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        • 한 가족에서 발생한 von Hippel-Lindau병 2예 -증례보고-

          김태영 ( Tae Young Kim ),박종태 ( Jong Tae Park ) 대한뇌종양학회 2002 대한뇌종양학회지 Vol.1 No.1

          von Hippel-Lindau disease(VHL) is a hereditary cancer syndrome caused by germline mutations of the VHL tumor suppressor gene, and manifested by hemangioblastomas in central nervous system, retinal angioma, cysts in liver, pancreas or kidney. Sometimes other systemic malignancies, such as renal cell carcinoma or pheochromocytoma, are associated. Major causes of death in VHL disease are associated with cerebellar hemangioblastoma or renal cell carcinoma. We have experienced two cases of VHL disease in a family. A son had multiple scattered hemangioblastomas in cerebellum, spinal cord, retinal angiomas and renal cyst. And his mother had a renal cell carcinoma in addition to a solid type hemangioblastoma in cerebellum. With a review of the literature, the authors present two cases of VHL disease in a family.

        • KCI등재

          악성 뇌교종의 유전자 검사 : 방사선학적 특징과 예후와의 관계

          유재원 ( Jae Won Yu ),김영준 ( Young Zoon Kim ),송영진 ( Young Jin Song ),김대철 ( Dae Cheol Kim ),한진영 ( Jin Yeong Han ),김기욱 ( Ki Uk Kim ) 대한뇌종양학회 대한신경종양학회 2014 Brain Tumor Research and Treatment Vol.2 No.1

          Objectives:Numerous genetic alterations are related to tumorigenesis and influence the radiological features of malignant glial tumor. We performed a cytogenetic analysis from a fresh tumor specimen and analyzed its relationship with radiological features and prognosis. Materials and Methods:Among the 29 patients with malignant glial tumor involved in cytogenetic analysis, 19 cases showing chromosomal abnormality were analyzed. Cytogenetic analysis was performed with pathologically proven fresh surgical specimen. Both medical records and radiological findings were reviewed to define the tumor, to evaluate peritumoral edema and to assess treatment results. Results:The most frequent genetic abnormality was observed in chromosome 7 (57.8 %). Complex karyotype presenting three or more abnormalities was noted in 11 cases (57.8 %). Chromosomal abnormalities, noted in more than three cases, were whole loss of Y (7 cases), whole gain of 7 (6 cases), whole gain of 2, whole gain of 5, whole gain of 12, 19q gain, 6p loss, 9p loss, and whole gain of 13 (3 cases). We reported that loss of chromosome 7 related to MDR-1 (Multidrug resistant gene) were correlated with good response of chemotherapy. Conclusions:A chromosomal analysis of malignant glioma can be perfomed to discover tumorigenic factors and to evaluate radiological features. Results of karyotyping is closely related to the clinical outcome and may be utilized in developing new therapeutic modalities.

        • 증례 : 후두부 양측 천막경유 접근법/대뇌 겸상막경유 접근법을 통한 겸천막수막종 수술 후 발생한 일시적 양측 전맹 - 증례보고 -

          이한일 ( Han Il Lee ),이병훈 ( Byoung Hun Lee ),권정택 ( Jeong Taik Kwon ) 대한뇌종양학회 2012 대한뇌종양학회지 Vol.11 No.2

          Falcotentorial meningiomas are rare. The infratentorial supracerebellar and the occipital transtentorial approaches are frequently used to reach the tumor. A 56-year-old female was admitted to the hospital because of headache. Magnetic resonance imaging (MRI) of her brain showed a 35×38×20 mm-sized tumor, suspected as a meningioma, with heterogeneous signal intensity in the pineal region. The patient was operated using the occipital bi transtentorial/transfalcine approach. The observed tumor was a fibrotic mass with calcification and was not pulled to one side after internal decompression. It was totally removed through the bilateral approach. Immediately after surgery, however, the patient complained of total blindness. Following steroid therapy, the patient showed remarkable improvement. The occipital bi transtentorial/transfalcine approach provides a well-exposed operation field and an optimized visibility of anatomical structures. However, the potential visual cortex injury should be considered due to undue, prolonged retraction.

        • 증례 : 제4뇌실의 수막종 - 증례보고 -

          한정인 ( Jung In Han ),김창현 ( Chang Hyun Kim ),문재곤 ( Jae Gon Moon ),조탁근 ( Tack Geun Cho ) 대한뇌종양학회 2012 대한뇌종양학회지 Vol.11 No.2

          Less than 50 cases of primary fourth ventricular meningioma are reported in literature. Most of them are hypo- to iso-signal intensity on T1-weighted images and iso- to mildly hyper-signal intensity on T2-weighted images compared with gray matter. Contrast enhancement is strong in all tumors, and the enhancement is homogeneous in 69% and heterogeneous in 31%. It could be harder to differentiate meningiomas of the fourth ventricle from ependymomas and choroid plexus papilloma. Most meningiomas in the fourth ventricle adhere to the choroid plexus. We present a new case and summarize features of magnetic resonance images.

        • 임상 : 내시경을 사용한 경비적 경접형동 수술에서의 뇌척수액 유출 예방에 대한 고찰

          박준상 ( Jun Sang Park ),강석구 ( Seok Gu Kang ),홍용길 ( Yong Gil Hong ),전신수 ( Sin Soo Jeun ) 대한뇌종양학회 2012 대한뇌종양학회지 Vol.11 No.2

          Objectives:The endoscopic endonasal transsphenoidal approach (EETSA) is increasingly being used to treat pituitary adenomas and other sellar/suprasellar pathologies. One important complication of the transsphenoidal approach is cerebrospinal fluid (CSF) leakage, which occurs in 0.4 to 9% of cases. We report our experience with EETSA and describe the me-thods that we use to prevent CSF leakage. Methods:A single surgeon performed EETSA on 170 consecutive patients between Feb 2004 and Apr 2011. Patients were divided into three groups based on their CSF leakage status as follows: no CSF leakage, minor CSF leakage, and major CSF leakage. Sellar floor reconstruction was performed according to this classification. In the no-CSF leakage group, sellar floor reconstruction was performed with oxidative cellulose (Surgicel®) only. In the second group (minor CSF leakage), sellar floor reconstruction was performed using autologous fat and bone grafts. Patients in the third group (major CSF leakage) underwent an additional reconstructive procedure of the skull base using the pedicled septal mucosal flap. Results:Of 170 patients, 30 (17.6%) showed CSF leakage in the operation field ; 24 (14.1%) were classified as having minor CSF leakage and 6 (3.5%) patients were classified as having major CSF leakage. Post-operative CSF leakage occurred in only two cases. Conclusion:CSF leakage, though relatively common in the operation field, can be prevented effectively with adequate reconstruction techniques. Assignment of patients to one of three groups based on their CSF leakage in the operation field and sellar floor reconstruction based on this classification resulted in favorable postoperative outcomes.

        • 임상 : 경접형동 접근에 의한 뇌하수체 선종 제거술 후 발생한 지연성 저나트륨혈증 : 임상 연구

          김정재 ( Jung Jae Kim ),김선호 ( Sun Ho Kim ),김의현 ( Eui Hyun Kim ) 대한뇌종양학회 2012 대한뇌종양학회지 Vol.11 No.2

          Objective:Delayed hyponatremia is a common complication after transsphenoidal surgery (TSS) for pituitary adenomas. We retrospectively evaluated our patients and tried to find possible associated risk factors of delayed hyponatremia. Methods:From 2006 until 2010, total 575 cases of pituitary adenomas were operated with TSS in a single institution. Thirty-one patients (5.3%) with delayed hyponatremia were compared to other 544 patients without delayed hyponatremia in the aspects of age, sex, Hardy classification, tumor size, hormonal type and activity on preoperative combined pituitary function test. Their postoperative outcomes were also evaluated in the aspects of tumor removal fashion and hormonal outcome on postoperative combined pituitary function test. Results:In 31 patients, delayed hyponatremia started 7.0 days after surgery (range : postoperative day 3-10). At the time of diagnosis of hyponatremia, serum level of sodium ranged from 111 mmol/L to 132 mmol/L (mean : 120.5 mmol/L) and mean duration of treatment was 4.l days (range : 2-9 days). Piecemeal tumor removal was more frequent in a group with delayed hyponatremia (p=0.035). The presence of postoperative hypopituitarism and aggravation of pituitary function were observed more frequently in a group with delayed hyponatremia (p=0.002 and p=0.017, respectively). Conclusion:Delayed hyponatremia is a common complication after TSS and potentially fatal. Piecemeal fashioned tumor removal, postoperative hypopituitarism and aggravation of pituitary function are associated with higher chance of delayed hyponatremia.

        • 임상 : 측뇌실 삼각에 발생한 뇌실내 수막종에 있어 상부 두정-후두 피질경유 접근법의 임상 결과 ; 24례 보고

          박세환 ( Se Hwan Park ),조진모 ( Jin Mo Cho ),김의현 ( Eui Hyun Kim ),김선호 ( Sun Ho Kim ),이규성 ( Kyu Sung Lee ),장종희 ( Jong Hee Chang ) 대한뇌종양학회 2012 대한뇌종양학회지 Vol.11 No.2

          Introduction:Intraventricular meningiomas are uncommon subtype of intracranial meningiomas. Trigonal meningiomas consist of the majority of intraventricular meningiomas. The superior parieto-occipital transcortical approach is the most popular approach for removal of them. We analyzed our experience in removal of the trigonal meningiomas that were resected using the superior parieto-occipital transcortical approach. Patients and Methods:Twenty-four patients underwent surgical removal of trigonal meningioma from 1997 to May 2012. Demographics, clinical features, surgical outcomes, histopathologic results and prognosis were analyzed. Results:Study population had a mean age of 51.2 years and a female preponderance of 1 : 1.7. The most common presenting symptom was chronic headache, which was followed by memory impairment, visual disturbance and hemiparesis. Total removal of the tumor was achieved in all cases. Twenty-two (91.7%) tumors were World Health Organization (WHO) grade I while two cases were WHO grade III. There were two cases of intracerebral hemorrhage in the surgical corridor, one case of transient contralateral hemiparesis with cognitive decline, one case of transient contralateral homonymous hemianopsia, one case of aggravation of visual field defect, and one case of hydrocephalus which was successfully treated by ventriculo-peritoneal shunt. Conclusion:The superior parieto-occipital approach is suitable for most of the trigonal meningiomas and total removal of them can be achieved safely.

        • 임상 : 악성 뇌교종의 유전자 검사 : 방사선학적 특징과 예후와의 관계

          유재원 ( Jae Won Yu ),김영준 ( Young Zoon Kim ),송영진 ( Young Jin Song ),김대철 ( Dae Cheol Kim ),한진영 ( Jin Yeong Han ),김기욱 ( Ki Uk Kim ) 대한뇌종양학회 2012 대한뇌종양학회지 Vol.11 No.2

          Objectives:Numerous genetic alterations are related to tumorigenesis and influence the radiological features of malignant glial tumor. We performed a cytogenetic analysis from a fresh tumor specimen and analyzed its relationship with radiological features and prognosis. Materials and Methods:Among the 29 patients with malignant glial tumor involved in cytogenetic analysis, 19 cases showing chromosomal abnormality were analyzed. Cytogenetic analysis was performed with pathologically proven fresh surgical specimen. Both medical records and radiological findings were reviewed to define the tumor, to evaluate peritumoral edema and to assess treatment results. Results:The most frequent genetic abnormality was observed in chromosome 7 (57.8 %). Complex karyotype presenting three or more abnormalities was noted in 11 cases (57.8 %). Chromosomal abnormalities, noted in more than three cases, were whole loss of Y (7 cases), whole gain of 7 (6 cases), whole gain of 2, whole gain of 5, whole gain of 12, 19q gain, 6p loss, 9p loss, and whole gain of 13 (3 cases). We reported that loss of chromosome 7 related to MDR-1 (Multidrug resistant gene) were correlated with good response of chemotherapy. Conclusions:A chromosomal analysis of malignant glioma can be perfomed to discover tumorigenic factors and to evaluate radiological features. Results of karyotyping is closely related to the clinical outcome and may be utilized in developing new therapeutic modalities.

        • 임상 : Leksell Gamma Knife Perfexion과 Model C의 치료계획 효용성 비교 : 임상연구

          김정재 ( Jung Jae Kim ),김기홍 ( Gi Hong Kim ),박용구 ( Yong Gou Park ),장종희 ( Jong Hee Chang ) 대한뇌종양학회 2012 대한뇌종양학회지 Vol.11 No.2

          Objective:The purpose of this study was to compare the dose planning between the Leksell Gamma Knife Perfexion (LGK PFX) and the Leksell Gamma Knife C (LGK C) using variable indices. Methods:A total of 100 cases, which were composed of 35 meningiomas, 20 vestibular schwannomas, 35 metastases, and 10 pituitary adenomas, were enrolled in this study. First, these cases were treated with the LGK PFX and then, were re-planned with the LGK C. We compared these two models in terms of the number of shots, the percentage of coverage, the conformity index (CI), Paddick’s conformity index (PCI), the gradient index (GI), and the beam on time. Results:The LGK PFX completely outperformed the LGK C in terms of GI and the LGK PFX tended to have a longer beam on time than that of the LGK C. However, in patients with schwannomas, the LGK PFX outperformed the LGK C in terms of the CI, PCI, and GI, and in patients with pituitary adenomas, the LGK PFX outperformed the LGK C in terms of the percentage of coverage, PCI, and GI with statistical significance. Conclusion:The LGK PFX is an entirely redesigned radiosurgery unit accompanied by the development of software. The LGK PFX is supposed to achieve highly conformal dose prescription consisting of many isocenters with a reasonable treatment time.

        • KCI등재

          재발성 뇌수막종의 진행적 악성 형질 변환 : 증례 보고

          이원석 ( Won Seok Lee ),곽호신 ( Ho Shin Gwak ),홍은경 ( Eun Kyeong Hong ),유헌 ( Heon Yoo ) 대한뇌종양학회 대한신경종양학회 2014 Brain Tumor Research and Treatment Vol.2 No.1

          We report a case of 39 year old man with stepwise malignant progression from benign to anaplastic meningioma with a transition of atypical meningioma. He received the 1st time craniotomy 5 years ago for parasagittal meningioma and the histopathological diagnosis was benign meningioma of WHO grade 1. Radiation was given to residual tumor at 54 Gy/27 fractions. Four years after the craniotomy, the tumor recurred. Second craniotomy was done and the biopsy was atypical meningioma of WHO grade 2. Residual tumor in the superior sagittal sinus regrew one year later and the third craniotomy was done with excision of involved superior sagittal sinus. The pathological diagnosis was still atypical meningioma, then. Three months after the 3rd craniotomy, the tumor recurred on both parasagittal area and remote cortical surface. The 4th craniotomy was done and the biopsy was turned out to be anaplastic meningioma of WHO grade 3. Adjuvant chemotherapy was given one month after, and the tumor showed mixed response of partial remission and new lesion. The 5th craniotomy was done for both residual tumor and bone flap infection and adjuvant chemotherapy was given again. Five months later, stereotactic radiosurgery was performed for residual enhancing lesion, which was in stable state. With this case, we`d like to discuss about possible genetic alterations associated with the malignant transformation of meningioma, and what can be effective therapy for such residual or recurrent meningiomas.

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