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시분할 직교 호모다인 검출을 이용한 연속변수 양자암호키분배
오준상,임경천,이준구 한국통신학회 2021 韓國通信學會論文誌 Vol.46 No.5
In the continuous-variable quantum key distribution (CVQKD) system, quadrature homodyne detection (QHD) can increase the secret key rate compared to the conventional homodyne detection (HD). Our new scheme of time-division quadrature homodyne detection (TDQHD) enables simultaneous detection of two quadratures with only one single homodyne interferometer in a time-division manner, unlike conventional QHD. In addition, in implementing the actual system, the need for a random phase modulation used for selection of the detection quadrature in the HD is eliminated, and hence practically the TDQHD can be implemented polarization independent, eliminating the impairment caused by polarization drifts in the fiber transmission system. 연속변수 양자암호키분배 (continuous-variable quantum key distribution, CVQKD) 시스템에서, 편광 분할을 이용한 기존 직교 호모다인 검출 (quadrature homodyne detection, QHD) 시스템은 기존의 호모다인 검출(homodyne detection, HD) 방식 대비 비밀키 생성률을 높일 수 있다. 우리가 제안한 시분할 직교 호모다인 검출(time-division quadrature homodyne detection, TDQHD) 시스템은 두 개의 호모다인 간섭계로 직교 호모다인 검출을 하는 기존 방식과 달리, 시분할 방식을 도입하여 하나의 호모다인 간섭계만으로 동시에 두 개의 직교하는 기저에 대한 양자 연속변수 검출을 가능하게 한다. 이 방식은 직교 호모다인 검출과 동일하게 기존 호모다인보다 향상된 비밀키 생성률을 얻을 수 있게 한다. 추가로 실제 시스템 구현에 있어, 기존 호모다인 검출에서 검출 기저선택을 위해 사용하는 임의의 위상 변조가 필요 없으며, 수신부를 편광에 독립적으로 구현할 수 있어 광섬유의 편광 흔들림에 의한 영향이 해소된다.
오준상,Deok-Hyo Yoon,Bhushan Shrestha,Hyung-Kyoon CHOI,Gi-Ho Sung 한국미생물학회 2019 The journal of microbiology Vol.57 No.1
Cordyceps militaris is a species of Cordyceps that is classified in the Cordycipitaceae family and is well known in East Asia as a traditional medicinal mushroom. Its artificial fruit body has been widely cultivated for commercial use in cosmetics, functional food, and medicine. To explore the metabolites associated with fruit body development, we conducted gas chromatography mass spectrometry (GC-MS) analyses based on developmental stage, which was divided into the growth period (stage 1, stage 2, and stage 3) and aging period (stage 4). We detected 39 biochemical metabolites associated with nucleotide, carbohydrate, and amino acid metabolism. Cordycepin, one of the representative bioactive compounds in C. militaris, was significantly enriched in stage 4 of aging period and is associated with glucose accumulation. The accumulation of cordycepin in stage 4 of aging period also seems to be related to the glutamine and glutamic acid pathway. Our results also showed enrichment of other bioactive compounds such as mannitol and xylitol in stage 4 of aging period. Our metabolomic profiling based on the developmental stages of C. militaris is useful for exploring bioactive compounds (e.g., cordycepin, mannitol, GABA, and xylitol) that are enriched in stage 4 of aging period and understanding the biosynthetic mechanisms associated with cordycepin production. Through optimization of fruit body cultivation by selecting stage 4 of aging period as a harvesting time, our findings can be utilized in food and medical applications of C. militaris in future.
오준상 ( Junsang Oh ),한상국 ( Sang-kuk Han ),부산쓰레스타 ( Bhushan Shrestha ),성기호 ( Gi-ho Sung ),성재모 ( Jae-mo Sung ) 한국자연치유학회 2019 Journal of Naturopathy Vol.8 No.2
목적: 매미에 기생하는 동충하초를 1990 년부터 2016년까지 매년 7월부터 10월까지 주로 한국에서 수집하고 분류하는 것이 목적이었다. 그러나 네팔, 베트남, 일본, 중국, 태국에서 자주 채집을 하였다. 방법: 매미에 기주로 한 동충하초를 산에서 채집하였다. 결과: 9개 속과 10개 종에 속하는 총 1,104개의 표본이 수집하였다. 가장 많은 수의 표본은 Ophiocordyceps (563개)이었고, 이어서 Isaria (361개), Polycephalomyces (73개), Cordyceps (70개), Beauveria (25개), Perennicordyceps (8개), Metarhizium (2개) 그리고 Purpureocillium (2개)이었다. Ophiocordyceps종 중. O. longissima는 563개 중에 총 426개의 표본으로 가장 많이 수집되었으며, 120개가 수집된 O. heteropoda와 17개의 표본이 있는 O. sobolifera이었다. 주로 한국에서 채집되었지만 C. ishikariensis는 네팔에서만 채집되었다. 새로운 특징은 Isaria cicada-like synnemata가 같은 숙주에서 C. ishikariensis stromata와 함께 자라는 것을 발견했다. 한국에서는 1,104개 중 총 691개의 표본이 제주도 한라산에서 발견되었다. 표본을 수집한 한국의 다른 산들은 대룡, 용문, 삼악, 설악, 구절, 두륜, 백암, 칠갑, 청등, 내장, 월출, 지리, 대룡산 등 이었다. 채집한 샘풀 중에서 3개는 미확정되었다. 결론: 총 1,104개의 표본은 9개의 속(genus), 10종류의 종(species)으로 분류되었고, 수집된 691개의 샘풀은 제주도 한라산에서 채집되었다. Purpose: The aim was to collect and classify the Cordyceps parasitized in cicadas from July to October every year from 1990 to 2016 in Korea. And they were frequently collected in Nepal, Vietnam, Japan, China, and Thailand. Methods: Cordyceps parasitizing cicadas collected in mountains and fields. Results: A total of 1,104 specimens were collected that belonged to 10 different species under nine genera. The highest number of samples belonged to Ophiocordyceps (563 specimens), followed by Isaria (361 specimens), Polycephalomyces (73 specimens), Cordyceps (70 specimens), Beauveria (25 specimens), Perennicordyceps (8 specimens), Metarhizium (2 specimens) and Purpureocillium(2 ones). Among Ophiocordyceps spp. O. longissima was most frequently collected with a total of 426 samples out of 563, followed by O. heteropoda with 120 ones and O. sobolifera with 17 specimens. The species mainly collected in Korea, but C. ishikariensis was collected in Nepal only. The new characteristic was that Isaria cicada-like synnemata were found growing together with C. ishikariensis stromata on the same host. In Korea, the collected 691 specimens in total out of 1,104 were found in Mt. Halla in Jeju Island. Other mountains in Korea where the samples were collected were Mountains Daeryong, Jiri, Yongmoon, Samag, Seolag, Gujeol, Duryun, Baegam, Chilgap, Chundeung, Naejang, Welchul, and Daeryong. The three samples were not identified. Conclusions: A total of 1,104 specimens belonged to 10 different species under nine genera, and the collected 691 samples were found in Mt. Halla in Jeju Island.
Efficient Utilization of Korean Medical Fungal Pathogen Resource Bank for Clinical Research
김자영,오준상,성기호,이혜영,최지선,이상헌,김민범,최선영 대한의진균학회 2019 대한의진균학회지 Vol.24 No.3
A "pathogen resource" contains information about pathogens (e.g., bacteria, fungi, viruses, and protozoa) and microbial derivatives (e.g., DNA, RNA, plasmid, clone, and cDNA). Pathogen resources are important for their potential use in healthcare research because they contain clinical and epidemiological information that is different from microbial resources. In October 2014, the "Nagoya Protocol" on access and benefit-sharing with the Convention on Biological Diversity was enacted to restrict the movement of transboundary pathogens and protect the natural pathogen resources of each country. On July 2017, the Korean Medical Fungal Pathogen Resource Bank (KMFRB) was established to secure, discover, and develop biological resources focused on medical fungi. KMFRB has since been operating under the National Culture Collection for Pathogens of the National Institute of Health based on the Act No. 13992. This report aims to provide general information regarding KMFRB and suggest efficient ways to utilize human fungal pathogen resources for clinical research.
김다연,김소현,안혜민,임사랑,오준상,최슬기,이홍진,어중혁,최형균 한국응용생명화학회 2015 Applied Biological Chemistry (Appl Biol Chem) Vol.58 No.1
Highbush blueberries (Vaccinium corymbosumL.) are cultivated worldwide for their fruit with unique tasteand potential health benefits. Blueray, Bluecrop, and Spartanare prominent among the various blueberry cultivars. Weperformed gas chromatography–mass spectrometry (GC–MS)-based metabolic profiling to differentiate the fruits ofthese three cultivars, and built an optimal partial leastsquares-discriminant analysis (PLS-DA) model to separatethem. Amino acids, fatty acids, organic acids, phenoliccompounds, and sugars were identified in the fruits. Theoptimized PLS-DA model for different cultivars of the fruitswas obtained by selecting variables based on a variable importancein the projection (VIP) cut-off value of 1.0. Caffeicacid, aspartic acid, acetic acid, threonolactone, inositol, xylose,glucoside, linolenic acid, mannose, altrose, glycinealanine, and valine were found to be relevant and contributingcompounds for differentiating cultivars. In addition, ahierarchical cluster analyses dendrogram pattern was correlatedwith the PLS-DA. This study suggested that GC–MSbasedmetabolic profiling coupled with multivariatestatistical analysis could be used to differentiate the fruits ofthree major highbush blueberry cultivars.