http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
분할 췌가 동반되지 않은 Santorinicele 3예
송란,주광로,장재영,남기덕,김남훈,이상길,동석호,김효종,김병호,장영운,이정일,장린 대한소화기내시경학회 2005 Clinical Endoscopy Vol.30 No.6
Santorinicele is defined as a focal cystic dilatation of the terminal portion of the dorsal pancreatic duct at the minor papilla. It is unclear whether a santorinicele is congenital or an acquired lesion secondary to relative obstruction and a weakness of the distal dorsal duct wall. Because almost all santorinicele reported to date have been associated with pancreas divisum, it has been assumed that santorinicele is related to the obstruction of pancreatic outflow and resultant pancreatitis that occurs in the pancreas divisum. We describe three cases of santorinicele without pancreatic divisum which were identified incidentally. (Korean J Gastrointest Endosc 2005;30:350-354) Santorinicele은 부유두로 개구하는 배측 췌관의 끝부분이 낭상으로 확장된 것으로 그 원인이 선천성 기형인지 또는 배측 췌관 말단의 부분적인 협착 및 약화로 인한 후천성 병변인지 아직 논란의 여지가 있다. 지금까지 보고된 모든 santorinicele은 분할 췌를 동반하였고 이 santorinicele에 의한 부유두의 부분적 협착이 췌관의 압력을 상승시켜 분할 췌 환자에서 췌장성 동통 및 재발성 췌장염이 발생하는 것으로 알려져 있다. 본 증례들은 기존의 보고와는 달리 분할 췌를 동반하지 않은 santorinicele로 췌장염 등의 임상적인 문제 없이 우연히 발견된 드문 예이다.
사건중심성이 외상 후 성장에 미치는 영향: 의도적 반추와 자아탄력성의 조절된 매개효과
송란,신희천,김은정 한국인지행동치료학회 2021 인지행동치료 Vol.21 No.3
본 연구에서는 외상 경험이 있는 대학생을 대상으로 사건중심성과 외상 후 성장 간의 관계를 의도적 반추가 매개하는지 살펴보고, 자아탄력성이 이러한 매개효과를 조절하는지 알아보기 위해 조절된 매개효과를 검증하였다. 이를 위해 대학생 231명을 대상으로 설문조사를 통해 사건중심성, 의도적 반추, 자아탄력성, 외상 후 성장을 측정하고 SPSS Macro를 사용하여 자료를 분석하였다. 본 연구의 결과는 다음과 같다. 첫째, 의도적 반추는 사건중심성과 외상 후 성장 간의 관계를 완전 매개하는 것으로 나타났다. 둘째, 사건중심성이 의도적 반추에 미치는 영향을 자아탄력성이 조절하는 것으로 나타났다. 즉, 자아탄력성이 높을수록 사건중심성이 의도적 반추에 미치는 영향력이 상승한다는 것이 확인되었다. 셋째, 조절된 매개효과가 나타났는데, 사건중심성과 외상 후 성장 간의 관계에서 의도적 반추의 매개효과는 자아탄력성이 높을수록 증가하는 것으로 나타났다. 이러한 결과를 토대로 본 연구의 의의 및 제한점과 향후 연구방향을 논의하였다. The purpose of the current study was to investigate whether deliberate rumination would mediate the relationship between event centrality and posttraumatic growth, and if such mediating effect would differ depending on the level of ego-resilience. Subjects were 231 university students who experienced traumatic events. They responded to the measures assessing for event centrality, deliberate rumination, ego-resilience, posttraumatic growth. The data was analyzed by using SPSS Macro. The main findings were as follows. First, deliberate rumination had a full mediating effect on the relationship between event centrality and posttraumatic growth. Second, ego-resilience moderated the association between event centrality and deliberate rumination. That is, as ego-resilience increased, the relationship between event centrality and deliberate rumination increased. Third, the moderated mediation model was supported in that the mediating effect of deliberate rumination on the relationship between event centrality and posttraumatic growth increased as ego-resilience increased. Based on the results, the implications and limitations of this study were discussed with suggestions for future research.
Clinical Features of Li-Fraumeni Syndrome in Korea
송란,공선영,최원영,이은경,우재연,한재홍,이시윤,강한성,정소연 대한암학회 2024 Cancer Research and Treatment Vol.56 No.1
Purpose Li-Fraumeni syndrome (LFS) is a hereditary disorder caused by germline mutation in <i>TP53</i>. Owing to the rarity of LFS, data on its clinical features are limited. This study aimed to evaluate the clinical characteristics and prognosis of Korean patients with LFS.Materials and Methods Patients who underwent genetic counseling and confirmed with germline <i>TP53</i> mutation in the National Cancer Center in Korea between 2011 and 2022 were retrospectively reviewed. Data on family history with pedigree, types of mutation, clinical features, and prognosis were collected.Results Fourteen patients with LFS were included in this study. The median age at diagnosis of the first tumor was 32 years. Missense and nonsense mutations were observed in 13 and one patients, respectively. The repeated mutations were p.Arg273His, p.Ala138Val, and pPro190Leu. The sister with breast cancer harbored the same mutation of p.Ala138Val. Seven patients had multiple primary cancers. Breast cancer was most frequently observed, and other types of tumor included sarcoma, thyroid cancer, pancreatic cancer, brain tumor, adrenocortical carcinoma, ovarian cancer, endometrial cancer, colon cancer, vaginal cancer, skin cancer, and leukemia. The median follow-up period was 51.5 months. Two and four patients showed local recurrence and distant metastasis, respectively. Two patients died of leukemia and pancreatic cancer 3 and 23 months after diagnosis, respectively.Conclusion This study provides information on different characteristics of patients with LFS, including types of mutation, types of cancer, and prognostic outcomes. For more appropriate management of these patients, proper genetic screening and multidisciplinary discussion are required. Purpose Li-Fraumeni syndrome (LFS) is a hereditary disorder caused by germline mutation in TP53. Owing to the rarity of LFS, data on its clinical features are limited. This study aimed to evaluate the clinical characteristics and prognosis of Korean patients with LFS. Materials and Methods Patients who underwent genetic counseling and confirmed with germline TP53 mutation in the National Cancer Center in Korea between 2011 and 2022 were retrospectively reviewed. Data on family history with pedigree, types of mutation, clinical features, and prognosis were collected. Results Fourteen patients with LFS were included in this study. The median age at diagnosis of the first tumor was 32 years. Missense and nonsense mutations were observed in 13 and one patients, respectively. The repeated mutations were p.Arg273His, p.Ala138Val, and pPro190Leu. The sister with breast cancer harbored the same mutation of p.Ala138Val. Seven patients had multiple primary cancers. Breast cancer was most frequently observed, and other types of tumor included sarcoma, thyroid cancer, pancreatic cancer, brain tumor, adrenocortical carcinoma, ovarian cancer, endometrial cancer, colon cancer, vaginal cancer, skin cancer, and leukemia. The median follow-up period was 51.5 months. Two and four patients showed local recurrence and distant metastasis, respectively. Two patients died of leukemia and pancreatic cancer 3 and 23 months after diagnosis, respectively. Conclusion This study provides information on different characteristics of patients with LFS, including types of mutation, types of cancer, and prognostic outcomes. For more appropriate management of these patients, proper genetic screening and multidisciplinary discussion are required.