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Piperlongumine 유도체 합성과 $Aflatoxin\;B_1$ 생성 억제 효과
이성은,최원식,이현상,이영행,박병수,Lee, Sung-Eun,Choi, Won-Sik,Lee, Hyun-Sang,Lee, Young-Haeng,Park, Byeoung-Soo 한국응용생명화학회 2003 한국농화학회지 Vol.46 No.4
Anti-aflatoxigenic studies on synthetic pyridione alkaloids were conducted. Seven derivatives using piperlongumine as a leading compound were prepared from 3,4,5-trimethoxycinnamic acid (TMCA). These derivatives were analyzed for their structural confrmation and purity by HPLC, GC, GC/MS and $1^H-NMR$. 1-piperidin-1-yl-3-(3,4,5-trimethoxyphenyl)propenone (1) reaction with piperidine; 1-morpholin-4-yl-3-(3,4,5-trimethoypenyl)propenone (2) with morpholine; 1-(3,5-dimethylpiperidin-1-yl)-3-(3,4,5-trimethoxyphenyl)propenone (3) with 3,5-dimethylpiperdine; 1-(2-methylpiperidine-1-yl)-3-(3,4,5-trimethoxyphenyl)propenone (4) with 2-methylpiperidine; 1-(3-hydroxypiperidin-1-yl)-3- (3,4,5-trimethoxyphenyl)propenone (5) with 3-hydroxypiperidine hydrochloride; 1-[3- (3,4,5-trimethoxyphenyl)acryloyl]piperidin-2-one (6) with ${\delta}-valerolactam;\; and\;ethyl\;1-[3-(3,4,5-trimethoxyphenyl)acyloyl]piperidine-4-carboxylate$ (7) with ethyl isonipectotate were synthesized respectively. All derivatives showed an inhibitory activity on aflatoxin $B_1$ production. In conclusion, we believe that they might be an agent for the control of mycotoxin in agricultural commodities. 필발 열매로부터 추출 및 분리한 piperlongurnine (1-[3-(3,4,5-trimethoxyphenyl)acryloyl]-5,6-dihydro-1H-pyridin-2-one)이 aflatoxin $B_1\;(AFB_1)$ 생성억제에 있어서 탁월한 효과가 입증되어 3,4,5-trimethoxycinnamic acid (TMCA)를 모체로 하여 1-piperidin-1-yl-3-(3,4,5-trimethoxyphenyl)propenone (1), 1-morpholin-4-yl-3-(3,4,5-trimetholfrphenyl)propenone (2), 1- (3,5-dimethylpiperidin-1-yl)-3-(3,4,5-trimethoxyphenyl)propenone (3), 1-(2-methylperidin-1-yl)-3-(3,4,5-trimethoxyphenyl)propenone (4), 1- (3-hydroxypiperidin-1-yl)-3-(3,4,5-trimethoxyphenyl)propenone (5), 1-[3-(3,4,5-trimethoxy-phenyl)acryloyl]piperidin-2-one (6) 및 ethyl 1-[3-(3,4,5-trimethoxyphenyl)acryloyl]piperidin-4-carboxylate (7)의 유도체를 합성하여 구조를 확인하고, 이 화합물들을 이용하여 $AFB_1$ 생성저해 효과를 측정하였다. Aspergillus flavus NRRL 2061로부터 생성되는 $AFB_1$ 생성저해에 대한 실험한 결과 모든 유도체 화합물에서 활성을 나타내었으며, 특히 화합물 (3)이 1000, 500, 250, 100및 $50\;{\mu}g/ml$에서 100, 95, 90, 53 및 10%의 생성저해를 나타냈다. 이러한 연구 결과 유도체 화합물 (3)은 항진균 독소제 개발을 위한 선도화합물로 이용하여 새로운 농약으로 개발이 가능할 것이라고 판단된다.
이성은,Lee, Sung-Eun 한국지역사회간호학회 1997 지역사회간호학회지 Vol.8 No.2
In Korea, the nosocomial infection control program is not well developed. This situation is created by a lack of interest from medical personnel and the medical payment system. This study identifies current problems and develops a model for nosocomial infection control. The studies of Lee & Kim(1995), Lee (1993) and SENIC project model were used to construct this model. 1. The problems of nosocomial infection control were identified as the following: dis approval by hospital authorities, lack of sources for program direction, lack of overall structure and function in the program, inadequate direct action, lack of education and training, and so on. 2. The problems are reorganized according to the 5 elements of system theory. 3. As a result, the new nosocomial infection control model was developed. The inputs of the model were the elements, resources and boundaries of nosocomial infection. With the new model, each hospital can evaluate their current programs and plan a new program for the better control of nosocomial infection.
아토피 피부염에 운용 가능한 경혈(經穴) 탐구 - 상용(常用) 본초(本草)를 중심으로
이성은,윤화정,고우신,Lee, Sung-Eun,Yoon, Hwa-Jung,Ko, Wo-Shin 대한한방안이비인후피부과학회 2018 한방안이비인후피부과학회지 Vol.31 No.2
Objectives : The purpose of this study is to investigate acupoints for atopic dermatitis which have similar impact with frequent herbs. Methods : We collected research materials in "The Journal of Korean Medicine Ophthalmology & Otolaryngology & Dermatology" published from Feburary, 2000 to September, 2017. The search terms are 'atopic Dermatitis', 'antiallergic', 'anti-inflammatory', 'antianaphylaxis', 'dermatitis' and we elected experimental researches about herbal medicine. Among the herbal medicine, we extracted frequent herbs using more than 5 times, and categorized through "Herbal Medicine". By Consulting "Principles of Meridians & Acupoints; A Guidebook for College Students", we matched frequent herbs and acupoints. Results : 1. There are 38 frequent herbs for study except Glycyrrhiza uralensis FISCH. because it was used for balance in herbal medicine. Arrange meridians in order of frequency, the most is 'Lung meridian'. Among the organs, the most related one with skin is 'Lung' and 'Lung meridian' can treat skin diseases. 2. We researched acupoints called 'specific acupoints' under elbow, knee because of clinical usage. Exceptively, SP6 and GV20 are not included in 'specific acupoints' but they can be effective for atopic dermatitis treatment. 3. Researching on MEDLINE about frequent herbs and acupoints, there are many studies that acupuncture is effective for reducing pruritus. Therefore, the acupoints which were mentioned in this study can be choosed for atopic dermatitis. Conclusions : We found several applicable acupoints for Atopic Dermatitis. We hope it will be useful in experiment such as randomized controllized trial on Atopic Dermatitis and acupuncture and futhermore in clinic.
확장 칼만필터를 이용한 수중 표적의 불안정 주파수선 추출 기법
이성은,황수복,남기곤,김재창,Lee, Sung-Eun,Hwang, Soo-Bok,Nam, Ki-Gon,Kim, Jae-Chang 한국음향학회 1996 韓國音響學會誌 Vol.15 No.6
수동 소나 시스템에서는 표적을 탐지, 추적 및 식별을 위하여 표적의 방사 소음으로부터 발생되는 주파수선을 주요 특징 인자로 활용한다. 이 연구에서는 수중 표적의 방사 소음으로부터 시간 영역의 표본화된 데이타를 이용한 불안정 주파수선의 추출 기법에 대하여 연구하였다. 불안정 주파수선은 시간에 따라 주파수선이 변화되어 나타나므로 불안정 주파수선 추출을 위하여 비선형 시스템에 유용한 확장 칼만 필터 알고리듬을 적용하였다. 모의 실험 및 표적 신호에 적용하여 제시한 방식이 불안정 주파수선을 추출할 수 있음을 보인다. In passive sonar system, frequency lines generated by underwater target are very important for detection, tracking and classification. In this paper, the extraction method of unstable frequency line from the time samples of the radiated noise of underwater target is studied. As unstable frequency line is time varying, an extended Kalman filter algorithm which is desirable for nonlinear system is applied to extract unstable frequency line. The proposed method shows good extraction of unstable frequency line by application of simulated signal and real target.
자바 프로그램의 재사용을 위한 자바 빈즈 컴포넌트의 추출 및 명세화 기법
이성은,김영익,류성열,Lee, Seong-Eun,Kim, Yeong-Ik,Ryu, Seong-Yeol 한국정보처리학회 2000 정보처리논문지 Vol.7 No.5
An important technical issue in recent software development is to make needed software by the composition of components that are assemblable, and configurable, and independently extracted. The main advantage of component-based software development is reducing development time and cost. It is more cost-effective in development time to use components that are already developed than developing from scratch. There are two ways of component-based software development: one is to compose self-developed components, and the other is to by the components developed by third-parties and compose them. In the second case, existing non component programs must can be used for reuse in the component development. In this paper, we approach two methods for increase of reusability of Java program. First, we suggest the technique of extracting the elements suitable for the Beans component model from Java program, and then we show a process and a guideline of converting the extract elements into the Beans component model. Second, we suggest a technique of automatically extracting component information from the Java Beans component, expressing them in XML, its is possible to reuse the efficient component environment.