Tourism Related Students in Busan. The results were analyzed and interpreted using multiple.regression analysis. First, Career barrier was negatively correlated with Character Strength and Career Adaptability. Second, sub-factors of career barrier which were indecisive personality, and the lack of self clarification, had significantly effected on career adaptability. Third, sub-factors of career barrier which were indecisive personality, and the lack of self clarification had significantly effected on character strength. Fourth, sub-factors of character strength which were wisdom, courageousness and integrity had significantly effected on career adaptability. Finally Character strength moderated partially on the relation between career barrier and career adaptability. Limitations of current study and suggestions for future investigations are included in the discussion.
유산균 발효 마늘 추출물의 oleic acid로 유도된 비알코올성 지방간에 대한 개선 효과
이희섭(Hee-Seop Lee),임원철(Won-Chul Lim),최지휘(Ji-Hwi Choi),유희종(Heui-Jong Yu),김기호(Ki-Ho Kim),이승현(Seung-Hyun Lee),조홍연(Hong-Yon Cho) 한국식품과학회 2014 한국식품과학회지 Vol.46 No.6
본 연구에서는 oleic acid로 유도시킨 비알코올성 지방간 HepG2 세포 모델을 활용하여 LAFGE의 비알코올성 지방간 개선 효과를 검토하고 RT-PCR과 Western blot으로 메카니즘을 해석하였다. LAFGE는 1 mg/mL 농도에서 NFGE보다 세포 내 지방축적을 약 1.5배 저해하였다. Fig. 5에 나타낸 바와 같이 LAFGE는 FAT/CD36 mRNA 발현을 감소시켜 세포 내로 유입되는 지방산의 양을 감소시켰으며, PPARα와 CPT-1의 mRNA 발현을 증강시킴으로써 지방산의 베타-산화를 촉진시켰다. 또한 LAFGE는 지방합성을 촉진하는 전사인자인 SREBP-1c와 그의 조절을 받는 FAS의 mRNA 발현 수준을 oleic acid 처리시보다 각각 51%와 35% 까지 크게 감소시켰다. 뿐만 아니라 LAFGE는 농도의존적으로 SREBP-1c와 FAS의 단백질 발현도 감소시켰다. 이 결과들은 LAFGE가 oleic acid처리에 의해 유도된 HepG2 세포 내의 지방 축적을 개선할 수 있음을 시사하였다. In this study, the ameliorating effects of lactic acid-fermented garlic extract (LAFGE) on non-alcoholic fatty liver were investigated using oleic acid-induced steatotic HepG2 cells. The ameliorating mechanism was analyzed by RTPCR and Western blot. Treatment with 1 mg/mL LAFGE decreased intracellular lipid accumulation approximately 1.5-fold, compared to that achieved with non-fermented garlic extract. LAFGE reduced fatty acid influx into hepatocytes through down-regulation of FAT/CD36 mRNA expression in the steatotic HepG2 cells. PPARα and CPT-1 mRNA expression was significantly up-regulated by LAFGE treatment of HepG2 cells as a consequence of activation of beta oxidation. Additionally, the treatment with 1 mg/mL LAFGE highly down-regulated mRNA expression of SREBP-1c and FAS to 51% and 35%, respectively. LAFGE showed concentration-dependent down-regulation patterns in protein expression of SREBP-1c and FAS, as determined by Western blot. These results suggest that LAFGE treatment improves hepatic steatosis triggered by the imbalance of hepatic lipid metabolism owing to oleic acid treatment.
한국판 상태-특성 분노표현척도를 이용한 한국 청소년의 분노 평가 및 우울과의 관계
김희연(Hee-Yun Kim),이명훈(Myung-Hoon Lee),배재남(Jae-Nam Bae),김철응(Chul-Eung Kim),유희정(Hee Jeong Yoo),이정섭(Jeong-Seop Lee) 대한소아청소년정신의학회 2015 소아청소년정신의학 Vol.26 No.4
Objectives:The purpose of this study was to assess anger of middle school adolescents in an urban community using State-Trait Anger Expression Inventory (STAXI)-Korean and Korean Child Behavior Checklist (K-CBCL), and to determine whether specific anger expression of adolescents is associated with certain psychopathology including depression. Methods:Data were collected from 395 middle school students and their parents in Incheon city. The students completed the STAXI, Children’s Depression Inventory, Korean version of Mood disorder Questionnaire, and Conners-Wells’ Adolescent Self-Report Scale (Short Form), and their parents completed the K-CBCL. Results:No significant correlation was observed between aggression subscale K-CBCL and each scale of the STAXI, except anger out (r=0.704). The scores for STAXI total and respective scales were significantly higher for female students than male students. A stepwise logistic regression model was used to explore the possible predictors for depression in adolescents and lower anger control and higher anger suppression were found to be predictors for depression in adolescence. Conclusion:There is a possibility of a large discrepancy between anger that the adolescents actually feel and parents’ judgment of their children’s anger. It must be considered in assessment of adolescent anger and use of further structured interviews is necessary. In addition, it may be useful to consider the anger expression style in adolescents who report depressive symptoms.
Smooth Muscle Tumor of Uncertain Malignant Potential ( STUMP ) 의 임상적·병리학적 고찰
이희종(Hee Jong Lee),유희석(Hee Sug Ryu),박영한(Young Han Park),주희재(Hee Jae Joo),양성천(Seung Chun Yang),오기석(Kie Suk Oh) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.10
목적 : 본 연구는 Smooth muscle tumor of uncertain malignant potential(이후 STUMP로 표기함)을 평활근 육종과 비교하여 임상적. 병리학적으로 고찰하고, 1994년 개정된 자궁평활근종 분류법으로 재분류후 그 결과를 임상경과와 비교하여, 새로운 분류법의 실용성을 검토하였다.연구방법 : 1995년부터 1999년까지 아주대학교병원 산부인과를 내원한 환자들 중 STUMP로 진단된 11례와 평활근 육종으로 진단된 7례의 의무기록과 조직표본을 통해 임상적 병리학적 소견을 검토하였고, 1994년 Kempson과 Hendrickson에 의해 정립된 자궁평활근종의 분류법에 의해 재분류하였다.결과 : 환자의 연령분포/ 분만력/ 폐경유무/ 호르몬제재 복용 기왕력은 양군에서 유의한 차이가 없었다. 가장 흔한 임상증상은 불규칙한 자궁출혈이었고 (STUMP 54%, 평활근 육종 62%), 수술전 초음파상 악성종양이 의심된 경우는 STUMP 군에서 1례(9%), 평활근 육종군에서 2례(29%)였다. STUMP 군 2례에서는 근종 절제술만으로 치료를 종결하였고 총 18례중 나머지 환자들은 전자궁 적출술 및 선택적 자궁부속기 절제술을 시행하였으며, 모든 예에서 재발이나 전이소견은 없었다. 총 18례 중 STUMP 10례와 평활근 육종 4례는 유사분열지수가 증가된 평활근종으로, STUMP 1례는 비정형 평활근종으로, 평활근 육종 3례는 같은 진단명으로 재분류되었다.결론 : STUMP에서 유사분열지수가 증가된 평활근종(leiomyoma with increased mitotic index)으로 재분류된 종양의 환자들은 모두 양호한 임상경과를 보여 본 연구에서 자궁평활근종의 새로운 분류법은 임상경과와 일치하였다. 이 경우 임신을 원하는 여성이면 근종 절제술만으로 치료를 종결할 수 있다. 그러나 재발가능성이 적은 비정형 평활근종(atypical leiomyoma with low risk recurrence)이나 저급악성도를 갖는 평활근종(smooth muscle tumor of low malignant potential)으로 분류된 예는 악성 임상경과의 가능성이 있어, 예후에 대한 장기적인 추적조사가 필요할 것으로 본다. Objective : To evaluate clinical-pathological aspects of smooth muscle tumor of uncertain malignant potential (STUMP), comparing those of leiomyosarcomas and to reclassify them according to the revised classification of smooth muscle tumor, and to investigate the clinical value of new classification.Methods : A retrospective review of clinical and pathological characteristics of 11 cases of STUMP and 7 cases of leiomyosarcoma was done at department of obstetrics and gynecology of Ajou university hospital from 1995 to 1999. They were reclassified according to the revised classification by Kempson and Hendrickson in 1994.Results : Patients' age, parity, status of menopause, history of hormonal use were not significantly different. Vaginal bleeding was most common clinical symptom in both groups(STUMP 55%, leiomyosarcoma 63%) and sarcomatous change was suspected in 1 case of STUMPs and 2 cases of leiomyosarcomas with preoperative transvaginal sonographic examination. Two cases of STUMP were treated with myomectomy only and hysterectomy with or without salpingo-oophorectomy was performed in all cases of leiomyosarcomas and 9 cases of 11 STUMPs. No adjuvant therapy was done and none recurred. Ten cases of STUMP and four cases of leiomyosarcoma were reclassified into leiomyoma with increased mitotic index, one STUMP into atypical leiomyoma, and three leiomyosarcomas remained in the same category by revised classification.Conclusion : Such tumors reclassified into leiomyoma with increased mitotic index showed benign clinical course and the results of this study support new classification. However, atypical leiomyoma with low risk recurrence and smooth muscle tumor with low malignant potential still have possibility of malignant clinical course.