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RISS 인기검색어
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- 저자 : 이기철(Gi-Chul Lee) (검색결과 69 건)
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Olanzapine이 백서의 Schedule-Induced Polydipsia에 미치는 영향
이기철,이경규,장환일,이정호,김현우,하준명,정재현,정홍경,Lee, Gi-Chul,Lee, Kyung-Kyu,Chang, Hwan-Il,Lee, Jung-Ho,Kim, Hyun-Woo,Ha, Jun-Myung,Jeong, Jae-Hyun,Jeong, Hong-Kyung 대한생물정신의학회 1999 생물정신의학 Vol.6 No.2
Object : This study was designed to evaluate the effects of olanzapine on the schedule-induced polydipsia(SIP) which is one of animal model of obsessive-compulsive disorder in rats. We administered olanzapine as a serotonin and dopamine blocking agent, fluoxetine as a selective serotonin reuptake inhibitor, and haloperidol for the dopamine antagonist to rats which showed schedule-induced polydipsic behavior. Methods : Spraque-Dawley rats weighing 200-250gm were individually housed and maintained and allowed free access to water. The rats were placed on a restricted diet. To induce polydipsia, rats were placed in the cage where a pellet dispenser automatically dispensed 90mg pellets on a fixed-time 60 seconds(FT-60s) feeding schedule over 150 minute test session per day. Water was available at all times in the cage. After 4 weeks of daily exposure to the FT 60s feeding schedule, experimental rats met a predetermined criterion for polydipsic behavior(greater than 3 times of water per session on average). 5 groups of rats were administered olanzapine(3mg/kg, i.p), olanzapine(10mg/kg, i.p), fluoxetine(5mg/kg, i.p.), haloperidol(0.1mg/kg, i.p.), and vehicle(1cc/kg, i.p.) for 3 weeks. The rats were tested once a week to access schedule induced polydipsic behavior. Water bottles were weighed before and after the 150-minute test session. The chronic effects of administration of experimental drugs on schedule induced polydipsic behavior were analyzed with ANOVA and Scheffe test as a posthoc comparison. In order to measure water consumption in non-polydipsic food-deprived rats, a separate group of rats(N=8) were individually housed and given a single bolus(14.5gm) of food per day which maintained them at their average body weight. Results and Conclusion : The results were as follows ; 1) After 4 weeks of scheduled feeding procedure, the experimental group showed significant differences than the bolus control in the amount of water consumption as compared with their average water intakes for 4 weeks. At the same periods, there were no differences between the experimental group and the bolus control in the body weight. 2) The fluoxetine group showed significant decrease in the amount of water intake over the 3 weeks of drug treatment as compared with their average amount of polydipsic water intakes. The olanzapine 3mg group showed significant decrease in the amount of water intake at 3rd weeks of drug treatment as compared with their average amount of polydipsic water intakes. The olanzapine 10mg group showed significant decrease in the amount of water intake at 2nd and 3rd weeks of drug treatment as compared with their average amount of polydipsic water intakes. However, the haloperidol group and the vehicle control group showed no changes of amounts of water intake for 3 weeks of treatment as compared with their average amount of polydipsic water intakes. 3) The fluoxetine group showed significantly lower amounts of water intake than the haloperidol group at 2nd weeks of drug treatment. And also the fluoxetine group showed significantly lower amounts of water intake than the haloperidol group and the vehicle control at 3rd weeks of drug treatment. The olanzapine 3mg group and the olanzapine 10mg group showed significantly lower amounts of water intake than the haloperidol group and the vehicle control at 3rd weeks of drug treatment. Above findings suggest that the fixed time feeding procedure for schedule-induced polydipsia as an animal model of obsessive compulsive disorder was effective to the evaluation of pharmacological challenge study. The authors assume that the serotonin hypothesis and the serotonin-dopamine interaction hypothesis are preferred to the dopamine hypothesis in the biological etiology of obsessive-compulsive disorder.
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선택적 세로토닌 재흡수차단제들이 만성 경도 스트레스 후의 백서에서 수동적 회피학습에 미치는 영향
이기철,장환일,Lee, Gi-Chul,Chang, Hwan-Il 대한생물정신의학회 1997 생물정신의학 Vol.4 No.2
The study was designed to evaluate the significant roles of SSRI in rat of depression model. Chronic exposure to mild unpredictable stress has been found to depress the consumption of sweet 1% sucrose solutions in the Sprague-Dawley rats. We applied the variety of 11 types of stress regimens and identified depressive behaviours(developed by Willner) in 70 Sprague-Dawley rats. Rats in experiments were stratified into 6 groups, ie ; 3 kinds of SSRI(paroxetine, fluoxetine, sertraline), clomipramine, choline and saline control. Memory function was evaluated by passive avoidance learning and retention test. The authors determined how long memory retention would remain improved with 24 hour, 1 week, 2 weeks, 3 weeks, and 4 weeks at training-testing interval in depressive states of the Sprague-Dawley rats. The results were as follows ; 1) There were no significant differences between the 6 groups at the 24 hour training-testing interval. 2) The paroxetine treated group showed significant differences from the control group at the 1 week and 2 weeks training-testing interval. 3) The paroxetine and the fluoxetine treated groups showed singificant differences from the control group at 3 week training-testing interval. 4) The paroxetine and the choline treated groups showed significant differences from the control group at 4 week training-testing interval. In summary, paroxetine had an effect on long term memory processing from 1st week to 4th week. Also, fluoxetine(at 3rd week) and choline(at 4th week) had effect on long term memory processing. Sertraline, clomipramine were ineffective on memory processing during 4 weeks observation. Possible explanations why paroxetine had early effect on memory processing than the other selective serotonin reuptake inhibitors are rapid bioavailability, which is the characteristics of pharmacokinetics of paroxetine. In clinical situation, author carefully suggest that SSRI would be beneficial to improve the memory function caused by depressive neurochemical changes.
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아편양 순응제가 백서의 억제된 자발적 교대행동에 미치는 영향
이기철,전성일,장환일,이정호,최영민,김성호,류정환,최미,Lee, Gi-Chul,Jeon, Seong-Il,Chang, Hwan-Il,Lee, Jung-Ho,Choi, Young-Min,Kim, Seong-Ho,Ryu, Jeong-Hwan,Choi, Mi 대한생물정신의학회 1999 생물정신의학 Vol.6 No.2
This study was designed to evaluate the effects of opioid receptor agonists on the spontaneous alternation behaviour in an animal model of obsessivecompulsive disorder in rats. According to the theory that dopamine is related to the biological etiology of obsessive-compulsive disorder, the effect of the nalbuphine(opioid kappa agonist) and the tramadol(opioid mu agonist), which act as manipulating agents on the inhibition or stimulation of dopamine release, in the spontaneous alternation behaviour were evaluated. 24 hours prior to the experiment, rats were food-deprived. These rats were put into the T-maze, in which white and black goal boxes were baited with small amounts of chocolate milk. Each rat was given 2 set of 7 trials during which it was placed in the start box and allowed to choose the one of the goal boxes for each time. After identifying the stable baseline of spontaneous alternation behaviour, nonselective 5-HT agonist 5-MeODMT(1.25mg/kg/IP) disrupted spontaneous alternation. Rats were stratified into fluoxetine(10mg/kg/IP), nalbuphine(10mg/kg/IP), tramadol(46.4mg/kg/IP), and saline(0.5cc/IP) injection group with experimental drug treatment for 21 days. The effects on the 5-MeODMT(1.25mg/kg/IP) induced disruption of spontaneous alternation behaviour were checked at the next day of discontinuation of drug treatment. The results were as follows ; 1) At the day after 21 days of the drug treatment, the nalbuphine treated group and the fluoxetine treated group showed significant difference from the tramadol treated group and the saline treated group in the 5-MeODMT(1.25mg/kg/IP) induced suppression of spontaneous alternation behaviour. 2) Within each drug treatment group, the fluoxetine treated group showed significant difference between before and after the treatment of fluoxetine in the 5-MeODMT(1.25mg/kg/IP) induced suppression of spontaneous alternation behaviour. And also, the nalbuphine treated group showed significant difference between before and after the treatment of nalbuphine in the 5-MeODMT(1.25mg/kg/IP) induced suppression of spontaneous alternation behaviour. There was no difference between the baseline and after the treatment of nalbuphine in the 5-MeODMT(1.25mg/kg/IP) induced suppression of spontaneous alternation behaviour. We indentified that the opioid kappa agonist that act as dopamine release inhibitor affect the spontaneous alternation behaviour which is an animal model of obsessive-compulsive disorder in rat.
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이상화의 「나의 침실로」, 「빼앗긴 들에도 봄은 오는가」 해석의 제문제
이기철(Lee Gi-Chul) 한국시학회 2002 한국시학연구 Vol.- No.6
the problem of interpretation of Lee sangwhoa poems “to my bedroom” “what spring comes wrenched a field” is extrinsic approach and intrinsic approach, two method. 1. method of extrinsic approach 1) selected korean poems 1920th and other poem book is the great part is defective on ‘textual decision’ 2) second problem is which year published “to my bed room” is 1918 or 1923? belong to my opinion , the work is writing 1918. 3) the third problem is too detective on textual decision of “what spring come wrenched a field”. and an omission of sixth stanza 2. method of Intrinsic approach 1) the problem of interpretation of important thesis of “to my bed room”, for example, “mokguji” “pearls of inherited with eyes” “bed room” “bed room is a cave of rebirth” etc. 2) the problem about “what spring come wrenched a field” write leaving spaces between words and punctuation marks etc. 3) but whole interpretation or critic of value is surpass work of 1920th korean resistance poems.
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이기철 ( Gi Chul Yi ),이재원 ( Jae Won Lee ),김용석 ( Yong Suk Kim ) 한국지리정보학회 2010 한국지리정보학회지 Vol.13 No.1
This study was carried out to find out the way to build a comprehensive wetland ecosystem database using the technique of remote sensing and Geographic Information System. A Landsat TM image (taken in Oct. 30, 2002), Kompsat-2 images (Jan. 17, 2008 & Nov. 20, 2008), LiDAR(Mar. 1, 2009) were used for the primary source for the image analysis. Field surveys were conducted March to August of 2009 to help image analysis and examine the results. An actual wetland vegetation map was created based on the field survey. Satellite images were analyzed by unsupervised and supervised classification methods and finally categorized into such classes as Phragmites australis community, mixed community, sand beach, Scirpus planiculmis community and non-vegetation intertidal area. The map of wetland productivity was developed based on the productivity of Phragmites australis and the relationship to the proximity of adjacent water bodies. The developed 3 dimensional wetland map showed such several potential applications as flood inundation, birds flyway viewsheds and benthos distribution. Considering these results, we concluded that it is possible to use the remote sensing and GIS techniques for producing wetland ecosystem spatial database and these techniques are very effective for the development of the national wetland inventory in Korea.
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정신과에 의뢰된 내과계 환자들에 대한 치료적 접근 -환자에 대한 평가와 이해 -
이정호,이기철,Lee, Jung-Ho,Lee, Gi-Chul 한국정신신체의학회 1993 정신신체의학 Vol.1 No.1
To understand and evaluate the patients who were referred for psychiatric consultation from medical departments, the authors reviewed the concept of disease, psychological reaction to disease, problems on psychiatric diagnosis and evaluation which were encountered at the medical ward. In addition, we reviewed what psychiatrists should do during consultation.
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