인삼과 진세노사이드의 항비만 효과에 대한 문헌 고찰

최문지,안진표,김애정,이명숙,Choi, Munji,An, Jinpyo,Kim, Ae Jung,Lee, Myoungsook The East Asian Society of Dietary Life 2014 동아시아식생활학회지 Vol.24 No.3

Compared to the large numbers of studies on the diabetes, hyperlipidemia and cancer therpeutic effects of ginseng, the anti-obese effect and mechanisms of ginsengs have not been studied as much. To determine the effects of ginseng on obesity, 14 keywords (ginseng, ginsenoside, obesity, weight, fat, diet, overeat, appetite, lipid, 3T3-L1, adipocyte, food intake, adipogenesis and lipolysis) were combined in searching a database. Fifty-six articles published from 1983 to 2012 as well as 656 patents registered until Aug $17^{th}$, 2012, were screened for anti-obese effects of ginseng. In the classification of experimental methods, 16 papers on 3T3-L1 cells, 38 papers on animals and three papers on human were reviewed. In terms of obese mechanisms of action, the most commonly used biomarkers were in order of lipid profiles > weight change > blood glucose > adipocytokine. Most ginseng studies on obesity focused on AMPK, $PPAR{\gamma}$, GLUT-4, PI3K and SREBP-1. Korean white ginseng extracts and Re repressed the lipogenesis genes such as PPARc2, SREBP-1c, LPL, FAS and DGAT1. However, ginseng or ginsenosides, PD (Rb1) and PT (Re), showed different or contradictory results. Water and ethanol extraction of ginseng showed contradictory effects on the secretion of inflammatory cytokines, wheras IL-6 was repressed by ethanol extracts and TNF-${\alpha}$ repressed by Re in vitro. Based on the literature, further studies on anti-obese mechanisms of ginseng, such as the inflammation-related obesity or cross signals between the adipocytes and the environments, are needed, instead of more studies on its hypolipidemic and hypoglycemic effects.

뽕잎(leaf of Morus alba)분말의 섭취가 고지방 식이를 섭취한 흰 쥐의 지질저하 및 항산화 효과에 미치는 영향

유승혜,안성희,복민아,김은정,장연,위해리,최세림,안진표,이명숙 誠信女子大學校 生活文化硏究所 2012 生活文化硏究 Vol.26 No.2

People are increasingly becoming interested in the power of phytochemicals to decrease the risk of cardiovascular diseases, because cardiovascular diseases are one of the leading causes of death. Morus alba leaves containing dietary fiber and rutin are said to lower cholesterol and triglyceride levels and to have antioxidant effects. This study investigates the effects of Morus alba leaves on lipid metabolism and antioxidant functions. Male Sprague-Dawley rats were divided into four groups randomly and put on the following diets for six weeks: normal (control), high fat (HF), high fat with 10% Morus alba leaves (B10), high fat with 15% Morus alba leaves (B15). Food efficiency ratio (FER) and weight gain were not decreased. However, food intakes were significantly increased (p=0.000). Total serum cholesterol in the B15 group was reduced by 5%, a higher percentage than that of the HF group and serum triglyceride in the B10 group was reduced by 53%, a higher percentage than that of the HF group. Liver cholesterol in the B15 group was reduced by 40%, a higher percentage than that of the HF group. Liver cholesterol levels in the B10 and B15 groups were reduced by 21% and 54% respectively, higher percentages than those of the HF group. In addition, the total cholesterol level of epididymal fat pads in the B15 and B10 groups was reduced by 44%, 57% lower than that of the HF group. The triglyceride level in the B10 group was decreased by 63% more than that of the HF group. ALT and AST activities, indicators of liver damage, were not increased. The SOD level did not change but TBARS differed between groups. These results indicate that Morus alba leaves have significant effects on the lipid metabolism of serum, liver and epididymis.

Anti-Obese Effects of Ginseng/Ginsenosides

Munji Choi(최문지),Jinpyo An(안진표),Ae Jung Kim(김애정),Myoungsook Lee(이명숙) 동아시아식생활학회 2014 동아시아식생활학회지 Vol.24 No.3

Humulus japonicus attenuates LPS-and scopolamine-induced cognitive impairment in mice

고준,박혜연,이다운,Maeng So-Young,이인복,서윤정,안진표,오원근,이철호,김경심 한국실험동물학회 2022 Laboratory Animal Research Vol.38 No.3

Background: Neuroinflammation plays an important role in cognitive decline and memory impairment in neurodegenerative disorders. Previously, we demonstrated that Humulus japonicus (HJ) has anti-inflammatory effects in rodent models of Alzheimer’s disease and Parkinson’s disease. The present study aimed to examine the protective potential of HJ extracts against lipopolysaccharide (LPS)-induced cognitive impairment and scopolamine-induced amnesia in mouse models. Cognitive improvement of mice was investigated by novel object recognition test. For analyzing effects on neuroinflammation, immunohistochemistry and quantitative real-time polymerase chain reaction (qRTPCR) assays were performed. Results: We found that the oral administration of HJ significantly improved cognitive dysfunction induced by LPS in a novel object recognition test. The LPS-induced activation of microglia was notably decreased by HJ treatment in the cortex and hippocampus. HJ administration with LPS also significantly increased the mRNA expression of interleukin (IL)-10 and decreased the mRNA expression of IL-12 in the parietal cortex of mice. The increased expression of LPS-induced complement C1q B chain (C1bq) and triggering receptor expressed on myeloid cells 2 (Trem2) genes was significantly suppressed by HJ treatment. In addition, HJ administration significantly improved novel object recognition in a scopolamine-induced amnesia mouse model. Conclusions: These findings revealed that HJ has a beneficial effect on cognitive impairment and neuroinflammation induced by systemic inflammation and on amnesia induced by scopolamine in mice.

고지방 식이를 섭취한 흰쥐에서 마테의(Ilex praguariensis) 중성지방과 콜레스테롤 저하 효과

박지연,안희정,정주현,변정은,이해진,장원원,위해리,최세림,안진표,이명숙 誠信女子大學校 生活文化硏究所 2012 生活文化硏究 Vol.26 No.2

With obesity caused by high fat intake having various adverse effects on people of today's society, the aim of this study is to examine the lowering effect of proportional mate intake on tissue triglyceride and cholesterol levels. Mate, binomial name Ilex paraguariensis, is a species of holly (family Aquifoliaceae), well-known as the source of the mate beverage, which is native to subtropical South America. Five-week-old male Sprague-Dawleys weighing about 200g were used for this experiment. These rats were fed on a diet mixed with 60% fat and instant Mate powder in market circulation. They were divided into four groups, with the control group on a normal diet (n=6), a group on a high fat diet (HFD) (n=6), a group on a high fat diet containing 2% mate powder (MT2) (n=6), and the last group on a high fat diet containing 4% mate powder (MT4) (n=6). The food efficiency ratio made no difference in the MT2 group compared to the HFD group. With the intake of mate powder, serum and tissue triglycerides were decreased in the MT2 group. Especially notable was the fall of triglyceride levels in the liver in the MT2 group by roughly 60%, compared to those of the HFD group. Cholesterol levels in epididymal fat pads were sig-nificantly decreased - by 60% - in the MT4 group compared to those of the HFD group. Also, as a result of DPPH(1,1-Diphenyl-2-picrylhydrazyl) assay, the anti-oxidant activity of Mate powder showed a similar level to that of vitamin E. These findings indicate that triglyceride and cholesterol levels in liver and epididymal fat pads are decreased by the intake of Mate powder. That the dose of Mate powder in the MT4 group had a signifiant effect means that Mate may be capable of interfering in triglyceride and cholesterol levels.

학생 중심으로 UI 를 개선한 기숙사 웹 서비스

유재영(Jaeyoung Yu),문동민(Dongmin Moon),박근원(Geunwon Park),손준호(Junho Shon),안진표(Jinpyo Ahn),이서윤(Seoyun Lee),박현주(Hyunju Park),김승민(Seungmin Kim) 한국HCI학회 2024 한국HCI학회 학술대회 Vol.2024 No.1

대학교에서 제공하는 다양한 웹 서비스들은 학생들에게 정보를 제공하는 창구의 역할을 하고 있다. 하지만 일부 서비스는 사용자인 학생의 상황을 고려하지 않고 서비스 하는 것으로 파악된다. 본 논문은 기존의 웹 서비스를 사용자인 학생 중심으로 개선한 과정을 고찰한다.