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고혈압 환자에서 24 시간 활동 혈압과 좌심실비대와의 상관관계에 대한 연구
김상욱(Sang Wook Kim),유재격(Jae Kyuk Rhoo),김현대(Hyun Dae Kim),이은우(Eun Woo Lee),이성윤(Sung Yun Lee),박승호(Seung Ho Park),류왕성(Wang Seong Ryu),유언호(Un Ho Ryoo) 대한내과학회 1993 대한내과학회지 Vol.45 No.1
Background: 24-hour noninvasive ambulatory blood pressure monitoring (ABPM) has been shown to be superior to casual BP in predicting target organ involvement in patients with hypertension and assessing anti-hypertensive therapy. This study was done to examine the relation of BP decline from day to night to the echocardiographic parameters of left ventricular anatomy in unselected hypertensive patients and normotensive subjects undergoing 24-hour noninvasive ABPM. Methods: The effect of variation of blood pressure on the echocardiographic parameters of left ventricular hypertrophy were investigated in 71 consecutive subjects. (47 patients with essential hypertension and 24 healthy normotensive subjects). 24-hour noninvasive ambulatory blood pressure monitoring and cross-sectional and M-mode echocardiography were done to examine the relation between ABPM and echocardiographic LVH. Results: 24-hour ambulatory blood pressure was lower than casual blood pressure, and weak relation was noted particularly in patients with mild-to-moderate hypertension. The continuous monitoring of BP throughout day shows characteristic circadian pattern. The highest BP was recorded at 10 am and lowest value was at 2 am-4 am. Ambulatory daytime blood pressure (6 am-8pm) was higher 15% than night-time blood pressure (8 pm-6 am), The correlation coefficient of daytime systolic blood pressure was r=0.42 (p<0.01), twenty-four hours systolic BP was r=0.41 (p<0.05). The daytime and 24 hours systolic BP seems to be more closely related to LVH than night-time BP, but the correlation was not high enough in our study. Conclusion: 24-hour ambulatory blood pressure monitoring is more useful than casual BP in patients with hypertension, and LVH in echocardiography is more closely related to daytime and 24 hours systolic BP than night-time BP.
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김경만,김치정,유언호,곽미향,유왕성,박종택 한국지질학회 1996 韓國脂質學會誌 Vol.6 No.2
This study was conducted to evaluate the property of lipoprotein(a)[Lp(a)] as an acute phase reactant. Lp(a) consists of low density lipoprotein and apolipoprotein(a), specific glycoprotein. It is generally accepted that high concentration Lp(a) is an independent risk factor for cardiovascular disease. However, Lp(a) level cannot be lowered by nonpharmacologic and pharmacologic methods for hyperlipidemia. Although Lp(a) is thought to be an acute phase reactant, there is still controversy. A total 22 premenopausal women who underwent transabdominal hysterectomy with/without unilateral salphingoophorectomy were enrolled. Lp(a) and lipid profiles were measured before, at 1 week and at 1 month after operation. In contrast to other lipids, Lp(a) concentration was elevated by 96.7% from 18.1±2.6 ㎎/dL to 35.6±27.1 ㎎/dL at 1 week after operation. At 1 month, the concentration returned to basal level. Low density lipoprotein cholesterol was lowered only by 11.2%, and total cholesterol and high density lipoprotein cholesterol decreased after operation. In conclusion, Lp(a) is thought to be an acute phase reactant and this property might be involved in the pathogenesis of atherosclerosis.
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고콜레스테롤 식이가 Spontaneously Hypertensive Rat의 체내지질과 항산화성 영양소 상태에 미치는 영향
유언호 ( Yu Eon Ho ),류왕성 ( Lyu Wang Seong ),김현대 ( Kim Hyeon Dae ),유재격 ( Yu Jae Gyeog ),최영선 ( Choe Yeong Seon ),이희숙 ( Lee Hui Sug ),조성희 ( Jo Seong Hui ) 대한내과학회 1993 대한내과학회지 Vol.44 No.5
Backgrounds: Hypertension and hypercholesterolemia are two of the most important risk factors for atherosclerosis and cardiovascular morbidity. The mechanism by which hypertension and hypercholesterolemia accelerates atherosclerosis is still uncertain. Methods: To investigate the effect of high cholesterol diet on lipid and antioxidant nutritent status in spontaneously hypertensive rat (SHR), SHRs and Wistar rats were fed diets with or without 2% cholesterol and 0.3% Na-taurocholate for 6 months. Results: SHRs became apparently hypertensive after 2 months of feedings, when their systolic pressure was over 180 mmHg. Heart weight-to-body weight ratios of SHRs were significantly higher than those of Wistar rats. Levels of serum total cholesterol were increased about two-folds and those of liver, ten-folds in both SHRs and Wistar rats by dietary cholesterol. Serum HDL-cholesterol of SHRs were significantly lower than those of Wistar rats and HDL·/total cholesterol. Serum TG levels were not changed, but liver levels increased by dietary cholesterol and lower in SHRs. Serum TBARS levels were higher in SHRs, but little changed by dietary cholesterol. Liver levels appeared to be higher in SHRs and cholesterol groups. Serum and liver vitamin E levels were lower in SHR. Serum vitamin A levels were little changed, but liver contents were somewhat decreased in SHRs and remarkably reduced by dietary cholesterol. Conclusions: It is concluded that hypertension and hypercholesterolemia, individually, result in accumulation of lipid peroxide as well as consumption of body tocopherol and retinol, which can be further augmented by coexistence of two abnormal conditions.
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