위식도접합부선암의 임상병리학적 특성

김한수,정오,박영규,김동의,류성엽,김영진,Kim, Han-Su,Jeong, Oh,Park, Young-Kyu,Kim, Dong-Yi,Ryu, Seong-Yeop,Kim, Young-Jin 대한위암학회 2008 대한위암학회지 Vol.8 No.4

목적: 위식도접합부선암의 임상병리학적 특성은 서구와 아시아 간의 많은 차이를 보인다고 알려져 있다. 그러나, 한국의 경우 위식도접합부선암의 유병율이 매우 낮고 이에 대한 연구 또한 부족하다. 따라서 저자들은 우식도접합부선암의 Siewert 분류에 따른 임상병리학적 특성을 조사하여 서구와 다른 국내 위식도접합부선암의 특성을 연구하고자 하였다. 대상 및 방법: 2004년 5월부터 2008년 2월까지 본원에서 위암으로 수술을 시행 받은 환자들을 대상으로 수술소견 및 병리 사진을 토대로 Siewert 분류법에 따라 위식도접합부선암을 분류하고, 의무기록을 바탕으로 환자들의 임상병리학적 특성들을 조사하였다. 결과: 위식도접합부선암은 전체 1,778예 중 70예(3.9%)였다. Siewert 1형은 3예(4.3%)로 매우 드물었으며, 2형과 3형이 각각 30예(42.8%) 37예(52.8%)였다. 2형이 3형에 비하여 평균연령이 높았으나(64세 vs 59세, P=0.049), 남녀비에는 차이가 없었다. 2형과 3형간에 Barrett 식도의 발현 정도나 Lauren 분류의 차이는 없었으나, 저분화암의 빈도는 3형에서 유의하게 높았다(P=0.045). 68예(97.1%)에서 근치적 절제가 시행되었으며, 각 아형간에 TNM 병기의 차이는 없었다. 결론: 국내의 위식도접합부선암은 매우 드물며 특히 1형의 유병율이 매우 낮다. 본 연구에서 서구의 보고와 부분적으로 일치하지 않는 병리학적 특성을 보였다. 향후 보다 많은 환자들을 대상으로 한국인의 위식도접합부선암의 특성을 연구할 필요가 있다. Purpose: Siewert's classification of adenocarcinoma of the esophagogastric junction (AEG) has been widely adopted, but there is a wide discrepancy of the clinicopathological features of AEG of the Asian patients as compared to that of the Western patients. The aim of this study was to investigate the clinicopathological characteristics of AEG according to the Siewert classification. Materials and Methods: Among the patients who underwent surgery for gastric carcinoma in our institution between May 2004 and February 2008, the AEG patients were selected based on their operation records and the photographs according to Siewert's classification. Results: There were 70 AEG patients (3.9%) among the total of 1,778 patients. There were 3 patients (4.3%) with type I, 30 patients (42.8%) with type II and 37 patients (52.8%) with type III. Curative resection (R0) was achieved in 68 cases (97.1%). No significant differences in gender, stage, Barrett's esophagus and the proximal margin were found between the patients with type II and type III AEG. The patients with type III were younger than the patients with type II (59 vs 64 years, respectively, P=0.049). Well differentiated histology (P=0.045) and the intestinal type (P=0.055) were significantly more frequent in the patients with type II as compared with that in the patients with type III. Conclusion: There was a striking difference of the Asian patients from the Western patients for the incidence of AEG (and especially type I). Some of the differences between type II and type III patients were similar to those of the previous Western studies. A large study is needed to investigate whether these features are typical in the Korean population.

피부화상에 의한 피부 및 간의 조직학적 변화에 관한 연구

김한수,김상수,김용권,Kim, Han-Soo,Kim, Sang-Soo,Kim, Yong-Kwon 대한물리치료과학회 2001 대한물리치료과학회지 Vol.8 No.1

In order to investigate a pathogenesis of liver damage induced by skin burn, thermal injury was induced by scald burn on entirely dorsal surface in rats (total body surface area 30%) except for inhalated injury. At 5 and 24 h after scald bum, biochemical assay and morphological changes in skin tissue, serum and liver tissue were examined. The effects of bum injury on the levels of glutathione, lipid peroxide and on the activities of oxygen free radical generating and scavenging enzymes have been determined in association with observing of histologic and ultrastructural changes, measuring the protein concentration in plasma, and counting the number of intravascular polymorphonuclear leukocytes. The activity of xanthine oxidase, an enzyme of oxygen free radical generating system. was elevated (p<0.01) in serum, but not in skin and in liver tissue. Futhermore, thermal injury decreased not only the protein concentration in plasma but also the number of leukocytes, that indicates induction of edema formation with protein exudation and inflammation by neutrophil infiltration into the internal organs. These data suggest that acute dermal scald burn injury leads to liver damage, that is related to elevation of xanthine oxidase activity in serum. Xanthine oxidase may be a key role in the pathogenesis of liver damage induced by skin burn.

몰로키아 분말을 첨가한 밀·보리 혼합 식빵의 제조 및 생리활성 평가

김한수,김영호,김애정,Kim, Han soo,Kim, Young Ho,Kim, Ae Jung 한국식품영양학회 2015 韓國食品營養學會誌 Vol.28 No.4

This study was performed to produce WBM (wheat and barley mixture) bread containing molokhia powder with quality characteristics and antioxidant activities. Analysis of the chromaticity of WBM prepared with molokhia powder showed that; the lightness and redness were decreased, but yellowness was increased. In mechanical properties, hardness, gumminess, and chewiness were significantly increased as the amount of molokhia powder was increased. However, cohesiveness was significantly decreased. In sensory evaluation, WBM bread containing 1.5% of molokhia powder (MB1.5) showed an overall high preference level. The total polyphenol content of molokhia powder EtOH extract and MB1.5 were 29.19 and 58.18 mg TAE/g, respectively. The total flavonoid contents of molokhia powder EtOH extract and MB1.5 were 20.62 mg and 33.25 mg RE/g, respectively. The radical scavenging ability ($IC_{50}$) of DPPH ($IC_{50}$) for molokhia powder EtOH extract and MB1.5 was 31.04 and $58.18{\mu}g/mL$, respectively while that of ABTS was 33.25 and $54.15{\mu}g/mL$, respectively. The ${\alpha}-glucosidase$ inhibitory effects of molokhia powder EtOH extract and MB1.5 were 494.88 and $814.88{\mu}g/mL$, respectively. MB bread containing 1.5% molokhia powder showed antioxidative effects and ${\alpha}-glucosidase$ inhibitory activity, meaning that not only molokhia but also MB1.5 bread has the potential to prevent chronic degenerative diseases such as diabetes.

기능성 음성 장애 치료의 고려사항

김한수,Kim, Han Su 대한후두음성언어의학회 2014 대한후두음성언어의학회지 Vol.25 No.2

Functional dysphonia (FD) is a voice disorder in the absence of structural or neurologic laryngeal pathology. FD is not a single disease but a disease entity. Therefore several voice disorders, which have completely different pathogenesis, are included in this category. The first step of treatment of FD is differentiating patient's voice symptoms from other organic voice disorders and other functional voice problems. Several different treatment modalities are included in the managements of FD. Voice therapy is in charge of the main role in treatment of FD. Medical treatment is also necessary when patient has general problems which would affect voice production. Vocal folds mucosal lesions can cause FD even the lesion is minor. In this case proper surgical intervention helps to improve the symptom of FD. Psychiatric consultation should be considered when the patient has psychological problems.

단면의 형상에 따른 철근콘크리트 기둥의 폭발저항 성능 평가

김한수,박재표,Kim, Han-Soo,Park, Jae-Pyo 한국전산구조공학회 2010 전산구조공학 Vol.23 No.4

현재 연쇄붕괴를 방지하기 위한 설계 방법으로 기둥제거 시나리오를 이용한 대체하중경로법을 주로 적용하고 있다. 하지만 실제로 폭발이 발생하여 기둥이 완전히 제거되지 않는 경우에 기둥제거 시나리오를 적용하면 보수적인 결과를 얻게 된다. 본 논문에서는 단일 기둥이 폭발하중을 받을 때의 거동을 평가함으로써 폭발이후에도 기둥이 연쇄붕괴 방지에 기여할 수 있는지 여부를 판단하였다. 하이드로코드인 AUTODYN을 이용하였으며, 같은 단면적과 높이를 갖는 사각형 기둥과 원형 기둥의 폭발저항성능을 비교하였다. 우선 AUTODYN을 이용한 폭발하중 산정 결과를 폭발실험값과 비교한 다음 간단한 폭발 예제를 통해 계산된 폭발압력파가 실제와 유사함을 입증하였다. 단면 형상에 따른 기둥의 폭발저항 성능 해석을 수행한 후 잔류변형을 이용한 평가법을 이용해 원형기둥이 사각형 기둥보다 폭발저항 성능이 더 우수함을 확인하였다. The alternative load path method based on a column removal scenario has been commonly used to protect building structures from being progressively collapsed due to probable blast loading. However, this method yields highly conservative result when the columns still have substantial load resisting capacity after blast. In this study, the behavior of RC columns with rectangular and circular sections under the blast loading was investigated and the remaining capacity of the partially damaged columns was compared. AUTODYN which is a hydrocode for the analysis of the structure on the impact and blast loading was used for this study. The blast loading was verified with the experiment results. The analysis results showed that the circular columns are preferable to the rectangular ones in respect of the blast resistance performance.

단면의 형상에 따른 철근콘크리트 기둥의 폭발저항 성능 평가

김한수,박재표,Kim, Han-Soo,Park, Jae-Pyo 한국전산구조공학회 2010 한국전산구조공학회논문집 Vol.23 No.4

현재 연쇄붕괴를 방지하기 위한 설계 방법으로 기둥제거 시나리오를 이용한 대체하중경로법을 주로 적용하고 있다. 하지만 실제로 폭발이 발생하여 기둥이 완전히 제거되지 않는 경우에 기둥제거 시나리오를 적용하면 보수적인 결과를 얻게 된다. 본 논문에서는 단일 기둥이 폭발하중을 받을 때의 거동을 평가함으로써 폭발이후에도 기둥이 연쇄붕괴 방지에 기여할 수 있는지 여부를 판단하였다. 하이드로코드인 AUTODYN을 이용하였으며, 같은 단면적과 높이를 갖는 사각형 기둥과 원형 기둥의 폭발저항성능을 비교하였다. 우선 AUTODYN을 이용한 폭발하중 산정 결과를 폭발실험값과 비교한 다음 간단한 폭발 예제를 통해 계산된 폭발압력파가 실제와 유사함을 입증하였다. 단면 형상에 따른 기둥의 폭발저항 성능 해석을 수행한 후 잔류변형을 이용한 평가법을 이용해 원형기둥이 사각형 기둥보다 폭발저항 성능이 더 우수함을 확인하였다. The alternative load path method based on a column removal scenario has been commonly used to protect building structures from being progressively collapsed due to probable blast loading. However, this method yields highly conservative result when the columns still have substantial load resisting capacity after blast. In this study, the behavior of RC columns with rectangular and circular sections under the blast loading was investigated and the remaining capacity of the partially damaged columns was compared. AUTODYN which is a hydrocode for the analysis of the structure on the impact and blast loading was used for this study. The blast loading was verified with the experiment results. The analysis results showed that the circular columns are preferable to the rectangular ones in respect of the blast resistance performance.

전산해석을 이용한 CFT 기둥의 폭발저항성능 평가

김한수,박재표,Kim, Han-Soo,Park, Jae-Pyo 대한건축학회 2011 대한건축학회논문집 Vol.27 No.3

In this paper, the blast resisting performance of the CFT columns was compared with that of the typical reinforced concrete columns and the reinforced concrete columns strengthened with steel jacket. AUTODYN which is a specialized hydrocode for the analysis of explosion and impact was used to simulate the structural behavior of the columns under the blast loading. The interaction between concrete and surrounding steel plates was modeled with two modeling methods, friction option and join option. The results from the frictional experiment were adopted to determine the friction coefficient in friction option. The CFT columns which have a similar P-M diagram with a reinforced concrete column were also investigated to compare the blast resisting performance and the static load resisting performance. According to the analysis results, the CFT column and the column with steel jacket showed much better blast resisting performance than the normal reinforced concrete column.

Pb(Z$n_{1/3}$N$b_{2/3}$)$O_3$-Pb(N$i_{1/3}$N$b_{2/3}$)$O_3$-PZT와 PLZT를 경사조성으로 하는 경사기능 압전엑튜에이터의 제조와 물성

김한수,최승철,최진호,Kim, Han-Su,Choe, Seung-Cheol,Choy, Jin-Ho 한국재료학회 1993 한국재료학회지 Vol.3 No.3

4.5 Pb($Zn_{1/3}Nb_{2/3})O_3-40.5Pb(Ni_{1/3}Nb_{2/3})O_3$-55PZT와 PLZT(10/70/30, 11/60/40)를 경사조성으로 하여 경사기능 재료를 제조하였으며, 그 유전 특성과 압전 변형율 특성을 조사하였다. 경사기능재료는 A/B/A의 세층으로 성형하고 소결한 후 한 층을 연마해내어 제작하였다. 닥터블레이드용 슬립에는 acrylic계 유기 결합제가 34-36wt% 혼합되었으며, 건조 후 균열이 없는 양호한 thick film을 제조하였다. $1250^{\circ}C$, 2시간의 소성에 의해 경사기능화된 시편은 Nb와 La등의 조성 차이에 의한 구배를 이루었으며, 구배영역은 약 30${\mu}$m 정도였다. 경사기능재료에서 유전상수나 큐리온도롸 같은 유전특성은 조합한 조성층의 특성들사이의 값을 나타내었다. 인가 전압에 따른 변형율 특성은 단일 조성의 시편보다 현저하게 증가하였다. 실제로 경사기능 압전엑튜에이터를 제조한 결과 약 3${\mu}$m/100V 정도의 변위향을 나타내었다. Functionally Gradient Materials(FGM) of 4.5Pb($Ni_{1/3}Nb_{2/3})O_3$-55PZT and PLZT(lO/70 /30, 11/60/40) were prepared. Its dielectric and piezoelectric strain properties were investigated. The FGM were pressed into A/B/ A configuration using two kinds of films, one layer(A) was eliminated from FGM by polishing after sintering at $l250^{\circ}C$, 2 hrs. The acrylic binder system was successfully applied for crack free film through doctor blade method. The thickness of gradent layer in FGM was about 30${\mu}$m. Dielectric properties of FGM show the average value of each side layer. The strain-electric field characteristics of FGM were significantly improved comparison with the other single compositions. The prepared FGM piezoelectric actuator shows about 3${\mu}$m/IOOV displacement.

다운제품의 선택과 취급

김한수,Kim, Han-Su 기술표준원 2005 기술표준 Vol.37 No.-

한국과 일본의 도시에 있어서 단위인구당의 시설수에 관하여

김한수,Kim, Han-Su 한국과학기술단체총연합회 1987 과학과 기술 Vol.20 No.8