대장암 환자에서 복막 전이에 대한 복수내 암태아 항원 (Carcinoembryonic Antigen)의 진단적 가치

송성은 ( Sung Eun Song ),최바울 ( Paul Choi ),김재현 ( Jae Hyun Kim ),정경원 ( Kyoungwon Jung ),김성은 ( Sung Eun Kim ),문원 ( Won Moon ),박무인 ( Moo In Park ),박선자 ( Seun Ja Park ) 대한소화기학회 2018 대한소화기학회지 Vol.71 No.6

Background/Aims: Diagnostic tests for carcinoembryonic antigen (CEA) in ascites have been performed in various malignant cases, but there is only few data on the applicability of CEA for colorectal cancer (CRC) patients with peritoneal carcinomatosis. We aimed to determine the usefulness of CEA in ascites (aCEA) as a diagnostic parameter for CRC with peritoneal carcinomatosis. Methods: Between January 2000 and May 2013, the medical records of 259 patients who underwent paracentesis for the evaluation of ascites were retrospectively reviewed. CRC patients with ascites (n=82) and patients with non-malignant ascites (n=177) were evaluated. Patients who had other malignancies, including gastric or ovarian cancer, with ascites were excluded. The optimal diagnostic cut-off value of aCEA for CRC with peritoneal carcinomatosis was determined using receiver operating characteristic curve analysis. The value of aCEA for predicting the occurrence of peritoneal carcinomatosis was evaluated using a logistic regression model. Results: The optimal cut-off value of aCEA to diagnose CRC with peritoneal carcinomatosis was 3.89 ng/mL, and the area under the curve for aCEA was 0.996 (sensitivity 96.3%, specificity 100%, positive predictive value 100%, negative predictive value 98.3%). Multivariate logistic regression analysis showed that aCEA was an independent factor predicting the occurrence of peritoneal carcinomatosis. Conclusions: In this study, we showed that aCEA may be a useful parameter for diagnosing CRC with peritoneal carcinomatosis, and we propose an optimal aCEA cut-off value of 3.89 ng/mL. Further study that includes patients with other malignant ascites may be necessary to validate these findings. (Korean J Gastroenterol 2018;71:332-337)

피부 편평세포암 및 전이의 임상조직학적 관찰(2006∼2016)

송성은 ( Sung Eun Song ),노기웅 ( Ki Woong Ro ),허은필 ( Eun Phil Heo ) 대한피부과학회 2017 大韓皮膚科學會誌 Vol.55 No.3

Background: Cutaneous squamous cell carcinoma (cSCC) is a malignant proliferation of keratinocytes of the epidermis. It may have the potential to metastasize distally in contrast to the cutaneous basal cell carcinoma. Objective: We investigated the recent trend of cSCC development from a clinical, histopathological, and prognostic perspective. Methods: One hundred and sixty cases of cSCC in patients who had visited the Samsung Changwon Hospital over the past 10 years (between 2006 and 2016) were retrospectively studied. We analyzed their age, sex, location, etiologic factor, histopathologic finding, and treatment. Results: The average age of cSCC was 77 years old and the sex ratio was 1:2.27. The most commonly involved location was the head and neck (73.13%). The etiologic factors were unknown (61.88%), actinic keratosis (23.13%), Bowen`s disease (10.63%), burn scar (2.5%), chronic eczema (0.63%) and chronic inflammatory disease (0.63%). The average tumor diameter and thickness were 18.1 mm and 3.58 mm, respectively. The degrees of differentiation were well-differentiated (68.75%), moderately differentiated (28.75%) and poorly differentiated (2.5%). The occurrence rate of cSCC metastasis was 6.25% (10 cases/160 cases). The most common primary locations of cSCC metastasis were the lower extremities (5 cases/10 cases) and head and neck (2 cases/10 cases). All 10 cases were metastasis to adjacent lymph nodes. Five cases showed metastasis to distant lymph nodes, the lungs, liver or bone. The average tumor diameter and thickness of cSCC metastasis were 45.3 mm and 9.46 mm, respectively. Histopathologically, the degrees of differentiation were well-differentiated, moderately differentiated and poorly differentiated type (4 cases, 5 cases, and 1 case, respectively). Conclusion: The location of the lower extremities (p=0.000) and a size larger than 20 mm (p=0.000) were related to cSCC metastasis. cSCC metastasis was found at an average of 7.5 months after diagnosis. High-risk cSCC patients should be followed closely, particularly during the first 2 years after diagnosis. (Korean J Dermatol 2017;55(3):178∼185)

급성 구인두 연하곤란으로 발현된 피부근염

송성은 ( Sung Eun Song ),박무인 ( Moo In Park ),문원 ( Won Moon ),박선자 ( Seun Ja Park ),김규종 ( Kyu Jong Kim ),김재현 ( Jae Hyun Kim ),김경미 ( Gyung Mi Kim ),김종국 ( Jong Kuk Kim ),심영주 ( Young Joo Sim ),이정민 ( Jung Min 대한소화기기능성질환·운동학회 2009 Journal of Neurogastroenterology and Motility (JNM Vol.15 No.1

Dermatomyositis is a rare autoimmune disorder afflicting an estimated 6-10 million people worldwide that has a distinct clinical entity identified by a characteristic skin rash and inflammatory myopathy. It can be combined with other connective tissue diseases such as systemic sclerosis or systemic lupus erythematosus. In addition to primary disturbances of limb muscle and skin, extramuscular manifestations include dysphagia, cardiac conduction abnormalities, interstitial lung disease or subcutaneous calcifications. Dysphagia occurs in 12%-54% of those with dermatomyositis, manifests gradually over weeks to months rather than in acutely, and is diagnosed with high-resolution esophageal manometry and video-fluoroscopic monitoring during swallowing. We report a case of dermatomyositis presenting initially with acute oropharyngeal dysphagia and review the available swallowing studies and related literature. (Kor J Neurogastroenterol Motil 2009;15:65-69)

자궁 적출술 및 고관절 치환술과 연관되어 하지에 발생한 Stewart-Treves Syndrome 1예

송성은 ( Sung Eun Song ),노기웅 ( Ki Woong Ro ),허은필 ( Eun Phil Heo ) 대한피부과학회 2018 大韓皮膚科學會誌 Vol.56 No.6

Stewart-Treves syndrome (STS) is a rare cutaneous angiosarcoma that develops in chronic lymphedema. The majority of STS is described in the upper extremity after aggressive locoregional therapy for breast cancer and is rarely reported in lower extremities. A 68-year-old woman presented with a 3-month history of multiple purpuric tumorous plaques and nodules on the right posterior thigh. She had a history of radical hysterectomy with lymph node dissection and postoperative radiotherapy due to uterine cervical cancer 16 years ago. She received right total hip replacement surgery due to hip joint avascular necrosis 14 years ago. She had suffered from chronic leg edema, especially on the right side. Skin biopsy on the right posterior thigh showed irregular vascular channels lined by atypical endothelial cells. Special stains showed positivity for CD31, CD34, factor VIII, and D2∼40, which are pan-vascular or lymphatic markers. She showed a pelvic mass and pelvic bone metastasis on radiologic staging work-up. She refused all treatment, including surgery, radiotherapy, and chemotherapy, except for pain control. She died 2 months after diagnosis of this highly malignant tumor. The lymphedema on both lower extremities after uterine cervical cancer treatment was aggravated especially on the right lower extremity after right total hip replacement surgery. Increased weight of the right lower extremity resulted in 4 episodes of recurrent hip dislocation. We contend that these multiple factors (uterine cervical cancer treatment, total hip replacement surgery on the right side, and recurrent hip dislocations) attributed to development of Stewart-Treves syndrome. We herein report a case of Stewart-Treves syndrome of the lower extremity following chronic leg lymphedema after uterine cervical cancer treatment and hip surgery. (Korean J Dermatol 2018;56(6):376∼379)

중,고등부 알파인 스키 선수들의 경기기록과 등속성 근기능 간의 상관 분석

송성일 ( Sung Il Song ),이한준 ( Han Joon Lee ),박은경 ( Eun Kyung Park ),이혜영 ( Hye Young Lee ),김용환 ( Yong Hwan Kim ),정인섭 ( In Sub Jung ),최혜정 ( Hye Jung Choi ),진영수 ( Young Soo Jin ) 대한스포츠의학회 2006 대한스포츠의학회지 Vol.24 No.1

증례 : 소화기 ; 위험인자가 없는 환자에게 발생한 대장 내시경에 의한 우측 허혈성 대장염 1예

이은미 ( Eun Mi Lee ),박선자 ( Seun Ja Park ),송성은 ( Sung Eun Song ),김재현 ( Jae Hyun Kim ),김규종 ( Kyu Jong Kim ),박무인 ( Moo In Park ),박동양 ( Dong Yang Park ) 대한내과학회 2010 대한내과학회지 Vol.79 No.3

저자 등은 평소 특별한 위험인자가 없었던 41세 여자 환자로 대장 내시경 시행 후 갑자기 발생한 혈변 및 우하복부 통증을 주소로 응급실에 내원하여 대장 내시경 및 복부 CT를 통해 대장 내시경에 의해 발생한 우측 대장의 허혈성 대장염으로 진단하고 금식 및 수액 공급 등의 보존적 치료로 회복된 예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Ischemic colitis is the most common form of intestinal ischemia. Although there are a variety of causes, the most common mechanism is acute, self-limited compromise in intestinal blood flow. Most cases of ischemic colitis are transient and resolve spontaneously, but right colon involvement is associated with poor outcome. Colonoscopy is the gold standard for the identification of colonic ischemia; however, very rarely, colonoscopy itself may induce ischemic colitis in patients with underlying predisposing factors, such as connective tissue disorders. We experienced a case of ischemic colitis of the right colon, following colonoscopy in a patient without risk factors. (Korean J Med 79:285-288, 2010)

국립재활원 뇌졸중 환자의 협진에 대한 인식 및 수요 조사 연구

임성민,송성은,Lim, Sung-Min,Song, Sung-Eun 대한예방한의학회 2011 대한예방한의학회지 Vol.15 No.1

Objective : The purpose of this study was survey about the recognition and demand on cooperative system between western and oriental medicine of stroke patients in National Rehabilitation Center. Methods : The participants were 205 stroke patients in the National Rehabilitation Center and investigated the recognition and demand on cooperative system between western and oriental medicine. Results : As to general characteristics of the group, 56.9% were male, 30.7% were in the 60~69 age, 24.3% of patients had an average income per month 1.0~2.0 million. In regard to disease status of patients, 53.8% were cerebral infarction, 35.8% were below 6 month in disease duration, 73.7% were none recurrence, 52.8% were hypertension as related disease, 74.5% were motor paralysis sequela. 83.2% were positive response in using oriental medicine department of National Rehabilitation Center. The most wanted therapy was acupuncture. Most of respondents expected that co-operative treatments were to be improving the cure effect for patients. And they wanted cooperative system combined evenly between western and oriental medicine, so the western doctors and the oriental doctors suggest the plan giving lots of medial benefits for patients. Conclusion : This survey showed the recognition and demand on cooperative system between western and oriental medicine of patients in National Rehabilitation Center. It is possible to realize patient's centered treatment under the stable and efficient cooperation of western and oriental medicine.

현가장치 운동량을 고려한 조향 안정성 향상

채유진,신병철,송성은,이형욱,Yujin, Chae,Byeong Cheol, Shin,Sung Eun, Song,Hyoungwook, Lee 한국교통대학교 융복합기술연구소 2022 융ㆍ복합기술연구소 논문집 Vol.12 No.1

This study has been carried out in order to improve the rolling problem by enhancing steering stability compared to the 2021 Student Car of the KNUT_EV team for KSAE. Among the various factors affecting steering performances, it was focused on the height of the centroid of weight, the motion ratio, and the spring deflection. In the 2022 Car, a pull rod suspension was used to reduce the height of the centroid of weight and designed with a structure of the rod and rocker to satisfy the target motion ratio. The spring deflection was testified by ADAMS and ABAQUS analysis, and the spring stiffness was selected at 350lb/inch and 450lb/inch for the front and rear wheels, respectively. As a result, the rolling angle of the 2022 Car was reduced compared to the 2021 Car, and the rolling phenomenon was improved.

전사방식 광조형 3차원 프린팅의 조형조건에 따른 이방성 고찰

장남훈(Nam-Hoon Chang),송성은(Sung-Eun Song),박근(Keun Park) 한국고분자학회 2018 폴리머 Vol.42 No.6

최근 3차원 프린팅 기술에 대한 많은 관심이 고조되고 있으며, 기존의 빠른 시제품 제작 용도에서 기능성 제품의 직접 제작으로 활용 범위를 넓히고 있다. 그러나 제품의 직접 제조에 활용되기 위해서는 적층 공정에 기반한 3차원 프린팅의 단점(낮은 형상정밀도, 긴 제작시간, 적층 방향으로의 기계적 물성 저하)을 극복해야 한다. 이중 적층 방향으로의 물성 저하는 제품의 이방성을 야기시키고, 결과적으로 3차원 프린팅으로 제작된 제품의 구조적 안전성을 적절히 예상하기 어렵게 만든다. 본 연구에서는 마스크 전사방식 광조형 프린터(DLP)로 각각 수평방향과 수직방향으로 제작한 조형물의 인장시험을 통해 기계적 물성을 고찰하고 조형조건에 따른 이방성의 차이를 비교하였다. 또한 실험결과의 분석을 통해 적절한 강도와 강성을 보장하면서도 등방성을 유지할 수 있는 조형조건을 획득하였다. Recently, 3D printing has obtained increasing attention, and extended its application from the traditional rapid prototyping to direct fabrication of functional parts. To be used as the direct fabrication process, however, 3D printing should overcome drawbacks due to its lamination process: low dimensional accuracy, long fabrication time and degeneration of mechanical properties along the lamination direction. This degeneration along the lamination direction results in anisotropic mechanical properties, which prevents appropriate prediction of structural safety of the 3D-printed parts. This study investigated mechanical properties of 3D-printed parts using a mask-projection type (digital light processing; DLP) 3D printer by comparing tensile test results for the specimens that were printed along horizontal and vertical directions. By analyzing experimental results, appropriate printing conditions could be obtained to satisfy high mechanical strength and stiffness as well as to maintain mechanical properties within isotropic range.

사용자의 동작을 인식하기 위한 입력 장치의 설계

박주현(Joo-Hyeon Park),송성도(Sung-Do Song),최지훈(Ji-Hoon Choi),김은주(Eun-Ju Kim),김선정(Sun-Jeong Kim),송창근(Chang-Geun Song) 한국멀티미디어학회 2009 한국멀티미디어학회 학술발표논문집 Vol.2009 No.1

본 논문은 레이싱 게임 참여자의 의도를 최대한 수용할 수 있도록 사용자의 동작을 인식하기 위한 장치로 센서를 부착한 하드웨어 입력 장치를 제안한다. 센서가 부착된 입력 장치를 통해 레이싱 게임 뿐만 아니라 다른 장르의 게임에도 적용 가능한 솔루션을 제공하고 Havok Physics Engine을 이용하여 차량의 물리를 시뮬레이션 한다.