역류성식도염 유발 흰쥐에 대한 이진탕가미방(二陳湯加味方)의 효과

김희준,임소연,곽민아,김대준,변준석,Kim, Hee-Jun,Lim, So-Yeon,Kwak, Min-A,Kim, Dae-Jun,Byun, Joon-Seok 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.1

Purpose : The object of this study was to observe the suppressive effects of Yijintang-gamibang (YJGMB), Yijintang with Atractylodis Rhizoma, Massa Medicata Fermentata, Hordei Fructus Germiniatus, and Coptidis Rhizoma. YJGMB has been traditionally used in Korean medicine for treating various digestive diseases. We tested it on the rat reflux esophagitis (RE) induced by pylorus and forestomach ligation in rats as compared with omeprazole, a well-known proton pump inhibitor. Method : Three different dosages of YJGMB 200, 100 and 50mg/kg, were orally pretreated once a day for 28 days before pylorus and forestomach ligation. Seven groups, each of 8 rats per group were used in the study. Six hours after pylorus and forestomach ligation, changes of the stomach and esophagus lesion areas, gastric volumes, acid and pepsin outputs, invasive lesion percentages, fundic mucosa and total thicknesses were measured as histomorphometry. The results were compared with omeprazole, antioxidant and proton pump inhibitor, and 30 and 10mg/kg treated groups in which the effects on RE were already confirmed. Results : As results of pylorus and forestomach ligation, marked increases of esophageal and gastric mucosa lesion areas, gastric volumes, acid outputs, pepsin outputs were observed with histopathological changes of RE, such as hemorrhages, ulcerative lesions and edematous changes on the fundic mucosa. However, these pylorus and forestomach ligation-induced RE were dose-dependently inhibited by treatment of 200, 100 and 50mg/kg of YJGMB. YJGMB 200mg/kg showed similar protective effects as compared with 30mg/kg of omeprazole in the present study, and more favorable effects were observed in 50mg/kg of YJGMB treated rats as compared with omeprazole 10mg/kg in the present study. Conclusion : The results obtained in this study suggest that YJGMB has favorable protective effects on the RE induced by pylorus and forestomach ligation. Therefore, it is expected that YJGMB will also show favorable effects on RE corresponding well to the suggestion of traditional Korean medicine. However, more detailed mechanism studies should be conducted in future with the screening of the biological active chemical compounds in herbs.

건설기업의 주식가격과 경영성과와의 상관관계 분석

김희준,김명선,김재준,Kim Hee-Joon,Kim Myung-Sun,Kim Jae-Jun 한국건설관리학회 2003 건설관리 : 한국건설관리학회 학회지 Vol.4 No.3

현대 건설 산업의 경쟁적인 사업 환경으로 인해 건설기업의 도산 가능성은 더욱 높아졌다. 이에 따라 성장위주의 경영에서 가치 중시 또는 수익 중심의 질적인 경영 환경으로의 전환이 요구된다. 현재 건설기업의 자본 조달은 대부분 금융기관을 통해 이루어지고 있다. 기업 규모의 성장에 따라 증권시장을 통한 자금조달의 형식을 갖추고 있지만, 기업 공개를 통한 정당한 수익성 배분이 이루어지지 못하고 있다. 특히 건설기업들은 기업 투명성에 대한 의식의 결여로 투자자들의 신뢰를 잃었고, 그로 인해 다시 주식시장을 통한 자금 조달에 실효성을 갖지 못하는 악순환이 계속되고 있다. 본 연구에서는 건설기업의 경영실태 파악을 위해 주식가격과 기업의 재무적 요인간의 상관성을 분석하였다. 이를 통해 상장건설기업의 주식가격과 기업경영성과 사이의 상관관계를 알아보고자 하였다. 또한 증권시장을 통한 기업 필요자본 조달의 필요성에 대하여 언급하고자 하였다. The bankruptcy possibility of construction firms have been higher by the environment of current construction industry. Thus, converting management environment for growth into that for value or profit is required. Nowadays, funds of construction firms is almost provided by financial institutions. As the firms' size grow, they have a form of fund provision through the securities market; however, fair distribution for returns is not practiced by opening company. Especially, construction firms lost trust of Investor by lack of awareness to firm clearness, and then a vicious cycle of no effectiveness in fund provision through securities market is continued again. On this study correlation between stock quotations and primary financial factors of firms in order to grasp actual management condition in construction firms was analyzed. By this, the correlation between stock quotations and the result of firm management was provided. Also, necessity of firm's capital provision was explained, thus ways to ensure firm clearness was searched.

승강압형 DC - DC 콘버어터에 있어서 제어회로의 보상에 관한 연구

김희준,이인환,Kim, Hee-Jun,Lee, In-Hwan 대한전자공학회 1990 전자공학회논문지 Vol. No.

본 논문에서는 스위칭 레귤레이터의 한 형태인 승강압형 DC-DC 콘버어터에 있어서 전달함수의 우반면에 존재하는 영점이 안정성에 대하여 미치는 영향을 고찰하였고, 출력전류의 변화에 대한 안정범위를 궤한이득을 통하여 구하였다. 이 결과로부터, 우반면에 영점이 존재하기 때문에 안정성이 저하됨을 알 수 있었다. 궤한제어회로에 극 보상을 하였고, 이경우 유효한 안정성의 범위를 이득대역폭적과 관련지어 구하였으며 실험을 통하여 이를 입증하였다. This paper investigated the effect of the zero on the right-half-plane on stability in the buck-boost DC-DC converter which is one type of the switching regulator, and the stability region in connection with the output current was shown by evaluating the feed-back gain. From the result it is shown that the stability decreases by the existence of the zero on the right-half-plane. We carried out a compensation by a pole in the feedback circuit and obtained the available stability region in relation to the gain band-width product. These results proved to be the validity by experiment.

간헐포기 소화 슬러지의 고분자 응집제에 의한 개량과 입도 분포 변화에 관한 연구

김희준,김성홍,최재성,Kim, Hee-Jun,Kim, Seong-Hong,Choi, Jae-Seong 한국환경보건학회 2004 한국환경보건학회지 Vol.30 No.3

Synthetic organic polyelectrolytes can be used to condition sludges to enhance their dewaterability. Intermittent aerobic digestion is an useful digestion technology and has many advantages like neutral pH, low installation cost and easiness to operation. The objectives of this study were to investigate the dewaterability of intemittent aerobic digestion sludge and to find the relationship between dewaterability and particle size distribution change under the conditioning of intermittent aerobic digestion sludge by cationic polyelectrolyte. Digested sludge from intermittent aerobic digestion was used and cationic polyacrylamide polymer was added as a conditioner. CST(capillary suction time), TTF(time-to-filtration) were tested as a dewaterability index and the number of particle distribution was analyzed using particle size analyzer. The results indicate that cationic polyelectrolytes is useful to enhance dewaterability of intermittent aerobic digestion sludge. Mean particle diameter was increased as polymer dosage increased and its value was reached up to 100 mm on the condition of optimal cationic polymer dosage. CST and TTF are well correlated with mean particle diameter when the weighting order is 1.7. By the optimal conditioning with cationic polymer, particles in the filtrate are also reduced significantly and this means that conditioning is helpful to main stream by reducing SS loading from return flow.

인도의 통상환경과 상관습에 대한 소고

김희준(Hee-Jun, Kim) 한국통상정보학회 2006 통상정보연구 Vol.8 No.3

The purpose of this study is to analyze trade environment and examine a commercial practices for a successful launching of Indian market In general, Indian trade environment is composed of a natural environment, religious peculiarity, history and politic and economic prospect. In order to understand Indian commercial practices and secure business achievements, its national character, mode of living, customs related to foods and social relations such as exchange of gifts, religious taboos, tendency of product preference should be recognized. The results of the study indicate mostly that even though an excellent brand image, a good quality and an efficient sales network are a basic factor for making of a successful business, practically it is more important to understand a business customs and national character of indian people. Because business is accomplished through relationship between human beings eventually.

MOSFET 동기정류를 이용한 저전압 능동 클램프 Forward 컨버터에 관한 연구

김희준(Hee Jun Kim),지호균(Ho Kyun Ji) 대한전기학회 1993 대한전기학회 학술대회 논문집 Vol.1993 No.11

GaN 소자의 AC특성 측정회로 연구

김희준(Hee-Jun Kim),정경훈(Kyung-Hoon Jung) 대한전기학회 2012 대한전기학회 학술대회 논문집 Vol.2012 No.11

본 논문에서는 GaN 소자의 AC특성 측정회로 연구에 대해 논하였다. GaN 소자는 공정상 Normallyon과 Normally-off 두 가지 소자로 구분된다. Normally-on 소자는 Negative Vgs(th)를 가지며 Normally-off 소자는 positive Vgs(th)를 가진다. 따라서 두 종류의 소자를 스위칭 하기 위한 Gate 구동 회로는 서로 다르게 구성되어야 한다. 본 논문에서는 Normally-off 소자를 위한 드라이브 IC 로 두 종류의 소자가 모두 스위칭이 되는 것을 확인하였다. 또한 일반적인 스위칭 테스트 회로에서는 RDS(on) 측정 시에 부하저항의 용량에 따른 문제가 발생하기 때문에 저항이 없는 스위칭 테스트 회로를 고안하고 제작함으로써 고전압에서도 저항 용량의 문제없이 RDS(on)측정이 가능하다는 것을 입증하였다.

청목폐(제품명)의 면역 증진 효과

김희준 ( Hee-jun Kim ),김보혜 ( Bohye Kim ),이미라 ( Mi-ra Lee ),선병국 ( Byung-kook Sun ),김왕권 ( Wang-kwon Kim ),정봉환 ( Bong-hwan Chung ),라문진 ( Moonjin Ra ),이용준 ( Yongjun Lee ) 강원대학교 농업생명과학연구원 2022 강원 농업생명환경연구 Vol.34 No.1

슬러지처리 : 수리동력학적 캐비테이션을 이용한 슬러지의 가용화

김희준 ( Hee Jun Kim ),이은영 ( Eun Young Lee ),허안희 ( An Hee Hur ),배재호 ( Jae Ho Bae ),( D. X. Nguyen ) 대한상하수도학회 2006 공동추계 학술발표회 논문집 Vol.2006 No.-

상피세포성장인자를 함유한 동결건조-재분산 리포좀의 입도분포 및 봉입률

김희준(Hee Jun Kim),유성운(Sung Un Yu),최영욱(Young Wook Choi) 대한약학회 1996 약학회지 Vol.40 No.6

Epidermal Growth Factor (EGF), discovered by Stanley Cohen in 1960, has a potential healing effect for wounds and bums. Considering wound care, in order to avoid physical stress at the wound surface and efficiently apply EGF, the need for viscous spraying solutions was essential. Viscous spraying solutions containing EGF were prepared by utilizing viscosity-building polymer, poloxamer 407, and by introducing liposome systems. On the other hand, EGF is purified on reverse HPLC gradient program with the mobile solvent of acetonitrile. It is necessary to observe liposomal EGF changes as the acetonitrile contents varied in order to introduce liposome systems at the step of EGF solution (at the time of EGF purifying). By evaluating the size distribution and entrapment efficiency of EGF liposome, it was possible to detemine the limit contents of acetonitrile and establish the optimal conditions for solution formulations. It has been revealed that, as the acetonitrile content increases, mean diameter of EGF liposomes increased and the width of size distribution tends to decrease. The limit contents of acetonitrile were 10%, since there was little difference to the acetonitrile free liposomes.