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안정우(Jung Woo Ahn),한창우(Chang Woo Han),최보율(Bo Yul Choi),김유미(Yu Mi Kim),남정현(Jung Hyun Nam),최준호(Joonho Choi),김석현(Seok Hyeon Kim) 대한스트레스학회 2008 스트레스硏究 Vol.16 No.3
목적: 이 연구의 목적은 우울증 진단을 받지 않은 일반 인구 집단에서 심박변이도(heart rate variability, HRV)와 우울증과의 연관성을 조사하여 우울증상에 따른 일반 인구 집단에서도 HRV의 변화가 있는지를 알아보는데 있다. 방법:경기도 소재 ○○군의 주민 중 건강증진 프로그램에 참가한 155명을 대상으로 하였다. 이중 HRV에 영향을 줄 수 있는 신체 질환을 가진 58명과 Beck’s depression inventory (BDI) 작성을 못한 2명을 배제한 95명의 short term electrode HRV를 측정하였고 BDI를 이용하여 우울증상을 조사하였다. 이들을 대상으로 HRV와 BDI 간의 연관성을 통계적으로 분석하였다. 결과: BDI와 HRV의 지표들 중 SDNN (standard deviation of the normal to normal interval), TP (total power), HF (high frequency), LF (low frequency), VLF (very low frequency), pNN50 (전체 normal to normal interval들 중 연속된 Normal to Normal Interval들의 변이가 50 ms 이상인 간격들의 비)이 유의하게 음의 상관관계를 가진 것으로 나타났으며 이 중 LF, HF, RMSSD (the square root of the mean squared differences of successive normal to normal intervals)는 BDI값을 이용하여 우울증을 중증 정도로 구분했을 때 유의하게 차이가 있었다. 결론: HRV의 일부 지표는 일반 인구에서 잠재성의 우울 증상의 정도를 측정할 수 있었다. Purpose: The purpose of this study is to investigate relationship between HRV (heart rate variability) and depressive symptoms in general population. This study was designed to examine the correlation of HRV and depressive symptom in general rural population. Methods: In 155 participants lived in the anonymous rural area of Gyeonggi-do, Korea, they participated in health promotion program with short term electrode HRV test and BDI (Beck’s depression inventory) self-report. Two participants were excluded due to fail to make out BDI and 58 participants were excluded because of some kinds of heart problems which were found after electrocardiogram and echocardiography exam of the health promotion program. We analyze HRV and BDI of remaining 95 subjects. Results: Our results showed that SDNN (standard deviation of the normal to normal interval), total power (TP), low frequency (LF), high frequency (HF) had negative correlation with BDI score, but only pNN50 (the proportion derived by dividing the number of interval differences of successive normal to normal intervals greater than 50 ms by the total number of normal to normal intervals) had positive correlation with BDI score. Also HF, LF and RMSSD (the square root of the mean squared differences of successive normal to normal intervals) are decreased by BDI severity grades increasing. Conclusion: In this findings of our study, some HRV variables seem to reflect subclinical depressive symptom severity in general rural population.
안정우,서지원,Ahn Jung-Woo,Seo Ji-Weon 한국반도체디스플레이기술학회 2005 반도체디스플레이기술학회지 Vol.4 No.4
This article contains the development of FPC bonder that used for repair or trial product. Nowadays, in FPO module process (including PDP) accept the thermo-compress bonding method when attach FPC(Flexible Printed Circuit Board), TCP(Tape Carrier Package) and COF(Chip on the FPC) by ACF(Anisotropic Conductive Film). This system consists of ACF attachment part, pre-bonding part, main bonding part, loading / unloading part. This composition is a stand-alone system, not an in-line system. Hereafter, this composition should be developing into in-line system in all area of FPD industry.
안송이(Song Ih Ahn),홍정우(Jung Woo Hong),신현정(Jennifer H. Shin) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.10
Sphingosylphosphoryl choline (SPC) is a bioreactive lipid, present in abnormally high concentrations in pancreatic cancer patients. SPC is known to facilitate cancer metastasis by altering cytokeratin network, enhancing cell migration. In this study we investigated the effects of SPC on cell migration behavior, focusing on the major players in cell migration, actin cytoskeleton structure and cell traction force rather than cytokeratin network. From our preliminary tests of immunofluorescence analysis and traction force microscopy, treatment of SPC induced higher expression of lamellipodia and lower traction force, respectively. These results concur to the fact that SPC enhances cell migration, since motile cells are known to actively express lamellipodia and form weak bindings to the substrate. We suggest that SPC stimulation in pancreatic cancer cells would enhance cell migration by modulating cellular traction force and actin cytoskeletal network, which in turn facilitates metastasis.
윤유식,김선형,최선미,문진석,강동근,김영,안영복,이종철,정우진,Yoon, Yoo-Sik,Kim, Sun-Hyoung,Choi, Sun-Mi,Moon, Jin-Seok,Kang, Dong-Kun,Kim, Young,Ahn, Young-Bok,Lee, Jong-Cheol,Jung, Woo-Jin 한국한의학연구원 2003 한국한의학연구원논문집 Vol.9 No.2
The goal of this study is construction and efficacy evaluation of MPC-25 (Magnetic Pain Control-25), a medical device using magnetic stimulation. MPC-25 consists of a main body containing power supply and control module and a bed containing magnetic core and coil. In distinction from electric pain control medical devices, magnetic pain control system is non-contact, so the patients need not take off their clothes to be treated. High amplitude current pulses are applied to a magnetic coil and induce time varying magnetic field generating eddy current in a conductor like human body. Clinical efficacy test was performed in patients suffering from musculoskeletal pain of lumbar, shoulder and joint. Degree of pain before and after treatment for 30 minutes was compared using Visual Analogous Scale. As a result, 14 cases out of 20 showed decreased pain perception, so the rate of efficacy is 70%. Reduction of pain perception was statistically significant (P=0.001 by Wilcoxon Signed Rank Test).
부신, 폐전이를 동반한 거대 간세포암 환자에서 경동맥 화학색전술, 방사선 치료, sorafenib을 병합하여 간내암과 부신전이의 완전관해를 경험한 1예
황상연 ( Sang Youn Hwang ),이선미 ( Seon-mi Lee ),임정우 ( Jung Woo Im ),김준석 ( Joon Suk Kim ),안상부 ( Sang Bu Ahn,),지은경 ( Eun Kyeong Ji ),최철원 ( Chul Won Choi ),양광모 ( Gwang-mo Yang ) 대한간암학회 2013 대한간암학회지 Vol.13 No.1
Extrahepatic metastasis (EHM) associated with hepatocellular carcinoma (HCC) has been increasing due to prolonged survival with recent advances in therapeutic approaches including locoregional therapy such as transarterial chemoemoblization (TACE), radiofrequency ablation and radiation therapy (RT). Though many guidelines recommended systemic therapy such as sorafenib in this situation, some clinicians or centers still select locoregional therapy because the survival improvement of 2 or 3 months by sorafenib is far from optimal. Moreover, some studies showed that complete and partial response of intrahepatic tumors can result in significant improvement of patient survival even in situation of EHM. Based on above suggestions, we herein offer our experience of a patient with complete remission of intrahepatic tumor and adrenal gland metastasis treated with combination therapy of TACE and RT and sorafenib. Further study, maybe regarding a combination of locoregional and systemic therapy (so called multidisciplinary approach), is necessary on how to manage HCC patients with EHM.
동정맥 단락을 동반한 4.8 cm의 침윤성 간세포암에서 정위체부방사선치료와 경동맥화학색전술로 종양의 완전관해를 경험한 1예
황상연 ( Sang Youn Hwang ),이선미 ( Seon Mi Lee ),임정우 ( Jung Woo Im ),김준석 ( Joon Suk Kim ),전기정 ( Ki Jeong Jeon ),안상부 ( Sang Bu Ahn ),지은경 ( Eun Kyeong Ji ),강현철 ( Hyun Cheol Kang ),최철원 ( Cheol Won Choi ),양광모 대한간암학회 2015 대한간암학회지 Vol.15 No.1
Infiltrative hepatocellular carcinoma (HCC) patients have a poor prognosis because most patients present with advanced disease. Although tumor size is small, ablation therapy is difficult because it is difficult to delineate tumor boundary and tumor often combined vascular invasion. Therefore many clinicians still try locoregional therapy (LRT) such as transarterial chemoembolization (TACE), radiation therapy (RT), or combination with LRT and sorafenib in this situation. Stereotactic body radiation therapy (SBRT) is new technology providing very highly conformal ablative radiation dose and is expected to salvage modality for HCC showed incomplete response of TACE due to combined arteriovenous (AV) shunts. Based on above suggestions, we herein offer our experience of a complete remission of tumor by combination of SBRT and TACE in a patient with infiltrative HCC. Further study, maybe regarding a combination of locoregional and systemic therapy is necessary on how to manage infiltrative HCC with AV shunts. (Journal of Liver Cancer 2015;15:64-69)
다발성 전이를 동반한 고령의 간세포암 환자에서 경동맥방사선색전술과 반복적 경동맥화학색전술로 간내암과 다발성 전이의 부분관해를 이룬 증례
황상연 ( Sang Youn Hwang ),이선미 ( Seon-mi Lee ),임정우 ( Jung Woo Im ),전기정 ( Ki Jeong Jeon ),안상부 ( Sang Bu Ahn ),박진영 ( Jin-young Park ) 대한간암학회 2018 대한간암학회지 Vol.18 No.2
The number of older adults with hepatocelluar carcinoma (HCC) has been increasing with longer life expectancy and earlier diagnosis and treatment. However, older patients have lesser function reserve of multiple organ systems, more disability rate. Therefore, the treatment of elderly HCC patients remains a challenge worldwide. Recently, studies suggests that the survival outcome of older patients may be comparable to that of younger patients and active treatment may achieve promising rates of local and systemic control in selected patients. Based on above suggestions, we herein offer our experience of a case achieved partial remission by sequential therapy of transarterial chemoembolization after transarterial radioemoblization in elderly HCC patient with multiple metastasis. Further study, maybe regarding a combination of locoregional and systemic treatment, is necessary on how to manage HCC in elderly patients. (J Liver Cancer 2018;18:151-156)
소라페닙 치료 실패 후 소라페닙과 Tegafur 병용요법을 통해 간세포암의 완전관해를 유도한 증례 1예
황상연 ( Sang Youn Hwang ),이선미 ( Seon-mi Lee ),임정우 ( Jung Woo Im ),전기정 ( Ki Jeong Jeon ),안상부 ( Sang Bu Ahn ),박진영 ( Jin-young Park ),최철원 ( Cheol-won Choi ),양광모 ( Kwang-mo Yang ) 대한간암학회 2017 대한간암학회지 Vol.17 No.1
Sorafenib is the only approved targeted agent as the first line systemic therapy for treatment of advanced hepatocellular carcinoma (HCC). However, the improvement of survival duration under 3 months is far from clinical satisfactory and most patients experience disease progression within 6 months after sorafenib therapy. Unfortunately, second line systemic therapy after treatment failure of sorafenib was not established and there were no clear guidelines for salvage treatment modalities. Recently, studies suggests that combination of sorafenib and single cytotoxic agent can be relatively effective and safe strategy that achieves promising rates of local and systemic control in advanced HCC patients. Based on above suggestions, we herein offer our experience of a case achieved complete remission by combination therapy of sorafenib and tegafur in the patient with progressed disease after sorafenib therapy. (J Liver Cancer 2017;17:88-93)