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      • KCI등재후보

        Pathophysiology of Age-Related Hearing Loss (Peripheral and Central)

        이규엽 대한청각학회 2013 Journal of Audiology & Otology Vol.17 No.2

        Age-related hearing loss (presbycusis) refers to bilaterally symmetrical hearing loss resulting from aging process. Presbycusis is a complex phenomenon characterized by audiometric threshold shift, deterioration in speech-understanding and speech-perception difficulties in noisy environments. Factors contributing to presbycusis include mitochondria DNA mutation, genetic disorders including Ahl, hypertension, diabetes, metabolic disease and other systemic diseases in the intrinsic aspects. Extrinsic factors include noise, ototoxic medication and diet. However, presbycusis may not be related to the intrinsic and extrinsic factors separately. Presbycusis affects not only the physical, cognitive and emotional activities of patients, but also their social functioning. As a result, patients’ quality of life deteriorates, compounded by various symptoms including depression, social isolation and lower self-esteem. Presbycusis is classified into six categories, as based on results of audiometric tests and temporal bone pathology, established by Schuknecht (1993): sensory, neural, metabolic or strial, cochlear conductive, mixed and indeterminate types. Among these, metabolic presbycusis is the mainstay of presbycusis types. Age-related changes also develop in the central hearing system. Functional decline of the central auditory system, caused by aging, reduces speech-understanding in noisy background and increase temporal processing deficits in gap-detection measures. This study reviews the literature on the age-related hearing loss.

      • KCI등재

        마우스 와우의 형태학적 검사방법

        이규엽 대한이비인후과학회 2011 대한이비인후과학회지 두경부외과학 Vol.54 No.7

        Hearing impairment is one of the most common sensory disorders in human. The major causes of sensorineural hearing loss are aging, noise, genetics, ototoxicity, and autoimmune. A better understanding of sensorineural hearing loss is required to understand the mechanisms by which specific causes lead to hearing impairment. The study of sensorineural hearing impairment in humans is limited by the inability to follow inner ear development and elucidate the true mechanism of hearing loss in human. Animal experiment is an essential part of research and testing in the life sciences. Because of the complicated structures of the inner ear, every morphological study is made to be appropriate for such a special tissue. Here I will outline the several morphological methods of the rodent inner ear covering such basic things including fixation, and sectioning.

      • KCI등재

        Do ecommerce firms perform better than non-ecommerce firms in Korea?

        이규엽 한국국제통상학회 2017 국제통상연구 Vol.22 No.4

        This paper describes and tests performance differences between ecommerce and non-ecommerce firms or establishments by using the 2010 Census for Korea. Although the number of ecommerce establishments makes up a small fraction of the economy, ecommerce establishments have a disproportionate weight in sales, employment, and wage. The paper finds that in manufacture ecommerce establishments have, on average, larger sales-per-worker and pay higher wage whereas in services ecommerce ones have higher sales-per- worker but pay no larger wage than their counterparts of a similar age and size in the same industry. It also adds quantile estimates showing that sales- per-worker differences between ecommerce and non-ecommerce establishments in manufacture are positive and statistically significant only at lower quantiles of the distribution. In services, sales-per-worker differences between them are positive and significant at most of distribution but turns to be negative, though not significant, at above upper quantile of the distribution.

      • KCI등재후보
      • KCI등재

        A Quantitative Trade Model with Unemployment

        이규엽 대외경제정책연구원 2019 East Asian Economic Review Vol.23 No.1

        I employ search-and-matching to a multi-country and multi-sector Ricardian model with input-output linkages, trade in intermediate goods, and sectoral heterogeneity, in order to quantify the welfare effects from tariff changes. The paper shows that labor market frictions can be a source of comparative advantage in the sense that better labor market conditions contribute to lower cost in production. Labor market frictions play a critical role in determining the probability of exporting goods to trading partners, and interact with bilateral trade share, price, expenditures, etc. Unemployment and changes in unemployment rates due to tariff reductions contribute welfare changes across countries, implying that welfare effects based on quantitative trade models with full-employment are likely to be biased. I confirm the biased welfare effects by revisiting Caliendo and Parro (2015), who conduct an analysis of the welfare effects from the NAFTA from 1993 to 2005. I show that the welfare gap between theirs and mine has a positive correlation with changes in observed unemployment rates across countries. With the constructed model, I further conduct counterfactual exercises by asking what would happen if China’s tariffs remain unchanged from 2006 to 2015. It turns out that there are mild welfare effects to trading partners in the world trading system.

      • KCI등재

        Two Cases of Acute Leukopenia Induced by Colchicine with Concurrent Immunosuppressants Use in Behçet’s Disease

        이규엽,김도영,장재용,방동식 연세대학교의과대학 2008 Yonsei medical journal Vol.49 No.1

        Colchicine-induced leukopenia usually occurrs in intentional or accidental overdoses or inappropriate use in combination with intravenous and oral colchine; however, there have been several reports of hematologic toxicity in short-term and small-dose colchicine medication courses. We present two cases of leukopenia induced by colchicine use concurrent with immunosuppressants in Behçet's disease. We postulate that the mechanism of colchicine-induced leukopenia might be the destruction of circulating leukocytes and an inhibition of leukocyte production by the immediate and direct toxic effect of colchicine on idiosyncrasies unique to each patient. The concurrently administered immunosuppressant might decrease the threshold for hematologic toxicity of colchicine in the leukocytes and their precursor cells.

      • 디지털 전환 시대의 디지털 통상정책 연구

        이규엽,최원석,박지현,엄주현,강민지,황운중 대외경제정책연구원 2022 정책연구 브리핑 Vol.2022 No.-

        ▶ 이 보고서의 목적은 중장기 디지털 통상정책의 방향과 주요 정책과제 제시임. - 디지털 무역과 디지털 무역장벽, 글로벌 디지털 통상규범의 제정 추이, 한국의 디지털 통상정책 추이와 쟁점, 한국의 디지털 통상정책에 대한 평가 등 ▶ 디지털 무역의 현황과 효과를 분석하고 국내기업의 디지털 무역장벽 실태를 조사함. - 기관 자료를 결합하여 한국의 온라인 서비스 수출 규모(하한값) 추정 - 전자상거래 여부에 따른 국내기업의 일인당 매출액 성장률 차이 추정 - 무작위 추출 디지털 무역장벽 실태 설문조사(업체 1,029곳 응답)를 통해 무역원활화, 디지털 상품, 데이터 규제 관련된 국내 전자상거래 수출기업의 애로사항 식별 ▶ WTO 전자상거래 협상 논의와 양자ㆍ지역 FTA 디지털 통상규범 제정 추이 검토 - [WTO] 데이터 관련 조항에서 쟁점이 부상함에 따라 당분간 협상이 지속될 전망 - [FTA] 강한 의무 조항으로 묶인 데이터 관련 조항이 포함된 무역협정 체결 빈도 증가 ▶ 한국의 디지털 통상정책을 살펴보고 국내 데이터 규제와 정책의 내용과 쟁점 점검 - 디지털 통상정책과 디지털 경제정책의 연계성을 강화할 필요가 있으며, 개인정보보호 관련 국내법이나 추진 정책의 주요 내용에 따라 쟁점이 부상함을 확인함. ▶ 한국의 디지털 통상정책 평가, 중장기 디지털 통상정책의 방향과 주요 정책과제 제시 - 국제 지표로 살펴본 한국의 디지털 통상환경은 중위권 수준으로 평가됨. - 기업과 소비자에 이롭고 성장을 촉진하기 위해 개방과 규칙에 기반을 둔 중장기 디지털 통상정책을 추진해 나가야 함. - 자체 평가 기준(통계와 실증 기반, 적극성과 선제성, 디지털 전환 촉진형, 추진체계의 효과성, 비전과 정책 방향)을 기초로 문제점을 식별하고 주요 정책과제 제시

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