국립암센터에서 치료한 설암 환자의 생존율 분석을 통한 예후인자 분석

김태운,조세형,민승기,이종호,김명진,박주용,최성원,Kim, Tae-Woon,Jo, Sae-Hyung,Min, Seung-Ki,Lee, Jong-Ho,Kim, Myung-Jin,Park, Joo-Yong,Choi, Sung-Weon 대한악안면성형재건외과학회 2010 Maxillofacial Plastic Reconstructive Surgery Vol.32 No.6

Purpose: The objective of this study is to evaluate the survival rate and influencing factors. Patients and Methods: We studied 104 patients who were diagnosed for squamous cell carcinoma of tongue and received curative treatment in oral oncology clinic of National Cancer Center from June 2001 to December 2009. Results: We found the following results. 1. The overall 5-year survival rate of tongue cancer was 67.0% and there was no significant statistical difference between male and female. 2. A lower survival rate was shown in patients under 40 years (42.2%) than over 40 years (75.5%)(P < 0.05). 3. 5-year survival rates of patients with tongue cancer classified by pTNM classification were 87.4% in early stage and 43.3% (P < 0.05). 4. A higher survival rate was seen in patients without cervical lymph node metastasis (82.0% > 44.1%)(P < 0.05). 5. A higher survival rate was seen in patients of tongue cancer with higher differenciation grade (P < 0.05). 6. It is well known that drinking and smoking have great influence on the survival rate of patients of squamous cell carcinoma of tongue. But these was no statistical significance. Conclusion: The overall 5-year survival rate of tongue cancer was 67.0% and it was mostly influenced by factors like age, pTNM stage, cervical lymph node metastasis, differentiation of cancer cell etc.

양측 협부 근점막 피판을 이용한 2차성 연구개 비인강 폐쇄 부전의 치료: 증례보고

김태운,최진영,Kim, Tae-Woon,Choi, Jin-Young 대한악안면성형재건외과학회 2010 Maxillofacial Plastic Reconstructive Surgery Vol.32 No.5

Velopharyngeal insufficiency is defined as a status in which nasal cavity and oral cavity can not be sepa-rated when speaking, swallowing by any reason. It has been treated by palatorrhaphy, pharyn-geal flap, local flap, free flap etc. When the size of the defect is small, it can be restored by palatorrhaphy, pharyngeal flap etc. But they are not proper for treatment of the large size of defect. In that case, local flap and free flap are more beneficial. Although large defect can be restored by free flap technique, but it is very complex, time-consuming and may bring about esthetical, functional complications of donor site. Buccinator myomucosal flap is a kind of local flap and reported for the first time by Bozola et al in 1989 and it has become a useful way for reconstruction of large intraoral defect. Authors experienced the use of buccinators myomucosal flap for treating secondary velopharyngeal insufficiency with large soft palate defect and obtained good result. So we report the case with literature reviews.

오패산(烏貝散)과 보두(寶豆)의 병용투여(倂用投與)가 위장관(胃腸管)에 미치는 영향(影響)

김태운,조종관,Kim, Tae-Woon,Cho, Chong-Kwan 대한한방내과학회 1994 대한한방내과학회지 Vol.15 No.2

In order to investigate the effect of BODUOPAE-SAN(BOS), experiments were performed on analgesic effect induced by acetic acid, duration of hypnosis induced by pentobarbital-Na in mice and gastric ucler in Shay rats and indomethacin induced gastric ulcer, HCI-ethanol induced gastrci lesion in rats and gastric juice secretion in Shay rats. The results are as followings. 1. BOS showed significantly an analgesic effect induced by acetic acid. 2. BOS prolonged the duration of hypnosis induced by pentobarbital-Na in rats 3. BOS rised the spontaneous motility of isolatied ileum of mice temporarily. 4. BOS depressed the gastric motility of rats significantly. 5. BOS showed an anti-ulcer effect in Shay rats and indometacine-induced ulcer rats significantly. 6. BOS reduced the ulcer index of the HCl-ethanol induced gastric lesion in rats. 7. BOS reduced the gastric juice secretion in Shay rats. From above results think BOS is more effective in comparison to the OPAESAN alone on gastrointestinal disorder.

소적백출산(消積白朮散)이 Bleomycin의 부작용감소(副作用減少)와 항암효과(抗癌效果)에 미치는 영향(影響)

김태운,손창규,조종관,Kim, Tae-Woon,Son, Chang-Kyu,Cho, Chong-Kwan 대한암한의학회 1999 大韓癌韓醫學會誌 Vol.5 No.1

l. Sojeokbaekchoolsan compound treatment decreased pulmonary fibrosis induced by Bleomycin. 2. At 1 and 2 days after bleomycin treatment, Sojeokbaekchoolsan compound treatment decreased the number of neutrophils in bronchoalveolar lavage than those of bleomycin alone treatment. 3. Sojeokbaekcoolsan compound treatment increased the Fc receptor mediated rosette activity of alveolar macrophage decreased by bleomycin treatment. 4, At 10 days after bleomycin treatment, Sojeokbaekchoolsan compound treatment decreased the lipid peroxidation of lung tissue than those of bleomycin alone treatment. 5. Anti-tumor activity of Sojeokbaekchoolsan and bleomycin compound group was higher than those of bleomycin alone treated group to ascitic tumor caused by Sarcoma-180 tumor cells.

에이전트를 이용한 글로벌 구매 외주환경의 구축

김태운,김홍배,현재명 ( Tae Woon Kim,Hong Bae Kim,Jae Myung Hyun ) 한국정보시스템학회 1997 정보시스템연구 Vol.6 No.2

The objective of this research is to construct and build a software platform to enable collaboration among enterprise headquarters, product designers, software engineers, manufacturing plants, and suppliers which are located at different remote locations via internet. In specific, agent technology is adopted as a software vehicle to automate demand and supply process in the internet environment. Agents are programs that act on behalf of their human users to perform laborious tasks such as information locating, accessing, filtering, integrating, adapting and resolving inconsistencies. Global competition is forcing the present day industry to produce high quality product more fast and inexpensively. In Korea, most labor-intensive industries have moved to China and other Asian countries for cost reduction. The need for fast information exchange has increased among the remote locations for the cooperation and coordination. In this research, a virtual global purchasing and ordering system will be constructed that distributes production schedule among remote places, acts as a bridge between the headquarters and manufacturing plants, distributes tasks and collates different solutions between demand and supply using agent. The external communication protocol takes HTML format, internal message handling requires SGML for document exchange, and KQML for agent implementation. The expected benefits will be: reduced cost of real-time information exchange, realization of global manufacturing environment, the maximum utilization of internet for the enterprise data exchange.

다중선형 회귀분석을 이용한 고립지역에서의 AADT 추정방안 연구

김태운,오주삼,Kim, Tae-woon,Oh, Ju-sam 대한토목학회 2015 대한토목학회논문집 Vol.35 No.4

This study estimates future AADT using historical AADT and socio-economic factors in isolated area. Multiple linear regression method by socio-economic factors are lower MAPE and higher R-square than using historical AADT. Analysis of socio-economic factors influence AADT in isolated typical areas, varied socio-economic factors influence on AADT. In isolated coastal areas, oil price influence on AADT. AADT forecasting model in isolated area is excellent when analysising $R^2$ and MAPE. It is assume that estimation of AADT in isolated area using multiple linear regression is accurate because of a little passed traffic volume and traffic volume fluctuation.

김일성 사후 북한의 대주변 4강 정책 변화추이에 관한 연구

김태운(Kim Tae-Woon) 부산대학교 한국민족문화연구소 2005 한국민족문화 Vol.25 No.-

This paper has analyzed the policy change trend of North Korea in relation to the surrounding four powers after the death of Kim Il-Sung. Since the death of Kim Il-Sung until the official power succession of Kim Jong-Il, the North Korean policy direction and goal were analyzed to be of no great difference compared with the period of Kim Il-Sung. This seems to derive from an aspect reflecting special attributes of the North Korean system to be consistent of the instructions of the late Kim Il-Sung, The preparation of optimal existence conditions appeared to be more urgent task to maintain the system as well. Since the succession of power, the policy toward those four countries transformed into an active policy direction. Particularly, there is a big difference in that the North Korea wants to receive a system guarantee, along with economic aid and cooperation, from the four surrounding powers. The multiple party talks operated in connection with the North Korean nuclear issue shows such an aspect of North Korea vividly. North Korea is also interested in the mutual cooperation system established with Russia and Japan as well as China in order to avoid the oppression policy of the US toward North Korea. The future policy direction and goal with regard to those four powers are likely to be unfolded focused on more active and practical benefits on the level of system leap, rather than its system protection. In this context, the Pyong- yang regime will focus on getting guarantee of its system, as well as offsetting the pressuring policy of the US toward the North Korea in the short-term. In the mid and long-term, North Korea will concentrate on economic cooperation and attraction of support from those countries aim- ing at system leap. In addition, the North Korea is forecast to promote a gradually balanced policy in relation to the four surrounding powers, amid trying to form a four powers cooperation system with China, Russia and Japan.

감비수 향 흡입이 절식을 유도한 쥐의 시상하부에서 섭식관련 신경전달물질의 발현과 인지력에 미치는 영향

김동현(Dong-Hyun Kim),고일규(Il-Gyu Ko),김성은(Sung-Eun Kim),김지은(Ji-Eun Kim),강연호(Yeon-Ho Kang),김태운(Tae-Woon Kim),지은상(Eun-Sang Ji),김용민(Yong-Min Kim),김이화(Ee-Hwa Kim),김정범(Jeong-Beum Kim),김동희(Dong-Hee Kim),김창주(Cha 대한스트레스학회 2010 스트레스硏究 Vol.18 No.3

본 연구는 절식을 유도한 ICR계 생쥐에서 감비수 향 흡입이 시상하부에서 leptin과 neuropeptide Y (NPY)의 발현에 미치는 영향과 단기 기억력에 미치는 효과를 알아보고자 하였다. ICR 계열 수컷 쥐 24마리를 무작위 추출법에 의해 대조군, 절식군, 절식과 감비수 향 흡입군(각 군 n=8)의 3군으로 분류하였다. 실험결과, 절식은 시상하부에서 leptin의 발현을 감소시켰고 NPY의 발현은 증가시켰다. 또한, 절식에 의하여 단기 기억력과 해마에서의 신경성장인자인 BDNF의 발현이 감소되었다. 반면에, 절식 중 감비수 향을 흡입 시 시상하부에서 leptin의 발현은 증가되었고 NPY의 발현은 감소되었다. 그리고 감비수 향의 흡입에 의하여 단기 기억력이 향상 되었고 해마에서의 신경성장인자인 BDNF의 발현이 증가되었다. 본 실험 결과, 감비수 향 흡입은 절식 시 증가된 음식섭취에 대한 욕구를 억제할 수 있으며 절식에 의하여 감소된 단기 기억력을 향상시키는 효과가 있음을 알 수 있었다. In the present study, we investigated the effects of Gambisu inhalation on the expressions of neurotransmitters implicated in the food intake in the hypothalamus and cognition using starved mice. For this, the effects of Gambisu inhalation on the expressions of leptin and neuropeptide Y (NPY) in the paraventricular nucleus (PVN) of hypothalamus of starved mice were evaluated by immunohistochemistry. Short-term memory of the mice was also assessed using a passive avoidance task and brain-derived neurothrophic factor (BDNF) expression in the hippocampus was determined by Western blot analysis. ICR mice were divided into three groups: control group, starvation group, and starvation with Gambisu inhalation group. The mice in the food-deprivation group were restricted food for 48 h. The mice in the Gambisu inhalation group were exposed to inhale Gambisu for 60 min twice a day for 2 consecutive days. The present results showed that food-deprivation decreased leptin expression and increased NPY expression in the PVN of the hypothalamus. Food-deprivation decreased short-term memory ability and also suppressed BDNF expression in the hippocampus. However, Gambisu inhalation increased leptin expression and decreased NPY expression in the PVN of hypothalamus under the starvation conditions. Gambisu inhalation alleviated starvation-induced short-term memory impairment and enhanced BDNF expression in the hippocampus under the starvation conditions. The present study revealed that Gambisu inhalation might suppress desire for food intake and exert beneficial effect on cognition by enhancing BDNF expression in the hippocampus under the starvation conditions. (Korean J Str Res 2010;18:209∼217)

도시경제발전을 위한 중소기업 네트워킹 정책 활성화의 한계에 대한 연구 -대구광역시의 사례를 중심으로-

김태운 ( Tae Woon Kim ) 한국경제지리학회 2013 한국경제지리학회지 Vol.16 No.3

This research addressed limits to promoting SMEs networking programs, especially with universities, in the context of national and regional policies for urban economic development, centering on the case of Daegu City. In large cities such as Daegu City, the strategy focusing on promoting SMEs networking activities, utilizing the advantages of urban economy, is likely to be necessary for urban economic development in knowledge-based economy. However, national and regional policy direction for urban economic development relied on exogenous strategies attracting firms, and regional S&T policies focused on universities and research institutes rather than SMEs, being strongly initiated by central government. Thus, to promote policies supporting local SMEs networking in Daegu City was seen as being difficult. Under these circumstances, region-specific policies related to support networking activities of SMEs might be dealt with neglectedly.

광역자치단체 과학기술정책의 수요 충족성에 대한 연구 -대구광역시의 사례를 중심으로-

김태운 ( Tae Woon Kim ) 한국정책학회 2013 한국정책학회보 Vol.22 No.3

This research explored trends, types and characteristics of research and development(R&D) policies of an upper level local government and analyzed their need fulfilment by comparing with substantial needs of local firms, focused on the case of Daegu City. According to the results of analysis, there were some gaps between the policies of Daegu City government and the needs of local firms. Although local firms needs diverse R&D programs, the policies focused on several areas such as high-tech and convergence R&D programs of universities, cultivation of R&D human resources, commercialization of R&D outcomes, and the attraction or establishment of research institutes. That is, the diversity of R&D program portfolios were weak, and thus R&D policies seemed to have difficulty in satisfying the needs of divers firms. Accordingly, several measures to improve these conditions are required as follows: the expansion of policy types and areas, the clarification of policy targer groups, the customized support based on firm characteristics, and the expansion of investigation regarding the policy needs of firms.