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Immunopathology and Immunotherapy of Inflammatory Skin Diseases
송아름,이상은,김종훈 대한면역학회 2022 Immune Network Vol.22 No.1
Recently, there have been impressive advancements in understanding of the immune mechanisms underlying cutaneous inflammatory diseases. To understand these diseases on a deeper level and clarify the therapeutic targets more precisely, numerous studies including in vitro experiments, animal models, and clinical trials have been conducted. This has resulted in a paradigm shift from non-specific suppression of the immune system to selective, targeted immunotherapies. These approaches target the molecular pathways and cytokines responsible for generating inflammatory conditions and reinforcing feedback mechanisms to aggravate inflammation. Among the numerous types of skin inflammation, psoriasis and atopic dermatitis (AD) are common chronic cutaneous inflammatory diseases. Psoriasis is a IL-17–mediated disease driven by IL-23, while AD is predominantly mediated by Th2 immunity. Autoimmune bullous diseases are autoantibody-mediated blistering disorders, including pemphigus and bullous pemphigoid. Alopecia areata is an organ-specific autoimmune disease mediated by CD8+ T-cells that targets hair follicles. This review will give an updated, comprehensive summary of the pathophysiology and immune mechanisms of inflammatory skin diseases. Moreover, the therapeutic potential of current and upcoming immunotherapies will be discussed.
Clinical and Histopathological Analyses of Glomus Tumors: An Institutional Experience of 29 Cases
송아름,유대산,조미연,김종훈,노미령 대한피부과학회 2022 대한피부과학회지 Vol.60 No.8
Background: Glomus tumors are benign mesenchymal neoplasms originating from the subcutaneous glomus body. It is often described as a painful nodule accompanied by tenderness and temperature sensitivity. Objective: To analyze the clinicopathologic features of glomus tumors and determine the correlations between thecharacteristics of glomus tumors and those of the patients. Methods: We reviewed the medical records and biopsy specimens of 29 cases of glomus tumors diagnosed betweenJune 2006 and May 2021 at a single tertiary hospital. Results: The male to female ratio was 2.6:1, and the mean age of onset was 44.3 years. All cases presented witha solitary lesion, and the most common location was the fingernail (15 cases, 51.7%). Sixteen tumors (55.2%) werelocated in the digits, all of which were subungual tumors. Among these, nine tumors (56.3%) were observed in thenail bed, and seven (43.7%) were observed in the nail matrix. Thirteen patients (44.8%) had extradigital tumors. Histopathologically, 12 cases were solid glomus tumors (41.4%), 15 were glomangiomas (51.7%), and one was aglomangiomyoma (3.4%). Myxoid stromal changes were observed in nine cases (31.0%), all of which weresubungual tumors. All tumors were removed. Postoperative nail deformities were observed in eight cases (50% ofsubungual tumors). Conclusion: At our clinic, glomus tumors were commonly seen as solitary nodules accompanied by pain ortenderness. More than half of the tumors were located in the subungual area, mostly in the fingernails. Tumorremoval alleviated the symptoms in most cases, but often resulted in residual nail dystrophy.
송아름 한국극예술학회 2017 한국극예술연구 Vol.0 No.56
김경욱의 『한국 영화는 무엇을 보는가-‘국제시장’에서 생긴 일』은 대부분의 천만 영화를 포함하는 한국형 블록버스터 영화들의 흥행 전략을 살피고, 이를 바탕으로 2014년 말 개봉하여 다음 해까지 사회적 이슈가 되었던 영화 <국제시장>을 꼼꼼히 분석한 책이다. 저자는 하이콘셉트에 기대고 있는 한국형 블록버스터 영화들이 비슷비슷해지고 있으며, <국제시장>에 깔려 있는 감정의 추동력 역시 같은 선상에 있는 것으로 본다. 이러한 하이콘셉트에 기대고 있는 <국제시장>이 선택하고 가공한 역사들은 주인공의 무모한 희생과 극복에 기대어 고통스러웠던 기억들은 철저히 지우고, 지배세력의 공식기억을 강화하는 방식으로 기울어져 있다. 저자는 이처럼 <국제시장>이 다분히 승자들만의 역사관으로 채워져 있다는 점을 들어 한국현대사를 바라보는 <국제시장>의 관점을 비판한다. 즉 저자는 <국제시장>이 지닌 위험성을 분석함으로써 현재의 한국 영화가 나아가고 있는 방향에 대한 우려를 표한다. 이 책은 저자가 전작에서부터 진행시켜온 논의가 일정부분 반복된다는 아쉬움을 남기지만, 감정적 설전이 먼저였던 <국제시장>에 대해 구체적인 분석을 내놓았다는 의의가 있다.
송아름,간호섭 한국패션비즈니스학회 2018 패션 비즈니스 Vol.22 No.1
Since the 20th century, there has been a growing interest in the new concept of fractals, a combination of mathematics and art, and the attempt to study the creative spatial aspects of the concept is being made. The purpose of this research is to examine artistic characteristics of fractal dimension and then analyze the types of fractal dimensions expressed in the fashion. Previous literature on fractals and dimension, and visual data on art and fashion collected over the Internet were used for analysis. Fractal dimension refers to the spatial concept of structural dimension of geometrical self-similarity. An analysis of the types of fractals seen in fashion revealed spatial expansion, the repetition in continual figures, superposition accordant to different sizes, and shades of different shapes. The aesthetic characteristics of fractal dimension appearing in fashions were examined based on analyses of fractal dimension types; the inherent characteristics of self-similarity, superimposition, and atypicality were found. Results obtained from this study are expected to be used as basic materials for the application of the design of fractal dimension into various perspectives of fashion.