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Wegener's Granulomatosis 폐병변의 세침흡인 세포학적 소견 - 1예 보고 -
서은주,권희정,민기옥,Seo, Eun-Joo,Kwon, Hi-Jeong,Min, Ki-Ouk 대한세포병리학회 1998 대한세포병리학회지 Vol.9 No.1
We described the findings of fine needle aspiration cytology of the lung from a patient with Wegener's granulomatosis. Early diagnosis and prompt treatment of the patients with Wegener's granulomatosis is essential for a better prognosis. However, the variety of clinical presentations and nonspecific radiologic infiltrates of Wegener's granulomatosis frequently make the diagnosis difficult. Although an open lung biopsy is required for a firm diagnosis, fine needle aspiration cytology & biopsy preparation can also provide an adequate tissue sample, when the findings of fine needle aspiration are considered with clinical manifestations and ANCA value in the serum. The cytologic smears showed scattered necrotic tissue fragments entrapping many neutrophils and occasional epithelioid cells. Multinucleated giant cells were infrequently observed. Ziehl-Neelsen stain for acid fast bacilli was negative. All the cytologic features recapitulated the histopathologic findings of purulent and necrotizing granulomatous inflammation seen in Wegener's granulomatosis.
단순반복염기서열의 변이 형태에 따른 위암 내시경 조직의 유전자형 분류
최영덕,최상욱,전은정,정정조,민기옥,이강훈,이성,유문간,Choi Young Deok,Choi Sang Wook,Jeon Eun Jeong,Jeong Jeong Jo,Min Ki Ouk,Lee Kang Hoon,Lee Sung,Rhyu Mun Gan 대한위암학회 2004 대한위암학회지 Vol.4 No.2
Purpose: Individual gastric cancers demonstrate complicated genetic alterations. The PCR-based analysis of polymorphic microsatellite sequences on cancer-related chromosomes has been used to detect chromosomal loss and microsatellite instability. For the purpose of preoperative usage, we analyzed the correspondance rate of the microsatellite genotype between endoscopic biopsy and surgical specimens. Materials and Methods: Seventy-three pairs of biopsy and surgical specimens were examined for loss of heterozygosity and microsatellite instability by using 40 microsatellite markers on eight chromosomes. Microsatellite alterations in tumor DNAs were classified into a high-risk group (baselinelevel loss of heterozygosity: 1 chromosomal loss in diffuse type and high-level loss of heterozygosity: 4 or more chromosomal losses) and a low-risk group (microsatellite instability and low-level loss of heterozygosity: 2 or 3 chromosomal losses in diffuse type or $1\∼3$ chromosomal losses in intestinal type) based on the extent of chromosomal loss and microsatellite instability. Results: The chromosomal losses of the biopsy and the surgical specimens were found to be different in 21 of the 73 cases, 19 cases of which were categorized into a genotype group of similar extent. In 100 surgical specimens, the high-risk genotype group showed a high incidence of nodal involvement (19 of 23 cases: $\leq$5 cm; 23 of 24 cases: >5 cm) irrespective of tumor size while the incidence of nodal involvement for the low-risk genotype group depended on tumor size (5 of 26 cases: $\leq$5 cm; 18 of 27 cases: >5 cm). Extraserosal invasion was more frequent in large-sized tumor in both the high-risk genotype group ($\leq$5 cm: 12 of 23 cases; >5 cm: 23 of 24 cases) and the low-risk genotype group ($\leq$5 cm: 7 of 26 cases; >5 cm: 16 of 27 cases). The preoperative prediction of tumor invasion and nodal involvement based on tumor size and genotype corresponded closely to the pathologic tumor stage (ROC area >0.7). Conclusion: An endoscopic biopsy specimen of gastric cancer can be used to make a preoperative genetic diagnosis that accurately reflect the genotype of the corresponding surgical specimen.
최현주,정지한,신정하,민기옥,강석진,이교영,유진영,Choi, Hyun-Joo,Jung, Ji-Han,Shin, Jung-Ha,Min, Ki-Ouk,Kang, Seok-Jin,Lee, Kyo-Young,Yoo, Jin-Young 대한세포병리학회 2007 대한세포병리학회지 Vol.18 No.1
Invasive micropapillary carcinoma (IMPC) of the breast is recently described rare variant of invasive ductal carcinoma. This variant has a distinctive histological features and aggressive biological behavior. We reviewed the cytologic features of eight cases of IMPC. The cytologic smears showed moderate to high cellularity and the tumor tissue was composed of atypical, angulated, cohesive clusters of neoplastic cells with a papillary to tubuloalveolar architecture, and a morular growth pattern without fibrovascular cores was seen on the histopathology. IMPC of the breast has distinctive cytologic features and it is important to make an early diagnosis via fine needle aspiration cytology due to this tumor's aggressive behavior.
송동섭(Dong Seob Song),한지연(Ji Youn Han),권희정(Hi Jeong Kwen),민기옥(Ki Ouk Min),이성수(Seong Su Lee),김현숙(Hyeon Sook Kim),서은주(Eun Joo Seo),이경식(Kyung Shik Lee),김문희(Moon Hee Kim),이은희(Eun Hee Lee) 대한내과학회 2000 대한내과학회지 Vol.58 No.6
N/A Ascites is a rare complication of multiple myeloma. When it develops, it is usually associated with extensive liver infiltration with plasma cells, infectious peritonitis or myelomatous peritoneal infiltration. Ascites caused by peritoneal infiltration is even less frequent than others. The majority of previously reported cases were characterized by an IgA paraprotein and lack of skeletal lesions. This rare extramedullary complication of myeloma has been unresponsive to therapy and rapidly fatal. Therefore, it is important to recognize myeloma as a cause of ascites and the presence of ascites heralds a poor prognosis of myeloma. We recently experienced a case of myeloma with ascites and reviewed the relevant literature of human myeloma presenting with the triad of ascites, relative or absolute sparing of the skeleton, and an IgA paraprotein. A 76-year-old man was presented with ascites early in the course of myeloma. He had no evidence of intra-abdominal plasmacytoma and skeletal lesions. Myelomatous ascites was demonstrated by the monoclonal immunoglobulin of IgA type in ascitic fluid. He was treated by plasmapheresis due to hyperviscosity syndrome and VAD combination chemotherapy. He was discharged with the improved clinical condition.(Korean J Med 58:686-691, 2000)
최승진 ( Seung Jin Choi ),지철 ( Cheol Ji ),안재근 ( Jae Geun Ahn ),민기옥 ( Ki Ouk Min ),김문찬 ( Moon Chan Kim ) 대한뇌종양학회 2004 대한뇌종양학회지 Vol.3 No.1
Malignant melanoma is a rare cancer in Korea as opposed to in Western countries, but its incidence is beginning to rise. The high tendency of a brain metastasis is a characteristic feature of this cancer and that is considerably related to the patitnt`s prognosis. However, a brain metastasis as a result of result of this tumor has been rarely reported in Korea particularly in the aspect of the specific treatment modalities and their outcomes. With reporting a patient with multiple brain metastases of malignant melanoma accompanied with a tumoral hemorrhage, the authors suggest that more aggressive trials of various treatments as well as an estimation of the outcomes will be needed despite the fact that a current multidisciplinary treatment has not yet increased the long term survival.
김효진 ( Hyo Jin Kim ),남선영 ( Sun Young Nam ),황성진 ( Seong Jin Hwang ),김찬주 ( Chan Joo Kim ),민기옥 ( Ki Ouk Min ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.12
Endometriosis is defined as condition, which is ectopic location of endometrial tissue other than uterus and cause many clinical symptoms. Among extrapelvic endometriosis, scar endometriosis secondary to surgery or procedure is very rare condition. We have experienced one interesting case of endometrioma in uterine wall cesarean section scar. The diagnosis was confirmed by histopathologic examination of the scar tissue taken after total abdominal hysterectomy.
이성은 ( Sung Eun Lee ),전은정 ( Eun Jung Jeon ),오정환 ( Jung Hwan Oh ),심건호 ( Kon Ho Shim ),이주하 ( Jennifer Lee ),김의형 ( Eui Hyung Kim ),최상욱 ( Sang Wook Choi ),민기옥 ( Ki Ouk Min ) 대한소화기학회 2008 대한소화기학회지 Vol.51 No.1
The most common metastatic sites of gastric cancer are liver, lung, bone and adrenal gland. However, skin metastases from gastric cancer are relatively rare. We herein report a case of advanced gastric cancer with perianal skin metastasis in a 70-year-old male. On admission, patient presented with epigastric pain. Endoscopy and abdominal CT scan demonstrated the stage IV gastric cancer. He had one painless nodule on perianal skin area, biopsy of that lesion showed a feature of poorly differentiated adenocarcinoma clinically from the stomach. We suspected that the perianal lesion was originated from gastric cancer. (Korean J Gastroenterol 2008;51:40-44)
권지영 ( Ji Young Kwon ),신우미 ( Woo Mi Shin ),윤종숙 ( Jong Sook Yoon ),황성진 ( Seong Jin Hwang ),박인양 ( In Yang Park ),민기옥 ( Ki Ouk Min ),김찬주 ( Chan Joo Kim ),김창이 ( Chang Yi Kim ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.7
복강임신은 자궁외 임신의 드문 형태이며 발생한 경우 급작스런 출혈 등의 결과를 낳을 수 있다. 이러한 복강내 임신이 성립된 경우라도 전형적인 증상을 나타내지 않으며 현재까지 진단에 도움을 줄 수 있는 명확한 방법이 알려져 있지 않다. 또한 복강내 임신이 발견된 경우라 할지라도 치료에 많은 난점을 내포하고 있다. 본 저자들은 3주전 자궁내 임신으로 오인하여 임신중절수술을 받았던 환자에서 갑자기 하복부 통증이 발생하여 초음파 검사와 더글라스와 천자술에 의하여 혈복강을 진단하였으나 명확히 자궁외 임신을 의심할 수 없는 상황에서 진단적 복강경을 시행하였다. 복강경 수술 중 우측 자궁천골인대에서 출혈성 낭종을 발견하여 절제 후 조직 검사를 통해 매우 드문 형태의 자궁외 임신으로 확인된 예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Abdominal pregnancy, a rare type of ectopic pregnancy is difficult to be suspected at its first presentation. The diagnosis of this rare disease may often be delayed, since early symptoms are usually non-specific. In some cases, delayed diagnosis of abdominal preganacy can be associated with catastrophic hemorrhage secondary to placental separation. A 24-year old woman visited our emergency unit, presenting with a sudden-onset low abdominal pain. She had undergone uterine curettage 3 weeks before. Transvaginal sonogram of the cul-de-sac revealed complex fluid consistent with blood. On diagnostic laparoscopic operation, we found a ruptured cystic, conception-like structure near the right uterosacral ligament. Histology of the resected structure finally showed chorionic villi consistent with abdominal pregnancy. In this report, we present an unusual case of abdominal pregnancy. This case underscores the careful ultrasonic determination of gestational location at early pregnancy.