교통문화지수 실태조사 개선방안에 관한 연구

박신형,이주용,권오훈,박신형,김주영 한국ITS학회 2019 한국ITS학회 학술대회 Vol.2019 No.04

도심부 연속류 구간 무인단속카메라 설치 효과분석에 관한 연구 - 대구광역시를 중심으로 -

박신형,권오훈,박신형 한국ITS학회 2017 한국ITS학회 학술대회 Vol.2017 No.04

기계학습 기반 9방향 안구 사진 자동 결합 프로그램

박신형,이우혁,강태신,조현경,한용섭,김지혜 대한안과학회 2023 대한안과학회지 Vol.64 No.8

Purpose: This study introduces a new machine learning-based auto-merge program (HydraVersion) that automatically combines multiple ocular photographs into single nine-directional ocular photographs. We compared the accuracy and time required to generate ocular photographs between HydraVersion and PowerPoint. Methods: This was a retrospective study of 2,524 sets of 250 nine-directional ocular photographs (134 patients) between March 2016 and June 2022. The test dataset comprised 74 sets of 728 photographs (38 patients). We measured the time taken to generate nine-directional ocular photographs using HydraVersion and PowerPoint, and compared their accuracy. Results: HydraVersion correctly combined 71 (95.95%) of the 74 sets of nine-directional ocular photographs. The average working time for HydraVersion and PowerPoint was 2.40 ± 0.43 and 255.9 ± 26.7 seconds, respectively; HydraVersion was significantly faster than PowerPoint (p < 0.001). Conclusions: Strabismus and neuro-ophthalmology centers are often unable to combine and store photographs, except those of clinically significant cases, because of a lack of time and manpower. This study demonstrated that HydraVersion may facilitate treatment and research because it can quickly and conveniently generate nine-directional ocular photographs. 목적: 본 연구는 각각의 방향을 주시하면서 촬영한 여러 장의 안구 사진을 한 장의 9방향 안구 사진으로 결합하는 새로운 인공지능기반 9방향 안구 사진 자동 결합 프로그램(HydraVersion)을 제안하고자 한다. 또한 HydraVersion의 정확도와 소요 시간을 기존의파워포인트(PowerPoint)를 이용하는 수작업과 비교하여, HydraVersion의 유용성에 대해 알아보고자 한다. 대상과 방법: 2016년 3월부터 2022년 6월까지 본원 외래에서 촬영한 9방향 안구 사진 중 134명의 사진 250세트 2,524장으로 후향적연구를 진행하였다. 그중 38명 74세트 728장은 평가데이터 세트로 구성하고, 각각의 방법(HydraVersion/PowerPoint)을 이용하여 9 방향 안구 사진을 생성하는데 소요된 시간을 측정하고 정확도를 평가하여 비교 분석하였다. 결과: HydraVersion은 74세트의 9방향 안구 사진 중 71세트(95.95%)를 정확하게 결합하였다. HydraVersion의 평균 소요 시간은2.40 ± 0.43초, Powerpoint의 평균 소요 시간은 255.9 ± 26.7초로 HydraVersion이 PowerPoint보다 빠르게 사진을 결합하였다(p<0.001). 결론: 그동안 일부 사시 및 신경안과 클리닉에서는 시간 및 인력 부족의 이유로 몇몇의 안구 사진들이 결합하지 못하고 낱장으로보관되었다. 본 연구에서 개발한 프로그램을 통해 빠르고 편리하게 9방향 안구 사진을 생성함으로써, 진료 및 연구에 많은 도움이될 것이라 기대한다.

청피 에탄올 추출물이 스트레스성 카테콜아민으로 유도한 간암세포의 전이를 억제하는 효과 및 기전 연구

박신형 한의병리학회 2024 동의생리병리학회지 Vol.38 No.1

Previous studies have highlighted the pivotal role of the β-adrenergic receptor (β-AR) signaling pathway in stimulating cancer metastasis induced by chronic stress. According to the theory of traditional Korean medicine, chronic stress can induce Qi stagnation. Based on the traditional role of premature citrus unshiu peel in moving Qi, we hypothesized that an ethanol extract of premature citrus unshiu peel (EPCU) can attenuate chronic stress-induced cancer progression. In this study, we investigated the potential role of EPCU on modulating the adrenergic agonists-induced metastatic properties of liver cancer cells. Our findings revealed that adrenergic agonists, including norepinephrine (NE), epinephrine (E), and isoproterenol (ISO), augmented the migratory capacity of Hep3B human hepatocellular carcinoma cells, which was completely abrogated by EPCU treatment in a concentration-dependent manner. Consistently, EPCU inhibited the E-induced invasive property of Hep3B cells in a dose-dependent manner. These results suggest that EPCU efficiently attenuates adrenergic agonists-induced metastatic abilities of liver cancer cells. As a molecular mechanism, EPF suppressed the phosphorylation of major components of β-AR signaling pathway, including Src, signal transducer and activator of transcription 3 (STAT3) and ERK, induced by E treatment. Taken together, our results demonstrate that EPCU impedes the adrenergic agonists-driven metastatic potential of cancer cells by inhibiting β-AR signaling pathway. This study provides basic evidence supporting the probable use of premature citrus unshiu peel to prevent metastasis in liver cancer patients under chronic stress.

소집단 독서교육 프로그램이 유아의 사회적 태도와 사회적 기술 증진에 미치는 효과

박신형 성균관대학교 生活科學硏究所 2003 生活科學 Vol.6 No.-

고속도로 터널부 구간과속단속 실효성 분석

박신형,이은진,권오훈 한국도로학회 2017 한국도로학회 학술대회 발표논문 초록집 Vol.2017 No.10

고속도로 터널부에서 발생하는 교통사고는 일반부와 다른 도로환경으로 인해 대형사고 발생 위험이 높은 구간이라 할 수 있다. 국내에서는 고속도로 터널부 사고 감소를 위한 대책의 일환으로 2007년부터 구간과속단속 시스템이 도입·운영되고 있다. 구간과속단속 시스템은 속도제어가 필요하다고 판단되는 도로구간을 대상으로 차량의 평균주행속도를 측정하여 제한속도 위반여부를 판단하는 시스템이다. 구간과속단속 시스템은 단속 장비가 설치된 지점에서만 속도를 줄이고, 지점 통과 후 다시 가속하는 ‘캥거루 드라이빙’에 따른 사고위험을 완화하고, 교통류 안정화를 통해 사고를 저감하는데 효과적인 교통관리기법으로 알려져 점차 도입이 확대되고 있다. 하지만 그 효과를 정량적으로 분석한 연구사례는 그리 많지 않으며, 특히 터널부에서의 효과를 함께 검토한 연구는 거의 전무한 실정이다. 이에 본 연구에서는 터널부를 포함하여 구간과속단속 시스템이 설치된 고속도로 6개 구간을 대상으로 시스템 설치 효과를 평가하기 위하여 시스템 설치 전·후의 교통사고, 교통량 및 속도 자료를 수집하여 분석을 실시하였다. 분석 결과 구간과속단속 구간 내에서는 평균속도와 속도 분산이 대부분 감소하여 구간과속단속이 교통류를 보다 안정된 상태로 형성하는데 기여하는 효과를 확인하였다. 또한 Empirical Bayes method와 Turning Point Analysis 기법을 적용하여 사고건수의 변화를 비교하고, Proportional Test를 통해 터널 내 사고 특성 변화를 관찰함으로써 구간과속단속 효과를 정량적으로 제시하고자 한다

Pelvic insufficiency fracture after radiotherapy in patients with cervical cancer in the era of PET/CT

박신형,김재철,이정은,박인규 대한방사선종양학회 2011 Radiation Oncology Journal Vol.29 No.4

Purpose: To determine the incidence, risk factors, and clinical characteristics of pelvic insufficiency fracture (PIF) in patients with cervical cancer. Materials and Methods: Between July 2004 and August 2009, 235 patients with non-metastatic cervical cancer were treated with definitive chemoradiation or postoperative radiotherapy. Among 235 patients, 117 (49.8%) underwent the first positron emission tomography/computed tomography (PET/CT) within 1 year after radiotherapy. The median radiation dose was 55 Gy (range, 45 to 60 Gy). Medical charts and imaging studies, including PET/CT, magnetic resonance imaging (MRI), CT, bone scintigraphy were reviewed to evaluate the patients with PIF. Results: Among 235 patients, 16 developed PIF. The 5-year detection rate of PIF was 9.5%. The 5-year detection rate of PIF in patients who underwent the first PET/CT within a year was 15.6%. The median time to development of PIF was 12.5 months (range, 5 to 30 months). The sites of fracture included 12 sacroiliac joints, 3 pubic rami, 3 iliac bones, and 1 femoral neck. Eleven of 16 patients having PIF complained of hip pain requiring medications. One patient required hospitalization for pain control. The significant risk factors of PIF were old age, body mass index less than 23, bone mineral density less than -3.5 SD, and the first PET/CT within a year after radiotherapy. Radiation dose and concurrent chemotherapy had no impact on PIF rate. Conclusion: PIFs were not rare after pelvic radiotherapy in cervical cancer patients in the era of PET/CT. Timely diagnosis and management of PIF can improve quality of life in patients with cervical cancer, in addition to reducing unnecessary medical expenses.

Comparison of Electron and X-Ray Beams for Tumor Bed Boost Irradiation in Breast-Conserving Treatment

박신형,김재철 한국유방암학회 2013 Journal of breast cancer Vol.16 No.3

Purpose: This study aimed to compare the dosimetric profiles of electron beams (EB) and X-ray beams (XB) for boosting irradiation in breast cancer patients who underwent breast-conserving surgery and postoperative radiotherapy. Methods: For 131 breast cancer patients who underwent breast-conserving surgery, we compared plans for EB and XB boost irradiation after wholebreast irradiation. The organs at risk (OAR) included the cardiac chambers, coronary arteries, ipsilateral lung, and skin. The conformity index (CI), inhomogeneity index (IHI), and dose-volume parameters for the planning target volume (PTV), and OAR were calculated. Postradiotherapy chest computed tomography scans were performed to detect radiation pneumonitis. Results:XB plans showed a significantly better CI and IHI for the PTVs,compared to the EB plans. Regarding OAR sparing, the XB reduced the high-dose volume at the expense of an increased Purpose: This study aimed to compare the dosimetric profiles of electron beams (EB) and X-ray beams (XB) for boosting irradiation in breast cancer patients who underwent breast-conserving surgery and postoperative radiotherapy. Methods: For 131 breast cancer patients who underwent breast-conserving surgery, we compared plans for EB and XB boost irradiation after wholebreast irradiation. The organs at risk (OAR) included the cardiac chambers, coronary arteries, ipsilateral lung, and skin. The conformity index (CI), inhomogeneity index (IHI), and dose-volume parameters for the planning target volume (PTV), and OAR were calculated. Postradiotherapy chest computed tomography scans were performed to detect radiation pneumonitis. Results:XB plans showed a significantly better CI and IHI for the PTVs,compared to the EB plans. Regarding OAR sparing, the XB reduced the high-dose volume at the expense of an increased low-dose volume. In 33 patients whose radiation fields includednipples, IHI was higher in the EB plans, whereas the presence ofa nipple in the radiation field did not interfere with the XB. EBtreatedpatients developed more subclinical radiation pneumonitis. Conclusion: XB plans were superior to EB plans in terms ofPTV coverage (homogeneity and conformity) and high-dose volumesparing in OAR when used as boost irradiation after breastconservingsurgery. A disadvantage of the XB plan was an increasedlow-dose volume in the OAR, but this was offset by theincreased electron energy. Consequently, tailored plans with eitherXB or EB are necessary to adapt to patient anatomic varianceand tumor bed geometric properties.

Local and regional recurrence following mastectomy in breast cancer patients with 1–3 positive nodes: implications for postmastectomy radiotherapy volume

박신형,이지연,이정은,강민규,김미영,박호용,정진향,채의수,이수정,김재철 대한방사선종양학회 2018 Radiation Oncology Journal Vol.36 No.4

Purpose: To determine the necessity of postmastectomy radiotherapy (PMRT) and which regions would be at risk for recurrence, we evaluated local and regional recurrence in breast cancer patients with 1–3 positive nodes and a tumor size of <5 cm. Materials and Methods: We retrospectively analyzed data of 133 female breast cancer patients with 1–3 positive nodes, and a tumor size of <5 cm who were treated with mastectomy followed by adjuvant systemic therapy between 2007 and 2016. The median follow-up period was 57 months (range, 12 to 115 months). Most patients (82.7%) were treated with axillary lymph node dissection. Adjuvant chemotherapy, endocrine therapy, and trastuzumab therapy were administered to 124 patients (93.2%), 112 (84.2%), and 33 (24.8%), respectively. The most common chemotherapy regimen was anthracycline and cyclophosphamide followed by taxane (71.4%). Results: Three patients (2.3%), 8 (6.0%), and 12 (9.0%) experienced local, regional, and distant failures, respectively. The 5-year cumulative risk of local recurrence, regional recurrence, distant metastasis, and disease-free survival was 3.1%, 8.0%, 11.7%, and 83.4%, respectively. There were no statistically significant clinicopathologic factors associated with local recurrence. Lymphovascular invasion (univariate p = 0.015 and multivariate p = 0.054) was associated with an increased risk of regional recurrence. Conclusion: Our study showed a very low local recurrence in patients with 1–3 positive nodes and tumor size of <5 cm who were treated with mastectomy and modern adjuvant systemic treatment. The PMRT volume need to be tailored for each patient’s given risk for local and regional recurrence, and possible radiation-related toxicities.

Virtual lymph node analysis to evaluate axillary lymph node coverage provided by tangential breast irradiation

박신형,김재철,이정은,박인규 대한방사선종양학회 2015 Radiation Oncology Journal Vol.33 No.1

Purpose: To investigate the coverage of axillary lymph node with tangential breast irradiation fields by using virtual lymph node (LN) analysis. Materials and Methods: Forty-eight women who were treated with whole breast irradiation after breast-conserving surgery were analyzed. The axillary and breast volumes were delineated according to the Radiation Therapy Oncology Group (RTOG) contouring atlas. To generate virtual LN contours, preoperative fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scans with identifiable LN were fused with the CT scans, and the virtual LN contour were delineated on the CT. Results: The median level I and II axillary volume coverage percentages at the VD95% line were 33.5% (range, 5.3% to 90.4%) and 0.6% (range, 0.0% to 14.6%), respectively. Thirty-one LNs in 18 patients were delineated (26 in level I and 5 in level II). In the level I axilla, 84.6% of virtual LNs were encompassed by the 95% isodose line. In the level II axilla, by contrast, none of the virtual LNs were encompassed by the 95% isodose volumes. There was a substantial discrepancy between the RTOG contouring atlas-based axillary volume analysis and the virtual LN analysis, especially for the level I axillary coverage. The axillary volume coverage was associated with the body mass index (BMI) and breast volume. Conclusion: The tangential breast irradiation did not deliver adequate therapeutic doses to the axillary region, particularly those in the level II axilla. Patients with small breast volumes or lower BMI showed reduced axillary coverage from the tangential breast fields. For axillary LN irradiation, individualized anatomy-based radiation fields for patients would be necessary.