胃炎治療劑의 藥理作用

高光浩 藥業新聞社 1983 (月刊) 醫藥情報 Vol.1983 No.8

초록집 ( 1992 . 5 . 6 ) : 제 1 분과 ( 합성 , 천연물 , 생명공학 ) ; 베타수용체의 추출 및 1 차 정제

고광호,신찬영,강현삼 한국응용약물학회 1992 학술대회 Vol.1992 No.1

흰쥐에서 출생 후 납중독애 의한 중추신경계 독성의 선택성 연구

고광호 嶺南大學校 環境問題硏究所 1989 環境硏究 Vol.8 No.2

The purpose of the present study was to address the question whether postnatally induced lead intoxication exhibits selective toxicity to specific central nervous system in newborn rats. Monoaminergic nervous system was chosen as an example of specific nervous system and monoamine oxidase (MAO) activity was determined as a criterion of specific lead poisoning while ??-ATPase activity was determined as a criterion of nonspecific lead poisoning. Wistar rats were employed in this experiment. Lead poisoning was induced by exposing newborn rats to either 0.05 of 0.2% lead acetate (PbAc2) in their drinking water from the time of parturition. At 3 weeks of age, all experimental newborn rats were removed from their dams. At 2, 4, 6 and 8 weeks of age MAO and ??-ATPase activities were assayed in 5 areas of experimental rats brain; telencephalon, diencephalon, midbrain, pons-medulla and cerebellum. In every case when the activity of enzyme was altered, MAO activities were increased but ??-ATPase activities were decreased compared to control group. Selective toxicity of lead poisoning to monoaminergic nervous system characterized by the change of MAO activity without concomitant change of Na?K?-APTase acitivty was found in telencephalon (2 weeks), midbrain (4 weeks), pons-medulla (2 weeks) and cerebellum (2, 4, 6, 8 weeks). The result in the present study suggests that postantally induced lead poisoning may exhibit selective toxicity to monoaminergic nervous system in newbron rats.

過鹽素酸나트륨支持溶液에서의 Cd(Ⅱ)폴라로그람에 관한 硏究

高光鎬 梨花女子大學校 韓國生活科學硏究院 1971 韓國生活科學硏究院 論叢 Vol.7 No.-

pH 3.0∼8.7範圍의 酸性, 中性, 알칼리性 過鹽素酸나트룸支持溶液 속에서의 Cd(Ⅱ)폴라로그람을 25˚C에서 Cd(Ⅱ)의 농도, 1×10^-3M, 2×10^-3M 및 4×10^-3M 에 대하여 ??하였다. 그결과 위 範圍의 pH 에서 Cd(Ⅱ)폴라로그람還元波의 限界電流는 擴散律速에 支配됨을 밝혔으며 이와 같이 pH範圍에서의 Cd(Ⅱ)의 還元波의 半波電位값으로서 -0.562volt(vs.S.C.E.)를 얻었다. The polarograms of Cd(Ⅱ) in sodium perchlorate solution were investigated in the range pH volues from 3.0 to 8.7 at three different concentrations,1×10^3M,2×10^3M and 4×10^3M of Cd(Ⅱ) and temperature of 25˚C.The reduction wave of diffusion control was found up to pH value of 8.7. Under the same pH range,the halfwave potential of reduction wave of Cd(Ⅱ) was found to be -0.562 volt vs.S.C.E.

고혈압 동물에서 혈압변동과 적혈구변형능의 상관성

고광호,이명걸,김낙두,조윤성,권석윤,윤재순 대한약학회 1987 약학회지 Vol.31 No.5

In cardiovascular disease the flow adaptation of erythrocytes can be affected by reduced shear stresses and metabolic influences on red cell fluidity as a consequence of tissue hypoxia. In addition there are indications that risk factors of cardiovascular diseases are able to decrease the intrinsic red cell deformability. Erythrocyte deformability was studied by the filtration technique of Reid et al. to investigate the relationship between blood pressure chances and erythrocyte deformability. In this experiment normotensive rats, spontaneously and DOCA-salt treated hypertensive rats were used. Erythrocyte deformability was significantly reduced by blood pressure elevation in hypertensive rats but was not fully recovered by normalization of blood pressure after antihypertensive drug treatment. Therefore other factors than blood pressure may be involved in erythrocyte deformability reduction during blood pressure elevation.

항바이러스제 개발전략 및 개정 임상시험법 - Trends in Antiviral Research and Revised Regulation on Clinical - ( 1999 . 11. 16 ) : Symposium Abstracts ; Award Lecture 간질발현에서의 중추노르아드레날린성 신경계 역할

고광호 한국응용약물학회 1999 학술대회 Vol.1999 No.2

DBA / 2J Mice 에서 청각성 경련 조절에 대한 중추신경계 도파민의 역할

고광호,김낙두 ( Kwang Ho Ko,Nak Doo Kim ) 생화학분자생물학회 1984 BMB Reports Vol.17 No.4

The effect of drug-induced changes of brain biogenic amines on audiogenic seizures was determined in DBA/2J mice. One group of mice received 1-dopa which induced a large increase in brain dopamine and norepinephrine contents. A second group of animals also received 1-dopa with diethyldithiocarbamate, a dopamine-β-hydroxylase inhibitor, pretreatment which caused an elevation of dopamine but not norepinephrine levels. A third group of mice received only diethyldithiocarbamate which did not cause any changes of brain dopamine or norepinephrine concentrations. Brain 5-hydroxytryptamine contents of mice were not changed by any of these drug treatments. There were dramatic reductions in the incidence of tonic extensor seizures in the first and the second groups of animals but not in the third group. Drug-induced reduction in seizure incidence of mice correlated with an increase in brain dopamine contents but not with changes in brain norepinephrine.

시트르酸나트륨 支持溶液에서의 Cd(Ⅱ)폴라로그람에 관한 硏究

高光鎬 梨花女子大學校 韓國生活科學硏究院 1978 韓國生活科學硏究院 論叢 Vol.20 No.-

pH 1.0∼8.0 範圍內에서 1.0x10^-1M 시트르酸나트륨支持電解質水溶液 속에서의 Cd(Ⅱ) 폴라로그람을 25℃에서 네 가지 다른 Cd(Ⅱ)의 농도 5.0x10^-4M, 1.0x10^-3M, 2.0x10^-3M alc 4.0x10^-3M에 대하여 極大抑制製 Triton X-100을 사용하여 調査하고 分析하였다. <Fig. 3> Effect of pHon the halfwave potential 원문을 참조하세요. 그 結果 이 範圍의 pH에서 Cd(Ⅱ)폴라로그람의 還元波의 限界電流는 擴散律速에 支配됨을 밝혔다. pH 1.0∼3.0 附近 領域까지는 半波電位의 값이 -0.576volt(vs. S.C.E)이고 이 값을 一定하게 유지하고 있음을 알았으며, 또한 이 값을 같은 이온세기로 된 Cd pH pH(Ⅱ)의 窒酸칼륨支持電解質水溶液에서의 半波電位의 값과 비교하면 그 값이 동일하다. pH 3.0 附近 이상으로부터는 半波電位의 값이 pH의 증가에 따라 부 쪽으로 이행하며 이 範位內의 半波電位의 값은 pH에 대한 선형함수임을 밝혔다. 이러한 잠정적인 半波電位값의 증가는 pH 6.0에서 끊이고 pH 6.5 附近에서 -0.654volts(vs. S.C.E.)로 되었으며, pH 6.0∼8.0 領域內에서 이 값으로 一定하게 維持되었다. 이 사실은 시트로酸나트륨支持電解質을 사용하면 pH 1.0∼3.0領域內에서는 Cd(Ⅱ)와 시트로酸이온은 錯物을 形成하지 않음을 나타내며 이보다 높은 pH 領域인 3.0∼6.5範位內에서는 Cd(Ⅱ)와 시트로酸이온 사이에 錯物이 形成됨을 나타낸다. 이러한 사실들로 미루어 보아 Cd(Ⅱ)의 半波電位의 값이 각각 一定하게 維持되는 pH 1.0∼3.0 및 6.5∼8.0 領域內에서 Cd(Ⅱ)의 定性 및 定量이 가능함을 推定하였다. The polarograms of Cd (Ⅱ) in 0.10M sodium citrate aqueous solution were in-vestigated in the range of pH values from 1.0 to 8.0 at four different concentrations, 5.0 X 10^-4M, 1.0 X 10^-3M, 2.0 X 10^-3M and 4.0 X 10^-3M of Cd (Ⅱ) at temperature of 25℃ and with applying the maximum suppressor of Triton X-100. The limiting currents of reduction wave of Cd (Ⅱ) were found to be the diffusion control in the above range of pH values. Up to pH value of 3.0, the halfwave potential was found to have a constant value of -0.576 volts (vs S.C.E.), and when compared with potassium nitrate solution of the same Cd (Ⅱ) concentration at the same ionic strength, it's value was identical with the latter under the condition of the same range of pH values from 1.0 to 3.0. The values of halfwave potential gradually decreased as pH value increased over 3.0, and the value of-0.654 volts (vs S.C.E.) was obtained at the pH value of 6.0 and the halfwave potential remained constant up to a pH value of 8.0. It showed that the complexes between cadmium citrate ion are not able to form in the range of pH values from 1.0 to 3.0, and at the range of pH values from 3.0 to 6.5. the complexes were formed in the citrate supporting electrolyte solution. Consequently, it was deduced that Cd (Ⅱ) is possible to detect and determine by qualitative and quantitative methods under the condition of pH values of 1.0∼3.0 and 6.0∼8.0, respectively.

GPS를 이용한 차량 연료차단 관성주행의 감지에 관한 연구

고광호,Ko, Kwang-Ho 한국디지털정책학회 2019 디지털융복합연구 Vol.17 No.11

대부분의 차량에 적용되어 있는 연료차단(fuel-cut) 관성주행은 변속기어 체결 상태에서 가속페달을 방치할 때 자동으로 작동하게 된다. 이 때 연료분사가 일시적으로 중단되므로 연비 향상 효과가 상당하다. 본 연구에서는 GPS를 이용하여 측정된 차속, 가속도, 도로구배 등의 신호를 바탕으로 하는 연료차단 관성주행 감지법을 제안하였다. 관성 주행시 작용하는 주행저항력에 의해 계산되는 가속도값과 GPS에서 실시간으로 측정되는 가속도값을 비교하는 방식이다. 실도로 주행 데이터를 측정하여 이 감지법을 평가한 결과 약 80% 수준의 정확도를 얻을 수 있었다. 도로구배가 다소 큰 12km 정도의 국도를 16분 동안 주행하면서 측정한 약 9,600개의 속도, 가속도, 도로구배 및 연료소모량 데이터에 감지법을 적용하여 얻은 결과이다. 인젝터 분사파형 분석을 위한 배선작업 등이 불필요하여 간단하게 연료차단여부를 판정할 수 있는 장점이 있다. 다만, 속도, 가속도 및 도로구배의 변화율이 연료소모량의 변화율에 비해 훨씬 크게 나타나기 때문에 감지법의 오차도 다소 증가하는 것을 알 수 있었다. The fuel-cut coast-down driving mode is activated when the acceleration pedal is released with transmission gear engaged, and it's a default function for electronic-controlled engine of vehicles. The fuel economy becomes better because fuel injection stops during fuel-cut driving mode. A fuel-cut detection method is suggested in the study and it's based on the speed, acceleration and road gradient data from GPS sensor. It detects fuel-cut driving mode by comparing calculated acceleration and realtime acceleration value. The one is estimated with driving resistance in the condition of fuel-cut driving and the other is from GPS sensor. The detection accuracy is about 80% when the method is verified with road driving data. The result is estimated with 9,600 data set of vehicle speed, acceleration, fuel consumption and road gradient from test driving on the road of 12km during 16 minutes, and the road slope is rather high. It's easy to detect fuel-cut without injector signal obtained by connecting wire. The detection error is from the fact that the variation range of speed, acceleration and road gradient data, used for road resistance force, is larger than the value of fuel consumption data.

브레이크 디스크 커버의 제동 열손상에 대한 실험적 연구

고광호,문병구 한국디지털정책학회 2015 디지털융복합연구 Vol.13 No.11