Malvidin Protects WI-38 Human Fibroblast Cells Against Stress-induced Premature Senescence

서혜린,최미진,최지명,고종철,고지연,조은주 대한암예방학회 2016 Journal of cancer prevention Vol.21 No.1

Background: Malvidin is one of the most abundant components in red wines and black rice. The effects of malvidin on aging and lifespan under oxidative stress have not been fully understood. This study focused on the anti-aging effect of malvidin on stress-induced premature senescence (SIPS) in WI-38 human lung-derived diploid fibroblasts. Methods: In order to determine the viability of WI-38 cells, MTT assay was conducted, and malondialdehyde level was determined using thiobarbituric acid-reactive substance assay. Protein expression of inflammation-related factors was also evaluated by Western blot analysis. Results: Acute and chronic oxidative stress via hydrogen peroxide (H2O2) treatment led to SIPS in WI-38 cells, which showed decreased cell viability, increased lipid peroxidation, and a shortened lifespan in comparison with non-H2O2-treated WI-38 cells. However, malvidin treatment significantly attenuated H2O2-induced oxidative stress by inhibiting lipid peroxidation and increasing cell viability. Furthermore, the lifespan of WI-38 cells was prolonged by malvidin treatment. In addition, malvidin downregulated the expression of oxidative stress-related proteins, including NF-B, COX-2, and inducible nitric oxide synthase. Furthermore, protein expression levels of p53, p21, and Bax were also regulated by malvidin treatment in WI-38 cells undergoing SIPS. Conclusions: Malvidin may potentially inhibit the aging process by controlling oxidative stress.

교차검증 기반 스태킹 방법을 이용한 공공자전거 수요 예측 모형 구축

서혜린 성균관대학교 응용통계연구소 2022 통계연구 Vol.22 No.-

여러 개의 단일 모형들을 결합해 예측 성능을 높히는 앙상블 방법 중 하나로 스태킹 방법이 Wolpert (1992)에 의해 제안되었다. 교차검증 기반 스태킹 방법은 기존의 스태킹 방법이 동일한 데이터로 여러 모형을 학습시킴으로써 발생하는 과적합 문제를 개선한다는 장점이 있다. 본 연구에서는 워싱턴 공공 자전거 수요 예측을 위해 교차검증 기반 스태킹 방법을 적용하고자 한다. 본 연구에서는 랜덤 포레스트 회귀, 인공신경망, 서포트 벡터 머신 회귀 등의 기계 학습 모형을 베이스 모형으로 이용하고 최종 모형으로 다중선형 회귀분석을 이용한 교차검증 기반 스태킹 방법을 고려하고, 개별 모형들과 성능을 비교한다.

북한이탈 간호대학생의 생활 경험

서혜린,신효경,윤수진,이은주,정혜원,최수민,신수진,이미선 이화여자대학교 간호학회 2018 이화간호학회지 Vol.- No.52

Purpose: The purpose of this study was to understand the life experiences of North Korean nursing students at a university in South Korea Methods: The participants of this study were 7 North Korean defector nursing students. The data were collected through individual in-depth interviews. All interviews were audio-taped and verbatim transcripts were made for the analysis. The collected data were analyzed through the van Manen's Hermeneutical Phenomenological method (1990). Results: On the analysis of 7 research participant’s interview, their life can be expressed as ‘The concealment of oneself from being seen as stranger’, ‘Having hard time learning due to academic background differences’, ‘Receiving support in South Korea and trying to give to society’, ‘Satisfied with the systems different from the North Korea’, ‘Still influenced by life in North Korea.’ Conclusion: This study provided a deep understanding of the life experiences of North Korean defector students who majored in nursing. In addition, this study suggested a need for development of support programs for North Korean defector nursing students and additional nursing education methods for them. Also this study is significant that it provides a basis to help South Koreans better understand North Korean defector nursing students’ life. Therefore, this study can relieve the difficulties of North Korean defector nurses when they perform their duties with South Korean nurses.

한국형아유르베다 심리유형 사례분석 연구

서혜린,윤천성 인문사회 21 2022 인문사회 21 Vol.13 No.4

A Case Study on the Psychological Types of Korean AyurvedaHeylyn Seo & Chunsung Youn Abstract: This study intends to identify the key characteristics of each psychological type as classified in the Korean Ayurveda Psychological Type (KAPTI) by using a case study. The case study was undertaken for a sample of 12 participants living in Seoul, Korea. KAPTI test was conducted over the period from January to March 2022 for the participants which consist of 4 Bata, 4 Pita, and 4 Kappa types. Key findings are as follows. First, Bata type participants had a common preference for working freely. Second, Pita type participants showed a commonality of expressing dynamic energy. Third, Kappa type participants were relaxed, and generally satisfied with their current situation. Finally, all participants were able to better understand their type and characteristics following the psychological type test. These findings suggest that the case study conducted could be useful in supporting that understanding one's own psychological type and characteristics could help recognize oneself under stress. Key Words: Korean-style Ayurveda Psychological Type (KAPTI), Psychological Type, Case Analysis, Psychological Characteristics, Stress 한국형아유르베다 심리유형 사례분석 연구서 혜 린*ㆍ윤 천 성** 연구 목적: 이 연구는 한국형아유르베다 심리유형검사(KAPTI) 사례분석을 통해 유형별 특성을 파악하는 데 목적이 있다. 연구 방법: 이를 위해 서울 거주 12명을 대상으로 사례분석 하였다. 2022년 1월부터 3월까지 3개월간 유형별로 바타형 4명, 피타형 4명, 카파형 4명, 총 12명에게 한국형아유르베다 심리유형검사 방법을 실시하였다. 연구 내용: 연구 결과는 다음과 같다. 첫째, 바타형 4명의 분석 결과, 자신이 자유롭게 일하기를 선호하는 공통점이 있었다. 둘째, 피타형 4명의 분석 결과, 역동적 에너지를 표출하는 공통점이 있었다. 셋째, 카파형 4명의 분석 결과, 느긋하고 여유가 있으며 대체로 자신들의 현 상황에 만족하는 공통점이 있었다. 12명의 연구대상자는 심리유형검사를 통해 자신의 유형과 특성을 이해하게 되는 결과를 나타냈다. 결론 및 제언: 이와 같은 결론의 도출로 유형별 자신의 심리적 특성, 본성을 이해함으로써 외부에서 받는 스트레스로부터 자신을 자각하고 인식하는 사례분석 자료로 활용되었으면 한다. 핵심어: 한국형아유르베다 심리유형검사(KAPTI), 심리유형, 사례분석, 심리적특성, 스트레스 □ 접수일: 2022년 7월 5일, 수정일: 2022년 7월 30일, 게재확정일: 2022년 8월 20일* 주저자, 서울벤처대학원대학교 융합산업학과 박사과정(First Author, Doctoral Course, Seoul Venture Univ., Email: tomboy7272@naver.com)** 교신저자, 서울벤처대학원대학교 융합산업학과 교수(Corresponding Author, Professor, Seoul Venture Univ., Email: staryoun@hanmail.net)

Anti-obesity Effect of Steamed Soybean and Fermented Steamed Soybean in High-fat Diet-induced Obese ICR Mice

서혜린,이아영,조계만,조은주,김현영 한국생약학회 2017 Natural Product Sciences Vol.23 No.1

This study was performed to investigate the ameliorating effects of steamed soybeans (SS) and fermented SS (FSS) on lipid metabolism in high-fat diet-induced obese mice. ICR mice were divided into four groups and given the following different diets: normal diet (ND), high-fat diet (HFD), HFD with 1% SS (HFD + SS), and HFD with 1% FSS (HFD + FSS). After 14 weeks, the body weight gain was higher in the HFD group compared with the ND group but lower in the HFD + FSS group compared with the HFD group. Plasma levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein-cholesterol, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were significantly higher in the HFD group compared to the ND group, but lower in the HFD + SS and HFD + FSS groups compared with the HFD group. In addition, leptin concentration in plasma was lower in the groups fed HFD + SS and HFD + FSS compared with the HFD group. The accumulation of hepatic TG and TC was significantly inhibited in the HFD + SS and HFD + FSS groups. Furthermore, SS and FSS attenuated lipid peroxidation and nitric oxide formation in the liver induced by the high-fat diet. These results suggest that soybeans, especially FSS, may be useful in preventing obesity-induced abnormalities in lipid metabolism.

授受補助動詞「てくれる」の意味分析

서혜린 한국일본어학회 2013 한국일본어학회 학술발표회 Vol.2013 No.9

나를 향해 미소 짓는 할미꽃

서혜린 샘터사 2021 월간 샘터 Vol.616 No.-

An Analysis on the Authority of the GCC Based on the Network Theory

서혜린 한국외국어대학교(글로벌캠퍼스) 중동연구소 2015 중동연구 Vol.34 No.1

The Gulf Cooperation Council has been the major international actor in the Middle East and Gulf region for more than 30 years since its establishment. Saudi Arabia, as the leader state of the GCC, has kept dominant authority in and out of the organization. From its economic resources – oil and natural gas mostly – the Saudi regime could exert occupy the upper position of the GCC network as the single hub at the center of the network. Moreover, the unique characteristics of the Islamic tradition bestowed the Saudi royal families the religious legitimacy as the fathers of Sunni Muslims, which they could use as the source of justification for their interventionist diplomatic strategies. The GCC itself also possessed a collective power as an independent actor. Their cohesiveness and unity was strengthened from the common threat of democratization calls after the Arab Spring and from the common enemy of Shia Crescent led by Iran. With a lot of national characters of the member states in common – Suuni Islam, political system of monarchy, rentier state economics, geographical location on the Arabian Peninsula, etc. –, the GCC was able to increase its influence over the Middle East as a closed network. As small states in Gulf region such as Qatar and UAE are growing both in economics and international politics, the dominance system of the GCC by Saudi Arabia has been facing several challenges in recent days. However, we cannot conclude that the GCC authority structure was completely changed and should keep our eyes on the intra- and inter-relations of the GCC network continuously.

우리 아이들이 달라졌어요!

서혜린 샘터사 2018 월간 샘터 Vol.585 No.-

산에서 보낸 여름밤의 대소동

서혜린 샘터사 2022 월간 샘터 Vol.629 No.-