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김중완,최혜경,손윤희,임종국,이항우,남경수,Kim, Joong-Wan,Choi, Hey-Kyung,Shon, Yun-Hee,Lim, Jong-Kook,Lee, Hang-Woo,Nam, Kyung-Soo 한국생약학회 1999 생약학회지 Vol.30 No.3
Lonicerae flos aqua-acupuncture solution (LFAS) and Lonicerae flos water-extracted solution (LFWS) were prepared and tested for chemopreventive potentials. Three biomarkers [quinone reductase (QR), ornithine decarboxylase (ODC), glutathione(GSH)] were used to test chemopreventive potential of LFAS. LFAS was potent inducer of QR activity in Hepa1c1c7 murine hepatoma cells, whereas LFWS is less potent. LFAS and LFWS were also induced QR activities in cultured human hepatoma Hep3B cells. The effect of LFAS and LFWS were tested on the growth of Acanthamoeba castellanii. Proliferation of Acanthamoeba castellanii was inhibited by LFAS and LFWS at concentrations of $0.1{\times},\;0.5{\times}\;1{\times},\;and\;3{\times}.$ In addition, GSH levels were increased about 2-fold with LFAS and 1.5-fold with LFWS in cultured murine hepa1c1c7 cells. LFAS and LFWS were also shown to increase GSH levels in human Hep3B cells. These results suggest that LFAS has chemopreventive potential by inducing QR activity, inhibition of ODC activity and increasing GSH levels.
한민식(Min-Sik Han),김태호(Tae-Ho Kim),박대균(Dae-Kyun Park),김순경(Soon-Kyung Kim),김중완(Joong-Wan Kim),전언찬(Eon-Chan Jeon) 한국기계가공학회 2007 한국기계가공학회 춘추계학술대회 논문집 Vol.2007 No.-
We produce master patern with the rapid prototyping and to research the process which produces the prototype with vacumm casting in study. In order to select the condition where the shrinkage which appears in each process becomes smallest it used the DOE. We could confirm error value using reverse engineering. After getting the P-value with the method due to the Full Factorial Design and the ANOVA 2-way it will be able to judge the factor which gives an effect to error. It applied the error of each process in the masterpattern and improves the Size Precision of vacuum casting prototype the method which it presented.